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Multinuclear MRI Reveals Early Efficacy of Stem Cell Therapy in Stroke
AbstractCompromised adult human mesenchymal stem cells (hMSC) can impair cell therapy efficacy and further reverse ischemic recovery. However, in vitro assays require extended passage to characterize cells, limiting rapid assessment for therapeutic potency. Multinuclear magnetic resonance imaging and spectroscopy (MRI/S) provides near real-time feedback on disease progression and tissue recovery. Applied to ischemic stroke,23Na MRI evaluates treatment efficacy within 24  h after middle cerebral artery occlusion, showing recovery of sodium homeostasis and lesion reduction in specimens treated with hMSC while1H MRS identifi...
Source: Translational Stroke Research - July 28, 2022 Category: Neurology Source Type: research

Shengui Sansheng San Ameliorates Cerebral Energy Deficiency via Citrate Cycle After Ischemic Stroke
Conclusion In summary, SSS extraction significantly ameliorates cerebral energy metabolism via boosting citrate cycle, which mainly embodies the enhancements of blood glucose concentration, glucose and lactate transportation and glucose utilization, as well as the regulations of relative enzymes activities in citrate cycle. These ameliorations ultimately resulted in numerous ATP yield after stroke, which improved neurological function and infarcted volume. Collectively, it suggests that SSS extraction has exerted advantageous effect in the treatment of cerebral ischemia. Ethics Statement All animal operations were accor...
Source: Frontiers in Pharmacology - April 22, 2019 Category: Drugs & Pharmacology Source Type: research

Aggregation of human mesenchymal stem cells enhances survival and efficacy in stroke treatment
In this study, we report the effects of short-term preconditioning of hMSCs via three-dimensional (3D) aggregation on stroke lesion recovery after intra-arterial (IA) transplantation of 3D aggregate-derived hMSCs (Agg-D hMSCs) in a transient middle cerebral artery occlusion (MCAO) stroke model. Compared with two-dimensional (2D) monolayer culture, Agg-D hMSCs exhibited increased resistance to ischemic stress, secretory function and therapeutic outcome. Short-term preconditioning via 3D aggregation reconfigured hMSC energy metabolism and altered redox cycle, which activated the PI3K/AKT pathway and enhanced resistance to in...
Source: Cytotherapy - September 17, 2019 Category: Cytology Source Type: research

Combined treatment of sodium ferulate, n-butylidenephthalide, and ADSCs rehabilitates neurovascular  unit in rats after photothrombotic stroke.
Combined treatment of sodium ferulate, n-butylidenephthalide, and ADSCs rehabilitates neurovascular unit in rats after photothrombotic stroke. J Cell Mol Med. 2018 Nov 12;: Authors: Zhao YH, Liu NW, Ke CC, Liu BW, Chen YA, Luo C, Zhang Q, Xia ZY, Liu RS Abstract The remodelling of structural and functional neurovascular unit (NVU) becomes a central therapeutic strategy after cerebral ischaemic stroke. In the present study, we investigated the effect of combined therapy of sodium ferulate (SF), n-butylidenephthalide (BP) and adipose-derived stromal cells (ADSCs) to ameliorate the injured NVU in the ph...
Source: J Cell Mol Med - November 12, 2018 Category: Molecular Biology Authors: Zhao YH, Liu NW, Ke CC, Liu BW, Chen YA, Luo C, Zhang Q, Xia ZY, Liu RS Tags: J Cell Mol Med Source Type: research

Combined treatment of sodium ferulate, n ‐butylidenephthalide, and ADSCs rehabilitates neurovascular unit in rats after photothrombotic stroke
AbstractThe remodelling of structural and functional neurovascular unit (NVU) becomes a central therapeutic strategy after cerebral ischaemic stroke. In the present study, we investigated the effect of combined therapy of sodium ferulate (SF),n‐butylidenephthalide (BP) and adipose‐derived stromal cells (ADSCs) to ameliorate the injured NVU in the photochemically induced thrombotic stroke in rats. After solely or combined treatment, the neovascularization, activation of astrocytes, neurogenesis, expressions of vascular endothelial grow th factor (VEGF) and claudin‐5 were assessed by immunohistochemical or immunofluore...
Source: Journal of Cellular and Molecular Medicine - November 12, 2018 Category: Molecular Biology Authors: Yong ‐Hua Zhao, Nai‐Wei Liu, Chien‐Chih Ke, Bo‐Wen Liu, Yi‐An Chen, Cheng Luo, Qian Zhang, Zhen‐Yan Xia, Ren‐Shyan Liu Tags: ORIGINAL ARTICLE Source Type: research

Meningioma preceding CASPR2 antibody limbic encephalitis with a stroke mimic: A case report
We report a contactin-associated protein-like 2-antibody (CASPR2-Ab)-positive patient who presented with atypical LE. Diagnoses: CASPR2-Ab-positive LE was the presumed diagnosis. Re-evaluation of cerebrospinal fluid (CSF) samples revealed autoantibodies targeting CASPR2 at an immunoglobulin G titer of 1:1. The clinical presentation of subacute onset seizures, abnormal electroencephalography, hypermetabolism on positron emission tomography, good immunotherapy response, and the presence of specific antibodies in serum supports a diagnosis of autoimmune LE. Intervention: The patient received glucocorticoids (1�...
Source: Medicine - June 11, 2021 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Extended Ischemic Recovery After Implantation of Human Mesenchymal Stem Cell Aggregates Indicated by Sodium MRI at 21.1  T
AbstractExtended therapeutic application remains a significant issue in the use of stem cell therapies to treat ischemic stroke. Along these lines, neurological recovery in a rodent model of ischemic stroke was evaluated following implantation of human mesenchymal stem cell aggregates (hMSC-agg), labeled with micron-sized particles of iron oxide, directly into the lateral ventricle contralateral to the ischemic lesion hemisphere. Longitudinally, disease progression and response to hMSC-agg therapy were assessed by1H and23Na magnetic resonance imaging (MRI) at 21.1  T to investigate cellular localization, migration, and re...
Source: Translational Stroke Research - February 7, 2022 Category: Neurology Source Type: research

Multinuclear MRI Reveals Early Efficacy of Stem Cell Therapy in Stroke
Transl Stroke Res. 2022 Jul 28. doi: 10.1007/s12975-022-01057-w. Online ahead of print.ABSTRACTCompromised adult human mesenchymal stem cells (hMSC) can impair cell therapy efficacy and further reverse ischemic recovery. However, in vitro assays require extended passage to characterize cells, limiting rapid assessment for therapeutic potency. Multinuclear magnetic resonance imaging and spectroscopy (MRI/S) provides near real-time feedback on disease progression and tissue recovery. Applied to ischemic stroke, 23Na MRI evaluates treatment efficacy within 24 h after middle cerebral artery occlusion, showing recovery of sodiu...
Source: Cell Research - July 28, 2022 Category: Cytology Authors: Shannon Helsper Xuegang Yuan F Andrew Bagdasarian Jacob Athey Yan Li Cesario V Borlongan Samuel C Grant Source Type: research

Sodium-23 magnetic resonance imaging has potential for improving penumbra detection but not for estimating stroke onset time
; Andrew J Fagan
Source: Journal of Cerebral Blood Flow - October 22, 2014 Category: Neurology Authors: Friedrich WetterlingLindsay GallagherJim MullinWilliam M HolmesChris McCabeI Mhairi MacraeAndrew J Fagan Tags: apparent diffusion coefficient middle cerebral artery occlusion onset of elevated tissue sodium penumbra sodium MRI Source Type: research

Influence of Gadolinium-Based Contrast Agents on Tissue Sodium Quantification in Sodium Magnetic Resonance Imaging
Conclusions Our study showed a quantitative influence of Dotarem and Gadovist on sodium relaxation times. However, quantification of TSC was not impaired, which was proven by worst case calculations and nonsignificant differences in vivo in an ischemic stroke patient. We suggest performing sodium imaging in useful clinical positions in protocols regardless of included Dotarem or Gadovist administrations. Being flexible in the study protocol design will strengthen ongoing sodium imaging investigations for various pathologies.
Source: Investigative Radiology - August 8, 2018 Category: Radiology Tags: Original Articles Source Type: research

First case of MELAS syndrome presenting with local brain edema requiring decompressive craniectomy
CONCLUSION: If the diagnosis and treatment are delayed, MELAS syndrome can cause serious brain edema, which may ultimately require decompressive craniectomy.PMID:34664704 | DOI:10.5137/1019-5149.JTN.34196-21.4
Source: Turkish Neurosurgery - October 19, 2021 Category: Neurosurgery Authors: Osman Yesilbas Esma Sengenc Melike Ersoy Olbak Derya Bako Oznur G ökce Nizam Mehmet Hakan Seyithanoglu Davut Pehlivan Serdar Ceylaner Dilara Icagasioglu Kursad Aydin Source Type: research

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