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Nutrition: Flavonoids

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Total 135 results found since Jan 2013.

Luteolin ameliorates lipopolysaccharide-induced microcirculatory disturbance through inhibiting leukocyte adhesion in rat mesenteric venules
Microcirculatory disturbance is closely associated with multiple diseases such as ischemic and septic stroke. Luteolin (3,4,5,7-tetrahydroxyflavone) is a vascular protective flavonoid present in several dietar...
Source: BMC Complementary and Alternative Medicine - January 14, 2021 Category: Complementary Medicine Authors: Jie Su, Han-Ting Xu, Jing-Jing Yu, Mei-Qiu Yan, Ting Wang, Ya-Jun Wu, Bo Li, Wen-Jie Lu, Chuan Wang, Shan-Shan Lei, Si-Min Chen, Su-Hong Chen and Gui-Yuan Lv Tags: Research article Source Type: research

Neurodegenerative diseases and Flavonoids: Special reference to kaempferol.
Abstract Neurodegenerative diseases like Alzheimer's disease, Parkinson's disease, Huntington's disease, Multiple Sclerosis and Ischemic stroke have become a major health problem worldwide. Pre-clinical studies have demonstrated the beneficial effects of flavonoids on neurodegenerative diseases and suggesting them to be used as therapeutic agents. Kaempferol is found in many plants such as tea, beans, broccoli,strawberriesand has neuroprotective effects against the development of many neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease and Huntington's disease. The present study summarizest...
Source: CNS and Neurological Disorders Drug Targets - January 29, 2021 Category: Drugs & Pharmacology Authors: Rahul, Siddique YH Tags: CNS Neurol Disord Drug Targets Source Type: research

Molecules, Vol. 26, Pages 2495: The Role of Resveratrol in Human Male Fertility
do E. Calogero Resveratrol (RSV) (3,4′,5 trihydroxystilbene) is a natural non-flavonoid polyphenol widely present in the Mediterranean diet. In particular, RSV is found in grapes, peanuts, berries, and red wine. Many beneficial effects of this molecule on human health have been reported. In fact, it improves some clinical aspects of various diseases, such as obesity, tumors, hypertension, Alzheimer’s disease, stroke, cardiovascular diseases, and diabetes mellitus. However, little is known about the relationship between this compound and male fertility and the few available results are often controversial. Therefore...
Source: Molecules - April 24, 2021 Category: Chemistry Authors: Laura M. Mongio ì Sarah Perelli Rosita A. Condorelli Federica Barbagallo Andrea Crafa Rossella Cannarella Sandro La Vignera Aldo E. Calogero Tags: Review Source Type: research

Natural Compounds as Medical Strategies in the Prevention and Treatment of Psychiatric Disorders Seen in Neurological Diseases
Psychiatric disorders are frequently encountered in many neurological disorders, such as Alzheimer’s and Parkinson diseases along with epilepsy, migraine, essential tremors, and stroke. The most common comorbid diagnoses in neurological diseases are depression and anxiety disorders along with cognitive impairment. Whether the underlying reason is due to common neurochemical mechanisms or loss of previous functioning level, comorbidities are often overlooked. Various treatment options are available, such as pharmacological treatments, cognitive-behavioral therapy, somatic interventions, or electroconvulsive therapy. Howev...
Source: Frontiers in Pharmacology - May 13, 2021 Category: Drugs & Pharmacology Source Type: research

Polyphenolic-Rich Compounds From Dillenia pentagyna (Roxb.) Attenuates the Doxorubicin-Induced Cardiotoxicity: A High-Frequency Ultrasonography Assisted Approach
Cardiovascular complications are the foremost concern in patients undergoing anticancer therapy. There is an unmet need to address the problems arising from the drug-induced toxicity for the long-term benefit of the patients undergoing chemotherapy. Alternative medicines are gaining their prosperity in addressing the various drug-induced organ toxicity. Dillenia pentagyna Roxb (DP) is an ethnomedicinal plant rich in flavonoids and phenolic contents. In India & Nepal, DP is a common ingredient of traditional medicines used to treat multiple ailments like inflammation, cancer, and diabetes. However, its protective role a...
Source: Frontiers in Pharmacology - May 17, 2021 Category: Drugs & Pharmacology Source Type: research

Wogonin Accelerates Hematoma Clearance and Improves Neurological Outcome via the PPAR- γ Pathway After Intracerebral Hemorrhage
In conclusion, our data suggest that wogonin facilitates hematoma clearance and neurobehavioral recovery by targeting PPAR-γ.
Source: Translational Stroke Research - June 18, 2021 Category: Neurology Source Type: research

Cytoprotective effects of the flavonoid quercetin by activating mitochondrial BK < sub > Ca < /sub > channels in endothelial cells
Biomed Pharmacother. 2021 Aug 12;142:112039. doi: 10.1016/j.biopha.2021.112039. Online ahead of print.ABSTRACTMitochondrial potassium channels have been implicated in cytoprotective mechanisms. Activation of the mitochondrial large-conductance Ca2+-regulated potassium (mitoBKCa) channel is important for protecting brain tissue against stroke damage as well as heart tissue against ischemia damage. In this paper, we examine the effect of the natural flavonoid quercetin as an activator of the mitoBKCa channel. Quercetin has a beneficial effect on many processes in the human body and interacts with many receptors and signaling...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 15, 2021 Category: Drugs & Pharmacology Authors: Rafa ł Paweł Kampa Aleksandra S ęk Adam Szewczyk Piotr Bednarczyk Source Type: research

Fisetin, potential flavonoid with multifarious targets for treating neurological disorders: An updated review
Eur J Pharmacol. 2021 Sep 10:174492. doi: 10.1016/j.ejphar.2021.174492. Online ahead of print.ABSTRACTNeurodegenerative disorders pose a significant health burden and imprint a debilitative impact on the quality of life. Importantly, aging is intricately intertwined with the progression of these disorders, and their prevalence increases with a rise in the aging population worldwide. In recent times, fisetin emerged as one of the potential miracle molecules to address neurobehavioral and cognitive abnormalities. These effects were attributed to its actions on several macromolecules and multiple molecular mechanisms. Fisetin...
Source: European Journal of Pharmacology - September 13, 2021 Category: Drugs & Pharmacology Authors: Ravula Arun Reddy Teegala Suraj Benerji Kalakotla Shanker Pasangulapati Jagadeesh Prasad Venkatesan Perumal Boyina Hemanth Kumar Source Type: research

The Protective Effect of Quercetin on Endothelial Cells Injured by Hypoxia and Reoxygenation
Conclusions: Our experiments show that quercetin can protect HBMECs from H/R, which contains promoting cell proliferation, cell migration and angiogenesis, reducing mitochondrial membrane potential damage and inhibiting cell apoptosis. This may be related to its antioxidation and inhibition of endoplasmic reticulum stress. At the same time, quercetin can increase the level of BBB connexin, suggesting that quercetin can maintain BBB integrity.
Source: Frontiers in Pharmacology - October 20, 2021 Category: Drugs & Pharmacology Source Type: research

Mechanism of Dihydromyricetin on Inflammatory Diseases
Inflammation plays a crucial role in a variety of diseases, including diabetes, arthritis, asthma, Alzheimer’s disease (AD), acute cerebral stroke, cancer, hypertension, and myocardial ischemia. Therefore, we need to solve the problem urgently for the study of inflammation-related diseases. Dihydromyricetin (DHM) is a flavonoid mainly derived from Nekemias grossedentata (Hand.-Mazz.) J.Wen and Z.L.Nie (N.grossedentata). DHM possesses many pharmacological effects, including anti-inflammatory (NLRP-3, NF-κB, cytokines, and neuroinflammation), antioxidant, improving mitochondrial dysfunction, and regulating autophagy and s...
Source: Frontiers in Pharmacology - January 18, 2022 Category: Drugs & Pharmacology Source Type: research

Dihydromyricetin ameliorates oxygen ‑glucose deprivation and re‑oxygenation‑induced injury in HT22 cells by activating the Wnt/β‑catenin signaling pathway
In conclusion, DMY protected HT22 cells from OGD/R‑induced oxidative stress and apoptosis, and its effects may be mediated by the activation of the Wnt/β‑catenin signaling pathway.PMID:35088876 | DOI:10.3892/mmr.2022.12619
Source: Molecular Medicine - January 28, 2022 Category: Molecular Biology Authors: Xiaoxiao Tao Yaping Jiang Xian Zheng Xiaoxiao Ji Feifei Peng Source Type: research