Psychometric Properties of Preference-Based Measures for Economic Evaluation in Amyotrophic Lateral Sclerosis: A Systematic Review.
Conclusion: This review highlights the need for more rigorously designed studies to assess the psychometric properties of generic PBMs in ALS and the development of an ALS specific PBM that adequately reflects the health concerns of individuals with ALS. PMID: 33575042 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - February 13, 2021 Category: Neurology Tags: Neurol Res Int Source Type: research

Novel Human-Centered Robotics: Towards an Automated Process for Neurorehabilitation.
Authors: Parre MD, Sujatha B Abstract The global requirement of patient rehabilitation has surged with time due to the growing number of accidents, injuries, age-related issues, and other aspects. Parallelly, the cost of treatment and patient care also increased in a manifold. Moreover, constant monitoring and support for the patients having physical disabilities have become an ongoing challenge to the medical system. Robotics-based neurorehabilitation has reduced the human error while assisting such patients, precisely interpreting the signals, and communicating to the patient. Gradual precise application and impr...
Source: Neurology Research International - February 12, 2021 Category: Neurology Tags: Neurol Res Int Source Type: research

Sensitivity of Awaji Criteria and Revised El Escorial Criteria in the Diagnosis of Amyotrophic Lateral Sclerosis (ALS) at First Visit in a Tunisian Cohort.
Authors: Ido BJF, Kacem I, Ouedraogo M, Nasri A, Mrabet S, Gargouri A, Ben Djebara M, Kabore BJ, Gouider R Abstract Background: Amyotrophic lateral sclerosis (ALS) is a fatal disease whose diagnosis and early management can improve survival. The most used diagnostic criteria are the revised El Escorial criteria (rEEC) and Awaji criteria (AC). The comparison of their sensitivities showed contradictory results. Our study aimed to compare the sensitivities of these two criteria in the diagnosis of definite ALS, at first visit, in a Tunisian hospital cohort. Materials and Methods: This was a retrospective study inc...
Source: Neurology Research International - February 10, 2021 Category: Neurology Tags: Neurol Res Int Source Type: research

Comparison of Cognitive Rehabilitation versus Donepezil Therapy on Memory Performance, Attention, Quality of Life, and Depression among Multiple Sclerosis Patients.
Authors: Shahpouri MM, Barekatain M, Tavakoli M, Mirmosayyeb O, Safaei A, Shaygannejad V Abstract Background: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system that affects cognitive performance and leads to depression and decreased quality of life (QOL). The current study aims to assess the effects of cognitive rehabilitation versus donepezil therapy on memory, attention, depression, and QOL in MS patients compared to placebo and control groups. Methods: Eighty MS patients were randomly selected from parallel randomized trials and divided into four groups: A: cognitive rehabilita...
Source: Neurology Research International - December 12, 2020 Category: Neurology Tags: Neurol Res Int Source Type: research

Effect of Task-Specific Training on Trunk Control and Balance in Patients with Subacute Stroke.
Conclusion: Task-specific training may be effective in improving the static and dynamic postural control and trunk ranges of motion among subacute stroke patients. PMID: 33294224 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - December 11, 2020 Category: Neurology Tags: Neurol Res Int Source Type: research

Acute Ischemic Stroke in COVID-19: Putative Mechanisms, Clinical Characteristics, and Management.
Authors: Ojo AS, Balogun SA, Idowu AO Abstract The emergence and spread of the highly contagious novel coronavirus disease (COVID-19) have triggered the greatest public health challenge of the last century. Aside from being a primary respiratory disease, acute ischemic stroke has emerged as a complication of the disease. While current evidence shows COVID-19 could cause ischemic stroke especially in severe disease, there are similarities in the risk factors for severe COVID-19 as well as ischemic stroke, underscoring the complex relationship between these two conditions. The pandemic has created challenges for acut...
Source: Neurology Research International - November 25, 2020 Category: Neurology Tags: Neurol Res Int Source Type: research

Nonadherence to Antiepileptic Medications and Its Determinants among Epileptic Patients at the University of Gondar Referral Hospital, Gondar, Ethiopia, 2019: An Institutional-Based Cross-Sectional Study.
Conclusions: Prevalence of nonadherence to antiepileptic medications among epileptic patients at the University of Gondar Referral Hospital was found to be high. Hence, giving health information about epilepsy and its management will help to reduce antiepileptic medications' nonadherence. PMID: 33194230 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - November 18, 2020 Category: Neurology Tags: Neurol Res Int Source Type: research

High Prevalence of Poststroke Depression in Ischemic Stroke Patients in Ethiopia.
Conclusion: Depressive symptoms after stroke are common in Ethiopian patients. Our study demonstrates female and aphasic patients are more likely to screen positive for PSD. Hence, screening all poststroke patients with different screening tools is practical, and further studies are needed to assess the validity of these screening tools and also to assess PSD as a predictor of stroke outcome. PMID: 33178458 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - November 14, 2020 Category: Neurology Tags: Neurol Res Int Source Type: research

Medication Beliefs and Adherence to Antiseizure Medications.
Conclusions: Ours is one of the very few studies that evaluated medication beliefs and their association with adherence to ASMs among elderly epilepsy patients in a non-western context. In our context, medication beliefs are likely to have an independent role in effecting adherence to ASMs, particularly the concern that "ASMs disrupt life." Treating physicians should cultivate good conscience about ASMs and evaluate the patient's medication beliefs early-on to identify those who might be at the risk of becoming nonadherent. PMID: 33163231 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - November 11, 2020 Category: Neurology Tags: Neurol Res Int Source Type: research

Neurocognitive Functioning among Children with Sickle Cell Anemia Attending SCA Clinic at MNH, Dar es Salaam, Tanzania.
Conclusion and Recommendation. Children with SCA had more impairment in terms of copying and IQ. We recommend assessment at the younger age group, increased sample size in future studies, and long-term cohort follow-up. PMID: 32953173 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - September 23, 2020 Category: Neurology Tags: Neurol Res Int Source Type: research

Pattern-Reversal Visual Evoked Potentials Tests in Persons with Type 2 Diabetes Mellitus with and without Diabetic Retinopathy.
Conclusions: The PRVEP test detected neurological changes, mainly as conductive alterations affecting mostly the foveal region prior to any overt DR clinical changes, and these alterations were heightened by the presence of DR clinical changes. PMID: 32908701 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - September 13, 2020 Category: Neurology Tags: Neurol Res Int Source Type: research

Corrigendum to "Effects of Number of Repetitions and Number of Hours of Shaping Practice during Constraint-Induced Movement Therapy: A Randomized Controlled Trial".
Corrigendum to "Effects of Number of Repetitions and Number of Hours of Shaping Practice during Constraint-Induced Movement Therapy: A Randomized Controlled Trial". Neurol Res Int. 2020;2020:1256231 Authors: Abdullahi A Abstract [This corrects the article DOI: 10.1155/2018/5496408.]. PMID: 32908702 [PubMed - in process] (Source: Neurology Research International)
Source: Neurology Research International - September 13, 2020 Category: Neurology Tags: Neurol Res Int Source Type: research

Minimizing the Diagnostic Delay in Amyotrophic Lateral Sclerosis: The Role of Nonneurologist Practitioners.
Conclusion: In relation to total survival time, the diagnostic delay of ALS appears to be proportionately very long, sometimes longer than that observed in previous studies (because it also included the total delay to diagnostic or treatment initiation). The rapid execution of useful additional tests by the first medical doctor, often GP (with the help of a neurologist), considerably reduces the diagnostic delay. The central role of GP seems to be crucial in the management of patients with ALS. The main objective is, of course, to initiate appropriate treatment and care as soon as possible. Finally, based on our results, w...
Source: Neurology Research International - May 28, 2020 Category: Neurology Tags: Neurol Res Int Source Type: research

Epidemiology of Epilepsy in Lubumbashi, Democratic Republic of Congo.
Conclusion: This study is a useful starting point from which health programs and health professionals can work to improve the diagnosis and quality of epilepsy management in our community. PMID: 32411462 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - May 16, 2020 Category: Neurology Tags: Neurol Res Int Source Type: research

Electricity, Neurology, and Noninvasive Brain Stimulation: Looking Back, Looking Ahead.
This article looks at their origins and their journey into noninvasive brain stimulation technique of transcranial direct current stimulation (tDCS), which is now popular in neuroscience research. PMID: 32328305 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - April 26, 2020 Category: Neurology Tags: Neurol Res Int Source Type: research

Epilepsy Treatment Outcome and Its Predictors among Ambulatory Patients with Epilepsy at Mizan-Tepi University Teaching Hospital, Southwest Ethiopia.
Authors: Zewudie A, Mamo Y, Feyissa D, Yimam M, Mekonen G, Abdela A Abstract Background: Epilepsy is among the most common neurological disorders which is highly treatable with currently available antiepileptic drugs at a reasonable price. In Ethiopia, despite a number of studies revealed high prevalence of epilepsy, little is known on predictors of poorly controlled seizures. Thus, the aim of this study was to assess epilepsy treatment outcome and its predictors among patients with epilepsy on follow-up at the ambulatory care unit of Mizan-Tepi University Teaching Hospital, Southwest Ethiopia. Methods: A hospi...
Source: Neurology Research International - April 26, 2020 Category: Neurology Tags: Neurol Res Int Source Type: research

Validation of an Individualized Measure of Quality of Life, Patient Generated Index, for Use with People with Parkinson's Disease.
Conclusion: This study demonstrates that nominated areas of QOL on the PGI provide comparable results to standard PRO measures, and provides evidence in support of the validity of this individualized measure in PD. PMID: 32292601 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - April 16, 2020 Category: Neurology Tags: Neurol Res Int Source Type: research

HMGB1 is a Potential Mediator of Astrocytic TLR4 Signaling Activation following Acute and Chronic Focal Cerebral Ischemia.
This study evaluated TLR4 signaling, and downstream mediators, in astrocytes, during acute and chronic phases post transient middle cerebral artery occlusion (MCAO). We also determined whether high mobility group box 1 (HMGB1), an endogenous TLR4 ligand, was sufficient to induce TLR4 signaling activation in astrocytes in vivo and in vitro. We injected HMGB1 into normal cortex, in vivo, and stimulated cultured astrocytes with HMGB1, in vitro, and determined TLR4, and downstream mediator, expression by immunohistochemistry. We found that expression of TLR4, and downstream mediators, such as inducible nitric oxide synthase (i...
Source: Neurology Research International - March 10, 2020 Category: Neurology Tags: Neurol Res Int Source Type: research

Structural Equation Modeling of Parkinson's Caregiver Social Support, Resilience, and Mental Health: A Strength-Based Perspective.
Authors: Tyler CM, Henry RS, Perrin PB, Watson J, Villaseñor T, Lageman SK, Smith ER, Curiel GR, Avila J, Jimenez Maldonado ME, Soto-Escageda JA Abstract Only scant literature has focused on social support in Parkinson's disease (PD) caregivers, and no studies to date have examined resilience in this population, despite both variables having been shown to be important in other caregiving populations. As a result, the purpose of the current study was to construct and validate a theoretical structural equation model whereby social support is associated with higher levels of resilience in PD caregivers and incr...
Source: Neurology Research International - February 29, 2020 Category: Neurology Tags: Neurol Res Int Source Type: research

Nine Hole Peg Test and Transcranial Magnetic Stimulation: Useful to Evaluate Dexterity of the Hand and Disease Progression in Amyotrophic Lateral Sclerosis.
We examined 28 ALS patients and 27 age-matched healthy controls. ALS patients and healthy controls underwent the nine hole peg test (NHPT) and TMS with RMT. Measurements in patients were repeated after three and six months. Results: At baseline, the median NHPT durations were 1,4-fold longer (p
Source: Neurology Research International - December 14, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Prevalence and Correlates of Neurocognitive Disorders among HIV Patients on Antiretroviral Therapy at a Kenyan Hospital.
Authors: Mugendi AG, Kubo MN, Nyamu DG, Mwaniki LM, Wahome SK, Haberer JE Abstract Background: HIV-associated neurocognitive disorders (HAND) represent a spectrum of cognitive abnormalities affecting attention, concentration, learning, memory, executive function, psychomotor speed, and/or dexterity. Our objectives in this analysis are to determine the prevalence of HAND and the covariates in a Kenyan population. Methods: We conducted a cross-sectional study in a convenient sample of people living with HIV on antiretroviral therapy (ART) attending routine care visits at the Kenyatta National Hospital HIV clinic ...
Source: Neurology Research International - November 30, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Utilization of a Parental Approach to Informed Consent in Intravenous Tissue Plasminogen Activator Administration Decision-Making: Patient Preference and Ethical Considerations.
Conclusion: Our results indicate that while paternalism is generally discouraged in the medical community, some degree of parental language may be preferred by patients in tough decision-making situations toward consent to receive medical interventions. PMID: 31583134 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - October 5, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Impaired Recent Verbal Memory in Pornography-Addicted Juvenile Subjects.
Authors: Prawiroharjo P, Ellydar H, Pratama P, Edison RE, Suaidy SEI, Amani NZ, Carissima D Abstract We aimed to find the differences in memory capabilities between pornography-addicted and nonaddicted juveniles. We enrolled 30 juveniles (12-16 y) consisting of 15 pornography addiction and 15 nonaddiction subjects. We used Rey Auditory Verbal Learning Test (RAVLT) to measure verbal memory, Rey-Osterrieth Complex Figure Test (ROCFT) for visual memory, along with Trail Making Test A and B (TMT-A and TMT-B) for attention. We found a significant reduction in the RAVLT A6 result of the addiction group (nonaddicti...
Source: Neurology Research International - September 20, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Practice Variations in the Use of Novel Oral Anticoagulants for Nonvalvular Atrial Fibrillation-Related Stroke among Stroke Neurologists in Saudi Arabia.
In conclusion, the practice of stroke neurologists is consistent with and supports the available evidence from observational studies on the time of initiation of NOACs. Our findings provide a guide for clinicians who manage nvAF-related stroke until more robust evidence from randomized controlled trials is available. PMID: 31531241 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - September 20, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Prevalence of Anti-JC Virus (JCV) Antibodies in the Multiple Sclerosis (MS) Population in Cyprus: A Retrospective Study.
Conclusions: Overall seroprevalence of anti-JCV antibodies in MS patients in Cyprus using the STRATIFY JCV assay was lower than the worldwide reported mean. Although previously reported, in our study, the anti-JCV antibody seropositivity was not associated with increasing age or sex. PMID: 31485350 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - September 7, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Effect of Different Doses and Times of FK506 on Different Areas of the Hippocampus in the Rat Model of Transient Global Cerebral Ischemia-Reperfusion.
Conclusions: It seems that FK506 can ameliorate the extent of apoptosis and may be a good candidate for the treatment of ischemia-induced brain damage. PMID: 31467711 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - September 1, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Hypertensive Patients' Knowledge of Risk Factors and Warning Signs of Stroke at Felege Hiwot Referral Hospital, Northwest Ethiopia: A Cross-Sectional Study.
Authors: Abate AT, Bayu N, Mariam TG Abstract Background: Stroke is a neurological condition which is a major cause of death and disability in many low- and middle-income countries. However, several modifiable risk factors are becoming significant. Hypertension is the most common stroke risk factor globally as well as in our country, Ethiopia. Objective: The aim of this study was to assess hypertensive patients' knowledge of risk factors and warning signs of stroke at Felege Hiwot Referral Hospital, Northwest Ethiopia, 2018. Method: An institutional based cross-sectional study design was conducted in May 01...
Source: Neurology Research International - July 26, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Clinical Profile, Functional Outcome, and Mortality of Guillain-Barre Syndrome: A Five-Year Tertiary Care Experience from Nepal.
Conclusion: Guillain-Barre syndrome is commonly seen in the young population. The most common symptom of Guillain-Barre syndrome was ascending paralysis. The in-hospital mortality rate of patients with GBS was 6.45%. PMID: 31275647 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - July 6, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Screening of Generalized Anxiety Disorder in Patients with Epilepsy: Using a Valid and Reliable Indonesian Version of Generalized Anxiety Disorder-7 (GAD-7).
This study aimed to obtain a valid and reliable Indonesian version of GAD-7, assess its accuracy, and finally evaluate the prevalence of GAD in Indonesian PWE along with its contributing factors. Methods: A cross-sectional study was conducted in Cipto Mangunkusumo General Hospital, Jakarta. The GAD-7 was translated and adapted using World Health Organization (WHO) steps. Validity, reliability, test-retest reliability, and diagnostic accuracy were evaluated. Then, epilepsy outpatients were screened for GAD using the Indonesian version of GAD-7. Results: Internal validity and reliability for Indonesian version of GAD...
Source: Neurology Research International - July 6, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Validity and Reliability of Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) in Indonesia and the Correlation with Quality of Life.
Conclusion: BICAMS is valid and reliable for assessing cognitive function of Indonesia MS patients. PMID: 31263596 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - July 3, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Spontaneous Subarachnoid Haemorrhage in Neurological Setting in Burkina Faso: Clinical Profile, Causes, and Mortality Risk Factors.
In conclusion, our study showed a poor frequency of spontaneous subarachnoid haemorrhage with high mortality. Hypertension was the most common cause of spontaneous subarachnoid haemorrhage. PMID: 31210989 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - June 19, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Clinical Features and Treatment in the Spectrum of Paroxysmal Dyskinesias: An Observational Study in South-West Castilla y Leon, Spain.
Authors: Manso-Calderón R Abstract Background: Paroxysmal dyskinesias (PxD) are a group of heterogeneous disorders characterized by intermittent episodes of involuntary movements. PxD include paroxysmal kinesigenic (PKD), nonkinesigenic (PNK), and exercise-induced (PED) varieties. Objectives: To define the phenotype of primary and secondary PxD forms. Methods: Twenty-two patients with PxD (9 men/13 women) were evaluated in two hospitals in south-west Castilla y Leon, Spain. Clinical features of the episodes, causes, family history, and response to treatment were collected. Results: Thirteen parti...
Source: Neurology Research International - June 13, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Visual and Auditory fMRI Paradigms for Presurgical Language Mapping: Convergent Validity and Relationship to Individual Variables.
Authors: Omisade A, O'Grady CB, Schmidt MH, Fisk JD Abstract Functional MRI (fMRI) has emerged as a safe alternative to invasive procedures for determining hemispheric language dominance prior to neurosurgery. Despite this, there are currently no standardized fMRI protocols that have been explored in healthy controls to determine the influence of individual patient variables on the results, which poses challenges in clinical interpretation of ambiguous findings in patient populations. In addition, most fMRI protocols are not suitable for individuals with visual or intellectual disabilities (IQ
Source: Neurology Research International - May 7, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Preference and Values of Stroke Interventions, Kingdom of Saudi Arabia.
Conclusion. Researchers found that the high percentage of participants had favorable response and positive perception toward providing acute stroke intervention and mechanical thrombectomy without informed consent. However, the study showed skeptical acceptance among participants regarding invasive surgical measures. PMID: 31057967 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - May 7, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Prominent T-Cell Responses against the Acetylcholine Receptor ε Subunit in Myasthenia Gravis.
Prominent T-Cell Responses against the Acetylcholine Receptor ε Subunit in Myasthenia Gravis. Neurol Res Int. 2019;2019:1969068 Authors: Neuhaus O, Wiesmüller KH, Hartung HP, Wiendl H Abstract The human acetylcholine receptor (AChR) is well characterized as the target antigen in myasthenia gravis (MG). Pathogenic antibody responses against the AChR alpha-chain have been investigated extensively and are of diagnostic and prognostic value. However, less is known on the pathogenetic relevance of T-cell responses against epitopes of the different AChR chains (alpha, epsilon, gamma). Using an e...
Source: Neurology Research International - April 4, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Public Willingness to Undergo Presymptomatic Genetic Testing for Alzheimer's Disease.
In conclusion, PGT for AD seems to be well accepted in this large Saudi cohort. The reasons cited are similar to those reported elsewhere in the literature. PMID: 30941216 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - April 4, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Direct Oral Anticoagulants in Patients Undergoing Urgent Reperfusion for Nonvalvular Atrial Fibrillation-Related Ischemic Stroke: A Brief Report on Literature Evidence.
Conclusion: Small sample size real life studies seem to demonstrate that the introduction of DOACs in the early phase of NVAF-related AIS undergoing urgent reperfusion is efficacious and safe. Prospective RCTs are necessary to confirm these findings. PMID: 30923637 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - March 31, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

"Encephalopathy Only Stroke Codes" (EoSC) Rarely Result in Stroke as Final Diagnosis.
"Encephalopathy Only Stroke Codes" (EoSC) Rarely Result in Stroke as Final Diagnosis. Neurol Res Int. 2019;2019:2105670 Authors: Chen PM, Meyer DM, Claycomb R, Agrawal K, Meyer BC Abstract Stroke codes prompted by isolated encephalopathy often result in nonstroke final diagnoses but require intensive stroke center resources. We assessed the likelihood of "Encephalopathy only Stroke Codes (EoSC)" resulting in a true stroke (EoSC CVA+) final diagnosis. 3860 patients were analyzed in a prospective stroke code registry from 2004 to 2016. EoSC was defined using a standard and an explorat...
Source: Neurology Research International - March 21, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Clinical Evaluation of Patients with Vestibular Dysfunction.
This article's goal is to help understand vestibular system and diagnose vestibular dysfunction in clinical practice. PMID: 30863640 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - March 14, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

The Impact of Cerebral Amyloid Angiopathy in Various Neurodegenerative Dementia Syndromes: A Neuropathological Study.
Conclusions: The present study shows that CAA is most frequently associated to AD but that only the severe form displays more cerebrovascular lesions. LBD is the second most frequent disease associated to CAA with a clear correlation between the incidence of the associated AD features and the increasing severity of the CAA. In PSP only 21% display mild CAA features. PSP, tau-FTLD, and CBD are part of the Pick complex diseases, who are known to have a favourable vascular profile which can explain their low incidence of cerebrovascular lesions, in contrast to AD and LBD brains. PMID: 30792924 [PubMed] (Source: Neurology ...
Source: Neurology Research International - February 24, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Beyond the Diagnosis: Lived Experiences of Persons with Spinal Cord Injury in a Selected Town in Ghana.
Conclusion. The findings from the study suggest that SCI is a life threatening condition and that persons with SCI grapple with a myriad of physical symptoms that range from chronic pain and paralysis of lower and/or upper limbs, to bladder and bowel incontinence. These physical symptoms have significant psychological and social effects on the functioning of the affected persons. PMID: 30792925 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - February 24, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Adverse Events of Antiepileptic Drugs Using Indonesian Version of Liverpool Adverse Events Profile.
Conclusion: The Indonesian version of LAEP was a valid and reliable instrument to screen AE of AEDs in PWE. Almost all the subjects in this study were suspected having AEs. Polytherapy was the independent factor of AE. PMID: 30595918 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - January 2, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Frequency of Different Types of Diagnostic Errors in Patients with Central Nervous System Infections: A Cross-Sectional Observational Study.
Conclusions: Although diagnosis and management of CNS infection in some patients are straightforward, clinical decision making in facing patients with complex scenarios often requires clinical reasoning instead of relying only on intuitive diagnosis. Justification in requesting diagnostic measures and interpretation of their results based on clinical findings and patient information could be a critical factor in preventing a substantial number of diagnostic errors in patients with CNS infection. PMID: 30581622 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - December 26, 2018 Category: Neurology Tags: Neurol Res Int Source Type: research

Potentiation of Antidepressant Effects of Agomelatine and Bupropion by Hesperidin in Mice.
The objective of present study was to assess the antidepressant effects of hesperidin combination with agomelatine or bupropion. Male Swiss Albino mice received treatment of saline, vehicle, 'hesperidin alone', 'agomelatine alone', hesperidin+agomelatine, 'bupropion alone', hesperidin+bupropion, and agomelatine+bupropion for 14 days. The immobility period was analysed 30 min after the treatment in forced swim and tail suspension tests. Dopamine and serotonin levels were analysed in hippocampus, cerebral cortex, and whole brain using HPLC with fluorescence detector. Hesperidin plus agomelatine treated group was better in te...
Source: Neurology Research International - December 7, 2018 Category: Neurology Tags: Neurol Res Int Source Type: research

The Effect of Hyperbaric Oxygen Therapy on Functional Impairments Caused by Ischemic Stroke.
Conclusions: Findings from this study support the idea of HBOT as a potential intervention following stroke. PMID: 30402285 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - November 9, 2018 Category: Neurology Tags: Neurol Res Int Source Type: research

Electrochemical Skin Conductance as a Marker of Painful Oxaliplatin-Induced Peripheral Neuropathy.
Authors: Delmotte JB, Tutakhail A, Abdallah K, Reach P, D'Ussel M, Deplanque G, Beaussier H, Coudoré F Abstract Purpose: Oxaliplatin is a platinum compound widely used in gastrointestinal cancer treatment but produces dose-limiting peripheral neuropathy. New insights into oxaliplatin-induced peripheral neuropathy (OIPN) assessment are needed to detect more effectively this condition. In this context, we conducted Canaloxa study, a prospective preliminary clinical trial that aimed to investigate how Electrochemical Skin Conductance (ESC), a parameter used in small fiber neuropathy assessment, could be helpful...
Source: Neurology Research International - October 27, 2018 Category: Neurology Tags: Neurol Res Int Source Type: research

Knowledge and Attitudes of Saudi Emergency Physicians toward t-PA Use in Stroke.
Conclusion: Our study detected inadequate knowledge and a negative attitude among Saudi emergency physicians toward t-PA use in acute stroke. This might negatively impact patient outcome. Therefore, we recommend developing urgent strategies to improve emergency physicians' knowledge, attitudes, and beliefs in the management of acute stroke. PMID: 30364030 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - October 27, 2018 Category: Neurology Tags: Neurol Res Int Source Type: research

Prevalence and Risk Factors for Depression among Caregivers of Alzheimer's Disease Patients in Saudi Arabia.
Conclusions: Prevalence of depression among AD caregiver is high. Risk factors for depression include patients' exposure to repeated falls and prolonged stay with patients. Therefore, psychiatric care should be provided to caregivers, home safety should be maintained to avoid falls, and several persons should interchangeably provide care to AD patients. PMID: 30305962 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - October 13, 2018 Category: Neurology Tags: Neurol Res Int Source Type: research

Assessment of Patients' Adherence to Antiepileptic Medications at Dessie Referral Hospital, Chronic Follow-Up, South Wollo, Amhara Region, North East Ethiopia.
Conclusion. Majority of epileptic patients in Dessie Referral Hospital was adherent to their AEDs treatment and among the determinants of adherence assessed the level of education and the side effect of drugs showed statistical significance. PMID: 30271635 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - October 4, 2018 Category: Neurology Tags: Neurol Res Int Source Type: research

Retrospective Analysis of Ventriculitis in External Ventricular Drains.
Conclusions: The c-EVD with prolonged antibiotics given for the duration of drain placement is not inferior to ac-EVD with pp-abx or ac-EVD with prolonged antibiotics for prevention of ventriculitis. The c-EVD with prolonged antibiotics is superior to c-EVD with pp-abx and conventional EVD without antibiotics for prevention of ventriculitis. Selection should include considerations for antibiotic stewardship and cost effectiveness. Future studies should also utilize clinical and CSF profile criteria in addition to positive CSF cultures for identifying ventriculitis to prevent line colonization from classification as ventric...
Source: Neurology Research International - September 26, 2018 Category: Neurology Tags: Neurol Res Int Source Type: research