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Total 40 results found since Jan 2013.

Scientists use AI to identify likely drug targets in search for Alzheimer ' s cure
Scientists use AI to identify likely drug targets in search for Alzheimer's cure A team led by a University of Arizona College of Medicine – Tucson scientist harnesses artificial intelligence to trace the path from a healthy brain cell to one afflicted by Alzheimer ' s disease. Anna C. Christensen Today College of Medicine – TucsonRui-Chang_khp-web.jpg Rui Chang, an associate professor of neurology, is leading a team at the College of Medicine – Tucson that uses artificial intelligence to trace the molecular path of the development of Alzheimer's disease.HealthCollege of Medicine - TucsonDeterminationE...
Source: The University of Arizona: Health - May 15, 2023 Category: Universities & Medical Training Authors: mittank Source Type: research

Fight Aging! Newsletter, September 12th 2022
Discussion of Present Drug Development to Target Senescent Cells Targeting Senescent Cells to Better Address Cancer and Consequences of Cancer Therapy Calorie Restriction Suppresses Generation of Immune Cells via Changes to the Gut Microbiome Arguing for an Expansion of the Hallmarks of Aging https://www.fightaging.org/archives/2022/09/arguing-for-an-expansion-of-the-hallmarks-of-aging/ The hallmarks of aging form a catalog of largely better studied changes in cells and tissues considered relevant, and possibly more important, in the onset and development of age-related degeneration and disease. This i...
Source: Fight Aging! - September 11, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Towards a unified approach for multiple myeloma care in Kenya - proceedings of the Inaugural Multiple Myeloma Congress
Pan Afr Med J. 2021 Dec 17;40:236. doi: 10.11604/pamj.2021.40.236.30742. eCollection 2021.ABSTRACTThe rising burden of multiple myeloma in Kenya has not been met by a commensurate effort for control. Patients and practitioners struggle with unavailability and unaffordability of diagnostics, drugs and stem cell transplant leading to presentation at advanced stages and under-treatment with increased morbidities and mortality. A concerted effort among stakeholders is urgently needed to develop strategies for myeloma control. The scarcity of providers also carries grave consequences for Kenyan patients. The Academic Model Prov...
Source: Cancer Control - February 18, 2022 Category: Cancer & Oncology Authors: Teresa Cherop Lotodo Beatrice Jepngetich Melly Kelvin Mogesa Manyega Mercy Oduor Valerie Magutu Fredrick Chite Asirwa Riyat Malkit Alfred Karagu Simon Onsongo Caroline Wafula Roselyne Yatich Pravas Chandra Mishra Austin Omondi Diana Flora Namaemba Yvette Source Type: research

Bipartite interaction sites differentially modulate RNA-binding affinity of a protein complex essential for germline stem cell self-renewal
Nucleic Acids Res. 2021 Dec 15:gkab1220. doi: 10.1093/nar/gkab1220. Online ahead of print.ABSTRACTIn C. elegans, PUF proteins promote germline stem cell self-renewal. Their functions hinge on partnerships with two proteins that are redundantly required for stem cell maintenance. Here we focus on understanding how the essential partner protein, LST-1, modulates mRNA regulation by the PUF protein, FBF-2. LST-1 contains two nonidentical sites of interaction with FBF-2, LST-1 A and B. Our crystal structures of complexes of FBF-2, LST-1 A, and RNA visualize how FBF-2 associates with LST-1 A versus LST-1 B. One commonality is th...
Source: Cell Research - December 15, 2021 Category: Cytology Authors: Chen Qiu Robert N Wine Zachary T Campbell Traci M Tanaka Hall Source Type: research

Tetraspanins in cell stemness and cancer initiation: markers or active players?
Trends Cell Biol. 2021 Dec 2:S0962-8924(21)00222-1. doi: 10.1016/j.tcb.2021.10.009. Online ahead of print.ABSTRACTTetraspanins mark stem cells and tumor initiating cells. Recent studies in adipose development, intestinal crypt remodeling, and muscle stem cells shed new light on the contribution of tetraspanins and their associated partners in cell fate determination. These studies reveal that these partnerships actively help guide precursor cell fate.PMID:34865939 | DOI:10.1016/j.tcb.2021.10.009
Source: Trends in Cell Biology - December 6, 2021 Category: Cytology Authors: Felipe Vences-Catalan Shoshana Levy Source Type: research

Data up to 8-years for Roche ’s OCREVUS (ocrelizumab) show early and ongoing treatment significantly reduced risk of requiring a walking aid in relapsing multiple sclerosis and disability progression in primary progressive multiple sclerosis
Basel, 13 October 2021 – Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced new long-term data that reinforce the benefit of early initiation and ongoing treatment of OCREVUS® (ocrelizumab) on disability progression in relapsing multiple sclerosis (RMS) and primary progressive MS (PPMS), as well as safety outcomes for an analysis of shorter 2-hour infusion in minority populations. OCREVUS data from all clinical trials consistently show a favourable benefit-risk profile over eight years. Roche and research partners will also present four late-breaking abstracts to share the latest data regarding COVID-19 and vaccine resp...
Source: Roche Investor Update - October 13, 2021 Category: Pharmaceuticals Source Type: news

Thomas Rando named director of UCLA Broad Stem Cell Research Center
Dr. Thomas Rando, a renowned neurologist and stem cell biologist, has been named director of the  Eli and Edythe Broad Center of  Regenerative Medicine and Stem Cell Research at UCLA.Rando, who was chosen after an international search, is currently a professor of neurology and neurological sciences at the medical school at Stanford University, where he also serves as director of the Glenn Center for the Biology of Aging and deputy director of the Stanford Center on Longevity. In addition, he is chief of neurology at the  Veterans Affairs Palo Alto Health Care System.His appointment is effective Oct. 1.“As a trailblazi...
Source: UCLA Newsroom: Health Sciences - July 7, 2021 Category: Universities & Medical Training Source Type: news

NIDCR's Summer 2021 E-Newsletter
Having trouble viewing this email? View it as a Web page. NIDCR's Summer 2021 E-Newsletter In this issue: NIDCR News Funding Opportunities & Related Notices NIH/HHS News Subscribe to NICDR News Science Advances   Grantee News   NIDCR News NIDCR to Release Report on Oral Health in America As a 20-year follow-up to the seminal Oral Health in America: A Report of the Surgeon General, NIDCR will release Oral Health in America: Advances and Challenges in the fall of 2021. The report will illuminate new directions in the prevention and t...
Source: NIDCR Science News - July 1, 2021 Category: Dentistry Source Type: news

NIDCR's Spring 2021 E-Newsletter
Having trouble viewing this email? View it as a Web page. NIDCR's Spring 2021 E-Newsletter In this issue: NIDCR News Funding Opportunities & Related Notices NIH/HHS News Subscribe to NICDR News Science Advances   Grantee News   NIDCR News NIDCR & NIH Stand Against Structural Racism NIDCR Director Rena D’Souza, DDS, MS, PhD, said in a statement that there is no place for structural racism in biomedical research, echoing remarks from NIH Director Francis Collins, MD, PhD, in his announcement of a new NIH initiative—called UNIT...
Source: NIDCR Science News - April 7, 2021 Category: Dentistry Source Type: news

Community-wide experimental evaluation of the PROSS stability-design method
This study demonstrates the strengths of community-wide efforts to probe the generality of new methods and recommends areas for future research to advance practically useful algorithms for protein science.PMID:33781758 | DOI:10.1016/j.jmb.2021.166964
Source: Mol Biol Cell - March 30, 2021 Category: Molecular Biology Authors: Yoav Peleg Renaud Vincentelli Brett M Collins Kai-En Chen Emma K Livingstone Saroja Weeratunga Natalya Leneva Qian Guo Kim Remans Kathryn Perez Gro E K Bjerga Øivind Larsen Ond řej Vaněk Ond řej Skořepa Sophie Jacquemin Arnaud Poterszman Svend Kjaer Source Type: research

Development of motor circuits: From neuronal stem cells and neuronal diversity to motor circuit assembly
Curr Top Dev Biol. 2021;142:409-442. doi: 10.1016/bs.ctdb.2020.11.010. Epub 2020 Dec 19.ABSTRACTIn this review, we discuss motor circuit assembly starting from neuronal stem cells. Until recently, studies of neuronal stem cells focused on how a relatively small pool of stem cells could give rise to a large diversity of different neuronal identities. Historically, neuronal identity has been assayed in embryos by gene expression, gross anatomical features, neurotransmitter expression, and physiological properties. However, these definitions of identity are largely unlinked to mature functional neuronal features relevant to m...
Source: Current Topics in Developmental Biology - March 12, 2021 Category: Biology Authors: Julia L Meng Ellie S Heckscher Source Type: research