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Procedure: Anesthesia

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Total 2417 results found since Jan 2013.

Scalp acupuncture attenuates neurological deficits in a rat model of hemorrhagic stroke.
CONCLUSIONS: Scalp acupuncture could improve neurological deficits in a rat model of hemorrhagic stroke. PMID: 28619309 [PubMed - in process]
Source: Complementary Therapies in Medicine - June 1, 2017 Category: Complementary Medicine Authors: Liu H, Sun X, Zou W, Leng M, Zhang B, Kang X, He T, Wang H Tags: Complement Ther Med Source Type: research

Carotid Artery Disease as a Predictor of In-Hospital Postoperative Stroke After Coronary Artery Bypass Grafting From 1999 to 2011
In this study, the risk factors for stroke after coronary artery bypass grafting (CABG) were examined. In particular, the role of asymptomatic carotid artery stenosis (both unilateral and bilateral) as a predictor of in-hospital postoperative stroke was investigated. Finally, the trends surrounding in-hospital postoperative stroke from 1999 to 2011 also were examined. The purpose of the study was to appropriately identify patients at high risk for stroke after CABG and spark discussion about the perioperative management of such patients.
Source: Journal of Cardiothoracic and Vascular Anesthesia - November 20, 2017 Category: Anesthesiology Authors: Amol Mehta, Ravi Choxi, Thomas Gleason, Lawrence Wechsler, Tudor Jovin, Parthasarathy D. Thirumala Tags: Original Article Source Type: research

Refinement of embolic stroke model in rats: effect of post-embolization anesthesia duration on arterial blood pressure, cerebral edema and mortality
Conclusions These data indicate that early discontinuation of isoflurane anesthesia after clot embolization permits an earlier hypertensive response that limits edema formation and mortality without significantly affecting infarct volume in survivors, thereby decreasing the required number of animals.
Source: Journal of Neuroscience Methods - June 20, 2018 Category: Neuroscience Source Type: research

Refinement of embolic stroke model in rats: Effect of post-embolization anesthesia duration on arterial blood pressure, cerebral edema and mortality
ConclusionsThese data indicate that early discontinuation of isoflurane anesthesia after clot embolization permits an earlier hypertensive response that limits edema formation and mortality without significantly affecting infarct volume in survivors, thereby decreasing the required number of animals.
Source: Journal of Neuroscience Methods - July 5, 2018 Category: Neuroscience Source Type: research

Effects of Temporary Functional Deafferentation in Chronic Stroke Patients: Who Profits More?
Abstract Temporary functional deafferentation (TFD) by an anesthetic cream on the stroke-affected forearm was shown to improve sensorimotor abilities of stroke patients. The present study investigated different predictors for sensorimotor improvements during TFD and indicated outcome differences between patients grouped in subcortical lesions only and lesions with any cortical involvement. Thirty-four chronic stroke patients were temporarily deafferented on the more affected forearm by an anesthetic cream. Somatosensory performance was assessed using von Frey Hair and grating orientation task; motor performance wa...
Source: Neural Plasticity - August 30, 2018 Category: Neurology Authors: Sens E, Franz M, Preul C, Meissner W, Witte OW, Miltner WHR, Weiss T Tags: Neural Plast Source Type: research

Neuroprotective Action of Human Wharton's Jelly-Derived Mesenchymal Stromal Cell Transplants in a Rodent Model of Stroke.
Abstract Wharton's jelly-derived mesenchymal stromal cells (WJ-MSCs) have distinct immunomodulatory and protective effects against kidney, liver, or heart injury. Limited studies have shown that WJ-MSCs attenuates oxygen-glucose deprivation-mediated inflammation in hippocampal slices. The neuroprotective effect of intracerebral WJ-MSC transplantation against stroke has not been well characterized. The purpose of this study was to examine the neuroprotective effect of human WJ-MSC (hWJ-MSC) transplants in an animal model of stroke. Adult male Sprague-Dawley rats were anesthetized and placed in a stereotaxic frame. ...
Source: Cell Transplantation - October 4, 2018 Category: Cytology Authors: Wu KJ, Yu SJ, Chiang CW, Lee YW, Yen BL, Tseng PC, Hsu CS, Kuo LW, Wang Y Tags: Cell Transplant Source Type: research

Anesthesia for endovascular treatment in anterior circulation stroke: A systematic review and meta ‐analysis
ConclusionsIn the overall analysis and observational studies, CS was associated with improved functional outcomes and relatively safe for anterior ischemic stroke compared with GA. While the pooled data from RCTs suggested that GA was associated with improved outcomes. The inconsistency indicated that more large ‐scale RCTs are required to evaluate what factors influenced the effect of the anesthesia methods on clinical outcomes.
Source: Brain and Behavior - December 3, 2018 Category: Neurology Authors: Xuefei Li, Zheng Hu, Qian Li, Yinping Guo, Shabei Xu, Wei Wang, Dan He, Xiang Luo Tags: REVIEW ARTICLE Source Type: research

Conformal Medical raises $9m Series B for anti-stroke cardiac implant
Conformal Medical said today that it raised $9 million in a Series B round for the anti-stroke cardiac implant it’s developing. Nashua, N.H.-based Conformal is working on a left atrial appendage seal to prevent stroke in atrial fibrillation patients. It’s designed to adapt to the each patient’s individual physiology, to be easier to implant with less imaging and without general anesthesia. The funding round was led by Catalyst Health Ventures and included “a supportive group of Series A investors,” Conformal said. “This financing will allow us to validate our novel sealing technology ...
Source: Mass Device - December 3, 2018 Category: Medical Devices Authors: Brad Perriello Tags: Cardiac Implants Featured Funding Roundup Wall Street Beat Conformal Medical Source Type: news

Anesthesia for endovascular treatment in anterior circulation stroke: A systematic review and meta ‐analysis
ConclusionsIn the overall analysis and observational studies, CS was associated with improved functional outcomes and relatively safe for anterior ischemic stroke compared with GA. While the pooled data from RCTs suggested that GA was associated with improved outcomes. The inconsistency indicated that more large ‐scale RCTs are required to evaluate what factors influenced the effect of the anesthesia methods on clinical outcomes.
Source: Brain and Behavior - December 3, 2018 Category: Neurology Authors: Xuefei Li, Zheng Hu, Qian Li, Yinping Guo, Shabei Xu, Wei Wang, Dan He, Xiang Luo Tags: REVIEW ARTICLE Source Type: research

A Canine Model of Hemorrhagic Transformation Using Recombinant Tissue Plasminogen Activator Administration After Acute Ischemic Stroke
Early reperfusion of occluded arteries via recombinant tissue plasminogen activator (rtPA) administration is considered to be an effective strategy for the treatment of acute ischemic stroke. However, delayed administration of rtPA may cause severe hemorrhagic transformation (HT) and undesirable neurological outcomes. The current study aims to establish a canine HT model using rtPA administration and to investigate the potential mechanisms underlying HT. Following anesthesia, two autologous clots were injected into the middle cerebral artery (MCA) to induce ischemic stroke. To induce reperfusion, rtPA (2 mg/kg) was adminis...
Source: Frontiers in Neurology - June 24, 2019 Category: Neurology Source Type: research

Association of Anesthetic Exposure Time With Clinical Outcomes After Endovascular Therapy for Acute Ischemic Stroke
Conclusion: Our data promotes the notion that ischemic stroke patients who require peri-interventional GA for EVT should be extubated as soon as possible after the procedure.
Source: Frontiers in Neurology - June 25, 2019 Category: Neurology Source Type: research

Unsedated Outpatient Percutaneous Endoscopic Gastrostomy in Stroke Patients: Is It Feasible and Safe?
This study sought to determine the feasibility and safety of outpatient, unsedated PEG implementation in stroke patients. This retrospective cohort study involved stroke victims who underwent unsedated outpatient PEG insertion from 2014 to 2017 at our Surgical Endoscopy Unit. Patients were given pharyngeal anesthesia with lidocaine 10% spray, while the PEG tube was placed under local anesthesia. The incidence of intraprocedural and postprocedural complications and 30-day mortality rate were recorded. Data from 127 cases were analyzed. The procedures were performed with minor, transient complications, which resolved after r...
Source: Surgical Laparoscopy, Endoscopy and Percutaneous Techniques - October 1, 2019 Category: Surgery Tags: Original Articles Source Type: research

Brain activity changes in a monkey model of central post-stroke pain.
Abstract Central post-stroke pain (CPSP) can occur after stroke in the somatosensory pathway that includes the posterolateral region of the thalamus. Tactile allodynia, in which innocuous tactile stimuli are perceived as painful, is common in patients with CPSP. Previous brain imaging studies have reported plastic changes in brain activity in patients with tactile allodynia after stroke, but a causal relationship between such changes and the symptoms has not been established. We recently developed a non-human primate (macaque) model of CPSP based on thalamic lesions, in which the animals show behavioral changes co...
Source: Experimental Neurology - October 31, 2019 Category: Neurology Authors: Nagasaka K, Takashima I, Matsuda K, Higo N Tags: Exp Neurol Source Type: research