Filtered By:
Specialty: Molecular Biology

This page shows you your search results in order of relevance. This is page number 10.

Order by Relevance | Date

Total 1564 results found since Jan 2013.

Bibliometric analysis and visualized study of research on autophagy in ischemic stroke
Conclusion: This bibliometric analysis helps us reveal the current research hotspots in the research field of autophagy in ischemic stroke and guide future research directions. Subsequent trends in this special field are likely to identify and develop novel autophagy-targeted therapy strategies to effectively prevent and treat ischemic stroke.PMID:37731738 | PMC:PMC10507179 | DOI:10.3389/fphar.2023.1232114
Source: Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Jiefang Chen Gaijie Chen Xiaojing Xu Long Chen Jiewen Zhang Feng Liu Source Type: research

Frequency of angiotensin II type 1 receptor gene polymorphism in Turkish acute stroke patients.
This study was performed in acute stroke patients in the Turkish population to determine the frequency of the A1166C polymorphism in the AT1 gene and to examine the role of this polymorphism in acute stroke development. In this study, 257 genomic DNA samples were analysed (from 206 acute stroke patients and 51 healthy individuals). Genomic DNA was prepared from peripheral blood using the salt-extraction method. The presence of the A1166C polymorphism in the AT1 gene was determined using the polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) method. PCR products were separated by 2% agarose gel ...
Source: J Cell Mol Med - April 1, 2013 Category: Molecular Biology Authors: Hulyam K, Aysegul B, Veysi GH, Demet O, Irfan D, Ertugrul C, Didem CT, Banu B, Miris D Tags: J Cell Mol Med Source Type: research

Common Genetic Conditions of Ischemic Stroke to Keep in Mind.
Abstract Stroke is a complex disease resulting from the interplay of genetics and environment. In some instances (mainly in young adults) stroke is the direct result of a monogenic disease. Among the monogenic causes of stroke, the diseases which are most frequently encountered in the adult general neurological practice are CADASIL, Fabry and mitochondrial diseases. Brain MRI and clinical features may frequently lead to a correct molecular diagnosis. Here we review the single-gene causes of ischemic stroke, with special regard to the associated features which may help in the diagnostic approach. PMID: 2532387...
Source: Current Molecular Medicine - October 10, 2014 Category: Molecular Biology Authors: Mancuso M, Orsucci D, Ienco EC, Brondi M, Simoncini C, Chiti A, Montano V, Terni E, Giannini N, Siciliano G, Bonuccelli U Tags: Curr Mol Med Source Type: research

Fibrinogen nitrotyrosination after ischemic stroke impairs thrombolysis and promotes neuronal death
Publication date: Available online 12 December 2014 Source:Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease Author(s): Gerard ILL-Raga , Ernest Palomer , Eva Ramos-Fernández , Francesc X. Guix , Mònica Bosch-Morató , Biuse Guivernau , Marta Tajes , Victòria Valls-Comamala , Jordi Jiménez-Conde , Angel Ois , Fernando Pérez-Asensio , Mario Reyes-Navarro , Carolina Caballo , Gabriel Gil-Gómez , Irene López-Vílchez , Ana M. Galán , Francesc Alameda , Ginés Escolar , Carlos Opazo , Anna Planas , Jaume Roquer , Miguel A. Valverde , Francisco J. Muñoz Ischemic stroke is an acute vascular event that c...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - December 25, 2014 Category: Molecular Biology Source Type: research

C-reactive protein levels and genetic variants of CRP as prognostic markers for combined cardiovascular endpoint (cardiovascular death, death from stroke, myocardial infarction, and stroke/TIA).
CONCLUSIONS: Both a CRP level ⩾5mg/l and SNP rs1800947 of the CRP gene were independent risk factors for further adverse CV events among patients with CVD within three years follow-up. PMID: 27580453 [PubMed - as supplied by publisher]
Source: Cytokine - August 26, 2016 Category: Molecular Biology Authors: Schulz S, Lüdike H, Lierath M, Schlitt A, Werdan K, Hofmann B, Gläser C, Schaller HG, Reichert S Tags: Cytokine Source Type: research

Non-Invasive Monitoring of CNS MHC-I Molecules in Ischemic Stroke Mice
Ischemic stroke is one of the leading causes of morbidity and mortality worldwide. The expression of major histocompatibility complex class I (MHC-I) molecules in the central nervous system, which are silenced under normal physiological conditions, have been reported to be induced by injury stimulation. The purpose of this study was to determine whether MHC-I molecules could serve as molecular targets for the acute phase of ischemic stroke and to assess whether a high-affinity peptide specific for MHC-I molecules could be applied in the near-infrared imaging of cerebral ischemic mice. Quantitative real-time PCR and Western...
Source: Theranostics - September 12, 2017 Category: Molecular Biology Authors: Jing Xia, Ying Zhang, Huanhuan Zhao, Jie Wang, Xueren Gao, Jinpeng Chen, Bo Fu, Yuqing Shen, Fengqin Miao, Jianqiong Zhang, Gaojun Teng Tags: Research Paper Source Type: research

MicroRNA-126/stromal cell-derived factor 1/C-X-C chemokine receptor type 7 signaling pathway promotes post-stroke angiogenesis of endothelial progenitor cell transplantation.
Authors: Shan C, Ma Y Abstract Stroke is the most common cause of mortality worldwide. Post-stroke angiogenesis is of great significance to the treatment of strokes. The aim of the present study was to investigate the mechanism underlying the angiogenesis-promoting effect of microRNA‑126 (miR‑126)‑associated signaling pathways using a stroke model in vivo and a cell migration model in vitro. Bone marrow‑derived endothelial progenitor cells (EPCs) were extracted and identified using a density gradient method. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) was performed to examin...
Source: Molecular Medicine Reports - February 4, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

In vivo imaging biomarkers of neuroinflammation in the development and assessment of stroke therapies - towards clinical translation
Modulation of the inflammatory microenvironment after stroke opens a new avenue for the development of novel neurorestorative therapies in stroke. Understanding the spatio-temporal profile of (neuro-)inflammatory imaging biomarkers in detail thereby represents a crucial factor in the development and application of immunomodulatory therapies. The early integration of quantitative molecular imaging biomarkers in stroke drug development may provide key information about (i) early diagnosis and follow-up, (ii) spatio-temporal drug-target engagement (pharmacodynamic biomarker), (iii) differentiation of responders and non-respon...
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Bastian Zinnhardt, Maximilian Wiesmann, Lisa Honold, Cristina Barca, Michael Sch ä fers, Amanda J Kiliaan, Andreas H Jacobs Tags: Review Source Type: research

Evidence and perspective for the role of the NLRP3 inflammasome signaling pathway in ischemic stroke and its therapeutic potential (Review).
Abstract Ischemic stroke is one of the main causes of death and disablement globally. The NLR family pyrin domain containing 3 (NLRP3) inflammasome is established as a sensor of detecting cellular damage and modulating inflammatory responses to injury during the progress of ischemic stroke. Inhibiting or blocking the NLRP3 inflammasome at different stages, including expression, assembly, and secretion, may have great promise to improve the neurological deficits during ischemic stroke. The current review provides a comprehensive summary of the current understanding in the literature of the molecular structure, exp...
Source: International Journal of Molecular Medicine - October 2, 2018 Category: Molecular Biology Authors: Ma C, Liu S, Zhang S, Xu T, Yu X, Gao Y, Zhai C, Li C, Lei C, Fan S, Chen Y, Tian H, Wang Q, Cheng F, Wang X Tags: Int J Mol Med Source Type: research

Pentraxin 3 promotes long-term cerebral blood flow recovery, angiogenesis, and neuronal survival after stroke
AbstractRestoration of cerebral blood flow (CBF) and upregulation of angiogenesis are crucial for brain repair and functional recovery after cerebral ischaemia. Pentraxin 3 (PTX3) is a key regulator of angiogenesis and is emerging as a promising target for cerebrovascular repair after stroke. Here, we investigated for the first time the role of PTX3 in long-term CBF, angiogenesis, and neuronal viability after ischaemic stroke induced by transient middle cerebral artery occlusion (MCAo). Lack of PTX3 had no effect on early brain damage, but significantly impaired restoration of CBF, 14 and 28  days after MCAo, compared to ...
Source: Journal of Molecular Medicine - October 13, 2018 Category: Molecular Biology Source Type: research

Combined treatment of sodium ferulate, n-butylidenephthalide, and ADSCs rehabilitates neurovascular  unit in rats after photothrombotic stroke.
Combined treatment of sodium ferulate, n-butylidenephthalide, and ADSCs rehabilitates neurovascular unit in rats after photothrombotic stroke. J Cell Mol Med. 2018 Nov 12;: Authors: Zhao YH, Liu NW, Ke CC, Liu BW, Chen YA, Luo C, Zhang Q, Xia ZY, Liu RS Abstract The remodelling of structural and functional neurovascular unit (NVU) becomes a central therapeutic strategy after cerebral ischaemic stroke. In the present study, we investigated the effect of combined therapy of sodium ferulate (SF), n-butylidenephthalide (BP) and adipose-derived stromal cells (ADSCs) to ameliorate the injured NVU in the ph...
Source: J Cell Mol Med - November 12, 2018 Category: Molecular Biology Authors: Zhao YH, Liu NW, Ke CC, Liu BW, Chen YA, Luo C, Zhang Q, Xia ZY, Liu RS Tags: J Cell Mol Med Source Type: research

The role and therapeutic potential of heat shock proteins in haemorrhagic stroke.
Abstract Heat shock proteins (HSPs) are induced after haemorrhagic stroke, which includes subarachnoid haemorrhage (SAH) and intracerebral haemorrhage (ICH). Most of these proteins function as neuroprotective molecules to protect cerebral neurons from haemorrhagic stroke and as markers to indicate cellular stress or damage. The most widely studied HSPs in SAH are HSP70, haeme oxygenase-1 (HO-1), HSP20 and HSP27. The subsequent pathophysiological changes following SAH can be divided into two stages: early brain injury and delayed cerebral ischaemia, both of which determine the outcome for patients. Because the mech...
Source: J Cell Mol Med - July 4, 2019 Category: Molecular Biology Authors: Shao A, Zhou Y, Yao Y, Zhang W, Zhang J, Deng Y Tags: J Cell Mol Med Source Type: research

Xanthohumol protects neuron from cerebral ischemia injury in experimental stroke.
In conclusion, the neuroprotective effects of XN showed in this study make XN a promising supplement for ischemic stroke protection. PMID: 32108303 [PubMed - as supplied by publisher]
Source: Molecular Biology Reports - February 26, 2020 Category: Molecular Biology Authors: Jiao Y, Cao Y, Lu X, Wang J, Saitgareeva A, Kong X, Song C, Li J, Tian K, Zhang S, Bai M, Li S, Zhang H, Wang L Tags: Mol Biol Rep Source Type: research

Serum tissue inhibitor of metalloproteinase-1 and risk of cognitive impairment after acute ischaemic stroke.
Abstract The expression of tissue inhibitor metalloproteinase-1 (TIMP-1) significantly increased after acute cerebral ischaemia and involved in neurodegeneration. The purpose was to prospectively investigate the relationship between serum TIMP-1 with post-stroke cognitive impairment. Our participants were from an ancillary study of China Antihypertensive Trial in Acute Ischemic Stroke. 598 ischaemic stroke patients from seven participating hospitals were included. Cognitive impairment was evaluated using Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) at 3 months. 316 (52.84%) or 384...
Source: J Cell Mol Med - May 19, 2020 Category: Molecular Biology Authors: Ge J, Li R, Yuan P, Che B, Bu X, Shao H, Xu T, Ju Z, Zhang J, Zhang Y, Zhong C Tags: J Cell Mol Med Source Type: research

Inhibition of microglial receptor-interacting protein kinase 1 ameliorates neuroinflammation following cerebral ischaemic stroke.
Abstract Microglia are rapidly activated following ischaemic stroke and participate in the induction of neuroinflammation, which exacerbates the injury of ischaemic stroke. However, the mechanisms regulating ischaemic microglia remain unclear. In the present study, middle cerebral artery occlusion and oxygen and glucose deprivation models were established for in vivo and vitro monitoring of experimental stroke. We applied recombinant human thioredoxin-1 (rhTrx-1) and Necrostatin-1 (Nec-1, inhibitor of RIPK1) to examine the role of receptor-interacting protein kinase 1 (RIPK1) in the development of inflammation in ...
Source: J Cell Mol Med - September 28, 2020 Category: Molecular Biology Authors: Jiao Y, Wang J, Zhang H, Cao Y, Qu Y, Huang S, Kong X, Song C, Li J, Li Q, Ma H, Lu X, Wang L Tags: J Cell Mol Med Source Type: research