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Therapy: Stem Cell Therapy
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Total 33 results found since Jan 2013.
Early depletion of M1 macrophages retards the progression of glucocorticoid-associated osteonecrosis of the femoral head
In conclusion, our study reveals the crucial involvement of M1 macrophages in the pathogenesis of GA-ONFH, highlighting their indispensable role in disease progression. Furthermore, early clearance emerges as a promising strategy for impeding the development of GA-ONFH.PMID:37481850 | DOI:10.1016/j.intimp.2023.110639
Source: International Immunopharmacology - July 23, 2023 Category: Allergy & Immunology Authors: Yannan Cheng Hui Chen Ping Duan Hao Zhang Yongle Yu Jiadong Yu Zirui Yu Lin Zheng Xin Ye Zhenyu Pan Source Type: research
Gene editing with 'pencil' rather than 'scissors' in human pluripotent stem cells
Stem Cell Res Ther. 2023 Jun 20;14(1):164. doi: 10.1186/s13287-023-03394-5.ABSTRACTOwing to the advances in genome editing technologies, research on human pluripotent stem cells (hPSCs) have recently undergone breakthroughs that enable precise alteration of desired nucleotide bases in hPSCs for the creation of isogenic disease models or for autologous ex vivo cell therapy. As pathogenic variants largely consist of point mutations, precise substitution of mutated bases in hPSCs allows researchers study disease mechanisms with "disease-in-a-dish" and provide functionally repaired cells to patients for cell therapy. To this e...
Source: Cell Research - June 20, 2023 Category: Cytology Authors: Ju-Chan Park Mihn Jeong Park Seung-Yeon Lee Dayeon Kim Keun-Tae Kim Hyeon-Ki Jang Hyuk-Jin Cha Source Type: research
Notch signaling sculpts the stem cell niche
Front Cell Dev Biol. 2022 Dec 20;10:1027222. doi: 10.3389/fcell.2022.1027222. eCollection 2022.ABSTRACTAdult stem cells depend on their niches for regulatory signaling that controls their maintenance, division, and their progeny differentiation. While communication between various types of stem cells and their niches is becoming clearer, the process of stem cell niche establishment is still not very well understood. Model genetic organisms provide simplified systems to address various complex questions, for example, how is a stem cell niche formed? What signaling cascades induce the stem cell niche formation? Are the mecha...
Source: Cancer Control - January 6, 2023 Category: Cancer & Oncology Authors: Ana-Maria Zamfirescu Andriy S Yatsenko Halyna R Shcherbata Source Type: research
Cancers, Vol. 14, Pages 4586: Employment among Childhood Cancer Survivors: A Systematic Review and Meta-Analysis
In conclusion, this systematic review and meta-analysis provides evidence that two-thirds of CCS are employed worldwide. Identifying vulnerable groups of CCS may allow for the design of multidisciplinary support strategies and interventions to promote employment in this population.
Source: Cancers - September 22, 2022 Category: Cancer & Oncology Authors: Alessandro Godono Francesco Felicetti Alessio Conti Marco Clari Margherita Dionisi-Vici Filippo Gatti Catalina Ciocan Tommaso Pinto Emanuela Arvat Enrico Brignardello Franca Fagioli Enrico Pira Tags: Systematic Review Source Type: research
Generation of Hepatocyte Organoids from Human iPS Cells
Methods Mol Biol. 2022;2544:51-70. doi: 10.1007/978-1-0716-2557-6_3.ABSTRACTHuman-induced pluripotent stem cells (hiPSCs) constitute a great source to generate specialized cells that can be employed in cell replacement therapy for a number of degenerative diseases. In this chapter, I describe a strategy to mass-produce fully functional hepatocyte organoids using hiPSCs interlaced with human adipose microvascular endothelial cells (HAMEC). Our unique technology employs a two-step strategy, consisting of the scalable generation of nearly spherical uniform-sized human embryoid bodies (hEBs), and the subsequent employment of a...
Source: Mol Biol Cell - September 20, 2022 Category: Molecular Biology Authors: Giuseppe Pettinato Source Type: research
Interferon- γ enhances the immunosuppressive ability of canine bone marrow-derived mesenchymal stem cells by activating the TLR3-dependent IDO/kynurenine pathway
CONCLUSION: Our findings substantiate that IFN-γ stimulation can enhance the immunomodulatory properties of cBMSCs by promoting TLR3-dependent activation of the IDO/kynurenine pathway, increasing the secretion of immunoregulatory molecules and strengthening interactions with T lymphocytes, which may provide a meaningful strategy for the clinical application of cBMSCs in immune-related diseases.PMID:35690960 | DOI:10.1007/s11033-022-07648-y
Source: Molecular Biology Reports - June 12, 2022 Category: Molecular Biology Authors: Jiaqiang Deng Danting Li Xiaoya Huang Weiyao Li Fangfang Zhao Congwei Gu Liuhong Shen Suizhong Cao Zhihua Ren Zhicai Zuo Junliang Deng Shumin Yu Source Type: research
Photobiomodulation effects on periodontal ligament stem cells: A systematic review of in-vitro studies
CONCLUSIONS: Photobiomodulation can enhance the stemness and differentiation capacities of periodontal ligament stem cells. Therefore, for PBM protocols, there remains no consensus amongst the scientific community. Statistical analyses performed here indicated that the employment of a near-infrared (NIR) wavelength of 940 nm may not yield a significant favourable outcome, although those within the 630 - 830 nm range did so. Concerning the fluence, it should not exceed 8 J/cm2 when therapy is applied by LED devices, and 4 J/cm2 when applied by lasers respectively.PMID:35638280 | DOI:10.2174/1574888X17666220527090321
Source: Current Stem Cell Research and Therapy - May 31, 2022 Category: Stem Cells Authors: Valina Mylona Eugenia Anagnostaki Nasim Chiniforush Hamidreza Barikani Edward Lynch Martin Grootveld Source Type: research
The Combination of Autologous Mesenchymal Stem cell-derived Exosomes and Neurotrophic Factors as an Intervention for Amyotrophic Lateral Sclerosis
Ann Anat. 2022 Mar 9:151921. doi: 10.1016/j.aanat.2022.151921. Online ahead of print.ABSTRACTAmyotrophic lateral sclerosis is a chronic progressive degeneration of motor neurons and has a high mortality. Riluzole and edaravone are the only approved medications currently being used for amyotrophic lateral sclerosis in clinical settings. However, they can lead to serious complications, such as injuries to the liver and kidney. To date, there is no effective treatment for amyotrophic lateral sclerosis. In this regard, investigations concerning the employment of exosomes, mesenchymal stem cells, and neurotrophic factors to ame...
Source: Annals of Anatomy - March 12, 2022 Category: Anatomy Authors: Yingying Ding Benson O A Botchway Yong Zhang Tian Jin Xuehong Liu Source Type: research
