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Specialty: Drugs & Pharmacology

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Total 5519 results found since Jan 2013.

Stroke prevention: knowledge of the general population in Riyadh Region, Saudi Arabia
CONCLUSIONS: Stroke knowledge among the population of Saudi Arabia is inadequate. The stroke knowledge is related to age and occupation.PMID:34533817 | DOI:10.26355/eurrev_202109_26649
Source: European Review for Medical and Pharmacological Sciences - September 17, 2021 Category: Drugs & Pharmacology Authors: S M Abdalla E Y Mohamed B A Almehmadi M A Alanazi H M Elsabagh Source Type: research

Real-World Management and Clinical Outcomes of Stroke Survivors With Atrial Fibrillation: A Population-Based Cohort in Spain
Conclusion: In this large population-based cohort using real-world data, nearly 30% of AF patients who suffered a stroke were untreated or treated with APT, which overall is not recommended. Treatment was started within 2 weeks as recommended, except for OAC + APT, which was started later. The strong association of APT treatment or non-treatment with the same treatment strategy before stroke occurrence suggests a strong therapeutic inertia and opposes recommendations. Patients under these two strategies had the highest rates of adverse outcomes. An inadequate prescription poses a great risk on patients with AF and stroke;...
Source: Frontiers in Pharmacology - December 13, 2021 Category: Drugs & Pharmacology Source Type: research

Long-term effectiveness and safety of cilostazol versus clopidogrel in secondary prevention of noncardioembolic ischemic stroke
ConclusionsThis real-world study suggests that cilostazol is effective and safe for noncardioembolic ischemic stroke and may be associated with better effectiveness in hypertensive patients compared to clopidogrel.
Source: European Journal of Clinical Pharmacology - June 13, 2023 Category: Drugs & Pharmacology Source Type: research

PPARs: A potential target for a disease-modifying strategy in stroke.
Abstract Stroke is one of the major causes of mortality and disability in adults in industrialized countries. Despite numerous preclinical studies and clinical trials in the field of cerebral ischemia, no pharmacological agent has been validated in the treatment of acute ischemic, except thrombolysis. Cerebral ischemia is not only a neuronal disease but it affects the entire neurovascular unit. The therapeutic strategy in stroke should be more global and combine preventive approaches, acute phase treatment and long-term care to improve recovery and prevent or treat affective and cognitive post-stroke consequences....
Source: Current Drug Targets - March 18, 2013 Category: Drugs & Pharmacology Authors: Ouk T, Potey C, Gautier S, Bastide M, Deplanque D, Staels B, Duriez P, Leys D, Bordet R Tags: Curr Drug Targets Source Type: research

Acute antithrombotic treatment of ischemic stroke.
Abstract Antithrombotic medication is a cornerstone of acute ischemic stroke treatment and secondary prevention. The efficacy of thrombolysis with alteplase in acute stroke has been demonstrated in several clinical trials. This safe and costeffective therapy has transformed the practice of stroke care and has led to subsequent trials of other antithrombotic medications for treatment of ischemic stroke in the acute phase. These antithrombotics include thrombolytic, antiplatelet and anticoagulant agents. While, no other medication has yet demonstrated adequate efficacy, our current and evolving understanding of infa...
Source: Current Vascular Pharmacology - May 24, 2014 Category: Drugs & Pharmacology Authors: Alderazi YJ, Grotta JC Tags: Curr Vasc Pharmacol Source Type: research

The Impact of Heart Failure and Left Ventricular Dysfunction in Predicting Stroke, Thromboembolism, and Mortality in Atrial Fibrillation Patients: A Systematic Review.
Abstract PURPOSE: Atrial fibrillation (AF) is commonly associated with structural heart disease. Although heart failure (HF) has been proposed as a risk factor for stroke, the coexistence of the 2 diseases increases disproportionally the risk of thromboembolic events. Our objective was to conduct a systematic review to assess the effect of HF on the end points of stroke, systemic embolism (SE), or mortality in patients with AF. METHODS: A literature search was performed to identify studies that examined stroke/ SE in relation to AF and HF. Overall, 405 articles satisfied the preinclusion criteria. FINDIN...
Source: Clinical Therapeutics - August 18, 2014 Category: Drugs & Pharmacology Authors: Agarwal M, Apostolakis S, Lane DA, Lip GY Tags: Clin Ther Source Type: research

Molecular genetics of coronary artery disease and ischemic stroke
Publication date: Available online 30 April 2015 Source:Personalized Medicine Universe Author(s): Yoshiji Yamada Coronary artery disease (CAD) and ischemic stroke are important clinical problems because they are associated with high mortality rates. The main causal and treatable risk factors of CAD and ischemic stroke include hypertension, dyslipidemia, diabetes mellitus, chronic kidney disease, and smoking. In addition, recent studies have highlighted the importance of genetic factors and their interactions with environmental factors in the development of CAD and ischemic stroke. Disease prevention is an important strat...
Source: Personalized Medicine Universe - May 1, 2015 Category: Drugs & Pharmacology Source Type: research

Increasing compliance with national quality measures for stroke through use of a standard order set.
CONCLUSION: A retrospective review of the treatment records of patients hospitalized for acute stroke showed that adherence to national guidelines was increased when providers used a standard order set. PMID: 25991597 [PubMed - in process]
Source: American Journal of Health-System Pharmacy : AJHP - May 21, 2015 Category: Drugs & Pharmacology Authors: Elder KG, Lemon SK, Costello TJ Tags: Am J Health Syst Pharm Source Type: research

Outcomes after stroke in patients receiving adjuvant therapy with traditional Chinese medicine: A nationwide matched interventional cohort study
Conclusions Hospitalized stroke patients who received routine care and adjuvant TCM therapy exhibited reduced adverse outcomes after admission within a 6-month follow-up period. Graphical abstract
Source: Journal of Ethnopharmacology - November 30, 2015 Category: Drugs & Pharmacology Source Type: research