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Specialty: Neurology
Therapy: Immunotherapy

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Total 17 results found since Jan 2013.

Vasculitic neuropathy following exposure to minocycline
Conclusions: Our findings suggest that the typical neuropathy associated with minocycline use is painful single or multiple mononeuropathy due to peripheral nerve vasculitis, which may also be accompanied by presumed CNS vasculitis (presenting as stroke).
Source: Neurology Neuroimmunology and Neuroinflammation - November 12, 2015 Category: Neurology Authors: Baratta, J. M., Dyck, P. J. B., Brand, P., Thaisetthawatkul, P., Dyck, P. J., Engelstad, J. K., Goodman, B., Karam, C. Tags: All Cerebrovascular disease/Stroke, Other cerebrovascular disease/ Stroke, All Immunology, Autoimmune diseases, Vasculitis Article Source Type: research

Stroke-Like Presentation of Paraneoplastic Cerebellar Degeneration: a Single-Center Experience and Review of the Literature
We report herein incidence and clinical features of hyperacute onset PCD, a vertebrobasilar stroke mimic. We performed a retrospective analysis of all suspected PCD cases referred to the Udine University Hospital between 2009 and 2017. Our center provides the only neuroimmunology laboratory for three provinces of the Friuli-Venezia Giulia region, Italy (983,190 people as of January 1, 2017). Inclusion criteria were (1) abrupt onset of neurological symptoms; (2) initial consideration of a vascular etiology; (3) final diagnosis of “definite PCD.” We also carried out a systematic review of the literature in order to ident...
Source: The Cerebellum - August 28, 2019 Category: Neurology Source Type: research

Arterial Spin Labeling Imaging Characteristics of Anti-leucine-rich Glioma-Inactivated 1 Encephalitis: A Qualitative and Quantitative Analysis
DiscussionIn this preliminary study of six patients, we demonstrate an ASL hyperperfusion pattern, with a possible predilection for the right mesial temporal lobe on both qualitative and quantitative assessments in patients with seropositive LGI1. Larger scale studies are necessary to further characterize the strength of these associations.
Source: Frontiers in Neurology - July 28, 2022 Category: Neurology Source Type: research

Giant cell arteritis with vertebral artery involvement —baseline characteristics and follow-up of a monocentric patient cohort
Vertebral artery (VA) involvement in giant cell arteritis (GCA) has rarely been reported. We aimed to evaluate the prevalence, patients’ characteristics, and immunotherapies used in patients with GCA and VA involvement at diagnosis and 1 year follow-up, retrospectively including patients being diagnosed between January 2011 and March 2021 in our department. Clinical features, laboratory data, VA imaging, immunotherapy, and 1 year follow-up data were analyzed. Baseline characteristics were compared to GCA patients without VA involvement. Among all 77 cases with GCA, 29 patients (37.7%) had VA involvement, as diagnosed b...
Source: Frontiers in Neurology - June 26, 2023 Category: Neurology Source Type: research

Neuroinflammation evoked by brain injury in a rat model of lacunar infarct.
Abstract Stroke is the leading cause of long-term, severe disability worldwide. Immediately after the stroke, endogenous inflammatory processes are upregulated, leading to the local neuroinflammation and the potentiation of brain tissue destruction. The innate immune response is triggered as early as 24 h post-brain ischemia, followed by adaptive immunity activation. Together these immune cells produce many inflammatory mediators, i.e., cytokines, growth factors, and chemokines. Our study examines the immune response components in the early stage of deep brain lacunar infarct in the rat brain, highly relevant to...
Source: Experimental Neurology - November 19, 2020 Category: Neurology Authors: Dabrowska S, Andrzejewska A, Kozlowska H, Strzemecki D, Janowski M, Lukomska B Tags: Exp Neurol Source Type: research

"Time is brain" in relapsing remitting multiple sclerosis : Current treatment concepts in immunotherapy.
DISCUSSION: For MS a "time is brain" concept would comprise an early initiation of first line therapy as well as sensitive and structured monitoring of disease activity under therapy in conjunction with a low threshold for timely treatment optimization to achieve sustained freedom from measurable disease activity. This approach may substantially improve the long-term outcome in patients who show insufficient response to platform therapies. The intersectorial collaboration in regional MS care networks involving office-based neurologists and specialized MS centers may facilitate the timely use of highly active therapies with...
Source: Der Nervenarzt - November 12, 2015 Category: Neurology Authors: Linker R, Kallmann BA, Kleinschnitz C, Rieckmann P, Mäurer M, Schwab S Tags: Nervenarzt Source Type: research

Neurologist ambulatory care, health care utilization, and costs in a large commercial dataset
Conclusion: Neurologist involvement with care is associated with greater unadjusted allowed payments, but fewer adverse events and less acute care utilization.
Source: Neurology - January 25, 2016 Category: Neurology Authors: Ney, J. P., Johnson, B., Knabel, T., Craft, K., Kaufman, J. Tags: Cost effectiveness/economic, Outcome research, Medical care, Billing, Insurance ARTICLE Source Type: research

Passive immunotherapy targeting amyloid-{beta} reduces cerebral amyloid angiopathy and improves vascular reactivity
Prominent cerebral amyloid angiopathy is often observed in the brains of elderly individuals and is almost universally found in patients with Alzheimer’s disease. Cerebral amyloid angiopathy is characterized by accumulation of the shorter amyloid-β isoform(s) (predominantly amyloid-β40) in the walls of leptomeningeal and cortical arterioles and is likely a contributory factor to vascular dysfunction leading to stroke and dementia in the elderly. We used transgenic mice with prominent cerebral amyloid angiopathy to investigate the ability of ponezumab, an anti-amyloid-β40 selective antibody, to attenuat...
Source: Brain - January 29, 2016 Category: Neurology Authors: Bales, K. R., ONeill, S. M., Pozdnyakov, N., Pan, F., Caouette, D., Pi, Y., Wood, K. M., Volfson, D., Cirrito, J. R., Han, B.-H., Johnson, A. W., Zipfel, G. J., Samad, T. A. Tags: Neurodegeneration - Cellular & Molecular Original Articles Source Type: research

Characteristics and pharmacodynamics of severe neuroinflammation in a child with neurolupus
We describe a child with extensive peripheral and CNS manifestations and multiorgan involvement. Multiple cellular and cytokine/chemokine markers indicated profound neuroinflammation with some components responsive, others resistant, to 3-agent immunotherapy.
Source: Neurology Neuroimmunology and Neuroinflammation - December 4, 2016 Category: Neurology Authors: Pranzatelli, M. R., McGee, N. R., Wang, Z. Y., Agrawal, B. K. Tags: All Immunology, Autoimmune diseases, Lupus Clinical/Scientific Notes Source Type: research

The role of amyloid beta clearance in cerebral amyloid angiopathy: more potential therapeutic targets
AbstractCerebral amyloid angiopathy (CAA) is characterized by the deposition of amyloid β-protein (Aβ) in the leptomeningeal and cortical blood vessels, which is an age-dependent risk factor for intracerebral hemorrhage (ICH), ischemic stroke and contributes to cerebrovascular dysfunction leading to cognitive impairment. However clinical prevention and treatment of the disease is ver y difficult because of its occult onset and severity of the symptoms. In recent years, many anti-amyloid β immunotherapies have not demonstrated clinical efficacy in subjects with Alzheimer’s disease (AD), and the failure may be due to th...
Source: Translational Neurodegeneration - August 17, 2017 Category: Neurology Source Type: research

Recurrent stroke due to antiphospholipid syndrome remitted by immunotherapy, not by anticoagulation therapy: A case report and literature review
Jin-Mo Park, Kyung Yoon EahAnnals of Indian Academy of Neurology 2019 22(2):250-252
Source: Annals of Indian Academy of Neurology - April 8, 2019 Category: Neurology Authors: Jin-Mo Park Kyung Yoon Eah Source Type: research

Recurrent Stroke in Giant Cell Arteritis Despite Immunotherapy
Conclusions: This case highlights several important features of strokes in GCA: the predilection for the dural entry point of cerebral blood vessels, the progression of disease despite steroids, and the need to quickly escalate treatment in these cases. As seen in our patient, however, this disease carries high morbidity and mortality and patients often have poor outcomes despite aggressive immunosuppression.
Source: The Neurologist - June 28, 2019 Category: Neurology Tags: Case Report/Case Series Source Type: research

Immunotherapy for Parkinson's disease.
Abstract With the increasing prevalence of Parkinson's disease, there is an immediate need to interdict disease signs and symptoms. In recent years this need was met through therapeutic approaches focused on regenerative stem cell replacement and alpha-synuclein clearance. However, neither have shown long-term clinical benefit. A novel therapeutic approach designed to affect disease is focused on transforming the brain's immune microenvironment. As disordered innate and adaptive immune functions are primary components of neurodegenerative disease pathogenesis, this has emerged as a clear opportunity for therapeuti...
Source: Neurobiology of Disease - January 20, 2020 Category: Neurology Authors: Schwab AD, Thurston MJ, Machhi JP, Olson KE, Namminga KL, Gendelman HE, Mosley RL Tags: Neurobiol Dis Source Type: research

The NMDA Receptor Antibody Paradox: A Possible Approach to Developing Immunotherapies Targeting the NMDA Receptor
N-methyl-D-aspartate receptors (NMDAR) play a key role in brain development and function, including contributing to the pathogenesis of many neurological disorders. Immunization against the GluN1 subunit of the NMDAR and the production of GluN1 antibodies is associated with neuroprotective and seizure-protective effects in rodent models of stroke and epilepsy, respectively. Whilst these data suggest the potential for the development of GluN1 antibody therapy, paradoxically GluN1 autoantibodies in humans are associated with the pathogenesis of the autoimmune disease anti-NMDA receptor encephalitis. This review discusses pos...
Source: Frontiers in Neurology - July 2, 2020 Category: Neurology Source Type: research

Neurologic Manifestations of Severe Acute Respiratory Syndrome Coronavirus 2 Infection
This article describes the spectrum of neurologic complications associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, their underlying pathology and pathogenic mechanisms, gaps in knowledge, and current therapeutic strategies. RECENT FINDINGS COVID-19 is the clinical syndrome caused by the novel coronavirus SARS-CoV-2. It can affect the entire neuraxis, and presentations in the acute phase are variable, although anosmia is a common manifestation. Encephalopathy is common in patients who are hospitalized and is often associated with multiorgan involvement. Immune-mediated encephaliti...
Source: CONTINUUM: Lifelong Learning in Neurology - August 1, 2021 Category: Neurology Tags: REVIEW ARTICLES Source Type: research