Differential seeding and propagating efficiency of α-synuclein strains generated in different conditions

ConclusionsThe different α-syn conformers generated in different conditions exhibited strain-specific pathology and propagation patterns from the periphery to the CNS, which further supports the view that α-syn strains may be responsible for the heterogeneity of pathological features and disease progresses among synuclein opathies.

Source: Translational Neurodegeneration - June 21, 2021 Category: Neurology Source Type: research