• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

CT within 6 hours of headache onset to rule out subarachnoid hemorrhage in nonacademic hospitals
Conclusions: Our results support a change of practice wherein a lumbar puncture can be withheld in patients with a head CT scan performed <6 hours after headache onset and reported negative for the presence of SAH by a staff radiologist in the described nonacademic setting.
Source: Neurology - May 11, 2015 Category: Neurology Authors: Blok, K. M., Rinkel, G. J. E., Majoie, C. B. L. M., Hendrikse, J., Braaksma, M., Tijssen, C. C., Wong, Y. Y., Hofmeijer, J., Extercatte, J., Kerklaan, B., Schreuder, T. H. C. M. L., ten Holter, S., Verheul, F., Harlaar, L., Pruissen, D. M. O., Kwa, V. I. Tags: All Headache, Diagnostic test assessment, CT, Subarachnoid hemorrhage ARTICLE Source Type: research

Spinal Cord Infarction as the Initial Presentation of Systemic Lupus Erythematosus (P2.077)
CONCLUSIONS:Aggressive therapy with high dose corticosteroids and intravenous cyclophosphamide followed by oral therapy may be a successful therapeutic approach to spinal cord infarcts secondary to systemic lupus erythematosus. Study Supported by: N/ADisclosure: Dr. Michael has nothing to disclose. Dr. Hayat has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Michael, A., Hayat, G. Tags: Neurological Consequences of Autoimmune Disease Source Type: research

A comprehensive simulation curriculum for neurology residents - preparing for future challenges in neurology (P4.188)
CONCLUSIONS: Our study demonstrates that integrating simulation in classical neurology didactics not only improves the knowledge base but improves competency and execution of high-risk time sensitive decisions in an emergency setting.Disclosure: Dr. Sabharwal has nothing to disclose. Dr. Saba has nothing to disclose. Dr. Szyld has nothing to disclose. Dr. Czeisler has nothing to disclose. Dr. Ishida has nothing to disclose. Dr. Lord has nothing to disclose. Dr. Rucker has nothing to disclose. Dr Balcer received personal compensation from Biogen Idec and consulting for Biogen Idec, Vaccinex and Genzyme. She is on a clinical...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Sabharwal, P., Saba, S., Szyld, D., Czeisler, B., Ishida, K., Lord, A., Rucker, J., Balcer, L., Sander, H., Galetta, S. Tags: Research Methodology and Education Source Type: research

Intrathecal Clonidine via Lumbar Puncture Decreases Blood Pressure in Patients With Poorly Controlled Hypertension
ConclusionsThis is the first clinical study in subjects with hypertension that demonstrates significant and profound acute reductions in blood pressure after a single dose of intrathecal clonidine. Future placebo‐controlled, dose‐escalating studies are warranted to assess the long‐term effects of intrathecal clonidine infusion via an implantable drug pump in patients with treatment‐resistant hypertension at risk of stroke or myocardial infarction.
Source: Neuromodulation: Technology at the Neural Interface - April 1, 2015 Category: Biotechnology Authors: Chris B. Komanski, Richard L. Rauck, James M. North, Kyung S. Hong, Robert D'Angelo, Keith R. Hildebrand Tags: Clinical Research Source Type: research

Dural puncture: an overlooked cause of cerebral venous thrombosis
Abstract Cerebral venous thrombosis (CVT) accounts for 0.5–1 % of all strokes. Although dural puncture is proposed as one of the rare risk factors, this association has only been mentioned in anecdotal reports. Headache, i.e., usually the first and the most frequent clinical symptom on admission, is often attributed to the dural puncture itself. We investigated the frequency of CVT following a recent dural puncture in our stroke database, together with the other risk factors. The computerized medical records of patients (n = 10,740) registered in our tertiary-care neurology clinic stroke database were review...
Source: Acta Neurologica Belgica - March 1, 2015 Category: Neurology Source Type: research

Board #153 - Research Abstract The Creation of a Simulator Value Index Tool by Connected Consensus (Submission #8590).
Conclusion: The product from this work (SVI Worksheet tool) can be applied aid the simulator purchase process across countries, institutions, and stakeholder. We are hopeful that simulator purchase processes might include the SVI Worksheet with the intention to maintain alignment with educational goals, while still accounting for other factors considered at the institutional level. At the same time, common measures might facilitate future communication across academic medical institutions and simulator industry. More evaluation is required following broad-scaled implementation. References: 1. Britt RC, Novosel TJ, Britt LD...
Source: Simulation in Healthcare: The Journal of the Society for Simulation in Healthcare - December 1, 2014 Category: Medical Equipment Tags: Abstracts: 2ND PLACE AWARD WINNER: PDF Only Source Type: research

miRNA Expression Profiles in Cerebrospinal Fluid and Blood of Patients with Acute Ischemic Stroke
Abstract The aims of the study were (1) to determine whether miRNAs (microRNAs) can be detected in the cerebrospinal fluid (CSF) and blood of patients with ischemic stroke and (2) to compare these miRNA profiles with corresponding profiles from other neurological patients to address whether the miRNA profiles of CSF or blood have potential usefulness as diagnostic biomarkers of ischemic stroke. CSF from patients with acute ischemic stroke (n = 10) and patients with other neurological diseases (n = 10) was collected by lumbar puncture. Blood samples were taken immediately after. Expression profiles in the ...
Source: Translational Stroke Research - October 30, 2014 Category: Neurology Source Type: research

Clinical management guidelines for subarachnoid haemorrhage. Diagnosis and treatment
Conclusions SAH is a severe and complex disease which must be managed in specialised centres by professionals with ample experience in relevant diagnostic and therapeutic processes.
Source: Neurologia - October 12, 2014 Category: Neurology Source Type: research

The BioFIND Study (Fox Investigation For New Discovery Of Biomarkers In Parkinson's Disease): Design And Methodology (P4.043)
CONCLUSIONS:The BioFIND study will provide a valuable biospecimen resource for the discovery and validation of novel biomarkers in typical, moderate to advanced PD. Promising markers can then be verified in longitudinal cohorts and more heterogeneous PD subjects.Study Supported by:This study is sponsored by MJFF with support from NINDS. We also thank supports from NIH CTSA (RNA).Disclosure: Dr. Kang has received personal compensation for activities with Caremark Inc. as a medical advisory board member. Dr. Kang has received research support from Allergan, Inc. Dr. Alcalay has received personal compensation for activities w...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Kang, U., Alcalay, R., Goldman, J., Henchcliffe, C., Hogarth, P., Tuite, P., Xie, T., Frasier, M., Kopil, C., Vincent, L., Willis, N., Casaceli, C., Rudolph, A. Tags: Movement Disorders: Parkinson ' s Disease Biomarkers Source Type: research

Stroke in Children with Human Immunodeficiency Virus in Botswana: A Report of Six Cases (P4.303)
CONCLUSIONS: The risk of stroke appears to be increased in children with HIV, though further controlled studies are necessary to further investigate this. Etiologies for stroke in children with HIV includes HIV vasculopathy, HIV cardiomyopathy, and opportunistic infections. Evaluation should include head imaging with vascular imaging, MRI with MRA if possible, and CT. The utility of lumbar puncture and hypercoaguability workup in this population needs to be investigated further. Given the difficulties of monitoring anticoagulation in this setting, low dose aspirin is a reasonable first line treatment.Disclosure: Dr. Khuran...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Khurana, E., Bearden, D. Tags: NeuroAIDS Source Type: research

What Causes Ataxia?
Discussion Coordination and balance problems are caused by various problems affecting the central and peripheral nervous system. Normal development of a child or weakness of a child are commonly mistaken for true ataxia. Ataxia specifically refers to “…impairment of the coordination of movement without loss of muscle strength.” If it is purely due to abnormalities of the cerebellum then there should be no changes in mental status, sensation or weakness. Sometimes it is difficult to determine if there are abnormalities in other areas. For example, Guillian-Barre often presents with difficulty or clumsy wal...
Source: PediatricEducation.org - March 31, 2014 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Pulse pressure is associated with Alzheimer biomarkers in cognitively normal older adults
Conclusions: PP elevation is associated with increased CSF P-tau and decreased Aβ1–42 in cognitively normal older adults, suggesting that pulsatile hemodynamics may be related to amyloidosis and tau-related neurodegeneration. The relationship between PP and CSF biomarkers is age-dependent and observed only in participants in the fifth and sixth decades of life.
Source: Neurology - December 2, 2013 Category: Neurology Authors: Nation, D. A., Edland, S. D., Bondi, M. W., Salmon, D. P., Delano-Wood, L., Peskind, E. R., Quinn, J. F., Galasko, D. R. Tags: Alzheimer's disease ARTICLE Source Type: research

The dynamics of soluble Fas/APO 1 apoptotic biochemical marker in acute ischemic stroke patients.
Conclusion: Study results confirmed the dynamic pattern of sFas/APO 1 in serum and cerebrospinal fluid of patients with acute ischemic stroke, suggesting the possible role of apoptosis in the pathogenesis of cerebral infarction. PMID: 24277959 [PubMed - as supplied by publisher]
Source: Advances in Medical Sciences - November 23, 2013 Category: Biomedical Science Authors: Mahovic D, Zurak N, Lakusic N, Sporis D, Zarkovic N, Stancin N, Puretic M Tags: Adv Med Sci Source Type: research

Grey matter and csf amyloid in early non-demented parkinson's disease: the incidence of cognitive impairment in cohorts with longitudinal evaluation in parkinson's disease (icicle-pd) study
Conclusion We report a significant correlation between reduced GM volume and lower Aβ1–40 and Aβ1–42 levels in patients with newly diagnosed PDND. These data suggest that even in early PD, CSF markers may be associated with measures of brain atrophy. Although neither GM loss nor Aβ1–40 or Aβ1–42 levels correlated with cognitive performance, we postulate that this reflects the very early nature of the neurodegenerative process in this cohort.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Duncan, G. W., Yarnall, A. J., Firbank, M. J., Barker, R. A., O'Brien, J. T., Burn, D. J. Tags: Dementia, Drugs: CNS (not psychiatric), Parkinson's disease, Stroke, Memory disorders (psychiatry) Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

Current management of post-varicella stroke in children: A literature review.
Abstract Among infectious factors, varicella-zoster virus (VZV) is a leading cause of central nervous system vasculopathy and stroke in childhood. Not only have viral markers been detected in the cerebrospinal fluid of affected patients, but also direct evidence of viral particles in the wall of cerebral arteries has been demonstrated in rare pathological specimens. This certainly reflects a localized infectious process likely associated with variable indirect inflammatory responses. Yet the usefulness in this setting of a lumbar puncture as well as of subsequent targeted antiviral and/or anti-inflammatory therapi...
Source: Archives de Pediatrie - July 6, 2013 Category: Pediatrics Authors: Monteventi O, Chabrier S, Fluss J Tags: Arch Pediatr Source Type: research

Pages: 1  2  3  4