Filtered By:
Specialty: Neurology
Nutrition: Antidoxidants

This page shows you your search results in order of relevance. This is page number 2.

Order by Relevance | Date

Total 165 results found since Jan 2013.

Associations between Uric Acid Level and 3-Month Functional Outcome in Acute Ischemic Stroke Patients Treated with/without Edaravone
Conclusions: In acute ischemic stroke, the favorable association between high UA levels and outcome at 90 days was not evident in patients treated with edaravone.Cerebrovasc Dis 2018;45:115 –123
Source: Cerebrovascular Diseases - March 20, 2018 Category: Neurology Source Type: research

Association analysis of Glutathione S-transferase omega-1 and omega-2 genetic polymorphisms and ischemic stroke risk in a Turkish population.
CONCLUSION: No significant difference was observed between the stroke patients and controls in terms of genotypes and allele distributions. Double combine haplotype CCAA was found to be protective against ischemic stroke when compare to other haplotypes. However, different genotypes of GSTO1 and GSTO2 were observed to have effects on stroke risk in subgroups of diabetics and smokers. In conclusion, the current study is the first to report this finding. PMID: 30417762 [PubMed - as supplied by publisher]
Source: Neurological Research - November 14, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Bilirubin and Ischemic Stroke: Rendering the Current Paradigm to Better Understand the Protective Effects of Bilirubin
AbstractNovel and innovative methods are critical in fostering new treatments and improving clinical outcomes in patients who suffer from ischemic stroke. Bilirubin has long been considered metabolic waste that can be harmful to the body; however, it is now becoming recognized as one of the body ’s most potent antioxidant, anti-inflammatory, and neuroprotective molecules. These properties facilitate bilirubin’s anti-atherogenic effects to impede and prevent the formation of thrombi in ischemic stroke. These functions allow for protection from neuronal injury during an ischemic state and suggest that elevated bilirubin ...
Source: Molecular Neurobiology - January 5, 2019 Category: Neurology Source Type: research

Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and wine; probiotics and vitamins in prevention of stroke, age-related cognitive decline, and Alzheimer disease.
Authors: Román GC, Jackson RE, Gadhia R, Román AN, Reis J Abstract The mechanisms of action of the dietary components of the Mediterranean diet are reviewed in prevention of cardiovascular disease, stroke, age-associated cognitive decline and Alzheimer disease. A companion article provides a comprehensive review of extra-virgin olive oil. The benefits of consumption of long-chain ω-3 fatty acids are described. Fresh fish provides eicosapentaenoic acid while α-linolenic acid is found in canola and soybean oils, purslane and nuts. These ω-3 fatty acids interact metabolically with ω-6 fatty acids mainly linoleic...
Source: Revue Neurologique - September 16, 2019 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Association of Paraoxonase-2 (C1053G) Gene Polymorphism with the Expression of Paraoxonase-2 Gene in Patients of Ischemic Stroke & #8211; A Pilot Study in Indian Population
Conclusion: Down-regulated Paraoxonase-2 gene expression, as evidenced by low mRNA levels in GG genotype may be one of the contributory factors in the progression of ischemic stroke.
Source: Neurology India - August 30, 2022 Category: Neurology Authors: Seema Kumari Ritu Singh Sudhir Chandra Mohit Mehndiratta Ekta Debnath Rajinder K Dhamija Source Type: research

Prognostic value of serum thioredoxin levels in ischemic stroke.
CONCLUSIONS: Serum Trx might be as a biomarker of cardioembolic stroke severity. Increased serum Trx levels could be a useful tool to predict good prognosis in patients with AIS. PMID: 28828929 [PubMed - as supplied by publisher]
Source: Neurological Research - August 24, 2017 Category: Neurology Tags: Neurol Res Source Type: research

Melatonin Regulates Neuroinflammation Ischemic Stroke Damage through Interactions with Microglia in Reperfusion phase.
In this study, we initially aimed to evaluate the therapeutic efficacy of melatonin intra-arterially and to clarify the underlying mechanisms. After that by using an in vitro approach, we evaluated the protective effects of melatonin on microglial cells following the hypoxia condition. Our results proved that a single dose of melatonin at the beginning of reperfusion phase improved structural and behavioral outcomes. Melatonin increased NeuN and decreased GFAP, Iba1 and active caspase-3 at protein level. Furthermore, melatonin elevated BDNF, MAP2, HSPA1A and reduced VEGF at mRNA level. We also showed that melatonin recepto...
Source: Brain Research - August 20, 2019 Category: Neurology Authors: Azedi F, Mehrpour M, Talebi S, Zendedel A, Kazemnejad S, Mousavizadeh K, Beyer C, Hassan Zarnani A, Taghi Joghataei M Tags: Brain Res Source Type: research

Hyperuricaemia as a prognostic factor for acute ischaemic stroke
ConclusionsSerum uric acid levels in patients with acute ischaemic stroke are significantly associated with functional prognosis at discharge, although this relationship is nonlinear. In fact, poorer prognosis is associated both with very low and with very high concentrations of uric acid. This suggests a dual role of uric acid in relation to stroke: on the one hand, as an associated risk factor, and on the other, as a possible neuroprotective factor due to its antioxidant effect.ResumenIntroducciónEn el proceso de búsqueda de biomarcadores para el pronóstico del ictus agudo, en los últimos años los estudios realizado...
Source: Neurologia - November 9, 2019 Category: Neurology Source Type: research

Rosmarinic acid protects rats against post-stroke depression after transient focal cerebral ischemic injury through enhancing antioxidant response.
Abstract Rosmarinic acid (RA), a natural polyphenol, possesses potent antioxidant and anti-inflammatory activities. To evaluate the ability of RA to cure ischemic stroke and post-stroke depression (PSD), rats were treated with various doses of RA after cerebral ischemia. Neurological deficits and infarct volume of the brain were measured. The activities of superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) were examined at different time points. In addition, a forced swimming test and sucrose preference test were performed to detect the anti-depressive effects of RA. Our results revealed RA administ...
Source: Brain Research - February 3, 2021 Category: Neurology Authors: Wang J, Wang S, Guo H, Li Y, Jiang Z, Gu T, Su B, Hou W, Zhong H, Cheng D, Zhang X, Fang Z Tags: Brain Res Source Type: research

Post-treatment with apocynin at a lower dose regulates the UPR branch of eIF2 α and XBP-1 pathways after stroke
Brain Res Bull. 2022 Feb 7:S0361-9230(22)00036-3. doi: 10.1016/j.brainresbull.2022.02.003. Online ahead of print.ABSTRACTStroke leads to disturbance in the physiology of the ER (Endoplasmic Reticulum) that triggers UPR (Unfolded Protein Response) pathways aimed to compensate neuronal cell damage. However, sustained UPR causes stressful conditions in the ER lumen forming abnormal protein aggregates. Stroke-induced oxidative stress also amalgamates with UPR to safeguard and ensure the proper functioning of brain cells. Thus we tested the effect of apocynin (a potent antioxidant) post-treatment in experimental stroke on the o...
Source: Brain Research Bulletin - February 10, 2022 Category: Neurology Authors: Venkata Prasuja Nakka Raghu Gogada Praveen Kumar Simhadri Mohammed Abdul Qadeer Prakash Babu Phanithi Source Type: research

Alpha‐7 nicotinic acetylcholine receptor agonist treatment reduces neuroinflammation, oxidative stress and brain injury in mice with ischemic stroke and bone fracture
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - July 10, 2014 Category: Neurology Authors: Zhenying Han, Li Li, Liang Wang, Vincent Degos, Mervyn Maze, Hua Su Tags: Original Article Source Type: research

Nobiletin promotes antioxidant and anti-inflammatory responses and elicits protection against ischemic stroke in vivo.
CONCLUSIONS: NOB may have a neuroprotective effect on cerebral ischemia, and this protection may be through upregulating Nrf2, HO-1 and downregulating NF-κB expression. PMID: 26874072 [PubMed - as supplied by publisher]
Source: Brain Research - February 10, 2016 Category: Neurology Authors: Zhang L, Zhang X, Zhang C, Bai X, Zhang J, Zhao X, Chen L, Wang L, Zhu C, Cui L, Chen R, Zhao T, Zhao Y Tags: Brain Res Source Type: research