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Total 269 results found since Jan 2013.

Metabolomic analysis and pharmacological validation of the cerebral protective effect of 3,4 ‑dihydroxybenzaldehyde on cerebral ischemia‑reperfusion injury
Mol Med Rep. 2023 Jan;27(1):9. doi: 10.3892/mmr.2022.12896. Epub 2022 Nov 11.ABSTRACT3,4‑Dihydroxybenzaldehyde (DBD), one of the active components of Gastrodia elata, has a cerebral protective effect and can effectively combat cerebral ischemia/reperfusion (I/R) injury in rats. However, the metabolite profiles and underlying mechanisms associated with DBD remain unclear. To explore the level of energy metabolism and pharmacological targets in brain tissue following DBD treatment of stroke. The right middle cerebral artery of the rats was occluded for 2 h and reperfused for 24 h to simulate brain I/R injury. Pharmacologic...
Source: Molecular Medicine Reports - November 11, 2022 Category: Molecular Biology Authors: Yuan Luo Pu Chen Liping Yang Xiaohua Duan Source Type: research

MT45 Cost-Effectiveness Analysis of Left Atrial Appendage Closure (LAAC) Device Vesus Warfarin and New Oral Anticoagulants (NOACS) in Patients with Atrial Fibrillation (AF) - Large Brazilian Healthcare Payer Perspective
The objective of the study was to evaluate the cost-effectiveness of LAAC with WATCHMAN device in the perspective of a large Brazilian healthcare payer with more than 18 million patients.
Source: Value in Health - June 1, 2023 Category: International Medicine & Public Health Authors: H. Tortele, S. Rodrigues, Cont ó M Source Type: research

With a broken promise, the government has handed the NHS over to the market | Clive Peedell
Reassurances on clinicians and local people controlling how services are commissioned look likely to be overturnedThe NHS needs to be reformed to remain true to its founding principles; the question is how. International evidence suggests that increasing marketisation and privatisation of healthcare services leads to greater expenditure, greater variations in care, reduced access to services, and erosion of professional standards. On that basis, the reforms have been heading in the wrong direction for a long time, with all the major political parties supporting policies that increase the role of the private sector in the N...
Source: Guardian Unlimited Science - March 3, 2013 Category: Science Authors: Clive Peedell Tags: Comment The Guardian Society Politics Privatisation NHS Andrew Lansley Comment is free Source Type: news

2013 Alzheimer's disease facts and figures.
This report provides information to increase understanding of the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality rates, health expenditures and costs of care, and effect on caregivers and society in general. It also explores the roles and unique challenges of long-distance caregivers, as well as interventions that target those challenges. An estimated 5.2 million Americans have AD. Approximately 200,000 people younger than 65 years with AD comprise the younger onset AD population; 5 million comprise the older onset AD population. Throughout the coming decades, the baby boom ...
Source: The Journal of Alzheimers Association - March 20, 2013 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

2013 Alzheimer's disease facts and figures
This report provides information to increase understanding of the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality rates, health expenditures and costs of care, and effect on caregivers and society in general. It also explores the roles and unique challenges of long-distance caregivers, as well as interventions that target those challenges. An estimated 5.2 million Americans have AD. Approximately 200,000 people younger than 65 years with AD comprise the younger onset AD population; 5 million comprise the older onset AD population. Throughout the coming decades, the baby boom ...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - March 1, 2013 Category: Geriatrics Authors: Alzheimer's Association Tags: Alzheimer's Association Report Source Type: research

Socioeconomic variation in the financial consequences of ill health for older people with chronic diseases: A systematic review
Abstract: Chronic disease has financial consequences for older adults, but it is unclear how this varies between conditions with different disease trajectories. The aim of this study was to review evidence on the financial burden associated with cancer, heart failure or stroke in older people, to identify those most at risk of financial adversity. We systematically searched nine databases for studies with data on the illness-related financial burden (objective), or on the perception of financial hardship (subjective), of older patients and/or their informal caregivers in high-income countries. We identified thirty-eight pa...
Source: Maturitas - February 6, 2013 Category: Primary Care Authors: Nicole K. Valtorta, Barbara Hanratty Tags: Reviews Source Type: research

Explaining health care expenditure variation: large‐sample evidence using linked survey and health administrative data
ABSTRACT Explaining individual, regional, and provider variation in health care spending is of enormous value to policymakers but is often hampered by the lack of individual level detail in universal public health systems because budgeted spending is often not attributable to specific individuals. Even rarer is self‐reported survey information that helps explain this variation in large samples. In this paper, we link a cross‐sectional survey of 267 188 Australians age 45 and over to a panel dataset of annual healthcare costs calculated from several years of hospital, medical and pharmaceutical records. We use this da...
Source: Health Economics - March 12, 2013 Category: Health Management Authors: Randall P. Ellis, Denzil G. Fiebig, Meliyanni Johar, Glenn Jones, Elizabeth Savage Tags: Special Issue Paper Source Type: research

Methods of accelerated atherosclerosis in diabetic patients
This article will focus on the effect of diabetes on the initiation and progression of arterial occlusive disease, preceded by a short outline of the enormous impact of this issue from a societal-economic perspective. Diabetes, a major healthcare issue The prevalence and associated costs of diabetes are expected to increase significantly. There are currently over 240...
Source: Heart - April 18, 2013 Category: Cardiology Authors: Pasterkamp, G. Tags: Diabetic heart disease, Health policy, Education in Heart, Drugs: cardiovascular system, Hypertension, Acute coronary syndromes, Stable coronary heart disease, Epidemiology, Diabetes, Metabolic disorders Source Type: research

Cost of Treating Strokes in U.S. Could Soar to $180B Annually by 2030
An aging population could double expenditures, American Heart Association says Source: HealthDay Related MedlinePlus Pages: Health Statistics, Stroke
Source: MedlinePlus Health News - May 22, 2013 Category: Consumer Health News Source Type: news

Empirical analysis of the long-term effects of telecare use in Nishi-aizu Town, Fukushima Prefecture, Japan.
Abstract This paper examined the long-term effects of the use of telecare (e-Health) on the residents of Nishi-aizu Town, Fukushima, Japan, between 2002 and 2010. We compared medical expenditure and days of treatment between telecare users (treatment group) and non-users (control group) based on receipt data obtained from the National Health Insurance, which is operated by the government. In previous studies, we used receipt data obtained for the years 2002 to 2006; this study expands the analysis period four more years with respect to respondents who were included in previous analyses. Ninety users and 118 non-us...
Source: Technology and Health Care - May 25, 2013 Category: Medical Equipment Authors: Akematsu Y, Nitta S, Morita K, Tsuji M Tags: Technol Health Care Source Type: research

Pharmacotherapy of obesity: clinical treatments and considerations.
Abstract Obesity is a world-wide epidemic associated with significant morbidity and mortality which costs billions of dollars per year. The associated related conditions are many and include heart disease, stroke, type II diabetes mellitus, sleep apnea and certain types of cancer. Given that it is a multifactorial problem, the treatments must also address the numerous causes associated with the development of obesity. The neurohormonal regulation of feeding and energy is a complex system often necessitating modification through more than 1 pathway to achieve weight loss. Therefore, in addition to lifestyle changes...
Source: The American Journal of the Medical Sciences - April 1, 2013 Category: Journals (General) Authors: Holes-Lewis KA, Malcolm R, O'Neil PM Tags: Am J Med Sci Source Type: research

Atrial fibrillation: Profile and burden of an evolving epidemic in the 21st century
Abstract: Background: Atrial fibrillation (AF) represents an increasing public health challenge with profound social and economic implications.Methods: A comprehensive synthesis and review of the AF literature was performed. Overall, key findings from 182 studies were used to describe the indicative scope and impact of AF from an individual to population perspective.Results: There are many pathways to AF including advancing age, cardiovascular disease and increased levels of obesity/metabolic disorders. The reported population prevalence of AF ranges from 2.3%–3.4% and historical trends reflect increased AF incidence. Es...
Source: International Journal of Cardiology - February 4, 2013 Category: Cardiology Authors: Jocasta Ball, Melinda J. Carrington, John J.V. McMurray, Simon Stewart Tags: Reviews Source Type: research

The role of nutrition, nutraceuticals, vitamins, antioxidants, and minerals in the prevention and treatment of hypertension.
Abstract Macronutrient and micronutrient deficiencies are very common in the general population and may be even more common in patients with hypertension and cardiovascular disease due to genetic or environmental causes and prescription drug use. These deficiencies will have an enormous impact on present and future cardiovascular health and outcomes, such as hypertension, myocardial infarction, stroke and renal disease, and on overall health costs. The diagnosis and treatment of these nutrient deficiencies can reduce blood pressure; improve vascular health, endothelial dysfunction, and vascular biology; and decrea...
Source: Alternative Therapies in Health and Medicine - September 20, 2013 Category: Complementary Medicine Authors: Houston MC Tags: Altern Ther Health Med Source Type: research

Mechanical efficiency of two commercial lever-propulsion mechanisms for manual wheelchair locomotion.
Abstract The purpose of this study was to (1) evaluate the mechanical efficiency (ME) of two commercially available lever-propulsion mechanisms for wheelchairs and (2) compare the ME of lever propulsion with hand rim propulsion within the same wheelchair. Of the two mechanisms, one contained a torsion spring while the other used a roller clutch design. We hypothesized that the torsion spring mechanism would increase the ME of propulsion due to a passive recovery stroke enabled by the mechanism. Ten nondisabled male participants with no prior manual wheeling experience performed submaximal exercise tests using both...
Source: J Rehabil Res Dev - February 1, 2014 Category: Rehabilitation Authors: Lui J, Macgillivray MK, Sheel AW, Jeyasurya J, Sadeghi M, Sawatzky BJ Tags: J Rehabil Res Dev Source Type: research