The Gold Coast criteria increases the diagnostic sensitivity for amyotrophic lateral sclerosis in a Chinese population
ConclusionsThe current study demonstrated that the Gold Coast criteria exhibited greater diagnostic sensitivity than the rEEC and Awaji criteria in a Chinese ALS population. The application of the Gold Coast criteria should be considered in clinical practice and future therapeutic trials. (Source: Translational Neurodegeneration)
Source: Translational Neurodegeneration - August 9, 2021 Category: Neurology Source Type: research
Multivariable clinical-genetic model for predicting dyskinesia in early-onset Parkinson ’s disease
(Source: Translational Neurodegeneration)
Source: Translational Neurodegeneration - July 29, 2021 Category: Neurology Source Type: research
Several miRNAs derived from serum extracellular vesicles are potential biomarkers for early diagnosis and progression of Parkinson ’s disease
ConclusionsThe 6 serum EV-derived miRNAs, hsa-miR-374a-5p, hsa-miR-374b-5p, hsa-miR-199a-3p, hsa-miR-28-5p, hsa-miR-22-5p and hsa-miR-151a-5p, may potentially be used as biomarkers for PD progression and for early diagnosis of PD in populations. (Source: Translational Neurodegeneration)
Source: Translational Neurodegeneration - July 28, 2021 Category: Neurology Source Type: research
Language training for oral and written naming impairment in primary progressive aphasia: a review
ConclusionThe majority of studies have demonstrated improvements of naming abilities following language treatments. Given the progressive nature of PPA, it is essential to apply language treatment in the early stages of the disease. (Source: Translational Neurodegeneration)
Source: Translational Neurodegeneration - July 16, 2021 Category: Neurology Source Type: research
The effects of transcranial direct current stimulation on gait in patients with Parkinson ’s disease: a systematic review
ConclusionstDCS is a promising intervention approach to improving gait in PD. Anodal tDCS over the motor areas has shown a positive effect on gait, but stimulation of other areas is less promising. However, the heterogeneities of methods and results have made it difficult to draw firm conclusions. Therefore, systematic explorations of tDCS protocols are required to optimize the efficacy. (Source: Translational Neurodegeneration)
Source: Translational Neurodegeneration - June 29, 2021 Category: Neurology Source Type: research
Inhibition of lysine methyltransferase G9a/GLP reinstates long-term synaptic plasticity and synaptic tagging/capture by facilitating protein synthesis in the hippocampal CA1 area of APP/PS1 mouse model of Alzheimer ’s disease
(Source: Translational Neurodegeneration)
Source: Translational Neurodegeneration - June 29, 2021 Category: Neurology Source Type: research
Metabolic changes in an animal model of amyotrophic lateral sclerosis evaluated by [18F]-FDG positron emission tomography
(Source: Translational Neurodegeneration)
Source: Translational Neurodegeneration - June 23, 2021 Category: Neurology Source Type: research
Differential seeding and propagating efficiency of α-synuclein strains generated in different conditions
ConclusionsThe different α-syn conformers generated in different conditions exhibited strain-specific pathology and propagation patterns from the periphery to the CNS, which further supports the view that α-syn strains may be responsible for the heterogeneity of pathological features and disease progresses among synuclein opathies. (Source: Translational Neurodegeneration)
Source: Translational Neurodegeneration - June 21, 2021 Category: Neurology Source Type: research
Parkinson ’s disease–associated VPS35 mutant reduces mitochondrial membrane potential and impairs PINK1/Parkin-mediated mitophagy
ConclusionOur findings extend the pool of evidence that the p.D620N mutation of VPS35 causes mitochondrial dysfunction and suggest a converging pathogenic mechanism among VPS35, PINK1 and Parkin in PD. (Source: Translational Neurodegeneration)
Source: Translational Neurodegeneration - June 15, 2021 Category: Neurology Source Type: research
Associations of cerebrospinal fluid amyloidogenic nanoplaques with cytokines in Alzheimer ’s disease
ConclusionThe cytokine levels were not associated with amyloid status in this cohort. The nanoplaque levels were negatively associated with MIP-1 β, MIP-1α and IL-8, which is in line with recent findings suggesting that the upregulation of some cytokine markers has a protective role and is negatively associated with AD progression. (Source: Translational Neurodegeneration)
Source: Translational Neurodegeneration - June 8, 2021 Category: Neurology Source Type: research
Disruption of orbitofrontal-hypothalamic projections in a murine ALS model and in human patients
ConclusionThis study provides converging murine and human data demonstrating the selective structural disruption of hypothalamic inputs in ALS as a promising factor contributing to the origin of the hypermetabolic phenotype. (Source: Translational Neurodegeneration)
Source: Translational Neurodegeneration - May 31, 2021 Category: Neurology Source Type: research
Neurodegenerative diseases: a hotbed for splicing defects and the potential therapies
AbstractPrecursor messenger RNA (pre-mRNA) splicing is a fundamental step in eukaryotic gene expression that systematically removes non-coding regions (introns) and ligates coding regions (exons) into a continuous message (mature mRNA). This process is highly regulated and can be highly flexible through a process known as alternative splicing, which allows for several transcripts to arise from a single gene, thereby greatly increasing genetic plasticity and the diversity of proteome. Alternative splicing is particularly prevalent in neuronal cells, where the splicing patterns are continuously changing to maintain cellular ...
Source: Translational Neurodegeneration - May 20, 2021 Category: Neurology Source Type: research
COVID-19 and Alzheimer ’s disease: how one crisis worsens the other
AbstractAlzheimer ’s disease (AD) has emerged as a key comorbidity of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The morbidity and mortality of COVID-19 are elevated in AD due to multiple pathological changes in AD patients such as the excessive expre ssion of viral receptor angiotensin converting enzyme 2 and pro-inflammatory molecules, various AD complications including diabetes, lifestyle alterations in AD, and drug-drug interactions. Meanwhile, COVID-19 has also been reported to cause various neurologic symptoms including cognitive impairment that may u...
Source: Translational Neurodegeneration - April 30, 2021 Category: Neurology Source Type: research
Effectiveness and mechanisms of adipose-derived stem cell therapy in animal models of Parkinson ’s disease: a systematic review and meta-analysis
AbstractAnimal models provide an opportunity to assess the optimal treatment way and the underlying mechanisms of direct clinical application of adipose-derived stem cells (ADSCs). Previous studies have evaluated the effects of primitive and induced ADSCs in animal models of Parkinson ’s disease (PD). Here, eight databases were systematically searched for studies on the effects and in vivo changes caused by ADSC intervention. Quality assessment was conducted using a 10-item risk of bias tool. For the subsequent meta-analysis, study characteristics were extracted and effect size s were computed. Ten out of 2324 published ...
Source: Translational Neurodegeneration - April 29, 2021 Category: Neurology Source Type: research
Acrolein scavenger dimercaprol offers neuroprotection in an animal model of Parkinson ’s disease: implication of acrolein and TRPA1
ConclusionsThese results further elucidated the acrolein-mediated pathogenesis and reinforced the critical role of acrolein in PD while providing strong arguments for anti-acrolein treatments as a novel and feasible strategy to combat neurodegeneration in PD. Considering the extensive involvement of acrolein in various nervous system illnesses and beyond, anti-acrolein strategies may have wide applications and broad impacts on human health. (Source: Translational Neurodegeneration)
Source: Translational Neurodegeneration - April 28, 2021 Category: Neurology Source Type: research
