Neurodegeneration-associated FUS is a novel regulator of circadian gene expression
ConclusionsTherefore, we have demonstrated FUS as a modulator of circadian gene expression, and provided novel mechanistic insights into the mutual influence between circadian control and neurodegeneration-associated proteins. (Source: Translational Neurodegeneration)
Source: Translational Neurodegeneration - October 12, 2018 Category: Neurology Source Type: research
CSF A β 1–42 level is associated with cognitive decline in early Parkinson’s disease with rapid eye movement sleep behavior disorder
ConclusionThese findings indicate that CSF A β1 –42 level is associated with global cognitive decline in early PD with RBD. The addition of CSF A β1 –42 to RBD testing increase the likelihood of identifying those at high risk for cognitive decline in early PD. (Source: Translational Neurodegeneration)
Source: Translational Neurodegeneration - October 8, 2018 Category: Neurology Source Type: research
Alpha-synuclein overexpression in the olfactory bulb initiates prodromal symptoms and pathology of Parkinson ’s disease
ConclusionsThese results demonstrate that expression of exogenous mutant α-syn in the OB induces pathological changes in the sensitive brain fields by transferring pathogenic α-syn to adjacent fields. This method may be useful for establishing an animal model of prodromal PD. (Source: Translational Neurodegeneration)
Source: Translational Neurodegeneration - September 28, 2018 Category: Neurology Source Type: research
Bis(9)-( −)-Meptazinol, a novel dual-binding AChE inhibitor, rescues cognitive deficits and pathological changes in APP/PS1 transgenic mice
ConclusionThese results indicate that B9M appears to have potential as an effective AChE inhibitor for the treatment of AD with symptom-relieving and disease-modifying properties. (Source: Translational Neurodegeneration)
Source: Translational Neurodegeneration - September 11, 2018 Category: Neurology Source Type: research
