LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology progression

ConclusionsThis work supports a protective role of LRRK2 kinase inhibition in G2019S carriers and provides a rational workflow for systematic evaluation of brain-wide phenotypes in therapeutic development.

http://link.springer.com/10.1186/s40035-024-00403-2

Source: Translational Neurodegeneration - March 4, 2024 Category: Neurology Source Type: research