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Nutrition: Sodium
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Total 20 results found since Jan 2013.
Sodium Tanshinone IIA Sulfonate Ameliorates Oxygen-glucose Deprivation/Reoxygenation-induced Neuronal Injury via Protection of Mitochondria and Promotion of Autophagy
Neurochem Res. 2023 Jul 12. doi: 10.1007/s11064-023-03985-x. Online ahead of print.ABSTRACTSodium tanshinone IIA sulfonate (STS) has shown significant clinical therapeutic effects in cerebral ischemic stroke (CIS), but the molecular mechanisms of neuroprotection remain partially known. The purpose of this study was to explore whether STS plays a protective role in oxygen-glucose deprivation/reoxygenation (OGD/R)-induced neuronal injury by regulating microglia autophagy and inflammatory activity. Co-cultured microglia and neurons were subjected to OGD/R injury, an in vitro model of ischemia/reperfusion (I/R) injury with or ...
Source: Neurochemical Research - July 12, 2023 Category: Neuroscience Authors: Zhi Ma Yue Wu Juan Xu Hui Cao Mingyang Du Haibo Jiang Feng Qiu Source Type: research
Effects of fasudil on blood –brain barrier integrity
ConclusionsOur findings suggest that fasudil is a BBB-protective agent against acute ischemic stroke.
Source: Fluids and Barriers of the CNS - June 3, 2022 Category: Neuroscience Source Type: research
Modeling ischemic stroke in a triculture neurovascular unit on-a-chip
ConclusionsThe NVU on-a-chip model presented here can be used for fundamental studies of NVU function in stroke and other neurological diseases and for investigation of potential restorative therapies to fight neurological disorders. Due to the platform ’s relatively high throughput and compatibility with automation, the model holds potential for drug compound screening.
Source: Fluids and Barriers of the CNS - December 14, 2021 Category: Neuroscience Source Type: research
Ten days of high dietary sodium does not impair cerebral blood flow regulation in healthy adults
Auton Neurosci. 2021 May 27;234:102826. doi: 10.1016/j.autneu.2021.102826. Online ahead of print.ABSTRACTHigh dietary sodium impairs cerebral blood flow regulation in rodents and is associated with increased stroke risk in humans. However, the effects of multiple days of high dietary sodium on cerebral blood flow regulation in humans is unknown. Therefore, the purpose of this study was to determine whether ten days of high dietary sodium impairs cerebral blood flow regulation. Ten participants (3F/7M; age: 30 ± 10 years; blood pressure (BP): 113 ± 8/62 ± 9 mmHg) participated in this randomized, cross-over design study. ...
Source: Autonomic Neuroscience - May 31, 2021 Category: Neuroscience Authors: Kamila U Migdal Austin T Robinson Joseph C Watso Matthew C Babcock Shannon L Lennon Christopher R Martens Jorge M Serrador William B Farquhar Source Type: research
Metabolic constraints of swelling ‐activated glutamate release in astrocytes and their implication for ischemic tissue damage
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - April 28, 2019 Category: Neuroscience Authors: Corinne S. Wilson,
Martin D. Bach,
Zahra Ashkavand,
Kenneth R. Norman,
Nina Martino,
Alejandro P. Adam,
Alexander A. Mongin Tags: Original Article Source Type: research
A Copernican Approach to Brain Advancement: The Paradigm of Allostatic Orchestration
The objective of this presentation is to explore historical, scientific, interventional, and other differences between the two paradigms, so that innovators, researchers, practitioners, policy-makers, patients, end-users, and others can gain clarity with respect to both the explicit and implicit assumptions associated with brain advancement agendas of any kind.
Over the course of three decades, a series of brain-centric, evolution-inspired insights have been articulated with increasing refinement, as principles of allostasis (Sterling and Eyer, 1988; Sterling, 2004, 2012, 2014). Allostasis recognizes that the role of the ...
Source: Frontiers in Human Neuroscience - April 25, 2019 Category: Neuroscience Source Type: research
Transcranial Direct Current Stimulation Use in Warfighting: Benefits, Risks, and Future Prospects
Conclusion
The aim of this paper was to examine whether military tDCS use can be efficacious and ethical in military settings. Our assessment is that tDCS offers a number of cognitive, motor, and perceptual enhancement opportunities which could provide value in military situations like training and operations. There is potential scope for use in a number of key areas that directly affect practical battlefield advantage and survivability, such as deceptive capabilities, risk-taking, threat detection, perception, and physiological improvement. Additionally, tDCS has the potential to improve command and control decision maki...
Source: Frontiers in Human Neuroscience - April 17, 2019 Category: Neuroscience Source Type: research
Activation of the α7 nicotinic acetylcholine receptor upregulates blood-brain barrier function through increased claudin-5 and occludin expression in rat brain endothelial cells
Publication date: Available online 16 November 2018Source: Neuroscience LettersAuthor(s): Ikuya Kimura, Shinya Dohgu, Fuyuko Takata, Junichi Matsumoto, Yohei Kawahara, Megumi Nishihira, Shohei Sakada, Takuya Saisho, Atsushi Yamauchi, Yasufumi KataokaAbstractThe blood-brain barrier (BBB) is formed by brain endothelial cells (BECs) and regulates brain homeostasis by restricting the entry of blood-borne substances into the brain. Recent in vivo studies have shown that administration of nicotinic acetylcholine receptor (nAChR) agonists protects against BBB disruption and neuroinflammation induced by stroke and traumatic brain ...
Source: Neuroscience Letters - November 16, 2018 Category: Neuroscience Source Type: research
A Pilot Primary Stroke Prevention Program for Elderly Korean Americans
Conclusion: This study demonstrated feasibility and effectiveness of the program to improve stroke knowledge and healthy behaviors in elderly Korean Americans.
Source: Journal of Neuroscience Nursing - November 13, 2018 Category: Neuroscience Tags: Article Source Type: research
