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Cystatin C Is a Crucial Endogenous Protective Determinant Against Stroke Basic Sciences
Conclusions—CysC is a crucial determinant contributing to endogenous neuroprotection. It is also a novel candidate for stroke treatment through maintaining lysosomal membrane integrity.
Source: Stroke - January 22, 2017 Category: Neurology Authors: Zongping Fang, Jiao Deng, Zhixin Wu, Beibei Dong, Shiquan Wang, Xiaodan Chen, Huang Nie, Hailong Dong, Lize Xiong Tags: Ischemic Stroke, Neuroprotectants Original Contributions Source Type: research

Hyperbaric Oxygen Therapy for Acute Ischemic Stroke Cochrane Corner
Source: Stroke - April 27, 2015 Category: Neurology Authors: Bennett, M. H., Weibel, S., Wasiak, J., Schnabel, A., French, C., Kranke, P. Tags: Acute Cerebral Infarction, Acute Stroke Syndromes, Embolic stroke, Emergency treatment of Stroke, Other Stroke Treatment - Medical Cochrane Corner Source Type: research

Delayed Hyperbaric Oxygen Therapy Promotes Neurogenesis Through Reactive Oxygen Species/Hypoxia-Inducible Factor-1{alpha}/{beta}-Catenin Pathway in Middle Cerebral Artery Occlusion Rats Basic Sciences
Conclusions— Delayed HBO enhanced endogenous neurogenesis and improved neurofunctional recovery in the late-chronic phase of stroke possibly mediated by ROS/HIF-1α/β-catenin pathway. Delayed HBO may serve as an alternative treatment to improve long-term recovery of stroke survivors.
Source: Stroke - May 27, 2014 Category: Neurology Authors: Hu, Q., Liang, X., Chen, D., Chen, Y., Doycheva, D., Tang, J., Tang, J., Zhang, J. H. Tags: Animal models of human disease, Other Stroke Treatment - Medical Basic Sciences Source Type: research

Hyperbaric oxygen treatment new player in stroke rehabilitation
Treatment with hyperbaric oxygen therapy can lead to significant neurologic improvements for stroke patients, show study results.
Source: MedWire News - Stroke - January 30, 2013 Category: Neurology Source Type: news

Hyperbaric oxygen therapy improves neurocognitive functions of post-stroke patients - a retrospective analysis.
CONCLUSIONS: HBOT induces significant improvements in all cognitive domains even in the late chronic stage. The selection of post-stroke patients for HBOT should be based on functional analysis and baseline cognitive scores rather than the stroke type, location or side of lesion. PMID: 31985478 [PubMed - as supplied by publisher]
Source: Restorative Neurology and Neuroscience - January 29, 2020 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Hyperbaric oxygen therapy in acute stroke: is it time for Justitia to open her eyes?
AbstractHypoxia is a critical component of neuronal death in patients with stroke. Therefore increasing oxygenation of brain tissue seems to be a logical therapy against cerebral ischemia. Oxygen therapy exists in two modalities: normobaric hyperoxia therapy and hyperbaric oxygen therapy (HBO). HBO is a therapeutic procedure in which pure (100%) oxygen is administered at greater than atmospheric pressure in HBO therapy chambers. In this review article, we aimed to summarize the current knowledge regarding the therapeutic use of HBO in acute stroke patients. Literature review and electronic search were performed using PubMe...
Source: Neurological Sciences - January 10, 2020 Category: Neurology Source Type: research

Osteopontin Mediates Hyperbaric Oxygen Preconditioning-Induced Neuroprotection Against Ischemic Stroke
Abstract Neurosurgical operations may result in surgical injury which would lead to postoperative neurological deficits. Hyperbaric oxygen preconditioning (HBO-PC) may be beneficial for such people. However, the exact mechanism underlying HBO-PC is not well known yet. The aim of this study is to explore the role of osteopontin (OPN) in HBO-PC-induced neuroprotection. The study consisted of two experiments. In experiment 1, Sprague Dawley (SD) rats were divided into four groups: sham group, HBO-PC sham group, stroke group, and HBO-PC group (HBO-PC + stroke). The animals in the second experiment were randomly a...
Source: Molecular Neurobiology - July 21, 2015 Category: Neurology Source Type: research

Hyperbaric Oxygen Therapy in Acute Ischemic Stroke: A Review
Stroke, also known as cerebrovascular disease, is a common and serious neurological disease, which is also the fourth leading cause of death in the United States so far. Hyperbaric medicine, as an emerging interdisciplinary subject, has been applied in the treatment of cerebral vascular diseases since the 1960s. Now it is widely used to treat a variety of clinical disorders, especially hypoxia-induced disorders. However, owing to the complex mechanisms of hyperbaric oxygen (HBO) treatment, the therapeutic time window and the undefined dose as well as some common clinical side effects (such as middle ear barotrauma), the wi...
Source: Interventional Neurology - November 7, 2014 Category: Neurology Source Type: research

Hyperbaric Oxygen Reduces Infarction Volume and Hemorrhagic Transformation Through ATP/NAD+/Sirt1 Pathway in Hyperglycemic Middle Cerebral Artery Occlusion Rats Basic Sciences
Conclusions—HBO induced activation of ATP/nicotinamide adenine dinucleotide/silent mating type information regulation 2 homolog 1 pathway and protected blood–brain barrier in hyperglycemic middle cerebral artery occlusion rats. HBO might be promising approach for treatment of acute ischemic stroke patients, especially patients with diabetes mellitus or treated with r-tPA (recombinant tissue-type plasminogen activator).
Source: Stroke - May 22, 2017 Category: Neurology Authors: Qin Hu, Anatol Manaenko, Hetao Bian, Zongduo Guo, Jun-Long Huang, Zhen-Ni Guo, Peng Yang, Jiping Tang, John H. Zhang Tags: Animal Models of Human Disease, Basic Science Research, Ischemia, Neuroprotectants Original Contributions Source Type: research

The Effect of Hyperbaric Oxygen Therapy on Functional Impairments Caused by Ischemic Stroke.
Conclusions: Findings from this study support the idea of HBOT as a potential intervention following stroke. PMID: 30402285 [PubMed]
Source: Neurology Research International - November 9, 2018 Category: Neurology Tags: Neurol Res Int Source Type: research

Stroke Due to Air Embolism Related to Laser Ablation of Accessory Vein (P4.357)
Conclusions: Air embolism leading to devastating stroke may occur few hours after laser treatment of varicose veins. Chest symptoms associated with the procedure should raise the possibility of air embolism. Immediate therapeutic measures like 100[percnt] oxygen, hyperbaric oxygen chamber and/or hypothermia should be considered to prevent neurologic complications.Disclosure: Dr. Kale has nothing to disclose. Dr. Javed has nothing to disclose. Dr. Pednekar has nothing to disclose. Dr. Sahni has nothing to disclose. Dr. Resor has nothing to disclose. Dr. Tenner has nothing to disclose. Dr. Ahluwalia-Singh has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Kale, P., Javed, B., Pednekar, N., Sahni, R., Resor, L., Tenner, M., Ahluwalia-Singh, B. Tags: Cerebrovascular Case Reports Source Type: research

Advances in Normobaric Hyperoxia Brain Protection in Experimental Stroke
As we all know that stroke is still a leading cause of death and acquired disability. Etiological treatment and brain protection are equally important. This review aimed to summarize the advance of normobaric-hyperoxia (NBHO) on brain protection in the setting of experimental stroke and brain trauma. We analyzed the data from relevant studies published on PubMed Central (PMC) and EMBASE, about NBHO on brain protection in the setting of experimental ischemic and hemorrhagic strokes and brain trauma, which revealed that NBHO had important value on improving hypoxia and attenuating ischemia damage. The mechanisms of NBHO invo...
Source: Frontiers in Neurology - January 30, 2020 Category: Neurology Source Type: research

An overview of hyperbaric oxygen preconditioning against ischemic stroke
This study comprehensively reviewed the pathophysiology of IS and revealed the underlying mechanism of HBO-PC in protection against IS. The preventive effects of HBO-PC against IS may include inducing antioxidant, anti-inflammation, and anti-apoptosis capacity; activating autophagy and immune responses; upregulating heat shock proteins, hypoxia-inducible factor-1, and erythropoietin; and exerting protective effects upon the blood-brain barrier. In addition, HBO-PC may be considered a safe and effective method to prevent IS in combination with stem cell therapy. Although the benefits of HBO-PC on IS have been widely observe...
Source: Metabolic Brain Disease - February 2, 2023 Category: Neurology Source Type: research

Variability in Approach to Treatment of Acute Central Retinal Artery Occlusion in US Teaching Hospitals (I6.003)
CONCLUSIONS: There is currently no consensus on how patients with acute CRAO should be managed and there is resulting wide variability in treatment trends. We propose an evidence-based protocol for acute management of these patients.Disclosure: Dr. Schrag has nothing to disclose. Dr. Youn has nothing to disclose. Dr. Patrylo has nothing to disclose. Dr. Schindler has nothing to disclose. Dr. Lavin has nothing to disclose. Dr. Kirshner has nothing to disclose. Dr. Greer has received personal compensation for activities with Bard Medical. Dr. Greer has received personal compensation in an editorial capacity for Seminars in Neurology.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Schrag, M., Youn, T., Patrylo, M., Schindler, J., Lavin, P., Kirshner, H., Greer, D. Tags: Future Directions and Challenges in Stroke Team Action Therapy (STAT) Data Blitz Presentations Source Type: research

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