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Procedure: Skin Graft
Therapy: Stem Cell Therapy
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Total 784 results found since Jan 2013.
The diagnostic conundrum of acute cutaneous graft-versus-host disease: biomarkers remain elusive
Arch Dermatol Res. 2023 Jul 22. doi: 10.1007/s00403-023-02671-w. Online ahead of print.ABSTRACTHematopoietic stem cell transplantation is increasing in frequency with graft-versus-host disease affecting many recipients. When the skin is involved, biopsy is routinely performed but often does not aid in definitive diagnosis. Here, we examine a cohort of 32 patients for potential biomarkers that can aid in the diagnosis of graft-versus-host disease. Neither blood short tandem repeat testing or neutrophil-lymphocyte ratios were predictive of rash etiology in hematopoietic stem cell transplant patients. However, skin short tand...
Source: Cell Research - July 22, 2023 Category: Cytology Authors: Aaron Tisack Sasank Konda Jesse Veenstra Source Type: research
Antimicrobial peptide-loaded decellularized placental sponge as an excellent antibacterial skin substitute against XDR clinical isolates
In this study, a biological-based sponge was made from decellularized human placenta (DPS) and then loaded with different concentrations (0, 16 µg/mL, 32 µg/mL, 64 µg/mL) of an antimicrobial peptide (AMP, CM11) to optimize an ideal antibacterial wound dressing. The decellularization of DPS was confirmed by histological evaluations and DNA content assay. The DPS loaded with different contents of antimicrobial peptides (AMPs) showed uniform morphology under a scanning electron microscope (SEM) and cytobiocompatibility for human adipose tissue-derived mesenchymal stem cells. Antibacterial assays indicated that the DPS/AMPs...
Source: Amino Acids - June 14, 2023 Category: Biochemistry Authors: Hatef Ghasemi Hamidabadi Sanaz Alizadeh Leila Mahboobi Zahra Khosrowpour Maryam Nazm Bojnordi Zahra Aliakbar Ahovan Majid Malekzadeh Shafaroudi Maria Zahiri Narendra Pal Singh Chauhan Mazaher Gholipourmalekabadi Source Type: research
Withaferin-A alleviates acute graft versus host disease without compromising graft versus leukemia effect
In conclusion, our study demonstrates the utility of WA for the prevention and treatment of aGvHD, which should be further evaluated in a clinical setting.PMID:37311352 | DOI:10.1016/j.intimp.2023.110437
Source: International Immunopharmacology - June 13, 2023 Category: Allergy & Immunology Authors: Saurabh Kumar Gupta Dievya Gohil Deepshikha Dutta Girish Ch Panigrahi Puja Gupta Kajal Dalvi Twinkle Khanka Subhash Yadav Rajiv Kumar Kaushal Akanksha Chichra Sachin Punatar Anant Gokarn Sumeet Mirgh Nishant Jindal Lingaraj Nayak Prashant R Tembhare Syed Source Type: research
Evaluation in a porcine wound model and long-term clinical assessment of an autologous heterogeneous skin construct used to close full-thickness wounds
Tissue Cell. 2023 Jun 2;83:102126. doi: 10.1016/j.tice.2023.102126. Online ahead of print.ABSTRACTAcute and chronic wounds involving deeper layers of the skin are often not adequately healed by dressings alone and require therapies such as skin grafting, skin substitutes, or growth factors. Here we report the development of an autologous heterogeneous skin construct (AHSC) that aids wound closure. AHSC is manufactured from a piece of healthy full-thickness skin. The manufacturing process creates multicellular segments, which contain endogenous skin cell populations present within hair follicles. These segments are physical...
Source: Tissue and Cell - June 9, 2023 Category: Cytology Authors: Nicholas Baetz Pratima Labroo Marytheresa Ifediba Devin Miller Kendall Stauffer Michael Sieverts Jessie Nicodemus-Johnson Eric Chan Ian Robinson James Miess Stephanie Roth Jenny Irvin Jake Laun Gerhard Mundinger Mark S Granick Stephen Milner Caroline Garr Source Type: research
Highly Pluripotent Adipose-Derived Stem Cell-Enriched Nanofat: A Novel Translational System in Stem Cell Therapy
This study aimed to characterize Hy-Tissue Nanofat product by investigating morphology, cellular yield, adipose-derived stem cell (ASC) proliferation rate and clonogenic capability, immunophenotyping, and differential potential. The percentage of SEEA3 and CD105 expression was also analyzed to establish the presence of multilineage-differentiating stress-enduring (MUSE) cell. Our results showed that the Hy-Tissue Nanofat kit could isolate 3.74 × 104 ± 1.31 × 104 proliferative nucleated cells for milliliter of the treated fat. Nanofat-derived ASC can grow in colonies and show high differentiation capacity into adipocytes...
Source: Cell Transplantation - May 27, 2023 Category: Cytology Authors: Lindsey Alejandra Quintero Sierra Reetuparna Biswas Anita Conti Alice Busato Riccardo Ossanna Nicola Zingaretti Pier Camillo Parodi Giamaica Conti Michele Riccio Andrea Sbarbati Francesco De Francesco Source Type: research
Interrater reproducibility of the Myoton and durometer devices to quantify sclerotic chronic graft-versus-host disease
Arch Dermatol Res. 2023 May 25. doi: 10.1007/s00403-023-02626-1. Online ahead of print.ABSTRACTChronic graft-versus-host disease (cGVHD) is a severe complication in long-term survivors of allogeneic hematopoietic stem cell transplantation. This disease is challenging to manage clinically due to a lack of validated tools to quantitatively measure skin sclerosis. The current gold standard for measuring skin sclerosis is the NIH Skin Score which has only moderate agreement among clinicians and experts. To more accurately assess skin sclerosis in cGVHD, the Myoton and durometer devices can be used to directly measure biomechan...
Source: Cell Research - May 25, 2023 Category: Cytology Authors: Shramana Ghosh Laura Baker Fuyao Chen Zain Khera Arved Vain Kathy Zhang Alexis Hood Hayden Smith Heidi Chen Madan Jagasia Eric Tkaczyk Source Type: research
A retrospective study of treatment and outcomes of patients with lymphoma undergoing hematopoietic stem cell transplantation: A single-center experience
CONCLUSIONS: Patients experienced severe symptoms such as oral mucositis, febrile neutropenia, and anemia due to HSCT, and necessary treatment was applied for the symptoms. Further clinical studies must determine the symptoms and patient outcomes associated with SCT. It is predicted that patients will benefit from regular follow-up of their symptoms and planning of appropriate evidence-based nursing interventions and that this will improve the quality of care to be offered to them and increase their life span.PMID:37201796 | DOI:10.1016/j.trim.2023.101855
Source: Transplant Immunology - May 18, 2023 Category: Transplant Surgery Authors: Merve Gozde Sezgin Hicran Bektas Source Type: research
Combinatorial inhibition of Tec kinases BTK and ITK is beneficial in ameliorating murine sclerodermatous chronic graft versus host disease
In conclusion, we observed substantial benefit for differential inhibition of Tec kinases in GVHD, with ITK being most efficacious and Th1 cells being more resistant to inhibition, matching the previously reported findings of a Th2 to Th1 selective pressure in cells treated with ibrutinib. Our data warrants the further development of ITK and ITK/BTK inhibitors with specific inhibitory ratios to improve the treatment of GVHD and other T-cell mediated diseases.PMID:37160943 | DOI:10.1038/s41409-023-02001-8
Source: Cancer Control - May 10, 2023 Category: Cancer & Oncology Authors: Senthilnathan Palaniyandi Ethan Strattan Reena Kumari Miranda Mysinger Natalya Hakim Melissa V Kesler Mutiah Apatira Fabiola Bittencourt Longcheng Wang Zhaozhong Jia Tarikere L Gururaja Ronald J Hill Gerhard C Hildebrandt Source Type: research
Soft tissue regeneration in animal models using grafts from adipose mesenchymal stem cells and peripheral blood fibrin gel
CONCLUSIONS: These initial conclusions might be considered a first step in generating safe bio-compatible engineered grafts specifically usable in post-traumatic tissue regeneration procedures.PMID:37140317 | DOI:10.26355/eurrev_202304_32161
Source: Pharmacological Reviews - May 4, 2023 Category: Drugs & Pharmacology Authors: T D Huynh H K Nguyen A M Inchingolo H L Bao Tran G Dipalma A Mancini K Cao Diem Nguyen M G Balzanelli P Distratis R Lazzaro T A Nguyen Ho E M Serlenga V Hung Pham G Romanos B T Nguyen B Rapone F Inchingolo C Isacco Gargiulo T Cong Tran Source Type: research
