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Infectious Disease: SARS

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A computable case definition for patients with SARS-CoV2 testing that occurred outside the hospital
CONCLUSION: COVID-19 cases that had testing done outside of the hospital can be reliably detected from the text in EHRs. Training on a proxy dataset was a suitable method for developing a highly performant classifier without labor-intensive labeling efforts.PMID:37425487 | PMC:PMC10322650 | DOI:10.1093/jamiaopen/ooad047
Source: Pain Physician - July 10, 2023 Category: Anesthesiology Authors: Lijing Wang Amy R Zipursky Alon Geva Andrew J McMurry Kenneth D Mandl Timothy A Miller Source Type: research

Fight Aging! Newsletter, July 10th 2023
In conclusion, the examination of the GBA can aid in understanding the etiology and development of NDs, which may benefit the improvement of clinical treatments for these disorders and ND interventions. This review indicates existing knowledge about the involvement of microbiota present in the gut in NDs and potential treatment options. The Aging of the Enteric Nervous System https://www.fightaging.org/archives/2023/07/the-aging-of-the-enteric-nervous-system/ The enteric nervous system is the nervous system of the intestines, and likely an important part of the relationship between the gut microbiome a...
Source: Fight Aging! - July 9, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Rare link between coronavirus vaccines and Long Covid –like illness starts to gain acceptance
COVID-19 vaccines have saved millions of lives, and the world is gearing up for a new round of boosters. But like all vaccines, those targeting the coronavirus can cause side effects in some people, including rare cases of abnormal blood clotting and heart inflammation. Another apparent complication, a debilitating suite of symptoms that resembles Long Covid, has been more elusive, its link to vaccination unclear and its diagnostic features ill-defined. But in recent months, what some call Long Vax has gained wider acceptance among doctors and scientists, and some are now working to better understand and treat its symptoms...
Source: ScienceNOW - July 3, 2023 Category: Science Source Type: news

Long COVID and its cardiovascular consequences: What is known?
Adv Clin Exp Med. 2023 Jun 30. doi: 10.17219/acem/167482. Online ahead of print.ABSTRACTThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused high morbidity and mortality and has been a source of substantial challenges for healthcare systems globally. Despite a full recovery, a significant proportion of patients demonstrate a broad spectrum of cardiovascular, pulmonary and neurological symptoms that are believed to be caused by long-term tissue damage and pathological inflammation, which play a vital role in disease development. Microvascular dysfunction also causes significant health problem...
Source: Adv Data - June 30, 2023 Category: Epidemiology Authors: Justyna Aleksandra Sk ładanek Micha ł Leśkiewicz Karolina Gumi ężna Piotr Baru ś Adam Piasecki Dominika Klimczak-Tomaniak Gra żyna Sygitowicz Janusz Kochman Marcin Grabowski Mariusz Tomaniak Source Type: research

Hamman's syndrome in SARS-CoV-2 pneumonia
Medicina (B Aires). 2023;83(3):475-478.ABSTRACTHamman's syndrome, or spontaneous pneumomediastinum, is the presence of air in the mediastinum without a history of previous pulmonary pathology, chest trauma or iatrogenesis. It has been described as a rare complication in patients with COVID-19 pneumonia. It is postulated that an increase in airway pressure associated with diffuse alveolar damage caused by the virus produces an air leak into the mediastinum. Chest pain and dyspnea associated with subcutaneous emphysema should make the treating physician suspicious. We introduce a 79-year-old patient who, during hospitalizati...
Source: Pain Physician - June 28, 2023 Category: Anesthesiology Authors: Gabriela L Belachur Carolina Holzer Gonzalo R Voboril Daniela C Carbone Patricia K Aruj Martin Durlach Source Type: research

Adverse effects of COVID-19 vaccination in patients with Transfusion Dependent Thalassemia (TDT): an observational study from a tertiary care centre in Punjab, India
Acta Haematol. 2023 Jun 16. doi: 10.1159/000531448. Online ahead of print.ABSTRACTVaccination against SARS-CoV2 is the most important weapon in the arsenal in the battle against COVID-19. There is concern about an increased risk of adverse effects in patients with transfusion-dependent thalassemia (TDT), which affects vaccine acceptance. A predesigned questionnaire was used to evaluate adverse effects (local/systemic within 90 days after vaccination) in participants >18 years of age with TDT. A total of 100 patients received 129 vaccine doses. The mean age of the patients was 24.3 ± 5.7 years and M: F ratio of 1.6:1. C...
Source: Acta Haematologica - June 18, 2023 Category: Hematology Authors: Shruti Kakkar Evani Jain Anirudh Jain Priyanka Dewan Source Type: research

Viruses, Vol. 15, Pages 1370: Do COVID-19 Vaccinations Affect the Most Common Post-COVID Symptoms? Initial Data from the STOP-COVID Register & ndash;12-Month Follow-Up
Viruses, Vol. 15, Pages 1370: Do COVID-19 Vaccinations Affect the Most Common Post-COVID Symptoms? Initial Data from the STOP-COVID Register–12-Month Follow-Up Viruses doi: 10.3390/v15061370 Authors: Mateusz Babicki Joanna Kapusta Karolina Pieniawska-Śmiech Żaneta Kałuzińska-Kołat Damian Kołat Agnieszka Mastalerz-Migas Piotr Jankowski Michał Chudzik Around the world, various vaccines have been developed to prevent the SARS-CoV-2 virus infection and consequently the COVID-19 disease. However, many patients continue to report persistent symptoms after the acute phase. Since gathering sc...
Source: Viruses - June 13, 2023 Category: Virology Authors: Mateusz Babicki Joanna Kapusta Karolina Pieniawska- Śmiech Żaneta Kałuzińska-Kołat Damian Ko łat Agnieszka Mastalerz-Migas Piotr Jankowski Micha ł Chudzik Tags: Article Source Type: research

Neurological manifestations of COVID-19 in pregnancy: a cross-sectional study
AbstractThe occurrence of neurological manifestations and complications in pregnant women compared to non-pregnant women with COVID-19 is unclear. This cross-sectional study included women aged over 18  years hospitalized with SARS-CoV-2 infection confirmed by RT-PCR from March to June 2020 in Recife, Brazil. We evaluated 360 women, including 82 pregnant patients who were significantly younger (27.5 vs. 53.6 years; p <  0.01) and less frequently obese (2.4% vs. 15.1%; p <  0.01) than the non-pregnant group. All pregnancies were confirmed using ultrasound imaging. Abdominal pain was the only more frequent CO...
Source: Journal of NeuroVirology - June 12, 2023 Category: Neurology Source Type: research

Immunological responses and adverse reactions of the heterologous second booster dose of BNT162b2 after two-dose CoronaVac for COVID-19 vaccination in healthcare workers of Faculty of Medicine, Naresuan University
CONCLUSION: This study demonstrated that a heterologous second booster dose of BNT162b2 after two doses of CoronaVac induced elevated IgG against the SARS-CoV-2-spike protein and caused minor adverse reactions in healthcare workers of the Faculty of Medicine, Naresuan University. This study was registered as Thailand Clinical Trials No. TCTR20221112001.PMID:37301707 | PMC:PMC10239901 | DOI:10.1016/j.vaccine.2023.06.017
Source: Vaccine - June 10, 2023 Category: Allergy & Immunology Authors: Supawadee Makanut Apirath Wangteeraprasert Wittawat Jitpewngam Jatuporn Ngoenkam Sutatip Pongcharoen Source Type: research

Neuroimmune Mechanisms Underlying Post-acute Sequelae of SARS-CoV-2 (PASC) Pain, Predictions from a Ligand-Receptor Interactome
AbstractPurpose of ReviewIndividuals with post-acute sequelae of SARS-CoV-2 (PASC) complain of persistent musculoskeletal pain. Determining how COVID-19 infection produces persistent pain would be valuable for the development of therapeutics aimed at alleviating these symptoms.Recent FindingsTo generate hypotheses regarding neuroimmune interactions in PASC, we used a ligand-receptor interactome to make predictions about how ligands from PBMCs in individuals with COVID-19 communicate with dorsal root ganglia (DRG) neurons to induce persistent pain. In a structured literature review of -omics COVID-19 studies, we identified ...
Source: Current Rheumatology Reports - June 10, 2023 Category: Rheumatology Source Type: research

Transient receptor potential ankyrin 1 (TRPA1) modulators: Recent update and future perspective
Eur J Med Chem. 2023 May 18;257:115392. doi: 10.1016/j.ejmech.2023.115392. Online ahead of print.ABSTRACTThe transient receptor potential ankyrin 1 (TRPA1) channel is a non-selective cation channel that senses irritant chemicals. Its activation is closely associated with pain, inflammation, and pruritus. TRPA1 antagonists are promising treatments for these diseases, and there has been a recent upsurge in their application to new areas such as cancer, asthma, and Alzheimer's disease. However, due to the generally disappointing performance of TRPA1 antagonists in clinical studies, scientists must pursue the development of an...
Source: European Journal of Medicinal Chemistry - June 3, 2023 Category: Chemistry Authors: Zelin Hu Ya Zhang Wenhan Yu Junjie Li Jiaqi Yao Jifa Zhang Jiaxing Wang Chengdi Wang Source Type: research