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Therapy: Stem Cell Therapy

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Randomized Trials of Autologous Hematopoietic Stem Cell Transplantation for Diffuse Cutaneous Systemic Sclerosis: Systematic Review and Meta-Analysis with Trial Sequential Analysis of Overall Mortality
Conclusions. Our analysis has sufficient information size to indicate that autologous SCT for patients with SSc and internal organ involvement is safe and efficacious. The magnitude of the reduction in long-term mortality of autologous SCT over other available therapies may be practice changing.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Patel, A., Lim, Y. J. Tags: 731. Clinical Autologous Transplantation: Results: Autologous Transplantation: Clonal Hematopoiesis, Microbiota, AML, NHL, and Autoimmune Diseases Source Type: research

Long-Term Safety and Efficacy of Autologous or Allogeneic Donor Stem Cell Transplantation in Patients with Behcet's Syndrome
Conclusion. SCT in BD appears to be safe and effective, with no clear difference in long-term survival or PFS by SCT type. AutoSCT is a beneficial treatment option for refractory BD. AlloSCT is also advantageous in BD, with less data in the refractory BD or post autoSCT salvage settings. Given the lack of a clinical trial, we present the most comprehensive evidence available supporting the practice changing role of SCT as a treatment option in BD.References. 1. Hatemi G, et al. 2018 update of the EULAR recommendations for the management of Behçet's syndrome. Annals of the Rheumatic Diseases 2018;77:808-18.Disclosure...
Source: Blood - November 21, 2018 Category: Hematology Authors: Patel, A., Lim, Y. J. Tags: 731. Clinical Autologous Transplantation: Results: Poster II Source Type: research

A Decade of Anti-Myeloma Vaccine Development through Early Phase Trials: A Systematic Review
ConclusionAnti-myeloma vaccination therapy appears to be well tolerated, which makes it a promising adjuvant therapeutic agent against MM. Current data reveals positive immunologic activity in most patients and there is possibility of promising clinical responses with further drug development.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Nunes Cavalcante Parr, N. C., Tariq, M. J., Usman, M., Fraz, M. A., Khan, A. Y., Samuel, S., Ijaz, A., Ahmad, M. Q., Khalil, M. J., Yasir, M., Amin, S. N., Safdar, A., Rafae, A., Anwer, F. Tags: 653. Myeloma: Therapy, excluding Transplantation Source Type: research

Younger Patients Are Impacted By Post-Transplant Lymphoproliferative Disorder: Findings from a Systematic Literature Review of Real-World Evidence
Conclusions: This SLR of published real-world studies demonstrates that the WMA at PTLD diagnosis (for studies with no age restrictions: 34.4 years for HCT and 38.6 years for SOT) is substantially lower than the reported average age at diagnosis for lymphomas (65 years), irrespective of study design and inclusion criteria. PTLD greatly impacts the pediatric population, with a quarter of HCT studies and a third of SOT studies focusing on this population. Currently, there is no indicated treatment for this ultra-rare disease with poor prognosis, indicating a clear unmet need for patients with PTLD that disproportionately aff...
Source: Blood - November 21, 2018 Category: Hematology Authors: Watson, C., Xu, H., Forsythe, A., Garib, S. A., Barlev, A. Tags: 902. Health Services Research-Malignant Diseases Source Type: research

Aerobic physical exercise for adult patients with haematological malignancies.
CONCLUSIONS: Eighteen, mostly small RCTs did not identify evidence for a difference in terms of mortality. Physical exercise added to standard care might improve fatigue and depression. Currently, there is inconclusive evidence regarding QoL, physical functioning, anxiety and SAEs .We need further trials with more participants and longer follow-up periods to evaluate the effects of exercise intervention for people suffering from haematological malignancies. To enhance comparability of study data, development and implementation of core sets of measuring devices would be helpful. PMID: 30702150 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - January 31, 2019 Category: General Medicine Authors: Knips L, Bergenthal N, Streckmann F, Monsef I, Elter T, Skoetz N Tags: Cochrane Database Syst Rev Source Type: research

B Cell Reconstitution and Influencing Factors After Hematopoietic Stem Cell Transplantation in Children
Nicolaas G. van der Maas, Dagmar Berghuis, Mirjam van der Burg and Arjan C. Lankester* Willem-Alexander Children's Hospital, Department of Pediatrics and Laboratory for Pediatric Immunology, Leiden University Medical Center, Leiden, Netherlands B cell reconstitution after hematopoietic stem cell transplantation (HSCT) is variable and influenced by different patient, donor, and treatment related factors. In this review we describe B cell reconstitution after pediatric allogeneic HST, including the kinetics of reconstitution of the different B cell subsets and the development of the B cell repertoire, and d...
Source: Frontiers in Immunology - April 11, 2019 Category: Allergy & Immunology Source Type: research

Pentraxin 3 in Cardiovascular Disease
Giuseppe Ristagno1*, Francesca Fumagalli1, Barbara Bottazzi2, Alberto Mantovani2,3,4, Davide Olivari1, Deborah Novelli1 and Roberto Latini1 1Department of Cardiovascular Research, Mario Negri Institute for Pharmacological Research IRCCS, Milan, Italy 2Humanitas Clinical and Research Center-IRCCS, Milan, Italy 3Humanitas University, Milan, Italy 4The William Harvey Research Institute, Queen Mary University of London, London, United Kingdom The long pentraxin PTX3 is a member of the pentraxin family produced locally by stromal and myeloid cells in response to proinflammatory signals and microbial moieties. The p...
Source: Frontiers in Immunology - April 16, 2019 Category: Allergy & Immunology Source Type: research

To Embed or Not: Network Embedding as a Paradigm in Computational Biology
Conclusion We have reviewed several classes of approaches for network embedding, including spectral-based methods, random-walk based approaches and deep neural network techniques. We have demonstrated the utility of these approaches in a broad set of applications, ranging from network alignment to community detection, protein function prediction, and network denoising. We have also discussed recent embedding approaches in pharmacogenomics. We were interested in seeing whether the field of network embedding indeed enhances the types of questions that can be answered using graph-based approaches and our conclusion is that t...
Source: Frontiers in Genetics - April 30, 2019 Category: Genetics & Stem Cells Source Type: research

Novel Stem Cells and Nucleic Acid-Based Vaccine Trials Against Viral Outbreak: A Systematic Evaluation During COVID-2019 Pandemic
AbstractThe current Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) outbreak, the cause of coronavirus disease (COVID-19), has influenced health globally. So far, there are no established management options and prophylaxis for those who have been exposed to SARS-CoV-2, and those who develop COVID-19. Documented scientific evidences in similar viral outbreaks in past suggested few therapy regimens. These rather have not shown promising results in management of current pandemic. So, in the current review, we are exploring novel treatment strategies and therapies that are being explored and are in clinical and pr...
Source: Indian Journal of Clinical Biochemistry - July 9, 2020 Category: Biochemistry Source Type: research

Targeting Stem Cells with Hyperthermia: Translational Relevance in Cancer Patients
Background: Tumor recurrences or metastases remain a major hurdle in improving overall cancer survival. In anticancer therapy, some patients inevitably develop chemo-/radiotherapy resistance at some point. Cancer stem cells are the driving force of tumorigenesis, recurrences, and metastases, contributing also to the failure of some cancer treatments.Summary: Emergent evidence suggests that stem cell diseases are at the base of human cancers, and tumor progression and chemo-/radiotherapy resistance may be dependent on just a small subpopulation of cancer stem cells. Hyperthermia can be a strong cancer treatment, especially ...
Source: Oncology - August 12, 2020 Category: Cancer & Oncology Source Type: research

Targeting Stem Cells with Hyperthermia: Translational Relevance in Cancer Patients.
Abstract BACKGROUND: Tumor recurrences or metastases remain a major hurdle in improving overall cancer survival. In anticancer therapy, some patients inevitably develop chemo-/radiotherapy resistance at some point. Cancer stem cells are the driving force of tumorigenesis, recurrences, and metastases, contributing also to the failure of some cancer treatments. SUMMARY: Emergent evidence suggests that stem cell diseases are at the base of human cancers, and tumor progression and chemo-/radiotherapy resistance may be dependent on just a small subpopulation of cancer stem cells. Hyperthermia can be a strong cance...
Source: Oncology - August 11, 2020 Category: Cancer & Oncology Authors: Ammendola M, Currò G, Memeo R, Curto LS, Luposella M, Zuccalà V, Pessaux P, Navarra G, Gadaleta CD, Ranieri G Tags: Oncology Source Type: research

Studying human reproductive biology through single-cell analysis and in vitro differentiation of stem cells into germ cell-like cells
AbstractBACKGROUNDUnderstanding the molecular and cellular mechanisms of human reproductive development has been limited by the scarcity of human samples and ethical constraints. Recently,in vitro differentiation of human pluripotent stem cells into germ cells and single-cell analyses have opened new avenues to directly study human germ cells and identify unique mechanisms in human reproductive development.OBJECTIVE AND RATIONALEThe goal of this review is to collate novel findings and insightful discoveries with these new methodologies, aiming at introducing researchers and clinicians to the use of these tools to study hum...
Source: Human Reproduction Update - May 28, 2020 Category: OBGYN Source Type: research

Modelling human embryogenesis: embryo-like structures spark ethical and policy debate
AbstractBACKGROUNDStudying the human peri-implantation period remains hindered by the limited accessibility of thein vivo environment and scarcity of research material. As such, continuing efforts have been directed towards developing embryo-like structures (ELS) from pluripotent stem cells (PSCs) that recapitulate aspects of embryogenesisin vitro. While the creation of such models offers immense potential for studying fundamental processes in both pre- and early post-implantation development, it also proves ethically contentious due to wide-ranging views on the moral and legal reverence due to human embryos. Lack of clari...
Source: Human Reproduction Update - July 26, 2020 Category: OBGYN Source Type: research

The Effect of Photobiomodulation on Human Mesenchymal Cells: A Literature Review
ConclusionsPhotobiomodulation is a promising technology that can impact on cell viability, differentiation, proliferation, or migration, leading to enhance its regenerative capacity.No Level AssignedThis journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authorswww.springer.com/00266.
Source: Aesthetic Plastic Surgery - February 22, 2021 Category: Cosmetic Surgery Source Type: research

Clinical applications of dental stem cells in modern regenerative medicine: A systematic review with updates
TY Alhazzazi, FT AlghamdiNigerian Journal of Clinical Practice 2021 24(4):457-463 The use of dental stem cells (DSCs) has emerged as a promising new approach for therapeutic purposes to treat dental and non-dental diseases. Thus, the aim of this systematic review was to compile all current information on the role and clinical applications of DSCs in modern regenerative medical therapy. PubMed and Google Scholar electronic databases were used to search the literature for relevant studies after applying specific inclusion and exclusion criteria. The search included articles that were published from 2009 to 2019. Several key...
Source: Nigerian Journal of Clinical Practice - April 13, 2021 Category: Rural Health Authors: TY Alhazzazi FT Alghamdi Source Type: research