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Total 3873 results found since Jan 2013.

Role of bone marrow-derived macrophages (BMDMs) in neurovascular interactions during stroke
Publication date: Available online 27 May 2019Source: Neurochemistry InternationalAuthor(s): Akriti Srivastava, Pranay Srivastava, Rajkumar VermaAbstractStroke is a leading cause of disability worldwide and hence remains a major medical concern. Besides several pathological features, such as excitotoxicity, peri-infarct depolarization, acidosis, reactive oxygen species generation, apoptosis, and necrosis, dysregulation of the immune system severely affects stroke outcomes. After stroke onset, microglia – the brain-resident macrophage immune cells – and peripheral immune cells affect stoke injury/recovery by releasing p...
Source: Neurochemistry International - May 28, 2019 Category: Neuroscience Source Type: research

Perioperative stroke associated in-hospital morbidity and in-hospital mortality in common non-vascular non-neurological surgery
This study identified perioperative stroke as an independent predictor of 30-day in-hospital morbidity and mortality following non-vascular, non-neurological surgery.
Source: Journal of Clinical Neuroscience - July 2, 2019 Category: Neuroscience Source Type: research

Association of COL4A2 Gene Polymorphisms with Lacunar Stroke in Xinjiang Han Populations
This study demonstrates that the COL4A2 gene could play a role in the pathogenesis of lacunar stroke in the Han population of China.
Source: Journal of Molecular Neuroscience - August 10, 2019 Category: Neuroscience Source Type: research

Efficacy of RehaCom cognitive rehabilitation software in activities of daily living, attention and response control in chronic stroke patients
ConclusionsIn conclusion, RehaCom cognitive rehabilitation software has improvement effect on ADL, attention and response control in patients with chronic stroke. Our study reveals a new information about the efficacy of computerized training in the rehabilitation of stroke patients.
Source: Journal of Clinical Neuroscience - September 6, 2019 Category: Neuroscience Source Type: research

Rosiglitazone ameliorates tissue plasminogen activator-induced brain hemorrhage after stroke.
CONCLUSIONS: RSG treatment protects against BBB damage and ameliorates HT in delayed tPA-treated stroke mice by activating PPAR-γ and favoring microglial polarization toward anti-inflammatory phenotype. PMID: 31756041 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - November 21, 2019 Category: Neuroscience Authors: Li Y, Zhu ZY, Lu BW, Huang TT, Zhang YM, Zhou NY, Xuan W, Chen ZA, Wen DX, Yu WF, Li PY Tags: CNS Neurosci Ther Source Type: research

Prevalence of hypohydration and its association with stroke severity and independence outcomes in acute ischemic stroke patients
Publication date: Available online 11 December 2019Source: Journal of Clinical NeuroscienceAuthor(s): Alex Buoite Stella, Marina Gaio, Giovanni Furlanis, Mariana Ridolfi, Miloš Ajčević, Arianna Sartori, Paola Caruso, Shawnda A. Morrison, Marcello Naccarato, Paolo ManganottiAbstractHypohydration has been suggested increasing the risk of vascular diseases, and it is associated with poor prognosis and worse functional outcome in stroke. Most studies have used blood parameters to determine patients’ hydration status. The aim of this study was to measure urine osmolality (uOsm) and its influence on stroke severity and inde...
Source: Journal of Clinical Neuroscience - December 12, 2019 Category: Neuroscience Source Type: research

Silencing of TXNIP Alleviated Oxidative Stress Injury by Regulating MAPK-Nrf2 Axis in Ischemic Stroke.
This study aimed to investigate the underlying molecular mechanism and propose the potential therapeutic strategy for ischemic stroke. Bioinformatics analysis based on a public microarray profile (GSE 61616) of ischemic stroke rats was performed as a pilot research. Oxidative stress was enriched as a significantly gene ontology item, and thioredoxin-interacting protein (TXNIP) and MAPK signaling were identified as the hub gene and pathway, respectively. The experiments in middle cerebral artery occlusion rats demonstrated that ischemia induced the activation of oxidative stress. The expressions of TXNIP, p-p38, p-JNK, p-ER...
Source: Neurochemical Research - December 18, 2019 Category: Neuroscience Authors: Tian Y, Su Y, Ye Q, Chen L, Yuan F, Wang Z Tags: Neurochem Res Source Type: research

The role of statins in cardioembolic stroke
ConclusionsThe use of statins in patients with cardioembolic stroke may be beneficial in some cases, preventing stroke recurrence and improving functional outcomes.
Source: Journal of Clinical Neuroscience - December 25, 2019 Category: Neuroscience Source Type: research

Potential microglia-based interventions for stroke.
Abstract A large number of families worldwide suffer from the physical and mental burden posed by stroke. An increasing number of studies aimed at the prevention and treatment of stroke have been conducted. Specifically, manipulating the immune response to stroke is under intense investigation. Microglia are the principal immune cells in the brain and are the first line of defense against the pathophysiology induced by stroke. Increasing evidence has suggested that microglia play diverse roles that depend on dynamic interactions with neurons, astrocytes, and other neighboring cells both in the normal brain and und...
Source: CNS Neuroscience and Therapeutics - February 15, 2020 Category: Neuroscience Authors: Li LZ, Huang YY, Yang ZH, Zhang SJ, Han ZP, Luo YM Tags: CNS Neurosci Ther Source Type: research

The Effects of Meditation, Race, and Anxiety on Stroke Survivor Resilience
CONCLUSION: The effects of meditation on stroke survivor resilience should be tested in larger clinical trials that would explore the influence of social determinants of health, perceived stress, race-related stress, and anxiety subtypes on resilience.
Source: Journal of Neuroscience Nursing - April 29, 2020 Category: Neuroscience Tags: Article Source Type: research

Macrophage –NLRP3 Inflammasome Activation Exacerbates Cardiac Dysfunction after Ischemic Stroke in a Mouse Model of Diabetes
In this study, we found that the cardiac dysfunction induced by ischemic stroke is more severe in a mouse model of type 2 diabetes. Meanwhile, M1-polarized macrophage in filtration and NLRP3 inflammasome activation increased in the cardiac ventricle after diabetic stroke. Importantly, the NLRP3 inflammasome inhibitor CY-09 restored cardiac function, indicating that the M1-polarized macrophage–NLRP3 inflammasome activation is a pathway underlying the brain–heart interaction after diabetic stroke.
Source: Neuroscience Bulletin - July 17, 2020 Category: Neuroscience Source Type: research

Community-Based Interventions for Stroke Provided by Nurses and Community Health Workers: A Review of the Literature
CONCLUSION Nurses and CHWs play a pivotal role in community-based care. Evidence suggests community-based interventions facilitate the necessary support for stroke survivors, caregivers, families, and communities to optimize stroke recovery. Data from this review illustrate a continued need for comprehensive programs designed to address the complex needs of stroke survivors and families when they return to their homes and communities.
Source: Journal of Neuroscience Nursing - July 30, 2020 Category: Neuroscience Tags: Literature Review Source Type: research

Performance of discrete, reciprocal, and cyclic movements of the ipsilesional upper limb in individuals after stroke.
Abstract Aiming movements of the upper limbs can be classified either as discrete, or reciprocal, or cyclic. The control of these movements after a stroke can be affected. The aim of this experimental, cross-sectional study was to characterize the performance of these movements after the right and left hemisphere chronic stroke. Thirty-six individuals aged between 40 and 70 years, right-handed, were allocated into three groups (control, right stroke, and left stroke). Participants were asked to perform aiming movements on a tablet. Individuals after stroke performed the tasks only with their ipsilesional limb, wh...
Source: Experimental Brain Research - July 30, 2020 Category: Neuroscience Authors: Carvalho DB, Freitas SMSF, Alencar FAD, Silva ML, Alouche SR Tags: Exp Brain Res Source Type: research

Caregiver Burden and Associated Factors Among Informal Caregivers of Stroke Survivors
BACKGROUND: Informal caregiving of stroke survivors often begins with intensity compared with the linear caregiving trajectories in progressive conditions. Informal caregivers of stroke survivors are often inadequately prepared for their caregiving role, which can have detrimental effects on their well-being. A greater depth of understanding about caregiving burden is needed to identify caregivers in most need of intervention. The purpose of this study was to examine caregiver burden and associated factors among a cohort of informal caregivers of stroke survivors. METHODS: A cross-sectional study of 88 informal caregivers ...
Source: Journal of Neuroscience Nursing - November 7, 2020 Category: Neuroscience Tags: Article Source Type: research

Regulatory T cells in ischemic stroke.
Abstract The pathophysiological mechanisms of neuroinflammation, angiogenesis, and neuroplasticity are currently the hotspots of researches in ischemic stroke. Regulatory T cells (Tregs), a subset of T cells that control inflammatory and immune responses in the body, are closely related to the pathogenesis of ischemic stroke. They participate in the inflammatory response and neuroplasticity process of ischemic stroke by various mechanisms, such as secretion of anti-inflammatory factors, inhibition of pro-inflammatory factors, induction of cell lysis, production of the factors that promote neural regeneration, and ...
Source: CNS Neuroscience and Therapeutics - January 20, 2021 Category: Neuroscience Authors: Wang H, Wang Z, Wu Q, Yuan Y, Cao W, Zhang X Tags: CNS Neurosci Ther Source Type: research