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Reflections on the Future of Medicine
Recently, I traveled through China. I climbed mountains, hiked through forests, crossed deep valleys. I visited cities of every size. I floated across lakes and traveled beautiful shorelines churning with life. As a man of a certain age, I began to compare the permanence of the timeless landscape with the evanescence of my own existence. Yet, as a scientist, I knew these reflections were flawed. Scientists are trained to think in terms of aeons, millenia, and lifetimes. Consider the paradox. Is it the solid mountain or fragile the forest that is permanent? Is it the massive shoreline cliffs or the teeming shore life that...
Source: Science - The Huffington Post - January 9, 2017 Category: Science Source Type: news

A Case of ALL Developing Posterior Reversible Encephalopathy Secondary to Hyponatremia
We describe a case of acute lymphoblastic leukemia in which PRES developed secondary to hyponatremia despite being normotensive during receipt of chemotherapy. Magnetic resonance imaging findings were suggestive of PRES. Partial diffusion restriction was observed in lesions in the bilateral occipitoparietal regions and the cerebellum. The patient was treated with appropriate medications with the resolution of his stroke-like symptoms. No neurological deficit was observed and clinical condition improved. The patient continued with chemotherapy. Early diagnosis and treatment of this syndrome is important in terms of preventi...
Source: Journal of Pediatric Hematology Oncology - October 26, 2017 Category: Hematology Tags: Online Articles: Clinical and Laboratory Observations Source Type: research

Determinants of exercise intolerance in breast cancer patients prior to anthracycline chemotherapy
We sought to interrogate previous reports that fitness in breast cancer patients was less than expected for community norms. As compared with healthy control subjects, we observed reduced oxygen consumption capacity in recently diagnosed breast cancer patients prior to treatment. This reduced capacity was associated with smaller heart size and reduced peak exercise cardiac output. This may suggest that reduced exercise conditioning is associated with breast cancer risk. AbstractWomen with early ‐stage breast cancer have reduced peak exercise oxygen uptake (peakVO2). The purpose of this study was to evaluate peakVO2 and r...
Source: Physiological Reports - January 10, 2019 Category: Physiology Authors: Rhys I. Beaudry, Erin J. Howden, Steve Foulkes, Ashley Bigaran, Piet Claus, Mark J. Haykowsky, Andre La Gerche Tags: Original Research Source Type: research

Delayed radiation-induced stroke mimics recurrent tumor in and adolescent with remote history of low-grade brainstem glioma
A 13-year-old female was diagnosed with a ponto- medullary brainstem glioma and following unsuccessful treatment with chemotherapy, underwent focal photon intensity modulated radiation therapy that resulted in a favorable response. Ten years later, the patient presented with acute onset left-sided hemiplegia and headaches. Magnetic resonance imaging (MRI) at presentation showed a large contrast- enhancing lesion with surrounding vasogenic edema and reduced diffusivity on diffusion- weighted imaging most concerning for a high grade secondary malignancy (Figure 1).
Source: Pediatric Neurology - June 4, 2019 Category: Neurology Authors: Lianne Q. Chau, Michael L. Levy, John Ross Crawford Tags: Short Communication Source Type: research

Delayed Radiation-Induced Stroke Mimics Recurrent Tumor in an Adolescent With Remote History of Low-Grade Brainstem Glioma
This 13-year-old girl was diagnosed with a ponto-medullary brainstem glioma, and following unsuccessful treatment with chemotherapy, she underwent focal photon intensity-modulated radiation therapy that resulted in a favorable response. Ten years later, she presented with acute left hemiplegia and headaches. Magnetic resonance imaging (MRI) at presentation showed a large contrast-enhancing lesion with surrounding vasogenic edema and reduced diffusivity on diffusion-weighted imaging, most concerning for a high-grade secondary malignancy (Fig 1).
Source: Pediatric Neurology - June 4, 2019 Category: Neurology Authors: Lianne Q. Chau, Michael L. Levy, John R. Crawford Tags: Clinical Letter Source Type: research

Unusual skull base metastasis from neuroendocrine tumor: a case report
ConclusionsIntracranial metastasis is rare in patients with neuroendocrine tumor, particularly in those with well-differentiated histology; skull base metastasis is even more uncommon. Management of intracranial metastasis from a rare tumor should always be discussed in a specialist multidisciplinary meeting. Surgery or radiotherapy, including stereotactic radiosurgery, should be considered in skull base metastases. Hormonal abnormalities may occur following radiotherapy to skull base metastases and should be monitored closely in the first few months post treatment.
Source: Journal of Medical Case Reports - August 29, 2019 Category: General Medicine Source Type: research

A Rare Case of Clival Metastasis in a Patient with Gastric Cancer.
We report a rare case of clival metastasis from gastric cancer. A 73-year-old man with advanced gastric cancer treated with nivolumab as a third-line chemotherapy experienced headache, tongue deviation, and difficulties in speaking clearly. We suspected stroke or brain metastasis, but brain contrast-enhanced magnetic resonance imaging demonstrated a clival mass, diagnosed as clival metastasis from gastric cancer. The tumor could not be identified by plain computed tomography and plain magnetic resonance imaging alone. He received palliative radiotherapy (30 Gy/10 fr); his symptoms improved gradually. Although metastasis fr...
Source: Internal Medicine - December 19, 2020 Category: Internal Medicine Tags: Intern Med Source Type: research

Comparison of impedance cardiography and cardiac magnetic resonance imaging for the evaluation of cardiac function in early-stage breast cancer patients
Objective. Breast cancer treatment can negatively impact cardiac function in some breast cancer patients. Current methods (MUGA, echocardiography) used in clinical practice to detect abnormal cardiac changes as a result of treatment suffer from important limitations. Use of alternative techniques that would offer safe, inexpensive and non-invasive cardiac function assessment in this population would be highly advantageous. The aim of this study was to examine the agreement between impedance cardiography (ICG) and cardiac magnetic resonance imaging (CMR) in quantifying stroke volume (SV), cardiac output (CO) and end-d...
Source: Physiological Measurement - November 3, 2021 Category: Physiology Authors: Erifyli Piastopoulou, Parvaiz Ali, Gianfilippo Bertelli, Martyn Heatley, Maung Moe, Chandramohan Murugesan, Gareth Stratton and Michael Lewis Source Type: research

Diffuse low-grade glioma misdiagnosed as acute cerebral infarction: A case report
We report a case of DLGG detected by computed tomography and magnetic resonance imaging (MRI). Patient concerns: A 58-year-old man suddenly phantom smells for half an hour and was previously healthy. Diagnoses: Computed tomography findings showed a leaf-shaped slightly hypodense shadow in the right temporal lobe with no obvious mass effect and an unclear boundary. MRI findings showed diffuse and slightly longer T1-weighted imaging (T1WI)/T2-weighted imaging (T2WI)signal in the right temporal lobe and hippocampus, slight hyperintensity on diffusion-weighted imaging, diffuse swelling in the right temporal lobe ...
Source: Medicine - September 2, 2022 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Neuroimaging findings and neurological manifestations in hospitalized COVID-19 patients: Impact of cancer and ventilatory support status
This study suggests COVID-19 is associated with neurological manifestations that may be visible with brain imaging techniques such as MRI. In our COVID-19 cohort, there was no association between cancer status and neuroimaging findings. Future studies might include more prospectively enrolled systematically characterized patients, allowing for more rigorous statistical analysis.
Source: PLoS One - March 24, 2023 Category: Biomedical Science Authors: Lily McCarthy Source Type: research

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