Agomirs upregulating carboxypeptidase E expression rescue hippocampal neurogenesis and memory deficits in Alzheimer ’s disease
ConclusionsCPE may regulate adult hippocampal neurogenesis via the CPE –BDNF–TrkB signaling pathway. This study supports the prospect of developing miRNA agomirs targeting CPE as biopharmaceuticals to counteract aging- and disease-related neurological decline in human brains. (Source: Translational Neurodegeneration)
Source: Translational Neurodegeneration - April 26, 2024 Category: Neurology Source Type: research
Focusing on mitochondria in the brain: from biology to therapeutics
AbstractMitochondria have multiple functions such as supplying energy, regulating the redox status, and producing proteins encoded by an independent genome. They are closely related to the physiology and pathology of many organs and tissues, among which the brain is particularly prominent. The brain demands 20% of the resting metabolic rate and holds highly active mitochondrial activities. Considerable research shows that mitochondria are closely related to brain function, while mitochondrial defects induce or exacerbate pathology in the brain. In this review, we provide comprehensive research advances of mitochondrial bio...
Source: Translational Neurodegeneration - April 17, 2024 Category: Neurology Source Type: research
The role of the brain renin-angiotensin system in Parkinson ´s disease
AbstractThe renin-angiotensin system (RAS) was classically considered a circulating hormonal system that regulates blood pressure. However, different tissues and organs, including the brain, have a local paracrine RAS. Mutual regulation between the dopaminergic system and RAS has been observed in several tissues. Dysregulation of these interactions leads to renal and cardiovascular diseases, as well as progression of dopaminergic neuron degeneration in a major brain center of dopamine/angiotensin interaction such as the nigrostriatal system. A decrease in the dopaminergic function induces upregulation of the angiotensin ty...
Source: Translational Neurodegeneration - April 15, 2024 Category: Neurology Source Type: research
CRISPR base editing-mediated correction of a tau mutation rescues cognitive decline in a mouse model of tauopathy
(Source: Translational Neurodegeneration)
Source: Translational Neurodegeneration - April 12, 2024 Category: Neurology Source Type: research
Stathmin 2 is a potential treatment target for TDP-43 proteinopathy in amyotrophic lateral sclerosis
(Source: Translational Neurodegeneration)
Source: Translational Neurodegeneration - April 11, 2024 Category: Neurology Source Type: research
Pathophysiological subtypes of mild cognitive impairment due to Alzheimer ’s disease identified by CSF proteomics
(Source: Translational Neurodegeneration)
Source: Translational Neurodegeneration - April 9, 2024 Category: Neurology Source Type: research
Whole-brain dopamine transporter binding pattern predicts survival in multiple system atrophy
(Source: Translational Neurodegeneration)
Source: Translational Neurodegeneration - April 2, 2024 Category: Neurology Source Type: research
Dietary fasting and time-restricted eating in Huntington ’s disease: therapeutic potential and underlying mechanisms
AbstractHuntington's disease (HD) is a devastating neurodegenerative disorder caused by aggregation of the mutant huntingtin (mHTT) protein, resulting from a CAG repeat expansion in the huntingtin geneHTT. HD is characterized by a variety of debilitating symptoms including involuntary movements, cognitive impairment, and psychiatric disturbances. Despite considerable efforts, effective disease-modifying treatments for HD remain elusive, necessitating exploration of novel therapeutic approaches, including lifestyle modifications that could delay symptom onset and disease progression. Recent studies suggest that time-restric...
Source: Translational Neurodegeneration - April 2, 2024 Category: Neurology Source Type: research
Overlaps and divergences between tauopathies and synucleinopathies: a duet of neurodegeneration
AbstractProteinopathy, defined as the abnormal accumulation of proteins that eventually leads to cell death, is one of the most significant pathological features of neurodegenerative diseases. Tauopathies, represented by Alzheimer ’s disease (AD), and synucleinopathies, represented by Parkinson’s disease (PD), show similarities in multiple aspects. AD manifests extrapyramidal symptoms while dementia is also a major sign of advanced PD. We and other researchers have sequentially shown the cross-seeding phenomenon of α-syn uclein (α-syn) and tau, reinforcing pathologies between synucleinopathies and tauopathies. The hi...
Source: Translational Neurodegeneration - March 26, 2024 Category: Neurology Source Type: research
Biases in α-synuclein immuno-quantitation: a core problem for basic and ancillary studies of Parkinson’s disease and multiple system atrophy
(Source: Translational Neurodegeneration)
Source: Translational Neurodegeneration - March 25, 2024 Category: Neurology Source Type: research
Putative novel CSF biomarkers of Alzheimer ’s disease based on the novel concept of generic protein misfolding and proteotoxicity: the PRAMA cohort
(Source: Translational Neurodegeneration)
Source: Translational Neurodegeneration - March 8, 2024 Category: Neurology Source Type: research
LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology progression
ConclusionsThis work supports a protective role of LRRK2 kinase inhibition in G2019S carriers and provides a rational workflow for systematic evaluation of brain-wide phenotypes in therapeutic development. (Source: Translational Neurodegeneration)
Source: Translational Neurodegeneration - March 4, 2024 Category: Neurology Source Type: research
Therapeutics for neurodegenerative diseases by targeting the gut microbiome: from bench to bedside
AbstractThe aetiologies and origins of neurodegenerative diseases, such as Alzheimer ’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD), are complex and multifaceted. A growing body of evidence suggests that the gut microbiome plays crucial roles in the development and progression of neurodegenerative diseases. Clinicia ns have come to realize that therapeutics targeting the gut microbiome have the potential to halt the progression of neurodegenerative diseases. This narrative review examines the alterations in the gut microbiome in AD, PD, ALS and HD, highlig...
Source: Translational Neurodegeneration - February 27, 2024 Category: Neurology Source Type: research
α-Synuclein oligomers potentiate neuroinflammatory NF-κB activity and induce Cav3.2 calcium signaling in astrocytes
ConclusionsOur work supports a causative link between the neuron-produced α-synuclein oligomers and sustained neuroinflammation in vivo and maps the signaling pathways that are stimulated in microglia and astrocytes. It also highlights the recruitment of astrocytic Cav3.2 channels as a potential neuroprotective mediator against the α-synuclein-induced neuroinflammation.Graphical Abstract (Source: Translational Neurodegeneration)
Source: Translational Neurodegeneration - February 21, 2024 Category: Neurology Source Type: research
Emerging role of senescent microglia in brain aging-related neurodegenerative diseases
AbstractBrain aging is a recognized risk factor for neurodegenerative diseases like Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), but the intricate interplay between brain aging and the pathogenesis of these conditions remains inadequately understood. Cellular senescence is considered to contribute to cellular dysfunction and inflammaging. According to the threshold theory of senescent cell accumulation, the vulnerability to neurodegenerative diseases is associated with the rates of senescent cell generation and clearance within the brain. Given the role of microgl...
Source: Translational Neurodegeneration - February 20, 2024 Category: Neurology Source Type: research
