Fisetin, potential flavonoid with multifarious targets for treating neurological disorders: An updated review

Eur J Pharmacol. 2021 Sep 10:174492. doi: 10.1016/j.ejphar.2021.174492. Online ahead of print.ABSTRACTNeurodegenerative disorders pose a significant health burden and imprint a debilitative impact on the quality of life. Importantly, aging is intricately intertwined with the progression of these disorders, and their prevalence increases with a rise in the aging population worldwide. In recent times, fisetin emerged as one of the potential miracle molecules to address neurobehavioral and cognitive abnormalities. These effects were attributed to its actions on several macromolecules and multiple molecular mechanisms. Fisetin belongs to a class of flavonoids, which is found abundantly in several fruits and vegetables. Fisetin has manifested several health benefits in preclinical models of neurodegenerative diseases such as Alzheimer's disease, Vascular dementia, and Schizophrenia. Parkinson's disease, Amyotrophic lateral sclerosis, Huntington's disease, Stroke, Traumatic brain injury (TBI), and age-associated changes. This review aimed to evaluate the potential mechanisms and pharmacological effects of fisetin in treating several neurological diseases. This review also provides comprehensive data on up-to-date recent literature and highlights the various mechanistic pathways pertaining to fisetin's role in treating various neurodegenerative diseases.PMID:34516952 | DOI:10.1016/j.ejphar.2021.174492
Source: European Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Source Type: research

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This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Ryan Limbocker, Silvia Errico, Denise Barbut, Tuomas P. J. Knowles, Michele Vendruscolo, Fabrizio Chiti, Michael Zasloff The natural products squalamine and trodusquemine are promising potential therapeutics against Alzheimer's, Parkinson's, and other neurodegenerative diseases for their ability to modulate protein aggregation processes and target protein misfolded oligomers that are toxic to neurons. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Conditions:   OSA;   Sleep Apnea;   Obstructive Sleep Apnea;   Alzheimer Disease Interventions:   Other: Supplemental Oxygen;   Device: Continuous Positive Airway Pressure Machine;   Other: Room Air Sponsor:   University of California, San Diego Recruiting
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Condition:   Parkinson Disease Intervention:   Other: No intervention will be offered Sponsors:   The Hong Kong Polytechnic University;   Chinese University of Hong Kong;   The University of Hong Kong;   Parkinson's Disease Foundation Not yet recruiting
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Condition:   Parkinson's Disease Intervention:   Drug: ABBV-951 Sponsor:   AbbVie Not yet recruiting
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