• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Differential Clearance of Rat and Human Bone Marrow-Derived Mesenchymal Stem Cells from the Brain After Intra-arterial Infusion in Rats.
Abstract Intra-arterial (i.a.) delivery of bone marrow-derived mesenchymal stem cells (BMMSCs) has shown potential as a minimally invasive therapeutic approach for stroke. The aim of the present study was to determine the whole-body biodistribution and clearance of technetium-99m ((99m)Tc)-labeled rat and human BMMSCs after i.a. delivery in a rat model of transient middle cerebral artery occlusion (MCAO) using single photon emission computed tomography (SPECT). Our hypothesis was that xenotransplantation has a major impact upon the behavior of cells. Male RccHan:Wistar rats were subjected to sham-operation or MCAO...
Source: Cell Transplantation - March 3, 2014 Category: Cytology Authors: Khabbal J, Kerkelä E, Mitkari B, Raki M, Nystedt J, Mikkonen V, Bergström K, Laitinen S, Korhonen M, Jolkkonen J Tags: Cell Transplant Source Type: research

Depressive symptoms, atherosclerotic burden and cerebral blood flow disturbances in a cohort of octogenarian men from a general population
Conclusion: In this population-based cohort of octogenarian men free from stroke or dementia, a proportion of subjects with depressive symptoms was low. Still, men with borderline or mild depression scores had lower social and physical activity, persistent smoking habit, worse peripheral circulation in legs, and cerebral perfusion changes in basal nuclei, thalamus and subcortical white matter. Regional CBF decline could be partly mediated by higher SBP.
Source: BMC Psychiatry - Latest articles - December 26, 2013 Category: Psychiatry Authors: Arkadiusz Siennicki-LantzLena André-PeterssonPer WollmerSölve Elmståhl Source Type: research

Combined 18F-FDG PET-CT and DCE-MRI to Assess Inflammation and Microvascularization in Atherosclerotic Plaques Brief Reports
Conclusions— There is a weak but significant positive correlation between inflammation on positron emission tomography/computed tomography and neovascularization as assessed with dynamic contrast–enhanced-MRI. Future studies should investigate which imaging modality has the highest predictive value for recurrent stroke, as these are not interchangeable. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00451529.
Source: Stroke - November 25, 2013 Category: Neurology Authors: Truijman, M. T. B., Kwee, R. M., van Hoof, R. H. M., Hermeling, E., van Oostenbrugge, R. J., Mess, W. H., Backes, W. H., Daemen, M. J., Bucerius, J., Wildberger, J. E., Kooi, M. E. Tags: Imaging, Carotid Stenosis, Computerized tomography and Magnetic Resonance Imaging, PET and SPECT Brief Reports Source Type: research

Systematic review of the diagnostic utility of spect imaging in dementia
Conclusion SPECT does have a diagnostic value, particularly in differentiating Alzheimer's disease from frontotemporal dementia and normal controls, however SPECT should not be used in isolation, rather it should be interpreted together with clinical data, neuropsychological assessment and structural brain imaging as an adjunctive diagnostic tool.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Yeo, J. M., Lim, X., Khan, Z., Pal, S. Tags: Dementia, Drugs: CNS (not psychiatric), Neuroimaging, Stroke, Memory disorders (psychiatry), Psychiatry of old age, Radiology, Radiology (diagnostics) Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), Lo Source Type: research

123I-Iomazenil Single Photon Emission Computed Tomography Visualizes Recovery of Neuronal Integrity by Bone Marrow Stromal Cell Therapy in Rat Infarct Brain Basic Sciences
Conclusions— The present findings strongly suggest that the BMSCs may enhance functional recovery by improving the neuronal integrity in the peri-infarct area, when directly transplanted into the infarct brain at clinically relevant timing. 123I-IMZ single photon emission computed tomography may be a promising modality to scientifically prove the beneficial effects of BMSC transplantation on the host brain in clinical situation.
Source: Stroke - September 23, 2013 Category: Neurology Authors: Saito, H., Magota, K., Zhao, S., Kubo, N., Kuge, Y., Shichinohe, H., Houkin, K., Tamaki, N., Kuroda, S. Tags: Animal models of human disease, Acute Cerebral Infarction, PET and SPECT, Other Stroke Treatment - Medical, Other Stroke Treatment - Surgical Basic Sciences Source Type: research

Monitoring Neuroprotective Effects Using Positron Emission Tomography With 11CITMM, a Radiotracer for Metabotropic Glutamate 1 Receptor Basic Sciences
Conclusions— [11C]ITMM-PET may be a useful technique for characterizing the change in mGlu1 level during the occurrence and progression of neuronal damage and for evaluating the neuroprotective effects of drugs after ischemia.
Source: Stroke - August 26, 2013 Category: Neurology Authors: Yui, J., Xie, L., Fujinaga, M., Yamasaki, T., Hatori, A., Kumata, K., Nengaki, N., Zhang, M.-R. Tags: PET and SPECT Basic Sciences Source Type: research

Pathological generosity: An atypical impulse control disorder after a left subcortical stroke.
We report on a case of pathological generosity secondary to a left lenticulocapsular stroke with hypoperfusion of several anatomically intact cortical areas. A 49-year-old man developed excessive and persistent generosity as he recovered from a left lenticulocapsular hematoma. His symptoms resembled an impulse control disorder. (99m)Tc-HMPAO SPECT demonstrated hypoperfusion mostly in the ipsilateral striatum, dorsolateral, and orbitofrontal cortex. This case study adds pathological generosity to the range of behavioral changes that may result from discrete unilateral lesions of the lenticular nucleus and nearby pathways. I...
Source: Neurocase - August 20, 2013 Category: Neurology Authors: Ferreira-Garcia R, Fontenelle LF, Moll J, de Oliveira-Souza R Tags: Neurocase Source Type: research

Cerebral hemodynamic benefits after carotid artery stenting in patients with near occlusion
Conclusions: Before CAS, patients with NO were more hemodynamically compromised than those with severe stenosis without NO. After CAS, significant cerebral hemodynamic improvement and normalization occurred long-term. Thus, from a hemodynamic perspective, CAS was effective in patients with NO.
Source: Journal of Vascular Surgery - July 26, 2013 Category: Surgery Authors: Fumiaki Oka, Hideyuki Ishihara, Shoichi Kato, Takayuki Oku, Akiko Yamane, Ichiro Kunitugu, Michiyasu Suzuki Tags: Clinical research studies Source Type: research

Effects of Noninvasive Brain Stimulation on Language Networks and Recovery in Early Poststroke Aphasia Clinical Sciences
Conclusions— Ten sessions of inhibitory rTMS over the right posterior inferior frontal gyrus, in combination with speech and language therapy, significantly improve language recovery in subacute ischemic stroke and favor recruitment of left-hemispheric language networks.
Source: Stroke - July 22, 2013 Category: Neurology Authors: Thiel, A., Hartmann, A., Rubi-Fessen, I., Anglade, C., Kracht, L., Weiduschat, N., Kessler, J., Rommel, T., Heiss, W.-D. Tags: Behavioral Changes and Stroke, PET and SPECT, Rehabilitation, Stroke, Other Stroke Treatment - Medical Clinical Sciences Source Type: research

Signal Intensity Changes for the Middle Cerebral Artery on 3-Dimensional Time-of-flight Magnetic Resonance Angiography Indicate Acute Hemodynamic Changes after Carotid Endarterectomy
In this study, we aimed to evaluate whether 3D-TOF-MRA could be used as an alternative to single-photon emission computed tomography (SPECT) for assessing the increase in the regional cerebral blood flow (rCBF) after carotid endarterectomy (CEA). To do this, we compared the SI of the middle cerebral artery (MCA) on magnetic resonance angiography (MRA) and the rCBF on SPECT.Methods: We enrolled 30 patients with internal carotid artery stenosis. SPECT and MRA were performed before and 3-4 days after CEA. rCBF was assessed using SPECT, and the SI of the MCA was assessed using single-slab 3D-TOF-MRA. Regions of interest were...
Source: Journal of Stroke and Cerebrovascular Diseases - July 1, 2013 Category: Neurology Authors: Kimitoshi Sato, Akira Kurata, Hidehiro Oka, Shinichi Kan, Yusuke Inoue, Yuji Asano, Kiyotaka Fujii Tags: Original Articles Source Type: research

Neurobiological insight into hyperbaric hyperoxia
ConclusionsThe present study firstly confirmed the rCBF distribution increase during HBO in sensory‐motor and visual cortices and it showed for the first time a higher perfusion tracer distribution in areas encompassed in dorsal attention system and in default mode network. These findings unfold both the externally directed cognition performance improvement related to the HBO and the internally directed cognition states during resting state conditions, suggesting possible beneficial effects in TBI and stroke patients.This article is protected by copyright. All rights reserved.
Source: Acta Physiologica - May 21, 2013 Category: Physiology Authors: Alessandro Micarelli, Hans Jacobsson, Stig A Larsson, Cathrine Jonsson, Marco Pagani Tags: Regular Paper Source Type: research

Posterior Fossa Syndrome After Cerebellar Stroke.
We report longitudinal clinical, neurocognitive and neuroradiological findings in a 71-year-old right-handed patient who developed PFS following a right cerebellar haemorrhage that was not surgically evacuated. During follow-up, functional neuroimaging was conducted by means of quantified Tc-99m-ECD SPECT studies. After a 10-day period of akinetic mutism, the clinical picture developed into cerebellar cognitive affective syndrome (CCAS) with reversion to a previously learnt accent, consistent with neurogenic foreign accent syndrome (FAS). No psychometric evidence for dementia was found. Quantified Tc-99m-ECD SPECT studies ...
Source: Cerebellum - April 11, 2013 Category: Neuroscience Authors: Mariën P, Verslegers L, Moens M, Dua G, Herregods P, Verhoeven J Tags: Cerebellum Source Type: research

Arterial Spin-Labeling Magnetic Resonance Imaging After Revascularization of Moyamoya Disease
Arterial spin labeling (ASL) magnetic resonance imaging (MRI) is a technique for depicting cerebral perfusion without contrast medium. The purpose of this study was to determine whether ASL can be used to detect hyperperfusion after revascularization for moyamoya disease as effectively as N-isopropyl-[123I]β-iodoamphetamine (123I-IMP) single-photon emission computed tomography (SPECT). Fifteen consecutive patients with moyamoya disease were included in the study. All patients underwent surgical revascularization. Postoperatively, regional cerebral blood flow (rCBF) was measured by flow-sensitive alternating inversion reco...
Source: Journal of Stroke and Cerebrovascular Diseases - June 21, 2012 Category: Neurology Authors: Toshiya Sugino, Takeshi Mikami, Kei Miyata, Kengo Suzuki, Kiyohiro Houkin, Nobuhiro Mikuni Tags: Original Articles Source Type: research

Perfusion status of the stroke-like lesion at the hyperacute stage in MELAS
Abstract: Hypoperfusion on single-photon emission computed tomography (SPECT) of the stroke-like lesion (SLL) at the hyperacute stage of mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS) is considered to be a supportive evidence of the mitochondrial angiopathy theory. Our objectives were to examine whether other neuroimages, especially transcranial color-coded sonography (TCCS), done at the hyperacute stage of stroke-like episode (SLE) is consistent with hypoperfusion of the SLL. We reviewed the magnetic resonance imaging (MRI), SPECT, cerebral angiography, and TCCS of a patient with MELAS ...
Source: Brain and Development - April 20, 2012 Category: Neurology Authors: Hsu-Ling Yeh, Yen-Kung Chen, Wei-Hung Chen, Han-Cheng Wang, Hou-Chang Chiu, Li-Ming Lien, Yau-Huei Wei Tags: Original articles Source Type: research

Usefulness of Dual and Fully Automated Measurements of Cerebral Blood Flow during Balloon Occlusion Test of the Internal Carotid Artery
This study was conducted to show the reliability of fully automated quantification of regional cerebral blood flow (rCBF) in balloon occlusion test (BOT) of the internal carotid artery (ICA). We also shows the usefulness of ratio of rCBF during BOT to rCBF at rest (BOT/rest ratio = rCBF during BOT/rCBF at rest) rather than asymmetry index (AI) during BOT (AI = occluded-side rCBF/contralateral rCBF).Methods: In the last 2 years, we performed the BOT on 10 consecutive patients (4 with intracranial aneurysms and 6 with head and neck tumors). During the BOT, mean stump pressure (MSTP) of the ICA was monitored. We measured cere...
Source: Journal of Stroke and Cerebrovascular Diseases - September 20, 2011 Category: Neurology Authors: Takeshi Torigai, Mitsuhito Mase, Takayuki Ohno, Hiroyuki Katano, Yusuke Nisikawa, Keita Sakurai, Shigeru Sasaki, Junko Toyama, Kazuo Yamada Tags: Original Articles Source Type: research

Pages: 1  2  3  4  5  6  7  8  9  10