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Intra ‐arterial transplantation of human bone marrow mesenchymal stem cells (hBMMSCs) improves behavioral deficits and alters gene expression in rodent stroke model
In conclusion, hBMMSCs administration significantly improves the behavioral deficits by improving motor and locomotor co‐ordination. The promoter of TSP1 and WNK1 genes was found to be hyper‐methylated in hBMMSCs group resulting in their decreased expression while the promoter of ANP and BDNF was found to be hypo‐methylated. This study might shed a light on how hBMMSCs affect the gene expression by modulating methylation status. This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - October 19, 2017 Category: Neuroscience Authors: Vibhuti, Rehan Khan, Alpana Sharma, Suman Jain, Sujata Mohanty, Kameshwar Prasad Tags: Original Article Source Type: research

P 4 Bioluminescence imaging visualizes osteopontin-induced neurogenesis and neuroblasts migration in the mouse brain after stroke
The phosphoglycoprotein osteopontin (OPN) is upregulated in the brain following cerebral ischemia, where is exerts neuroprotective properties. We previously demonstrated OPN to increase survival and proliferation of neural stem cells (NSC) in vitro and in vivo. In culture, OPN additionally promotes NSC migration as well as a neuronal differentiation fate. Based on these data, we hypothesized OPN to induce NSC migration as well as neurogenesis in vivo as well. We here aimed to establish and visualize these effects using non-invasive in vivo imaging.
Source: Clinical Neurophysiology - September 8, 2017 Category: Neuroscience Authors: R. Rogall, A. Pikhovych, A. Bach, M. Hoehn, S. Couillard-Despres, G.R. Fink, M. Schroeter, M.A. Rueger Tags: Poster Source Type: research

Stem Cell Therapy for Abrogating Stroke-Induced Neuroinflammation and Relevant Secondary Cell Death Mechanisms
Publication date: Available online 23 July 2017 Source:Progress in Neurobiology Author(s): Connor Stonesifer, Sydney Corey, Shaila Ghanekar, Zachary Diamandis, Sandra A. Acosta, Cesar V. Borlongan Ischemic stroke is a leading cause of death worldwide. A key secondary cell death mechanism mediating neurological damage following the initial episode of ischemic stroke is the upregulation of endogenous neuroinflammatory processes to levels that destroy hypoxic tissue local to the area of insult, induce apoptosis, and initiate a feedback loop of inflammatory cascades that can expand the region of damage. Stem cell therapy has ...
Source: Progress in Neurobiology - July 23, 2017 Category: Neuroscience Source Type: research

Electrical Preconditioning of Stem Cells
Cool Science The ability to manipulate hNPCs via a conductive scaffold creates a new approach to optimize stem cell-based therapy and determine which factors (such as VEGF-A) are essential for stroke recovery: Paul M. Georgea, Tonya M. Blissb, Thuy Huab, Alex Leed, Byeongtaek Oh, Alexa Levinson, Swapnil Mehta, Guohua Sun, Gary K. Steinberg.Electrical preconditioning of stem cells with a conductive polymer scaffold enhances stroke recovery. doi.org/10.1016/j.biomaterials.2017.07.020...anti βIII-tubulin (1:500, Neuromics, Edina, MN)...Image: Neural progenitors were labeled with anti-ratNestinpolyclonal antibody (Cat#:GT1511...
Source: Neuromics - July 17, 2017 Category: Neuroscience Tags: Human Neural Progenitors nestin antibody Stem cell markers Tuj 1 (Neuron-specific class III beta-tubulin) antibody Tuj-1 antibody Source Type: news

mfat ‐1 transgene protects cultured adult neural stem cells against cobalt chloride–mediated hypoxic injury by activating Nrf2/ARE pathways
Abstract Ischemic stroke is a devastating neurological disorder and one of the leading causes of death and serious disability in adults. Adult neural stem cell (NSC) replacement therapy is a promising treatment for both structural and functional neurological recovery. However, for the treatment to work, adult NSCs must be protected against hypoxic‐ischemic damage in the ischemic penumbra. In the present study, we aimed to investigate the neuroprotective effects of the mfat‐1 transgene on cobalt chloride (CoCl2)‐induced hypoxic‐ischemic injury in cultured adult NSCs as well as its underlying mechanisms. The results ...
Source: Journal of Neuroscience Research - June 22, 2017 Category: Neuroscience Authors: Junfeng Yu, Haiyuan Yang, Bin Fang, Zhengwei Zhang, Ying Wang, Yifan Dai Tags: RESEARCH ARTICLE Source Type: research

mfat ‐1 transgene protects cultured adult neural stem cells against cobalt chloride‐mediated hypoxic injury by activating Nrf2/ARE pathways
Abstract Ischemic stroke is a devastating neurological disorder and one of the leading causes of death and serious disability in adults. Adult neural stem cell (NSC) replacement therapy is a promising treatment for both structural and functional neurological recovery. However, for the treatment to work, adult NSCs must be protected against hypoxic‐ischemic damage in the ischemic penumbra. In the present study, we aimed to investigate the neuroprotective effects of the mfat‐1 transgene on cobalt chloride (CoCl2)‐induced hypoxic‐ischemic injury in cultured adult NSCs as well as its underlying mechanisms. The results ...
Source: Journal of Neuroscience Research - June 22, 2017 Category: Neuroscience Authors: Junfeng Yu, Haiyuan Yang, Bin Fang, Zhengwei Zhang, Ying Wang, Yifan Dai Tags: Research Article Source Type: research

ZL006 promotes migration and differentiation of transplanted neural stem cells in male rats after stroke
In this study, we transplanted exogenous NSCs into the ipsilateral hemisphere of male rats in combination with ZL006 treatment after ischemic stroke. We show that ZL006 treatment facilitates the migration of transplanted NSCs into the ischemia‐injured area and promotes neuronal differentiation of these cells, which is not due to a direct effect of ZL006 on exogenous NSCs but is associated with increased phosphorylation of cAMP response element–binding protein (CREB) in neurons and favorable microenvironment. Moreover, improved functional outcome in the ZL006‐treated group was also found. Taken together, our data indi...
Source: Journal of Neuroscience Research - May 17, 2017 Category: Neuroscience Authors: Dong ‐Liang Wang, Xiao‐Dan Qian, Yu‐Hui Lin, Bin‐Bin Tian, Hai‐Ying Liang, Lei Chang, Hai‐Yin Wu, Dong‐Ya Zhu, Chun‐Xia Luo Tags: RESEARCH ARTICLE Source Type: research

Stem Cell Transplantation Therapy for Multifaceted Therapeutic Benefits after Stroke
Publication date: Available online 18 March 2017 Source:Progress in Neurobiology Author(s): Ling Wei, Zheng Z. Wei, Michael Qize Jiang, Osama Mohamad, Shan Ping Yu One of the exciting advances in modern medicine and life science is cell-based neurovascular regeneration of damaged brain tissues and repair of neuronal structures. The progress in stem cell biology and creation of adult induced pluripotent stem (iPS) cells has significantly improved basic and pre-clinical research in disease mechanisms and generated enthusiasm for potential applications in the treatment of central nervous system (CNS) diseases including strok...
Source: Progress in Neurobiology - March 24, 2017 Category: Neuroscience Source Type: research

Bone marrow mesenchymal stem cells-conditioned medium enhances vascular remodeling after stroke in type 2 diabetic rats
In conclusion, enhanced expression of Ang1 and Tie2 in ischemic brain after BMSCs-CM treatment of stroke may contribute to the improved functional recovery after stroke in type 2 diabetic rats.
Source: Neuroscience Letters - February 26, 2017 Category: Neuroscience Source Type: research

Transplantation with hypoxia ‐preconditioned mesenchymal stem cells suppresses brain injury caused by cardiac arrest–induced global cerebral ischemia in rats
Cardiac arrest–induced global cerebral ischemia is a main cause of neurological dysfunction in emergency medicine. Transplantation with bone marrow mesenchymal stem cells (MSCs) has been used in stroke models to repair the ischemic brain injury, but it is little studied in models with global cerebral ischemia. In the present study, a hypoxia precondition was used to improve the efficacy of MSC transplantation, given the low survival and migration rates and limited differentiation capacities of MSCs. We found that hypoxia can increase the expansion and migration of MSCs by activating the PI3K/AKT and hypoxia‐inducible f...
Source: Journal of Neuroscience Research - February 9, 2017 Category: Neuroscience Authors: Ji ‐wen Wang, Yu‐ru Qiu, Yue Fu, Jun Liu, Zhi‐Jie He, Zi‐tong Huang Tags: Research Article Source Type: research

Effects of Neural Stem Cell and Olfactory Ensheathing Cell Co-transplants on Tissue Remodelling After Transient Focal Cerebral Ischemia in the Adult Rat.
In this study, we address this challenge by testing whether co-grafting of NSCs with olfactory ensheathing cells (OECs), a special type of glia with proven neuroprotective, immunomodulatory, and angiogenic effects, can promote graft survival and host tissue remodelling. Transient focal cerebral ischemia was induced in adult rats by a 60-min middle cerebral artery occlusion (MCAo) followed by reperfusion. Ischemic lesions were verified by neurological testing and magnetic resonance imaging. Transplantation into the globus pallidus of NSCs alone or in combination with OECs was performed at two weeks post-MCAo, followed by hi...
Source: Neurochemical Research - January 23, 2017 Category: Neuroscience Authors: Augestad IL, Nyman AK, Costa AI, Barnett SC, Sandvig A, Håberg AK, Sandvig I Tags: Neurochem Res Source Type: research

Evaluations of Intravenous Administration of CD34+ Human Umbilical Cord Blood Cells in a Mouse Model of Neonatal Hypoxic-Ischemic Encephalopathy
This study suggests that the treatment protocol needs to be optimized for each pathological condition.Dev Neurosci
Source: Developmental Neuroscience - January 20, 2017 Category: Neuroscience Source Type: research

Evaluations of Intravenous Administration of CD34 < sup > + < /sup > Human Umbilical Cord Blood Cells in a Mouse Model of Neonatal Hypoxic-Ischemic Encephalopathy
This study suggests that the treatment protocol needs to be optimized for each pathological condition.Dev Neurosci
Source: Developmental Neuroscience - January 19, 2017 Category: Neuroscience Source Type: research

Targeting antioxidant enzyme expression as a therapeutic strategy for ischemic stroke
Publication date: Available online 30 December 2016 Source:Neurochemistry International Author(s): Stephanie M. Davis, Keith R. Pennypacker During ischemic stroke, neurons and glia are subjected to damage during the acute and neuroinflammatory phases of injury. Production of reactive oxygen species (ROS) from calcium dysregulation in neural cells and the invasion of activated immune cells are responsible for stroke-induced neurodegeneration. Scientists have failed thus far to identify antioxidant-based drugs that can enhance neural cell survival and improve recovery after stroke. However, several groups have demonstrated ...
Source: Neurochemistry International - December 30, 2016 Category: Neuroscience Source Type: research

Sex differences in stroke therapies
Stroke is the fifth leading cause of death and acquired disability in aged populations. Women are disproportionally affected by stroke, having a higher incidence and worse outcomes than men. Numerous preclinical studies have discovered novel therapies for the treatment of stroke, but almost all of these have been shown to be unsuccessful in clinical trials. Despite known sex differences in occurrence and severity of stroke, few preclinical or clinical therapeutics take into account possible sex differences in treatment. Reanalysis of data from studies of tissue plasminogen activator (tPA), the only currently FDA‐approved...
Source: Journal of Neuroscience Research - November 6, 2016 Category: Neuroscience Authors: Farida Sohrabji, Min Jung Park, Amanda H. Mahnke Tags: Review Source Type: research

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