• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Administration of sonic hedgehog protein induces angiogenesis and has therapeutic effects after stroke in rats
Publication date: 3 June 2017 Source:Neuroscience, Volume 352 Author(s): Sheng-cai Chen, Ming Huang, Quan-wei He, Yan Zhang, Elvis Nana Opoku, Hang Yang, Hui-juan Jin, Yuan-peng Xia, Bo Hu The Sonic hedgehog (Shh) signaling pathway is recapitulated in response to ischemic injury. Here, we investigated the clinical implications of Shh protein in the ischemic stroke and explored the underlying mechanism. Intracerebroventricular injection of Shh, Cyclopamine, or anti-vascular endothelial growth factor (VEGF) was performed immediately after permanent middle cerebral artery occlusion (pMCAO) surgery and lasted for 7days (d). P...
Source: Neuroscience - April 26, 2017 Category: Neuroscience Source Type: research

Stem Cell Transplantation Therapy for Multifaceted Therapeutic Benefits after Stroke
Publication date: Available online 18 March 2017 Source:Progress in Neurobiology Author(s): Ling Wei, Zheng Z. Wei, Michael Qize Jiang, Osama Mohamad, Shan Ping Yu One of the exciting advances in modern medicine and life science is cell-based neurovascular regeneration of damaged brain tissues and repair of neuronal structures. The progress in stem cell biology and creation of adult induced pluripotent stem (iPS) cells has significantly improved basic and pre-clinical research in disease mechanisms and generated enthusiasm for potential applications in the treatment of central nervous system (CNS) diseases including strok...
Source: Progress in Neurobiology - March 24, 2017 Category: Neuroscience Source Type: research

Motor compensation and its effects on neural reorganization after stroke
Nature Reviews Neuroscience 18, 267 (2017). doi:10.1038/nrn.2017.26 Author: Theresa A. Jones Stroke instigates a dynamic process of repair and remodelling of remaining neural circuits, and this process is shaped by behavioural experiences. The onset of motor disability simultaneously creates a powerful incentive to develop new, compensatory ways of performing daily activities. Compensatory movement strategies that are
Source: Nature Reviews Neuroscience - March 23, 2017 Category: Neuroscience Authors: Theresa A. Jones Tags: Review Source Type: research

Contrasting roles of immune cells in tissue injury and repair in stroke: The dark and bright side of immunity in the brain
Publication date: Available online 27 February 2017 Source:Neurochemistry International Author(s): Aditya Rayasam, Martin Hsu, Gianna Hernández, Julie Kijak, Anders Lindstedt, Christian Gerhart, Matyas Sandor, Zsuzsanna Fabry Despite considerable efforts in research and clinical studies, stroke is still one of the leading causes of death and disability worldwide. Originally, stroke was considered a vascular thrombotic disease without significant immune involvement. However, over the last few decades it has become increasingly obvious that the immune responses can significantly contribute to both tissue injury and protect...
Source: Neurochemistry International - February 26, 2017 Category: Neuroscience Source Type: research

Transplantation with hypoxia ‐preconditioned mesenchymal stem cells suppresses brain injury caused by cardiac arrest–induced global cerebral ischemia in rats
Cardiac arrest–induced global cerebral ischemia is a main cause of neurological dysfunction in emergency medicine. Transplantation with bone marrow mesenchymal stem cells (MSCs) has been used in stroke models to repair the ischemic brain injury, but it is little studied in models with global cerebral ischemia. In the present study, a hypoxia precondition was used to improve the efficacy of MSC transplantation, given the low survival and migration rates and limited differentiation capacities of MSCs. We found that hypoxia can increase the expansion and migration of MSCs by activating the PI3K/AKT and hypoxia‐inducible f...
Source: Journal of Neuroscience Research - February 9, 2017 Category: Neuroscience Authors: Ji ‐wen Wang, Yu‐ru Qiu, Yue Fu, Jun Liu, Zhi‐Jie He, Zi‐tong Huang Tags: Research Article Source Type: research

Effects of Neural Stem Cell and Olfactory Ensheathing Cell Co-transplants on Tissue Remodelling After Transient Focal Cerebral Ischemia in the Adult Rat.
In this study, we address this challenge by testing whether co-grafting of NSCs with olfactory ensheathing cells (OECs), a special type of glia with proven neuroprotective, immunomodulatory, and angiogenic effects, can promote graft survival and host tissue remodelling. Transient focal cerebral ischemia was induced in adult rats by a 60-min middle cerebral artery occlusion (MCAo) followed by reperfusion. Ischemic lesions were verified by neurological testing and magnetic resonance imaging. Transplantation into the globus pallidus of NSCs alone or in combination with OECs was performed at two weeks post-MCAo, followed by hi...
Source: Neurochemical Research - January 23, 2017 Category: Neuroscience Authors: Augestad IL, Nyman AK, Costa AI, Barnett SC, Sandvig A, Håberg AK, Sandvig I Tags: Neurochem Res Source Type: research

Delayed Treatment of 6-Bromoindirubin-3'-oxime Stimulates Neurogenesis and Functional Recovery after Focal Ischemic Stroke in Mice.
Abstract Glycogen synthase kinase 3β (GSK3β) was originally identified as a regulator for glycogen metabolism and is now an important therapeutic target for a variety of brain disorders including neurodegenerative diseases due to it's pivotal role in cellular metabolism, proliferation and differentiation. In the development of stroke therapies focusing on tissue repair and functional recovery, promoting neurogenesis is a main approach in regenerative medicine. In the present investigation, we explored the effects of a GSK3β specific inhibitor, 6-Bromoindirubin-3'-oxime (BIO), on regenerative activities of neuro...
Source: International Journal of Developmental Neuroscience - January 18, 2017 Category: Neuroscience Authors: Wang LL, Li J, Gu X, Wei L, Yu SP Tags: Int J Dev Neurosci Source Type: research

Overexpression of Mitofusin2 decreased the reactive astrocytes proliferation in vitro induced by oxygen-glucose deprivation/reoxygenation
This study is to elucidate the role of Mfn2 in reactive astrocytes induced by oxygen-glucose deprivation/reoxygenation(OGD/R) model in vitro. Up-expression in EdU staining and protein level of GFAP, PCNA and CyclinD1, demonstrates the distinct activation and proliferation of astrocytes after the stimulation of OGD/R. Meanwhile, Mfn2 was proved to be down-regulated both in gene and protein levels. Pretreatment of cells with adenoviral vector encoding Mfn2 gene increased Mfn2 expression and subsequently attenuated OGD-induced astrocyte proliferation. Down-regulation of Ras-p-Raf1-p-ERK1/2 pathway and cell cycle arrest were f...
Source: Neuroscience Letters - January 2, 2017 Category: Neuroscience Source Type: research

Acute bithalamic infarct manifesting as sleep-like coma: A diagnostic challenge
Publication date: December 2016 Source:Journal of Clinical Neuroscience, Volume 34 Author(s): Asaf Honig, Ruth Eliahou, Roni Eichel, Ari Aharon Shemesh, Tamir Ben-Hur, Eitan Auriel Bilateral thalamic infarction (BTI) typically presents as a sleep-like coma (SLC) without localizing signs, posing a diagnostic challenge that may lead the treating physician to search for toxic or metabolic causes and delay treatment. We review our experience with BTI of different etiologies, and emphasize the critical role of timely imaging, diagnosis, and management in a series of 12 patients with a presentation of SLC and acute BTI who were...
Source: Journal of Clinical Neuroscience - November 10, 2016 Category: Neuroscience Source Type: research

Partial MHC class II constructs as novel immunomodulatory therapy for stroke
Publication date: Available online 31 October 2016 Source:Neurochemistry International Author(s): Gil Benedek, Arthur A. Vandenbark, Nabil J. Alkayed, Halina Offner The worldwide prevalence of stroke continues to rise despite recent successes in treating acute ischemic stroke. With limited patient eligibility and associated risk of tPA and mechanical thrombectomy, new preventive and therapeutic modalities are needed to stave the rising wave of stroke. Inflammation plays a key role in brain damage after cerebral ischemia, and novel therapies that target pro-inflammatory cells have demonstrated promise for treatment for str...
Source: Neurochemistry International - October 31, 2016 Category: Neuroscience Source Type: research

Methylene Blue promotes cortical neurogenesis and ameliorates behavioral deficit after photothrombotic stroke in rats
We report that MB significantly enhanced cell proliferation and neurogenesis, as evidenced by the increased co-localizations of BrdU/NeuN, BrdU/DCX, BrdU/MAP2 and BrdU/Ki67 in the peri-infarct zone compared with vehicle controls. MB thus effectively limited infarct volume and improved neurological deficits compared to PT control animals. The effects of MB were accompanied with an attenuated level of reactive gliosis and release of pro-inflammatory cytokines, as well as elevated levels of cytochrome c oxidase activity and ATP production in peri-infarct regions. Our study provides important information that MB has the abilit...
Source: Neuroscience - September 11, 2016 Category: Neuroscience Source Type: research

Repairing the Brain by SCF+G-CSF Treatment at 6 Months Postexperimental Stroke: Mechanistic Determination of the Causal Link Between Neurovascular Regeneration and Motor Functional Recovery
This study provides novel insights into the development of new restorative strategies for stroke recovery.
Source: ASN Neuro - August 8, 2016 Category: Neuroscience Authors: Cui, L., Wang, D., McGillis, S., Kyle, M., Zhao, L.-R. Tags: Original Article Source Type: research

Lentivirus-Mediated Overexpression of MicroRNA-210 Improves Long-Term Outcomes after Focal Cerebral Ischemia in Mice.
CONCLUSION: MiR-210 is a crucial ischemic stroke-associated MicroRNAs and a potential target for the stroke therapy. PMID: 27390218 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - July 7, 2016 Category: Neuroscience Authors: Zeng LL, He XS, Liu JR, Zheng CB, Wang YT, Yang GY Tags: CNS Neurosci Ther Source Type: research

Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke
Publication date: Available online 7 May 2016 Source:Progress in Neurobiology Author(s): Xiao-Yi Xiong, Liang Liu, Qing-Wu Yang Microglia/macrophages are the major immune cells involved in the defence against brain damage. Their morphology and functional changes are correlated with the release of danger signals induced by stroke. These cells are normally responsible for clearing away dead neural cells and restoring neuronal functions. However, when excessively activated by the damage-associated molecular patterns following stroke, they can produce a large number of proinflammatory cytokines that can disrupt neural cel...
Source: Progress in Neurobiology - June 2, 2016 Category: Neuroscience Source Type: research

Functions and Mechanisms of Microglia/Macrophages in Neuroinflammation and Neurogenesis during Stroke
Publication date: Available online 7 May 2016 Source:Progress in Neurobiology Author(s): Xiao-Yi Xiong, Liang Liu, Qing-Wu Yang Microglia/macrophages are the major immune cells involved in the defence against brain damage. Their morphology and functional changes are correlated with the release of danger signals induced by stroke. These cells are normally responsible for clearing away dead neural cells and restoring neuronal functions. However, when excessively activated by the damage-associated molecular patterns following stroke, they can produce a large number of proinflammatory cytokines that can disrupt neural cel...
Source: Progress in Neurobiology - May 7, 2016 Category: Neuroscience Source Type: research

Pages: 1  2  3  4  5  6  7  8  9