Minimizing the Diagnostic Delay in Amyotrophic Lateral Sclerosis: The Role of Nonneurologist Practitioners.
Conclusion: In relation to total survival time, the diagnostic delay of ALS appears to be proportionately very long, sometimes longer than that observed in previous studies (because it also included the total delay to diagnostic or treatment initiation). The rapid execution of useful additional tests by the first medical doctor, often GP (with the help of a neurologist), considerably reduces the diagnostic delay. The central role of GP seems to be crucial in the management of patients with ALS. The main objective is, of course, to initiate appropriate treatment and care as soon as possible. Finally, based on our results, w...
Source: Neurology Research International - May 28, 2020 Category: Neurology Tags: Neurol Res Int Source Type: research

Epidemiology of Epilepsy in Lubumbashi, Democratic Republic of Congo.
Conclusion: This study is a useful starting point from which health programs and health professionals can work to improve the diagnosis and quality of epilepsy management in our community. PMID: 32411462 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - May 16, 2020 Category: Neurology Tags: Neurol Res Int Source Type: research

Electricity, Neurology, and Noninvasive Brain Stimulation: Looking Back, Looking Ahead.
This article looks at their origins and their journey into noninvasive brain stimulation technique of transcranial direct current stimulation (tDCS), which is now popular in neuroscience research. PMID: 32328305 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - April 26, 2020 Category: Neurology Tags: Neurol Res Int Source Type: research

Epilepsy Treatment Outcome and Its Predictors among Ambulatory Patients with Epilepsy at Mizan-Tepi University Teaching Hospital, Southwest Ethiopia.
Authors: Zewudie A, Mamo Y, Feyissa D, Yimam M, Mekonen G, Abdela A Abstract Background: Epilepsy is among the most common neurological disorders which is highly treatable with currently available antiepileptic drugs at a reasonable price. In Ethiopia, despite a number of studies revealed high prevalence of epilepsy, little is known on predictors of poorly controlled seizures. Thus, the aim of this study was to assess epilepsy treatment outcome and its predictors among patients with epilepsy on follow-up at the ambulatory care unit of Mizan-Tepi University Teaching Hospital, Southwest Ethiopia. Methods: A hospi...
Source: Neurology Research International - April 26, 2020 Category: Neurology Tags: Neurol Res Int Source Type: research

Validation of an Individualized Measure of Quality of Life, Patient Generated Index, for Use with People with Parkinson's Disease.
Conclusion: This study demonstrates that nominated areas of QOL on the PGI provide comparable results to standard PRO measures, and provides evidence in support of the validity of this individualized measure in PD. PMID: 32292601 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - April 16, 2020 Category: Neurology Tags: Neurol Res Int Source Type: research

HMGB1 is a Potential Mediator of Astrocytic TLR4 Signaling Activation following Acute and Chronic Focal Cerebral Ischemia.
This study evaluated TLR4 signaling, and downstream mediators, in astrocytes, during acute and chronic phases post transient middle cerebral artery occlusion (MCAO). We also determined whether high mobility group box 1 (HMGB1), an endogenous TLR4 ligand, was sufficient to induce TLR4 signaling activation in astrocytes in vivo and in vitro. We injected HMGB1 into normal cortex, in vivo, and stimulated cultured astrocytes with HMGB1, in vitro, and determined TLR4, and downstream mediator, expression by immunohistochemistry. We found that expression of TLR4, and downstream mediators, such as inducible nitric oxide synthase (i...
Source: Neurology Research International - March 10, 2020 Category: Neurology Tags: Neurol Res Int Source Type: research

Structural Equation Modeling of Parkinson's Caregiver Social Support, Resilience, and Mental Health: A Strength-Based Perspective.
Authors: Tyler CM, Henry RS, Perrin PB, Watson J, Villaseñor T, Lageman SK, Smith ER, Curiel GR, Avila J, Jimenez Maldonado ME, Soto-Escageda JA Abstract Only scant literature has focused on social support in Parkinson's disease (PD) caregivers, and no studies to date have examined resilience in this population, despite both variables having been shown to be important in other caregiving populations. As a result, the purpose of the current study was to construct and validate a theoretical structural equation model whereby social support is associated with higher levels of resilience in PD caregivers and incr...
Source: Neurology Research International - February 29, 2020 Category: Neurology Tags: Neurol Res Int Source Type: research

Nine Hole Peg Test and Transcranial Magnetic Stimulation: Useful to Evaluate Dexterity of the Hand and Disease Progression in Amyotrophic Lateral Sclerosis.
We examined 28 ALS patients and 27 age-matched healthy controls. ALS patients and healthy controls underwent the nine hole peg test (NHPT) and TMS with RMT. Measurements in patients were repeated after three and six months. Results: At baseline, the median NHPT durations were 1,4-fold longer (p
Source: Neurology Research International - December 14, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Prevalence and Correlates of Neurocognitive Disorders among HIV Patients on Antiretroviral Therapy at a Kenyan Hospital.
Authors: Mugendi AG, Kubo MN, Nyamu DG, Mwaniki LM, Wahome SK, Haberer JE Abstract Background: HIV-associated neurocognitive disorders (HAND) represent a spectrum of cognitive abnormalities affecting attention, concentration, learning, memory, executive function, psychomotor speed, and/or dexterity. Our objectives in this analysis are to determine the prevalence of HAND and the covariates in a Kenyan population. Methods: We conducted a cross-sectional study in a convenient sample of people living with HIV on antiretroviral therapy (ART) attending routine care visits at the Kenyatta National Hospital HIV clinic ...
Source: Neurology Research International - November 30, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Utilization of a Parental Approach to Informed Consent in Intravenous Tissue Plasminogen Activator Administration Decision-Making: Patient Preference and Ethical Considerations.
Conclusion: Our results indicate that while paternalism is generally discouraged in the medical community, some degree of parental language may be preferred by patients in tough decision-making situations toward consent to receive medical interventions. PMID: 31583134 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - October 5, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Impaired Recent Verbal Memory in Pornography-Addicted Juvenile Subjects.
Authors: Prawiroharjo P, Ellydar H, Pratama P, Edison RE, Suaidy SEI, Amani NZ, Carissima D Abstract We aimed to find the differences in memory capabilities between pornography-addicted and nonaddicted juveniles. We enrolled 30 juveniles (12-16 y) consisting of 15 pornography addiction and 15 nonaddiction subjects. We used Rey Auditory Verbal Learning Test (RAVLT) to measure verbal memory, Rey-Osterrieth Complex Figure Test (ROCFT) for visual memory, along with Trail Making Test A and B (TMT-A and TMT-B) for attention. We found a significant reduction in the RAVLT A6 result of the addiction group (nonaddicti...
Source: Neurology Research International - September 20, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Practice Variations in the Use of Novel Oral Anticoagulants for Nonvalvular Atrial Fibrillation-Related Stroke among Stroke Neurologists in Saudi Arabia.
In conclusion, the practice of stroke neurologists is consistent with and supports the available evidence from observational studies on the time of initiation of NOACs. Our findings provide a guide for clinicians who manage nvAF-related stroke until more robust evidence from randomized controlled trials is available. PMID: 31531241 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - September 20, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Prevalence of Anti-JC Virus (JCV) Antibodies in the Multiple Sclerosis (MS) Population in Cyprus: A Retrospective Study.
Conclusions: Overall seroprevalence of anti-JCV antibodies in MS patients in Cyprus using the STRATIFY JCV assay was lower than the worldwide reported mean. Although previously reported, in our study, the anti-JCV antibody seropositivity was not associated with increasing age or sex. PMID: 31485350 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - September 7, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Effect of Different Doses and Times of FK506 on Different Areas of the Hippocampus in the Rat Model of Transient Global Cerebral Ischemia-Reperfusion.
Conclusions: It seems that FK506 can ameliorate the extent of apoptosis and may be a good candidate for the treatment of ischemia-induced brain damage. PMID: 31467711 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - September 1, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Hypertensive Patients' Knowledge of Risk Factors and Warning Signs of Stroke at Felege Hiwot Referral Hospital, Northwest Ethiopia: A Cross-Sectional Study.
Authors: Abate AT, Bayu N, Mariam TG Abstract Background: Stroke is a neurological condition which is a major cause of death and disability in many low- and middle-income countries. However, several modifiable risk factors are becoming significant. Hypertension is the most common stroke risk factor globally as well as in our country, Ethiopia. Objective: The aim of this study was to assess hypertensive patients' knowledge of risk factors and warning signs of stroke at Felege Hiwot Referral Hospital, Northwest Ethiopia, 2018. Method: An institutional based cross-sectional study design was conducted in May 01...
Source: Neurology Research International - July 26, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Clinical Profile, Functional Outcome, and Mortality of Guillain-Barre Syndrome: A Five-Year Tertiary Care Experience from Nepal.
Conclusion: Guillain-Barre syndrome is commonly seen in the young population. The most common symptom of Guillain-Barre syndrome was ascending paralysis. The in-hospital mortality rate of patients with GBS was 6.45%. PMID: 31275647 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - July 6, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Screening of Generalized Anxiety Disorder in Patients with Epilepsy: Using a Valid and Reliable Indonesian Version of Generalized Anxiety Disorder-7 (GAD-7).
This study aimed to obtain a valid and reliable Indonesian version of GAD-7, assess its accuracy, and finally evaluate the prevalence of GAD in Indonesian PWE along with its contributing factors. Methods: A cross-sectional study was conducted in Cipto Mangunkusumo General Hospital, Jakarta. The GAD-7 was translated and adapted using World Health Organization (WHO) steps. Validity, reliability, test-retest reliability, and diagnostic accuracy were evaluated. Then, epilepsy outpatients were screened for GAD using the Indonesian version of GAD-7. Results: Internal validity and reliability for Indonesian version of GAD...
Source: Neurology Research International - July 6, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Validity and Reliability of Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) in Indonesia and the Correlation with Quality of Life.
Conclusion: BICAMS is valid and reliable for assessing cognitive function of Indonesia MS patients. PMID: 31263596 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - July 3, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Spontaneous Subarachnoid Haemorrhage in Neurological Setting in Burkina Faso: Clinical Profile, Causes, and Mortality Risk Factors.
In conclusion, our study showed a poor frequency of spontaneous subarachnoid haemorrhage with high mortality. Hypertension was the most common cause of spontaneous subarachnoid haemorrhage. PMID: 31210989 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - June 19, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Clinical Features and Treatment in the Spectrum of Paroxysmal Dyskinesias: An Observational Study in South-West Castilla y Leon, Spain.
Authors: Manso-Calderón R Abstract Background: Paroxysmal dyskinesias (PxD) are a group of heterogeneous disorders characterized by intermittent episodes of involuntary movements. PxD include paroxysmal kinesigenic (PKD), nonkinesigenic (PNK), and exercise-induced (PED) varieties. Objectives: To define the phenotype of primary and secondary PxD forms. Methods: Twenty-two patients with PxD (9 men/13 women) were evaluated in two hospitals in south-west Castilla y Leon, Spain. Clinical features of the episodes, causes, family history, and response to treatment were collected. Results: Thirteen parti...
Source: Neurology Research International - June 13, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Visual and Auditory fMRI Paradigms for Presurgical Language Mapping: Convergent Validity and Relationship to Individual Variables.
Authors: Omisade A, O'Grady CB, Schmidt MH, Fisk JD Abstract Functional MRI (fMRI) has emerged as a safe alternative to invasive procedures for determining hemispheric language dominance prior to neurosurgery. Despite this, there are currently no standardized fMRI protocols that have been explored in healthy controls to determine the influence of individual patient variables on the results, which poses challenges in clinical interpretation of ambiguous findings in patient populations. In addition, most fMRI protocols are not suitable for individuals with visual or intellectual disabilities (IQ
Source: Neurology Research International - May 7, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Preference and Values of Stroke Interventions, Kingdom of Saudi Arabia.
Conclusion. Researchers found that the high percentage of participants had favorable response and positive perception toward providing acute stroke intervention and mechanical thrombectomy without informed consent. However, the study showed skeptical acceptance among participants regarding invasive surgical measures. PMID: 31057967 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - May 7, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Prominent T-Cell Responses against the Acetylcholine Receptor ε Subunit in Myasthenia Gravis.
Prominent T-Cell Responses against the Acetylcholine Receptor ε Subunit in Myasthenia Gravis. Neurol Res Int. 2019;2019:1969068 Authors: Neuhaus O, Wiesmüller KH, Hartung HP, Wiendl H Abstract The human acetylcholine receptor (AChR) is well characterized as the target antigen in myasthenia gravis (MG). Pathogenic antibody responses against the AChR alpha-chain have been investigated extensively and are of diagnostic and prognostic value. However, less is known on the pathogenetic relevance of T-cell responses against epitopes of the different AChR chains (alpha, epsilon, gamma). Using an e...
Source: Neurology Research International - April 5, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Public Willingness to Undergo Presymptomatic Genetic Testing for Alzheimer's Disease.
In conclusion, PGT for AD seems to be well accepted in this large Saudi cohort. The reasons cited are similar to those reported elsewhere in the literature. PMID: 30941216 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - April 5, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Direct Oral Anticoagulants in Patients Undergoing Urgent Reperfusion for Nonvalvular Atrial Fibrillation-Related Ischemic Stroke: A Brief Report on Literature Evidence.
Conclusion: Small sample size real life studies seem to demonstrate that the introduction of DOACs in the early phase of NVAF-related AIS undergoing urgent reperfusion is efficacious and safe. Prospective RCTs are necessary to confirm these findings. PMID: 30923637 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - March 31, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

"Encephalopathy Only Stroke Codes" (EoSC) Rarely Result in Stroke as Final Diagnosis.
"Encephalopathy Only Stroke Codes" (EoSC) Rarely Result in Stroke as Final Diagnosis. Neurol Res Int. 2019;2019:2105670 Authors: Chen PM, Meyer DM, Claycomb R, Agrawal K, Meyer BC Abstract Stroke codes prompted by isolated encephalopathy often result in nonstroke final diagnoses but require intensive stroke center resources. We assessed the likelihood of "Encephalopathy only Stroke Codes (EoSC)" resulting in a true stroke (EoSC CVA+) final diagnosis. 3860 patients were analyzed in a prospective stroke code registry from 2004 to 2016. EoSC was defined using a standard and an explorat...
Source: Neurology Research International - March 21, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Clinical Evaluation of Patients with Vestibular Dysfunction.
This article's goal is to help understand vestibular system and diagnose vestibular dysfunction in clinical practice. PMID: 30863640 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - March 14, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

The Impact of Cerebral Amyloid Angiopathy in Various Neurodegenerative Dementia Syndromes: A Neuropathological Study.
Conclusions: The present study shows that CAA is most frequently associated to AD but that only the severe form displays more cerebrovascular lesions. LBD is the second most frequent disease associated to CAA with a clear correlation between the incidence of the associated AD features and the increasing severity of the CAA. In PSP only 21% display mild CAA features. PSP, tau-FTLD, and CBD are part of the Pick complex diseases, who are known to have a favourable vascular profile which can explain their low incidence of cerebrovascular lesions, in contrast to AD and LBD brains. PMID: 30792924 [PubMed] (Source: Neurology ...
Source: Neurology Research International - February 24, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Beyond the Diagnosis: Lived Experiences of Persons with Spinal Cord Injury in a Selected Town in Ghana.
Conclusion. The findings from the study suggest that SCI is a life threatening condition and that persons with SCI grapple with a myriad of physical symptoms that range from chronic pain and paralysis of lower and/or upper limbs, to bladder and bowel incontinence. These physical symptoms have significant psychological and social effects on the functioning of the affected persons. PMID: 30792925 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - February 24, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Adverse Events of Antiepileptic Drugs Using Indonesian Version of Liverpool Adverse Events Profile.
Conclusion: The Indonesian version of LAEP was a valid and reliable instrument to screen AE of AEDs in PWE. Almost all the subjects in this study were suspected having AEs. Polytherapy was the independent factor of AE. PMID: 30595918 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - January 2, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research

Frequency of Different Types of Diagnostic Errors in Patients with Central Nervous System Infections: A Cross-Sectional Observational Study.
Conclusions: Although diagnosis and management of CNS infection in some patients are straightforward, clinical decision making in facing patients with complex scenarios often requires clinical reasoning instead of relying only on intuitive diagnosis. Justification in requesting diagnostic measures and interpretation of their results based on clinical findings and patient information could be a critical factor in preventing a substantial number of diagnostic errors in patients with CNS infection. PMID: 30581622 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - December 26, 2018 Category: Neurology Tags: Neurol Res Int Source Type: research

Potentiation of Antidepressant Effects of Agomelatine and Bupropion by Hesperidin in Mice.
The objective of present study was to assess the antidepressant effects of hesperidin combination with agomelatine or bupropion. Male Swiss Albino mice received treatment of saline, vehicle, 'hesperidin alone', 'agomelatine alone', hesperidin+agomelatine, 'bupropion alone', hesperidin+bupropion, and agomelatine+bupropion for 14 days. The immobility period was analysed 30 min after the treatment in forced swim and tail suspension tests. Dopamine and serotonin levels were analysed in hippocampus, cerebral cortex, and whole brain using HPLC with fluorescence detector. Hesperidin plus agomelatine treated group was better in te...
Source: Neurology Research International - December 7, 2018 Category: Neurology Tags: Neurol Res Int Source Type: research

The Effect of Hyperbaric Oxygen Therapy on Functional Impairments Caused by Ischemic Stroke.
Conclusions: Findings from this study support the idea of HBOT as a potential intervention following stroke. PMID: 30402285 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - November 9, 2018 Category: Neurology Tags: Neurol Res Int Source Type: research

Electrochemical Skin Conductance as a Marker of Painful Oxaliplatin-Induced Peripheral Neuropathy.
Authors: Delmotte JB, Tutakhail A, Abdallah K, Reach P, D'Ussel M, Deplanque G, Beaussier H, Coudoré F Abstract Purpose: Oxaliplatin is a platinum compound widely used in gastrointestinal cancer treatment but produces dose-limiting peripheral neuropathy. New insights into oxaliplatin-induced peripheral neuropathy (OIPN) assessment are needed to detect more effectively this condition. In this context, we conducted Canaloxa study, a prospective preliminary clinical trial that aimed to investigate how Electrochemical Skin Conductance (ESC), a parameter used in small fiber neuropathy assessment, could be helpful...
Source: Neurology Research International - October 27, 2018 Category: Neurology Tags: Neurol Res Int Source Type: research

Knowledge and Attitudes of Saudi Emergency Physicians toward t-PA Use in Stroke.
Conclusion: Our study detected inadequate knowledge and a negative attitude among Saudi emergency physicians toward t-PA use in acute stroke. This might negatively impact patient outcome. Therefore, we recommend developing urgent strategies to improve emergency physicians' knowledge, attitudes, and beliefs in the management of acute stroke. PMID: 30364030 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - October 27, 2018 Category: Neurology Tags: Neurol Res Int Source Type: research

Prevalence and Risk Factors for Depression among Caregivers of Alzheimer's Disease Patients in Saudi Arabia.
Conclusions: Prevalence of depression among AD caregiver is high. Risk factors for depression include patients' exposure to repeated falls and prolonged stay with patients. Therefore, psychiatric care should be provided to caregivers, home safety should be maintained to avoid falls, and several persons should interchangeably provide care to AD patients. PMID: 30305962 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - October 13, 2018 Category: Neurology Tags: Neurol Res Int Source Type: research

Assessment of Patients' Adherence to Antiepileptic Medications at Dessie Referral Hospital, Chronic Follow-Up, South Wollo, Amhara Region, North East Ethiopia.
Conclusion. Majority of epileptic patients in Dessie Referral Hospital was adherent to their AEDs treatment and among the determinants of adherence assessed the level of education and the side effect of drugs showed statistical significance. PMID: 30271635 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - October 4, 2018 Category: Neurology Tags: Neurol Res Int Source Type: research

Retrospective Analysis of Ventriculitis in External Ventricular Drains.
Conclusions: The c-EVD with prolonged antibiotics given for the duration of drain placement is not inferior to ac-EVD with pp-abx or ac-EVD with prolonged antibiotics for prevention of ventriculitis. The c-EVD with prolonged antibiotics is superior to c-EVD with pp-abx and conventional EVD without antibiotics for prevention of ventriculitis. Selection should include considerations for antibiotic stewardship and cost effectiveness. Future studies should also utilize clinical and CSF profile criteria in addition to positive CSF cultures for identifying ventriculitis to prevent line colonization from classification as ventric...
Source: Neurology Research International - September 26, 2018 Category: Neurology Tags: Neurol Res Int Source Type: research

Serotonin Reuptake Inhibitors in Obstructive Sleep Apnea: Associations in People with and without Epilepsy.
Conclusions: SRIs represent a potential treatment option for OSA and may demonstrate a more robust association with reduced OSA severity in PWE compared to PWO. PMID: 30245877 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - September 26, 2018 Category: Neurology Tags: Neurol Res Int Source Type: research

Genetic Influences on Cognition in Idiopathic Parkinson's Disease.
Authors: Amer H, Shehata H, Rashed LA, Helmy H, El-Jaafary S, Sabbah A, Ibrahim W PMID: 30155299 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - August 31, 2018 Category: Neurology Tags: Neurol Res Int Source Type: research

Maximizing the Survival of Amyotrophic Lateral Sclerosis Patients: Current Perspectives.
Authors: Khairoalsindi OA, Abuzinadah AR Abstract Amyotrophic lateral sclerosis is a neurodegenerative disease that leads to loss of the upper and lower motor neurons. Almost 90% of all cases occur in the sporadic form, with the rest occurring in the familial form. The disease has a poor prognosis, with only two disease-modifying drugs approved by the United States Food and Drug Administration (FDA). The approved drugs for the disease have very limited survival benefits. Edaravone is a new FDA-approved medication that may slow the disease progression by 33% in a selected subgroup of ALS patients. This paper covers ...
Source: Neurology Research International - August 31, 2018 Category: Neurology Tags: Neurol Res Int Source Type: research

Prevalence of Stroke Risk Factors and Their Distribution Based on Stroke Subtypes in Gorgan: A Retrospective Hospital-Based Study-2015-2016.
Conclusion: Overall, hypertension, diabetes mellitus, and dyslipidemia were the major risk factors of stroke in Gorgan. Establishment of stroke registry (population- or hospital-based) for the province is recommended. PMID: 30147952 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - August 28, 2018 Category: Neurology Tags: Neurol Res Int Source Type: research

Effect of Gravity and Task Specific Training of Elbow Extensors on Upper Extremity Function after Stroke.
Conclusions: The results of this study provide an evidence that antigravity positions can be used as a centrally presented facilitator of elbow extension. Additionally, task specific training was effective in improving upper extremity function and elbow extension range of motion. PMID: 30112205 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - August 18, 2018 Category: Neurology Tags: Neurol Res Int Source Type: research

Diagnosis of Encephalopathy Based on Energies of EEG Subbands Using Discrete Wavelet Transform and Support Vector Machine.
Authors: Jacob JE, Nair GK, Iype T, Cherian A Abstract EEG analysis in the field of neurology is customarily done using frequency domain methods like fast Fourier transform. A complex biomedical signal such as EEG is best analysed using a time-frequency algorithm. Wavelet decomposition based analysis is a relatively novel area in EEG analysis and for extracting its subbands. This work aims at exploring the use of discrete wavelet transform for extracting EEG subbands in encephalopathy. The subband energies were then calculated and given as feature sets to SVM classifier for identifying cases of encephalopathy from ...
Source: Neurology Research International - August 1, 2018 Category: Neurology Tags: Neurol Res Int Source Type: research

Stroke Prevalence in a Coastal Town on the Black Sea Coast in Turkey: Community Based Study.
Conclusion: The results of this study give the prevalence rate of stroke among the Turkish population living in a rural area. Due to a lack of other similar studies, it is impossible to make any data comparison. However, the results of this study help shed light on the stroke prevalence rate. PMID: 30057814 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - August 1, 2018 Category: Neurology Tags: Neurol Res Int Source Type: research

The Effects of Induction and Treatment of Intracranial Hypertension on Cerebral Autoregulation: An Experimental Study.
This study aimed to analyse cerebral autoregulation (CA) during induction and treatment of intracranial hypertension (ICH) in an experimental model. Materials and Methods: Landrace and Duroc piglets were divided into mild and severe ICH groups. Four or seven millilitres of saline solution was infused into paediatric bladder catheter inserted in the parietal lobe (balloon inflation). After 1.5 h, a 3% saline solution was infused via venous catheter, and 30 min later, the bladder catheter balloon was deflated (surgery). The cerebral static autoregulation (sCA) index was evaluated using cerebral blood flow velocities (CBF...
Source: Neurology Research International - July 28, 2018 Category: Neurology Tags: Neurol Res Int Source Type: research

Neuropsychiatric Involvement in Juvenile-Onset Systemic Lupus Erythematosus.
Conclusion: The presence of headache, mood disorders, psychosis, depression, and other neuropsychological manifestations in a patient with JSLE should prompt investigations into diagnosis of the primary nervous system involvement in order to reduce mortality and morbidity. PMID: 30002929 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - July 15, 2018 Category: Neurology Tags: Neurol Res Int Source Type: research

Can Chaotic Analysis of Electroencephalogram Aid the Diagnosis of Encephalopathy?
Authors: Jacob JE, Cherian A, Gopakumar K, Iype T, Yohannan DG, Divya KP Abstract Chaotic analysis is a relatively novel area in the study of physiological signals. Chaotic features of electroencephalogram have been analyzed in various disease states like epilepsy, Alzheimer's disease, sleep disorders, and depression. All these diseases have primary involvement of the brain. Our study examines the chaotic parameters in metabolic encephalopathy, where the brain functions are involved secondary to a metabolic disturbance. Our analysis clearly showed significant lower values for chaotic parameters, correlation dimensi...
Source: Neurology Research International - July 15, 2018 Category: Neurology Tags: Neurol Res Int Source Type: research

Effectiveness and Adverse Effect of Intravenous Lacosamide in Nonconvulsive Status Epilepticus and Acute Repetitive Seizures in Children.
This study is registered to Thai Clinical Trials Registry (TCTR) and the trial registration number is TCTR20180508004. PMID: 29984000 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - July 11, 2018 Category: Neurology Tags: Neurol Res Int Source Type: research

The Early Outcomes of Nurse Case Management in Patients with Acute Ischemic Stroke Treated with Intravenous Recombinant Tissue Plasminogen Activator: A Prospective Randomized Controlled Trial.
Conclusion: The nurse case management should provide some benefits in the acute stroke system. Although the early benefit is demonstrated in our study, further studies are needed to ensure the long-term benefit and confirm its profit in patients with acute ischemic stroke. PMID: 29977617 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - July 8, 2018 Category: Neurology Tags: Neurol Res Int Source Type: research