Fisetin, potential flavonoid with multifarious targets for treating neurological disorders: An updated review
Eur J Pharmacol. 2021 Sep 10:174492. doi: 10.1016/j.ejphar.2021.174492. Online ahead of print.ABSTRACTNeurodegenerative disorders pose a significant health burden and imprint a debilitative impact on the quality of life. Importantly, aging is intricately intertwined with the progression of these disorders, and their prevalence increases with a rise in the aging population worldwide. In recent times, fisetin emerged as one of the potential miracle molecules to address neurobehavioral and cognitive abnormalities. These effects were attributed to its actions on several macromolecules and multiple molecular mechanisms. Fisetin belongs to a class of flavonoids, which is found abundantly in several fruits and vegetables. Fisetin has manifested several health benefits in preclinical models of neurodegenerative diseases such as Alzheimer's disease, Vascular dementia, and Schizophrenia. Parkinson's disease, Amyotrophic lateral sclerosis, Huntington's disease, Stroke, Traumatic brain injury (TBI), and age-associated changes. This review aimed to evaluate the potential mechanisms and pharmacological effects of fisetin in treating several neurological diseases. This review also provides comprehensive data on up-to-date recent literature and highlights the various mechanistic pathways pertaining to fisetin's role in treating various neurodegenerative diseases.PMID:34516952 | DOI:10.1016/j.ejphar.2021.174492
ConclusionsTEVAR seems to offer advantages in terms of early mortality and complications rate. Moreover, data on late mortality and re-intervention are encouraging to consider endovascular treatment comparable to open repair for acute thoracic aorta emergency on long-term follow-up.
Beaconsfield MP Joy Morrissey said the money would push doctors to see more patients face-to-face in surgeries or at home, taking pressure off hospitals during the busy winter period in the NHS.
ConclusionSleep problems are common in long-term CRC survivors; however, sleep quality and duration was not associated with BMI, WC, and diet quality in this population. It is unknown why the results differ from findings in the general population.
DEMENTIA cases have seen a staggering increase over the years. Doing all you can to help prevent the brain degenerative condition should be on the forefront of most minds. What are five of the best foods to help reduce your risk?
HAIR loss is a normal part of ageing with most losing roughly 100 strands per day. However, when it becomes excessive a certain vegetable juice could prove effective as a hair loss treatment.
In conclusion, mitophagy pathways play an important role in maintaining physiological homeostasis, are involved in the mechanisms of aging and neurodegenerative disorders, and represent promising targets for the development of potential therapeutic agents aimed at regulating mitochondria quality control in neurons and glial cells. A significant number of molecules that induce or inhibit mitophagy are currently under consideration, which may be useful for testing hypotheses or developing drugs for the treatment of neurodegenerative diseases. The validation of promising drugs in animal and cell models, including neurons and ...
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Ryan Limbocker, Silvia Errico, Denise Barbut, Tuomas P. J. Knowles, Michele Vendruscolo, Fabrizio Chiti, Michael Zasloff The natural products squalamine and trodusquemine are promising potential therapeutics against Alzheimer's, Parkinson's, and other neurodegenerative diseases for their ability to modulate protein aggregation processes and target protein misfolded oligomers that are toxic to neurons. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Conditions: OSA; Sleep Apnea; Obstructive Sleep Apnea; Alzheimer Disease Interventions: Other: Supplemental Oxygen; Device: Continuous Positive Airway Pressure Machine; Other: Room Air Sponsor: University of California, San Diego Recruiting
Condition: Parkinson Disease Intervention: Other: No intervention will be offered Sponsors: The Hong Kong Polytechnic University; Chinese University of Hong Kong; The University of Hong Kong; Parkinson's Disease Foundation Not yet recruiting
Condition: Parkinson's Disease Intervention: Drug: ABBV-951 Sponsor: AbbVie Not yet recruiting