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Therapy: Stem Cell Therapy

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Total 2351 results found since Jan 2013.

Towards clinical translation of 'second-generation' regenerative stroke therapies: hydrogels as game changers?
Trends Biotechnol. 2021 Nov 20:S0167-7799(21)00255-9. doi: 10.1016/j.tibtech.2021.10.009. Online ahead of print.ABSTRACTStroke is an unmet clinical need with a paucity of treatments, at least in part because chronic stroke pathologies are prohibitive to 'first-generation' stem cell-based therapies. Hydrogels can remodel the hostile stroke microenvironment to aid endogenous and exogenous regenerative repair processes. However, no clinical trials have yet been successfully commissioned for these 'second-generation' hydrogel-based therapies for chronic ischaemic stroke regeneration. This review recommends a path forward to im...
Source: Trends in Biotechnology - November 24, 2021 Category: Biotechnology Authors: John D Totten Hani A Alhadrami Essam H Jiffri Calum J McMullen F Philipp Seib Hilary V O Carswell Source Type: research

Contraceptive drug, Nestorone, enhances stem cell-mediated remodeling of the stroke brain by dampening inflammation and rescuing mitochondria
Free Radic Biol Med. 2022 Mar 24:S0891-5849(22)00123-X. doi: 10.1016/j.freeradbiomed.2022.03.020. Online ahead of print.ABSTRACTIschemic stroke remains a significant unmet need causing massive mortality and morbidity due to few treatment options with limited therapeutic window. The progestin Nestorone® (segesterone acetate) displays high affinity for the progesterone receptor in exerting its potent birth control and hormone replacement therapy. Accumulating evidence implicates a new utility of Nestorone in affording neuroprotection in a variety of central nervous system diseases, including stroke. However, the mechanism o...
Source: Free Radical Biology and Medicine - March 28, 2022 Category: Biology Authors: Jea-Young Lee Vanessa Castelli Narender Kumar Regine Sitruk-Ware Cesario V Borlongan Source Type: research

Treatments in Ischemic Stroke: Current and Future
Background and Aim: Despite progress made over the last 30 years, stroke is still a leading cause of disability and mortality; likewise, its burden is expected to increase over the next decades, due to population growth and aging. The development of drugs with better safety-efficacy profiles as well as strategies able to improve ischemic stroke management from the pre-hospital setting is needed.Summary: The pathophysiology of ischemic stroke involves multiple pathways resulting in cerebral artery obstruction and brain tissue ischemia. To date, the only approved drug for acute ischemic stroke is intravenous thrombolytic alt...
Source: European Neurology - August 2, 2022 Category: Neurology Source Type: research

JAK2/STAT3 pathway mediates neuroprotective and pro-angiogenic treatment effects of adult human neural stem cells in middle cerebral artery occlusion stroke animal models
In this study, adult human neural stem cells (ahNSCs) derived from temporal lobe surgical samples were used (to avoid ethical and safety issues), and their therapeutic effects on ischemic stroke were examined using middle cerebral artery occlusion animal models. 5 × 105 ahNSCs was directly injected into the lateral ventricle of contralateral brain hemispheres of immune suppressed rat stroke models at the subacute phase of stroke. Compared with the mock-treated group, ahNSCs reduced brain tissue atrophy and neurological sensorimotor and memory functional loss. Tissue analysis demonstrated that the significant therapeutic e...
Source: Aging - November 29, 2022 Category: Biomedical Science Authors: Geun-Hyoung Ha Eun Ji Kim Jee Soo Park Ji Eun Kim Hyun Nam Je Young Yeon Sun-Ho Lee Kyunghoon Lee Chung Kwon Kim Kyeung Min Joo Source Type: research

Mitochondrial transplantation and immune response of human bone marrow mesenchymal stem cells for the Therapeutic of ischemic stroke
Curr Stem Cell Res Ther. 2023 May 5. doi: 10.2174/1574888X18666230505103407. Online ahead of print.ABSTRACTIschemic stroke is the leading cause of death and disability worldwide, with increasing incidence and mortality, imposing a significant social and economic burden on patients and their families. However, cerebral vascular occlusion leads to acute loss of neurons and destruction of synaptic structures. The limited treatment options cannot adequately address intra-neuronal mitochondrial dysfunction due to stroke. Therefore, stem cell-derived mitochondria transplantation plays an important role in neuronal protection and...
Source: Cell Research - May 8, 2023 Category: Cytology Authors: Yidong Liao Jiang Ming Wenxue Song Guangtang Chen Junshuan Cui Longcai He Zili Wang Xudong Wang Mingsong Xiong Hua Yang Kaya Xu Source Type: research

The Battle of the Sexes for Stroke Therapy: Female- Versus Male-Derived Stem Cells.
Abstract Cell therapy is a major discipline of regenerative medicine that has been continually growing over the last two decades. The aging of the population necessitates discovery of therapeutic innovations to combat debilitating disorders, such as stroke. Menstrual blood and Sertoli cells are two gender-specific sources of viable transplantable cells for stroke therapy. The use of autologous cells for the subacute phase of stroke offers practical clinical application. Menstrual blood cells are readily available, display proliferative capacity, pluripotency and angiogenic features, and, following transplantation ...
Source: CNS and Neurological Disorders Drug Targets - February 28, 2013 Category: Drugs & Pharmacology Authors: Kaneko Y, Pabon MM, Dailey T, Weinbren NL, Rizzi J, Tamboli C, Vasconcellos J, Kuzmin-Nichols N, Sanberg PR, Eve DJ, Tajiri N, Borlongan CV Tags: CNS Neurol Disord Drug Targets Source Type: research

Colony stimulating factors (including erythropoietin, granulocyte colony stimulating factor and analogues) for stroke.
CONCLUSIONS: There are significant safety concerns regarding EPO therapy for stroke. It is too early to know whether other CSFs improve functional outcome. PMID: 23797623 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - June 24, 2013 Category: Journals (General) Authors: Bath PM, Sprigg N, England T Tags: Cochrane Database Syst Rev Source Type: research

Transgenic Overproduction of Omega-3 Polyunsaturated Fatty Acids Provides Neuroprotection and Enhances Endogenous Neurogenesis after Stroke.
Abstract Strokes are devastating as there are no current therapies to prevent the long term neurological deficits that they cause. Soon after ischemic stroke, there is proliferation and differentiation of neural stem/progenitor cells as an important mechanism for neuronal restoration. However, endogenous neurogenesis by itself is insufficient for effective brain repair after stroke as most newborn neurons do not survive. One fascinating strategy for stroke treatment would thus be maintaining the survival and/or promoting the differentiation of endogenous neural stem/progenitor cells. Using transgenic (Tg) mice ove...
Source: Current Molecular Medicine - August 22, 2013 Category: Molecular Biology Authors: Hu X, Zhang F, Leak RK, Zhang W, Iwai M, Stetler RA, Dai Y, Zhao A, Gao Y, Chen J Tags: Curr Mol Med Source Type: research