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Effects of low-frequency repetitive transcranial magnetic stimulation and neuromuscular electrical stimulation on upper extremity motor recovery in the early period after stroke: a preliminary study.
CONCLUSION: LF-rTMS with or without NMES seems to facilitate the motor recovery in the paretic hand of patients with acute/subacute ischemic stroke. TMS or the combination of TMS + NMES may be a promising additional therapy in upper limb motor training. Further studies with larger numbers of patients are needed to establish their effectiveness in upper limb motor rehabilitation of stroke. PMID: 28327054 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - March 22, 2017 Category: Neurology Authors: Tosun A, Türe S, Askin A, Yardimci EU, Demirdal SU, Kurt Incesu T, Tosun O, Kocyigit H, Akhan G, Gelal FM Tags: Top Stroke Rehabil Source Type: research

Predictors and Biomarkers of Treatment Gains in a Clinical Stroke Trial Targeting the Lower Extremity Clinical Sciences
Conclusions— A multimodal model incorporating behavioral and fMRI measures best predicted treatment-induced changes in gait velocity in a clinical trial setting. Results also suggest potential use of fMRI measures as biomarkers of treatment gains.
Source: Stroke - July 28, 2014 Category: Neurology Authors: Burke, E., Dobkin, B. H., Noser, E. A., Enney, L. A., Cramer, S. C. Tags: Exercise/exercise testing/rehabilitation, Other Treatment, Behavioral Changes and Stroke, Computerized tomography and Magnetic Resonance Imaging, Rehabilitation, Stroke Clinical Sciences Source Type: research

Acupuncture for Post-stroke Shoulder-Hand Syndrome: A Systematic Review and Meta-Analysis
Conclusions: Acupuncture therapy seems effective for motor function, pain relief and activities of daily living in stroke patients with mild SHS, when it is used in combination with rehabilitation. The low certainty of evidence downgrades our confidence in making recommendations to clinical practice. Introduction Shoulder-hand syndrome (SHS) is a common condition among people who have had a stroke, with its reported prevalence ranging from 12% to 49% (1, 2). The main symptoms of SHS include pain, hyperalgesia, joint swelling and limitations in range of motion (ROM) (3). Post-stroke SHS is also named type I complex ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Brain effective connectivity during motor-imagery and execution following stroke and rehabilitation
This study expands our understanding of motor network involved during two different tasks, which are commonly used during rehabilitation following stroke. A clear understanding of the effective connectivity networks leads to a better treatment in helping stroke survivors regain motor ability.
Source: NeuroImage: Clinical - June 28, 2015 Category: Radiology Source Type: research

Understanding Brain Reorganization in Infants With Perinatal Stroke Through Neuroexcitability and Neuroimaging.
DISCUSSION: Study results will enhance our understanding of brain reorganization in infants with perinatal stroke. We expect these results will also guide the development of early interventions designed to mitigate maladaptive neuroplastic changes and improve long-term motor outcomes. PMID: 28350777 [PubMed - in process]
Source: Physical Therapy - March 31, 2017 Category: Physiotherapy Authors: Chen CY, Georgieff M, Elison J, Chen M, Stinear J, Mueller B, Rao R, Rudser K, Gillick B Tags: Pediatr Phys Ther Source Type: research

Synergic Effects of Rehabilitation and Intravenous Infusion of Mesenchymal Stem Cells After Stroke in Rats.
CONCLUSIONS: The data indicate that the combined therapy of daily rehabilitation and intravenous infusion of MSCs improved functional outcome in a rat MCAO model. PMID: 27174259 [PubMed - in process]
Source: Physical Therapy - October 31, 2016 Category: Physiotherapy Authors: Sasaki Y, Sasaki M, Kataoka-Sasaki Y, Nakazaki M, Nagahama H, Suzuki J, Tateyama D, Oka S, Namioka T, Namioka A, Onodera R, Mikami T, Wanibuchi M, Kakizawa M, Ishiai S, Kocsis JD, Honmou O Tags: Phys Ther Source Type: research

Understanding Brain Reorganization in Infants With Perinatal Stroke Through Neuroexcitability and Neuroimaging
Discussion: Study results will enhance our understanding of brain reorganization in infants with perinatal stroke. We expect these results will also guide the development of early interventions designed to mitigate maladaptive neuroplastic changes and improve long-term motor outcomes.
Source: Pediatric Physical Therapy - March 30, 2017 Category: Pediatrics Tags: Study Protocol Source Type: research

Influence of Combined Transcranial Direct Current Stimulation and Motor Training on Corticospinal Excitability in Children With Unilateral Cerebral Palsy
Conclusion This proof-of-principle study evaluated the influence of cathodal contralesional tDCS on corticospinal excitability in pediatric participants with UCP. A hypothesized decrease in contralesional excitability was noted in participants in the Active+CIMT group, however, the efficacy of tDCS to modulate corticospinal excitability was not statistically different than the Sham+CIMT group. A more detailed understanding of how tDCS impacts M1 neurophysiology will be essential to inform future clinical trials on the optimal dosing parameters, based on individual brain circuitry, to explore the potential functional benef...
Source: Frontiers in Human Neuroscience - April 23, 2019 Category: Neuroscience Source Type: research

Neurophysiological Analysis of Intermanual Transfer in Motor Learning
In this study, MEPs were induced during the subject’s imaged kinesthetic MI. This involves recalling muscle contraction based on a muscle sensory image and was reported to indicate the activity of brain regions similar to those involved in actual muscle contraction (Ruby and Decety, 2001). In the transfer training group, the muscle sensory image evaluation correlated to the actual task execution with the right hand. As a result, it was easy to recall the kinesthetic MI for the training task, thus affecting MI of the non-trained limbs so that MEP changes occurred in the left hand’s MI. In addition, brain exc...
Source: Frontiers in Human Neuroscience - April 17, 2019 Category: Neuroscience Source Type: research

Study Protocol: Multimodal Longitudinal Assessment of Infant Brain Organization and Recovery in Perinatal Brain Injury
DISCUSSION: This protocol will identify bioindicators of motor outcome and neuroplasticity and subsequently inform early detection, diagnosis, and intervention strategies for infants with perinatal stroke, brain bleeds, and related diagnoses.PMID:35385465 | DOI:10.1097/PEP.0000000000000886
Source: Physical Therapy - April 6, 2022 Category: Physiotherapy Authors: Catarina Saiote Ellen Sutter Annette Xenopoulos-Oddsson Raghavendra Rao Michael Georgieff Kyle Rudser Colleen Peyton Douglas Dean Ryan M McAdams Bernadette Gillick Source Type: research

E-135 Dejerine-roussy syndrome in the setting of right sigmoid sinus thrombosis: a unique case report
DiscussionThis case illustrates the important clinical aspects and physical findings needed to diagnose DRS. The presence of focal allodynia and hyperalgesia with recent cerebrovascular incidents provides significant evidence for DRS. The purpose of this case is to provide awareness and to increase clinical suspicion of DRS during examination, especially in the setting of cerebral venous sinus occlusion as infarction alone may not present as atypical allodynia.Disclosures S. Nittala: None. C. Jara: None. D. Raza: None. J. Cazzaniga: None. D. Filippi: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Nittala, S., Jara, C., Raza, D., Cazzaniga, J., Filippi, D. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

What Causes Ataxia?
Discussion Coordination and balance problems are caused by various problems affecting the central and peripheral nervous system. Normal development of a child or weakness of a child are commonly mistaken for true ataxia. Ataxia specifically refers to “…impairment of the coordination of movement without loss of muscle strength.” If it is purely due to abnormalities of the cerebellum then there should be no changes in mental status, sensation or weakness. Sometimes it is difficult to determine if there are abnormalities in other areas. For example, Guillian-Barre often presents with difficulty or clumsy wal...
Source: PediatricEducation.org - March 31, 2014 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Lower-extremity Dynamometry as a Novel Outcome Measure in a Double-blind, Placebo-controlled, Feasibility Trial of Intravenous Immunoglobulin (IVIG) for HIV-associated Myelopathy
Conclusion: We conclude that an adequately powered clinical trial of IVIG for HIVM would likely require a prolonged recruitment period and multiple participating sites. Lower limb dynamometry is a useful outcome measure for HIVM, which might also be useful in other HIV-related gait disorders. KEYWORDS: Dynamometry, intravenous immunoglobulin (IVIG), human immunodeficiency virus (HIV), myelopathy INTRODUCTION Human immunodeficiency virus (HIV)-associated myelopathy (HIVM) is a rare but well-described neurologic complication of HIV; it was first described early in the acquired immunodeficiency syndrome (AIDS) epidemic, and i...
Source: Innovations in Clinical Neuroscience - February 1, 2018 Category: Neuroscience Authors: ICN Online Editor Tags: Assessment Tools Current Issue Demyelinating Disease Movement Disorders Neurodegenerative Disease Neurology Original Research Primary Care Technology Trial Methodology Dynamometry human immunodeficiency virus (HIV) intravenous immu Source Type: research