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Therapy: Stem Cell Therapy
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Total 54597 results found since Jan 2013.
Laminin alpha-3 and thrombospondin-1 differently regulate the survival and differentiation of hepatocytes and hepatic stem cells from neonatal mice
Am J Transl Res. 2021 Nov 15;13(11):12684-12693. eCollection 2021.ABSTRACTThe aim of this study was to search and identify the extracellular matrix/adhesion molecules potentially regulating liver regeneration. By using pathway-focused PCR array, we investigated the dynamic changes in the expression of extracellular matrix and adhesion molecules in normal livers or cholestatic livers following partial hepatectomy in adult mice. To confirm the data from PCR array, we further evaluated how laminin alpha-3 and thrombospondin-1 mediate the survival and differentiation of matured hepatocytes and immature hepatic stem cells by us...
Source: Cell Research - December 27, 2021 Category: Cytology Authors: Shuai Zhang Heba E Sharaf Eldin Wei-Li Gu Tao-Sheng Li Source Type: research
Application of vascular endothelial cells in stem cell medicine
World J Clin Cases. 2021 Dec 16;9(35):10765-10780. doi: 10.12998/wjcc.v9.i35.10765.ABSTRACTStem cell medicine is gaining momentum in the development of therapy for various end-stage diseases. The search for new seed cells and exploration of their application prospects are topics of interest in stem cell medicine. In recent years, vascular endothelial cells (VECs) have attracted wide attention from scholars. VECs, which form the inner lining of blood vessels, are critically involved in many physiological functions, including permeability, angiogenesis, blood pressure regulation, immunity, and pathological development, such ...
Source: Atherosclerosis - January 20, 2022 Category: Cardiology Authors: Qing-Qing Liang Lei Liu Source Type: research
Biomarkers for Diagnosing Febrile Illness in Immunocompromised Children: A Systematic Review of the Literature
This study aims to assess the performance of biomarkers used for the prediction of bacterial, viral, and fungal infection in immunocompromised children upon presentation with fever.METHODS: We performed a literature search using PubMed and MEDLINE and In-Process & Other Non-indexed Citations databases. Cohort and case-control studies assessing biomarkers for the prediction of bacterial, viral, or fungal infection in immunocompromised children vs. conventional microbiological investigations were eligible. Studies including adult patients were eligible if pediatric data were separately assessable. Data on definitions use...
Source: Cancer Control - April 4, 2022 Category: Cancer & Oncology Authors: Fabian J S van der Velden Andrew R Gennery Marieke Emonts Source Type: research
Algorithmic reconstruction of glioblastoma network complexity
iScience. 2022 Mar 28;25(5):104179. doi: 10.1016/j.isci.2022.104179. eCollection 2022 May 20.ABSTRACTGlioblastoma is a complex disease that is difficult to treat. Network and data science offer alternative approaches to classical bioinformatics pipelines to study gene expression patterns from single-cell datasets, helping to distinguish genes associated with the control of differentiation and aggression. To identify the key molecular regulators of the networks driving glioblastoma/GSC and predict their cell fate dynamics, we applied a host of data theoretic techniques to gene expression patterns from pediatric and adult gl...
Source: Cancer Control - April 28, 2022 Category: Cancer & Oncology Authors: Abicumaran Uthamacumaran Morgan Craig Source Type: research
Stem cell transplantation for systemic sclerosis
CONCLUSIONS: Non-myeloablative selective and myeloablative selective HSCT had moderate-certainty evidence for improvement in event-free survival, and skin thicknesscompared to cyclophosphamide. There is also low-certainty evidence that these modalities of HSCT improve physical function. However, non-myeloablative selective HSCT and myeloablative selective HSCT resulted in more serious adverse events than cyclophosphamide; highlighting the need for careful risk-benefit considerations for people considering these HSCTs. Evidence for the efficacy and adverse effects of non-myeloablative non-selective HSCT is limited at this t...
Source: Cochrane Database of Systematic Reviews - July 29, 2022 Category: General Medicine Authors: Sebastian Bruera Harish Sidanmat Donald A Molony Maureen D Mayes Maria E Suarez-Almazor Kate Krause Maria Angeles Lopez-Olivo Source Type: research
Mesenchymal Stem Cell-Conditioned Medium Promotes Functional Recovery Following Spinal Cord Injury: A Systematic Review and Meta-analysis
CONCLUSIONS: Based on the results of the present study, it can be concluded that MSC-CM administration in SCI models improves motor recovery. The efficacy of this treatment strategy significantly increases at doses higher than 120 μL.PMID:36348669 | PMC:PMC9605759 | DOI:10.22603/ssrr.2022-0004
Source: Cell Research - November 9, 2022 Category: Cytology Authors: Arash Sarveazad Amirmohammad Toloui Aida Moarrefzadeh Hanieh Ghasemian Nafchi Arian Madani Neishaboori Mahmoud Yousefifard Source Type: research
Aberrant N-glycolylneuraminic acid in breast MCF-7 cancer cells and cancer stem cells
Front Mol Biosci. 2022 Nov 7;9:1047672. doi: 10.3389/fmolb.2022.1047672. eCollection 2022.ABSTRACTN-Glycolylneuraminic acid (Neu5Gc) is not normally detected in humans because humans lack the hydroxylase enzyme that converts cytidine-5'-monophosphate-N-acetylneuraminic acid (CMP-Neu5Ac) to CMP-Neu5Gc; thus, any Neu5Gc appearing in the human body is aberrant. Neu5Gc has been observed in human cancer cells and tissues. Moreover, antibodies against Neu5Gc have been detected in healthy humans, which are obstacles to clinical xenotransplantation and stem cell therapies. Thus, the study of Neu5Gc in humans has important patholog...
Source: Cancer Control - November 24, 2022 Category: Cancer & Oncology Authors: Wenqian Yang Yuan Jiang Qulian Guo Zhixin Tian Zhigang Cheng Source Type: research
The Efficiency of Stem Cells (SCs) Differentiation into Functional Hepatocytes for Treating Liver Disorders: A Systematic Review
Biomed Res Int. 2023 Jan 12;2023:4868048. doi: 10.1155/2023/4868048. eCollection 2023.ABSTRACTStem cells provided new opportunity to treat various diseases, including liver disorders. Stem cells are unspecialized cells, stimulating influential research interest be indebted to their multipotent self-renewal capacity and differentiation characteristics into several specialized cell types. Many factors contribute to their differentiation into different cell types such as insulin producing cells, osteoblast, and hepatocytes. Accordingly, wide range methods and materials have been used to transform stem cells into hepatocytes, ...
Source: Cell Research - January 23, 2023 Category: Cytology Authors: Marzieh Nemati Zahra Ebrahimi Sareh Abolhassani Fatemeh Nemati Bahareh Ebrahimi Aliakbar Alizadeh Source Type: research
TRIM8: a double-edged sword in glioblastoma with the power to heal or hurt
Cell Mol Biol Lett. 2023 Jan 23;28(1):6. doi: 10.1186/s11658-023-00418-z.ABSTRACTGlioblastoma multiforme (GBM) is an aggressive primary brain tumor and one of the most lethal central nervous system tumors in adults. Despite significant breakthroughs in standard treatment, only about 5% of patients survive 5 years or longer. Therefore, much effort has been put into the search for identifying new glioma-associated genes. Tripartite motif-containing (TRIM) family proteins are essential regulators of carcinogenesis. TRIM8, a member of the TRIM superfamily, is abnormally expressed in high-grade gliomas and is associated with po...
Source: Cellular and Molecular Biology Letters - January 23, 2023 Category: Biochemistry Authors: Hamed Hosseinalizadeh Omid Mohamadzadeh Mohammad Saeed Kahrizi Zahra Razaghi Bahabadi Daniel J Klionsky Hamed Mirzei Source Type: research
The Efficiency of Stem Cells (SCs) Differentiation into Functional Hepatocytes for Treating Liver Disorders: A Systematic Review
Biomed Res Int. 2023 Jan 12;2023:4868048. doi: 10.1155/2023/4868048. eCollection 2023.ABSTRACTStem cells provided new opportunity to treat various diseases, including liver disorders. Stem cells are unspecialized cells, stimulating influential research interest be indebted to their multipotent self-renewal capacity and differentiation characteristics into several specialized cell types. Many factors contribute to their differentiation into different cell types such as insulin producing cells, osteoblast, and hepatocytes. Accordingly, wide range methods and materials have been used to transform stem cells into hepatocytes, ...
Source: Biomed Res - January 23, 2023 Category: Research Authors: Marzieh Nemati Zahra Ebrahimi Sareh Abolhassani Fatemeh Nemati Bahareh Ebrahimi Aliakbar Alizadeh Source Type: research
TRIM8: a double-edged sword in glioblastoma with the power to heal or hurt
Cell Mol Biol Lett. 2023 Jan 23;28(1):6. doi: 10.1186/s11658-023-00418-z.ABSTRACTGlioblastoma multiforme (GBM) is an aggressive primary brain tumor and one of the most lethal central nervous system tumors in adults. Despite significant breakthroughs in standard treatment, only about 5% of patients survive 5 years or longer. Therefore, much effort has been put into the search for identifying new glioma-associated genes. Tripartite motif-containing (TRIM) family proteins are essential regulators of carcinogenesis. TRIM8, a member of the TRIM superfamily, is abnormally expressed in high-grade gliomas and is associated with po...
Source: Mol Biol Cell - January 23, 2023 Category: Molecular Biology Authors: Hamed Hosseinalizadeh Omid Mohamadzadeh Mohammad Saeed Kahrizi Zahra Razaghi Bahabadi Daniel J Klionsky Hamed Mirzei Source Type: research
Bone Marrow Aspirate Concentrate versus Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells for Combined Cartilage Regeneration Procedure in Patients Undergoing High Tibial Osteotomy: A Systematic Review and Meta-Analysis
Conclusions: Both BMAC and hUCB-MSCs with HTO improved clinical outcomes in varus knee OA patients, and there was no difference in clinical outcomes between them. However, hUCB-MSCs were more effective in articular cartilage regeneration than BMAC augmentation.PMID:36984635 | PMC:PMC10059261 | DOI:10.3390/medicina59030634
Source: Medicina (Kaunas) - March 29, 2023 Category: Universities & Medical Training Authors: Dojoon Park Youn Ho Choi Se Hyun Kang Hae Seok Koh Yong In Source Type: research
