Filtered By:
Specialty: Drugs & Pharmacology
Education: Study

This page shows you your search results in order of relevance. This is page number 12.

Order by Relevance | Date

Total 3586 results found since Jan 2013.

A novel small-molecular CCR5 antagonist promotes neural repair after stroke
In this study we characterized the therapeutic potential of a novel CCR5 antagonist A14 in treating ischemic stroke mice. A14 was discovered in screening millions compounds in the Chemdiv library based on the molecular docking diagram of CCR5 and maraviroc. We found that A14 dose-dependently inhibited the CCR5 activity with an IC50 value of 4.29 μM. Pharmacodynamic studies showed that A14 treatment exerted protective effects against neuronal ischemic injury both in vitro and vivo. In a SH-SY5Y cell line overexpressing CCR5, A14 (0.1, 1 μM) significantly alleviated OGD/R-induced cell injury. We found that the expression o...
Source: Acta Pharmacologica Sinica - May 17, 2023 Category: Drugs & Pharmacology Authors: Qing-Lin Wu Li-Yuan Cui Wen-Yu Ma Sha-Sha Wang Zhao Zhang Zhong-Ping Feng Hong-Shuo Sun Shi-Feng Chu Wen-Bin He Nai-Hong Chen Source Type: research

Review of Economics and Cost-Effectiveness Analyses of Anticoagulant Therapy for Stroke Prevention in Atrial Fibrillation in the US.
CONCLUSIONS: This review identified several areas of uncertainty regarding the economic benefit of anticoagulants. The generalizability of cost-effectiveness results of anticoagulant therapy in AF based on clinical trial data must be confirmed by comparative effectiveness research conducted in the real-world setting. PMID: 23606551 [PubMed - in process]
Source: The Annals of Pharmacotherapy - May 1, 2013 Category: Drugs & Pharmacology Authors: von Schéele B, Fernandez M, Hogue SL, Kwong WJ Tags: Ann Pharmacother Source Type: research

Enteric-Coated Aspirin Versus Other Antiplatelet Drugs in Acute Non-Cardioembolic Ischemic Stroke: Post-marketing Study in Japan.
CONCLUSION: It seems that these results showed the safety and efficacy of the enteric-coated aspirin in acute stroke care in Japanese patients. Incidence of hemorrhagic events was comparable between the enteric-coated aspirin group and the other antiplatelet drugs group. PMID: 24385407 [PubMed - as supplied by publisher]
Source: Advances in Therapy - January 3, 2014 Category: Drugs & Pharmacology Authors: Takahashi S, Mizuno O, Sakaguchi T, Yamada T, Inuyama L Tags: Adv Ther Source Type: research

Cost-Effectiveness of Apixaban Versus Other New Oral Anticoagulants for Stroke Prevention in Atrial Fibrillation.
CONCLUSIONS: Although our analysis was limited by the absence of head-to-head trials, based on the indirect comparison data available, our model projects that apixaban may be a cost-effective alternative to dabigatran 150 mg BID, dabigatran 110 mg BID, and rivaroxaban 20 mg once daily for stroke prevention in AF patients from the perspective of the United Kingdom National Health Services. PMID: 24508420 [PubMed - as supplied by publisher]
Source: Clinical Therapeutics - February 5, 2014 Category: Drugs & Pharmacology Authors: Lip GY, Kongnakorn T, Phatak H, Kuznik A, Lanitis T, Liu LZ, Iloeje U, Hernandez L, Dorian P Tags: Clin Ther Source Type: research

Effects of delayed puerarin treatment in long-term neurological outcomes of focal ischemic stroke in rats
Conclusions: Delayed treatment of puerarin initiated at 24 h after stroke is beneficial with improved long-term neurological outcomes and reduced infarction volume in focal ischemic stroke in rats. Enhanced vascular remodeling by puerarin might at least partially contribute to its beneficial effects.
Source: Indian Journal of Pharmacology - March 24, 2014 Category: Drugs & Pharmacology Authors: Minghua WuSen LiangLi MaYang HanXiusheng ZhangChengcheng Xu Source Type: research

Of mice and men – modeling post‐stroke depression experimentally
Summary At least one third of stroke survivors suffer from depression. The development of comorbid depression after stroke is clinically highly significant, because post‐stroke depression is associated with increased mortality, slows recovery and leads to worse functional outcomes. Here, we review the evidence that post‐stroke depression can be effectively modeled in experimental rodents via a variety of approaches. This opens an exciting new window onto the neurobiology of depression and permits probing potential underlying mechanisms such as disturbed cellular plasticity, neuroendocrine dysregulation, neuroinflammati...
Source: British Journal of Pharmacology - May 19, 2014 Category: Drugs & Pharmacology Authors: G Kronenberg, K Gertz, A Heinz, M Endres Tags: Review Article – Animal Models in Psychiatry Research Themed Issue Source Type: research

Of mice and men: modelling post‐stroke depression experimentally
At least one‐third of stroke survivors suffer from depression. The development of comorbid depression after stroke is clinically highly significant because post‐stroke depression is associated with increased mortality, slows recovery and leads to worse functional outcomes. Here, we review the evidence that post‐stroke depression can be effectively modelled in experimental rodents via a variety of approaches. This opens an exciting new window onto the neurobiology of depression and permits probing potential underlying mechanisms such as disturbed cellular plasticity, neuroendocrine dysregulation, neuroinflammation, an...
Source: British Journal of Pharmacology - July 2, 2014 Category: Drugs & Pharmacology Authors: G Kronenberg, K Gertz, A Heinz, M Endres Tags: REVIEW Source Type: research

Optimisation of secondary prevention of stroke: a qualitative study of stroke patients’ beliefs, concerns and difficulties with their medicines
ConclusionsMany of the difficulties stroke patients have adhering to secondary prevention strategies are potentially preventable with tailored information provision and appropriate monitoring and follow‐up by primary healthcare professionals. We have designed an intervention addressing the identified barriers to medicine taking, the impact of which is currently being measured in a randomised controlled trial of a pharmacist‐led home‐based clinical medication review in stroke patients.
Source: International Journal of Pharmacy Practice - March 9, 2014 Category: Drugs & Pharmacology Authors: Caroline Souter, Anne Kinnear, Moira Kinnear, Gillian Mead Tags: Research Paper Source Type: research

Dual antiplatelet therapy with clopidogrel and aspirin after ischemic stroke: A review of the evidence.
CONCLUSION: Currently available evidence does not substantiate the widespread use of long-term aspirin with clopidogrel for the secondary prevention of ischemic stroke or TIA. PMID: 26386103 [PubMed - in process]
Source: American Journal of Health-System Pharmacy : AJHP - September 21, 2015 Category: Drugs & Pharmacology Authors: Davis KA, Miyares MA, Dietrich E Tags: Am J Health Syst Pharm Source Type: research

Gene expression profiling in stroke: relevance of blood-brain interaction.
Abstract Biomarker profiling is utilized to identify diagnostic and prognostic candidates for stroke. Clinical and preclinical biomarker data suggest altered circulating immune responses may illuminate the mechanisms of stroke recovery. However, the relationship between peripheral blood biomarker profile(s) and brain profiles following stroke remains elusive. Data show that neutrophil lymphocyte ratio (NLR) predicts stroke outcome. Neutrophils release Arginase 1 (ARG1) resulting in T lymphocyte suppression in peripheral blood. Interestingly, the cellular response to stroke may have implications for known biomarker...
Source: Current Opinion in Pharmacology - November 9, 2015 Category: Drugs & Pharmacology Authors: Asano S, Chantler PD, Barr TL Tags: Curr Opin Pharmacol Source Type: research

A comparison of stroke severity proxy measures for claims data research: a population‐based cohort study
ConclusionsUsing the SSI facilitated risk adjustment for stroke severity in mortality models for patients with AIS. The SSI is a viable methodological tool for stroke outcome studies using the NHIRD. Copyright © 2015 John Wiley & Sons, Ltd.
Source: Pharmacoepidemiology and Drug Safety - December 22, 2015 Category: Drugs & Pharmacology Authors: Sheng‐Feng Sung, Solomon Chih‐Cheng Chen, Cheng‐Yang Hsieh, Chung‐Yi Li, Edward Chia‐Cheng Lai, Ya‐Han Hu Tags: Original Report Source Type: research

Residential medication management reviews of antithrombotic therapy in aged care residents with atrial fibrillation: assessment of stroke and bleeding risk
This study found anticoagulants were underutilized in eligible older people with AF. Guideline‐recommended stroke scoring systems, in combination with bleeding risk assessment, may assist RMMR service providers in determining the net clinical benefit of antithrombotic therapy in older adults with AF.
Source: Journal of Clinical Pharmacy and Therapeutics - March 31, 2016 Category: Drugs & Pharmacology Authors: P. S. Nishtala, R. L. Castelino, G. M. Peterson, P. J. Hannan, M. S. Salahudeen Tags: Original Article Source Type: research

Cholinergic anti-inflammatory pathway and stroke.
Abstract Stroke is devastating cerebrovascular event which is responsible for 6.7 million deaths each year worldwide. Inflammation plays an important role in the pathophysiology of stroke. Targeting inflammation after stroke is highly actual topic for both experimental and clinical research. Cholinergic anti-inflammatory pathway (CHAIP) is a physiological mechanism by which central nervous system regulates immune response and controls inflammation. Vagus nerve, spleen and α7 nicotinic acetylcholine receptor (α7 nAChR) are the main components of CHAIP. Targeting cholinergic anti-inflammatory pathway is a promisin...
Source: Current Drug Delivery - January 31, 2017 Category: Drugs & Pharmacology Authors: Duris K, Lipkova J, Jurajda M Tags: Curr Drug Deliv Source Type: research

Systolic hypertension related single nucleotide polymorphism is associated with susceptibility of ischemic stroke.
CONCLUSIONS: Our study suggests that genetic variants in systolic pressure-related genotypes may contribute to the etiology of ischemic stroke. PMID: 28682427 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - July 7, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research