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Specialty: Neurology
Education: Study
Therapy: Statin Therapy
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Total 244 results found since Jan 2013.
Co-morbidity and clinically significant interactions between antiepileptic drugs and other drugs in elderly patients with newly diagnosed epilepsy
Conclusions Elderly patients with newly diagnosed epilepsy are at high risk of clinically relevant pharmacokinetic interactions with other drugs, especially if exposed to carbamazepine, but these interactions can be controlled via rational drug choices and with prediction of the possible drug-to-drug interactions. Patients on dihydropyridine calcium-channel blockers, statins, warfarin, and risperidone face the highest risk of interactions.
Source: Epilepsy and Behavior - June 14, 2017 Category: Neurology Source Type: research
Co-morbidity and clinically significant interactions between antiepileptic drugs and other drugs in elderly patients with newly diagnosed epilepsy.
CONCLUSIONS: Elderly patients with newly diagnosed epilepsy are at high risk of clinically relevant pharmacokinetic interactions with other drugs, especially if exposed to carbamazepine, but these interactions can be controlled via rational drug choices and with prediction of the possible drug-to-drug interactions. Patients on dihydropyridine calcium-channel blockers, statins, warfarin, and risperidone face the highest risk of interactions.
PMID: 28622547 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - June 13, 2017 Category: Neurology Authors: Bruun E, Virta LJ, Kälviäinen R, Keränen T Tags: Epilepsy Behav Source Type: research
Stroke-like migraine attacks in long term survivors of high grade glioma. (P1.174)
Conclusions:Stroke-like migraine attacks are difficult to treat and the pathophysiology is unknown. With more sophisticated imaging techniques, a better understanding of this phenomenon will aid in the treatment and prophylaxis of the syndrome with a goal of improving quality of life for this small but slowly growing population.Disclosure: Dr. New has nothing to disclose. Dr. Mirza has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: New, P., Mirza, H. Tags: Neuro-oncology: Gliomas I Source Type: research
Ultra-early Institution of Statin Treatment is Associated with Improved Outcomes Among Acute Ischemic Stroke Patients Receiving Thrombolytic Treatment (P5.150)
Conclusions:Ultra-early institution of statin treatment in acute ischemic stroke patients treated with IV rt-PA with or without endovascular treatment was associated with improved outcome at both 3 and 12 monthsDisclosure: Dr. Saleem has nothing to disclose. Dr. Qureshi has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Saleem, M., Qureshi, A. Tags: Clinical Neuro-rehabilitation Source Type: research
High Rate of Stenosis Progression Identified with Routine Carotid Doppler Surveillance (P5.284)
Conclusions:Among this prospective cohort of asymptomatic ≥50% carotid stenosis subjects followed with carotid Doppler imaging, high rates of carotid stenosis progression occurred despite contemporary intensive medical management, and significant TIA/stroke rates were also noted, especially among those with ≥80% stenosis. These results support further study of routine carotid Doppler surveillance in management of asymptomatic carotid stenosis.Study Supported by:Grants from the American Heart Association (15GRNT25270010), NIH (1 U54GM104938) and the VA Clinical Science Research & Development Service (CX000340)Disc...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Kirkpatrick, A., Stoner, J., Tafur, A., Elias, A., Prodan, C. Tags: SubAcute Interventional Therapies in Cerebrovascular Disease Source Type: research
Cerebral blood flow evaluation of intensive rosuvastatin therapy in stroke/transient ischemic attack patients with intracranial arterial atherosclerotic stenosis study: Rationale and design
ConclusionThe CEIRIS trial about the effects of statin on the temporal hemodynamic progression of ICAS may extend our understanding of the basic pathophysiology and mechanisms of stroke in ICAS patients.
With the use of computed tomography perfusion, we aim to evaluate the impact of Rosuvastatin on cerebral hemodynamic changes, as well as the downstream perfusion. This trial concerning the effects of statin on the temporal hemodynamic progression of intracranial atherosclerotic stenosis (ICAS) may extend our understanding of the basic pathophysiology and mechanisms of stroke in ICAS patients.
Source: Brain and Behavior - April 1, 2017 Category: Neurology Authors: Xuting Zhang, Ying Zhou, Sheng Zhang, Wenhong Ding, Min Lou Tags: METHODS Source Type: research
The effect of statin use in acute ischemic stroke patients treated with thrombolytic therapy
This study investigated the effects of statins for the acute ischemic stroke patients after thrombolysis on the stroke outcome considering statin intensity and time window.
Source: Journal of Stroke and Cerebrovascular Diseases - March 18, 2017 Category: Neurology Authors: Jong-Moo Park, Tae Kyoung Kim, Eui Sung Jung, Kyusik Kang, Woung-Woo Lee, Jungju Lee, Ohyun Kwon, Byung-Kun Kim Source Type: research
Statin Adherence and the Risk of Stroke: A Dose-Response Meta-Analysis
ConclusionImproved adherence to statins was associated with a lower risk of stroke, particularly of IS.
Source: CNS Drugs - March 12, 2017 Category: Neurology Source Type: research
Left ventricular wall motion abnormalities are associated with stroke recurrence
Conclusions:
This study suggests that LVWMA, even when unassociated with high-risk cardioembolic sources, could be an independent predictor for stroke recurrence in patients with ischemic stroke.
Source: Neurology - February 5, 2017 Category: Neurology Authors: Choi, J.-Y., Cha, J., Jung, J.-M., Seo, W.-K., Oh, K., Cho, K.-H., Yu, S. Tags: Cardiac, Embolism, Infarction ARTICLE Source Type: research
Stroke Epidemiology and Risk Factor Management
This article reviews the current recommendations for the management of each of these modifiable risk factors.
Recent Findings: It has been documented that some blood pressure medications may increase variability of blood pressure and ultimately increase the risk for stroke. Stroke prevention typically includes antiplatelet therapy (unless an indication for anticoagulation exists), so the most recent evidence supporting use of these drugs is reviewed. In addition, emerging risk factors, such as obstructive sleep apnea, electronic cigarettes, and elevated lipoprotein (a), are discussed.
Summary: Overall, secondary stroke p...
Source: CONTINUUM: Lifelong Learning in Neurology - February 1, 2017 Category: Neurology Tags: Review Articles Source Type: research
Simvastatin Promotes Hematoma Absorption and Reduces Hydrocephalus Following Intraventricular Hemorrhage in Part by Upregulating CD36
AbstractWe previously found that hematoma worsens hydrocephalus after intraventricular hemorrhage (IVH) via increasing iron deposition and aggravating ependymal cilia injury; therefore, promoting hematoma absorption may be a promising strategy for IVH. Recently, some investigations imply that simvastatin has the ability of accelerating hematoma absorption. Thus, this study was designed to examine the efficacy of simvastatin for IVH in rats. Intracerebral hemorrhage with ventricular extension was induced in adult male Sprague –Dawley rats after autologous blood injection. Simvastatin or vehicle was administered orally at ...
Source: Translational Stroke Research - January 18, 2017 Category: Neurology Source Type: research
The Japan Statin Treatment Against Recurrent Stroke (J-STARS) Echo Study: Rationale and Trial Protocol
The preventive effect of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) on progression of carotid intima-media complex thickness (IMT) has been shown exclusively in nonstroke Western patients. The Japan Statin Treatment Against Recurrent Stroke (J-STARS) Echo Study aims to determine the effect of pravastatin on carotid IMT in Japanese patients with hyperlipidemia who developed noncardioembolic ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - December 20, 2016 Category: Neurology Authors: Kazunori Toyoda, Kazuo Minematsu, Masahiro Yasaka, Yoji Nagai, Naohisa Hosomi, Hideki Origasa, Kazuo Kitagawa, Shinichiro Uchiyama, Masatoshi Koga, Masayasu Matsumoto, J-STARS Investigators Source Type: research
Interaction of incidental microbleeds and prior use of antithrombotics with early hemorrhagic transformation: Causative or protective ?
Conclusion: Presence of incidental CMBs was not associated with increased risk for early HT of an ischemic stroke. Interestingly, the prior intake of antiplatelets was found to be protective against HT of ischemic stroke.
Source: Annals of Indian Academy of Neurology - November 21, 2016 Category: Neurology Authors: Konark Malhotra Monica Khunger Bichun Ouyang David S Liebeskind Yousef M Mohammad Source Type: research
Effects of preoperative statin use on perioperative outcomes of carotid endarterectomy
ConclusionsTaking statins prior to CEA did not seem to affect the risk of major perioperative ischemic events and death, most likely due to the extremely low overall incidence of perioperative complications.
Recent reports have shown that the preoperative use of statins has a protective role after noncardiac vascular and cardiac surgery, attenuating the perioperative incidence of stroke, myocardial infarction, and death. Only few studies, however, have investigated on the benefit of statin use in patients undergoing carotid endarterectomy for severe carotid disease, reporting variable results. Findings from our study show...
Source: Brain and Behavior - September 30, 2016 Category: Neurology Authors: Enzo Ballotta, Antonio Toniato, Filippo Farina, Claudio Baracchini Tags: Original Research Source Type: research
U ‐curve relation between cholesterol and prior ischemic stroke
ConclusionOur hypothesis was falsified. The association between lower cholesterol levels and higher frequency of prior ischemic stroke in patients with cholesterol <5.5 mmol/L cannot be solely an effect of aggressive statin treatment in patients with prior ischemic stroke, as the association pertained also to patients who did not use statin.
Previous studies on ischemic stroke patients have shown conflicting results concerning the association between cholesterol level and patient outcome. We hypothesized that acute ischemic stroke patients with increased cholesterol on admission more frequently had experienced prior i...
Source: Brain and Behavior - August 31, 2016 Category: Neurology Authors: Gerd Haga Bringeland, Aliona Nacu, Ulrike Waje ‐Andreassen, Lars Thomassen, Halvor Naess Tags: Original Research Source Type: research
