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Kidney Function and Prevalent and Incident Frailty.
CONCLUSIONS: In community-dwelling elders, lower eGFRcys was associated with a higher risk of prevalent and incident frailty whereas lower eGFRSCr was not. These findings highlight the importance of considering non-GFR determinants of kidney function.
PMID: 24178972 [PubMed - as supplied by publisher]
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 31, 2013 Category: Urology & Nephrology Authors: Dalrymple LS, Katz R, Rifkin DE, Siscovick D, Newman AB, Fried LF, Sarnak MJ, Odden MC, Shlipak MG Tags: Clin J Am Soc Nephrol Source Type: research
Improved sex drive after bariatric surgery
The health risks of obesity are well known, with increased risk of cardiovascular diseases, type 2 diabetes, stroke and certain cancers. But what is not so well known is how it affects women's sex drive and satisfaction, something researchers from the University of Pennsylvania set out to explore. In a study, published in JAMA Surgery this month, Prof. David B. Sarwer, of the University's Perelman School of Medicine, and colleagues conducted a study with women who underwent bariatric surgery...
Source: Health News from Medical News Today - November 5, 2013 Category: Consumer Health News Tags: Obesity / Weight Loss / Fitness Source Type: news
The extra‐pancreatic effects of GLP‐1 receptor agonists: a focus on the cardiovascular, gastrointestinal and central nervous systems
Abstract
The glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) exenatide and liraglutide have been shown to improve glycaemic control and beta‐cell function with a low risk of hypoglycaemia in people with type 2 diabetes. GLP‐1 receptors are also expressed in extra‐pancreatic tissues and trial data suggest GLP‐1RAs also have effects beyond their glycaemic actions. Preclinical studies using native GLP‐1 or GLP‐1RAs provide substantial evidence for cardioprotective effects, while clinical trial data have demonstrated beneficial actions on hypertension and dyslipidaemia in people with type 2 diabetes. Sig...
Source: Diabetes, Obesity and Metabolism - December 24, 2013 Category: Endocrinology Authors: J Seufert, B Gallwitz Tags: Unsolicited Review Article Source Type: research
No pain, no gain? Getting the most out of exercise
Staying in shape has all sorts of benefits, from maintaining heart health to warding off dementia and cancerInactivity – fuelled by cars and a sedentary work life – has been dubbed the biggest public health problem of the 21st century, a global pandemic with dramatic impact on peoples wellbeing. The latest reports suggest that around the world it was responsible for 5.3 million deaths in 2008 – around one in 10 – more deaths than smoking.Not only does exercise make you fitter, it can also ward off numerous and often unexpected diseases, from heart attacks, to diabetes, some forms of cancer and dementia. There are t...
Source: Guardian Unlimited Science - January 13, 2014 Category: Science Authors: Catherine de Lange Tags: Cycling Fitness Sport Running Transport Yoga Weightlifting Features UK news Life and style Cycle hire schemes The Observer Swimming Science Source Type: news
A safe, effective diet pill - the elusive holy grail
Trade in illegal, ineffective drugs flourishes as pharmaceutical industry repeatedly fails to produce successful pillAttempts to invent a safe and effective diet pill have foundered time and again, allowing the internet trade in illegal and ineffective herbal supplements and dangerous drugs, such as DNP, to flourish.A successful diet pill could make billions for the pharmaceutical industry, but efforts to date have ended in disaster, with patients harmed, drugs banned and massive compensation paid out.Fen-phen, an appetite suppressant, was the most spectacular failure. It was withdrawn in the US in 1997 after causing wides...
Source: Guardian Unlimited Science - January 14, 2014 Category: Science Authors: Sarah Boseley Tags: The Guardian Diets and dieting Drugs trade Healthcare industry World news Pharmaceuticals industry & wellbeing Health policy Society Politics UK news Life and style Public services policy Business Science Source Type: news
Inhibition of Transforming Growth Factor-{beta} Attenuates Brain Injury and Neurological Deficits in a Rat Model of Germinal Matrix Hemorrhage Basic Sciences
Conclusions—
Increased level of TGF-β1 and activation of the TGF-β pathway associate with the development of brain injury after GMH. SD208 inhibits GMH-induced activation of the TGF-β pathway and leads to an improved developmental profile, partial recovery of cognitive and motor functions, and attenuation of GMH-induced brain atrophy and hydrocephalus.
Source: Stroke - February 24, 2014 Category: Neurology Authors: Manaenko, A., Lekic, T., Barnhart, M., Hartman, R., Zhang, J. H. Tags: Animal models of human disease, Neuroprotectors Basic Sciences Source Type: research
Obese kids: inadequate sleep may increase heart disease risk
Telling adolescents to get enough sleep can sometimes be a tall order, but a new study in The Journal of Pediatrics reminds us just how important a good night's sleep can be. It suggests obese youths who do not get adequate sleep may increase their risk for developing diabetes, heart disease and stroke.The researchers, from the University of Michigan Health System and Baylor University, say the combination of inadequate sleep and obesity has been linked to raised risks of cardiovascular diseases in adults and younger children.
Source: Health News from Medical News Today - March 6, 2014 Category: Consumer Health News Tags: Obesity / Weight Loss / Fitness Source Type: news
Acute left sided numbness and weakness in a weightlifter
Conclusion
Practitioners should be aware of the potential adverse nutritional consequences of supplement consumption. The extent to which this case was influenced by the history of concussions is unknown, but should not be dismissed.
Source: British Journal of Sports Medicine - March 11, 2014 Category: Sports Medicine Authors: Reeser, J. Tags: Abstracts from the IOC World Conference on Prevention of Injury & amp; Illness in Sport, Monaco 2014 Source Type: research
Modest weight loss does not decrease cardiovascular morbidity and mortality in adults with type 2 diabetes
Commentary on: Wing RR, Bolin P, Brancati FL, et al.. Look AHEAD Research Group. Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med 2013;369:145–54. Context Diet, physical activity and weight loss are recommended in the management of type 2 diabetes. This recommendation is largely based on short-term intervention studies which show improvements in cardiovascular risk factors including glycaemic control, lipids, blood pressure and inflammation. The Look AHEAD (Action for Health in Diabetes) randomised controlled trial (RCT) studied the impact of long-term weight loss through an...
Source: Evidence-Based Medicine - March 19, 2014 Category: Internal Medicine Authors: Davis, N. J., Goswami, G. Tags: Clinical trials (epidemiology), Epidemiologic studies, Immunology (including allergy), Drugs: cardiovascular system, Stroke, Hypertension, Diet, Ischaemic heart disease, Diabetes Therapeutics Source Type: research
The Look AHEAD Study: Implications for Clinical Practice Go Beyond the Headlines
On Friday, October 19, 2012, the National Institutes of Health (NIH) announced that the lifestyle “intervention was stopped early in NIH-funded study of weight loss in overweight and obese adults with type 2 diabetes after finding no harm, but no cardiovascular benefits.” The primary study question of the long-term Look AHEAD (Action for Health in Diabetes) Study had been answered. An intensive lifestyle intervention program aimed at a 10% weight loss and 175 minutes of physical activity per week did not reduce cardiovascular events (defined as heart attack, stroke, hospitalization for angina, or death) in people with ...
Source: Journal of the American Dietetic Association - March 21, 2014 Category: Nutrition Authors: Linda M. Delahanty Tags: Commentary Source Type: research
Association between serum bilirubin and cardiovascular disease in an overweight high risk population from the SCOUT trial
Conclusion: Bilirubin was not a risk-factor independent from other traditional cardiovascular risk-factors in our population.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - February 18, 2014 Category: Nutrition Authors: M.E. Jørgensen, C. Torp-Pedersen, N. Finer, I. Caterson, W.P.T. James, U.F. Legler, C. Andersson Tags: Liver abnormalities, diabetes and cardiovascular risk Source Type: research
In women, increased dietary antioxidants are associated with reduced risk of developing heart failure
Commentary on Rautiainen S, Levitan EB, Mittleman MA, et al.. Total antioxidant capacity of diet and risk of heart failure: a population-based prospective cohort of women. Am J Med 2013;126:494–500. Implications for practice and research A diet rich in natural antioxidants may reduce the risk of developing heart failure. Well-designed intervention studies are needed to investigate the effect of a diet rich in antioxidants on heart failure incidence. Context Heart failure is a syndrome comprising symptoms such as breathlessness alongside objective evidence of cardiac dysfunction. This is a common condition with a cons...
Source: Evidence-Based Nursing - June 17, 2014 Category: Nursing Authors: McKeown, P., McKeag, N. Tags: Drugs: cardiovascular system, Heart failure, Stroke, Diet, Vitamins and supplements, Ischaemic heart disease, Diabetes, Medical humanities, Alcohol, Health education, Smoking, Health effects of tobacco use, Tobacco use Women ' s health Source Type: research
Weight loss herbal intervention therapy (W-LHIT) a non-appetite suppressing natural product controls weight and lowers cholesterol and glucose levels in a murine model
Conclusions:
W-LHIT significantly and safely reduced body weight, normalized glucose and cholesterol levels in obese mice, without suppression of appetite, and increased adipocyte PPARgamma and FABP4 gene expression.
Source: BMC Complementary and Alternative Medicine - July 23, 2014 Category: Complementary Medicine Authors: Nan YangDanna ChungChangda LiuBanghao LiangXiu-Min Li Source Type: research
Changes in ventricular‐arterial coupling during decongestive therapy in acute heart failure
ConclusionAn early improvement in ventricular‐arterial coupling was observed after diuretic‐related decongestive therapy in ADHF patients, and was related to decreased effective arterial elastance rather than to change in LV contractility.This article is protected by copyright. All rights reserved.
Source: European Journal of Clinical Investigation - September 1, 2014 Category: Journals (General) Authors: E Berthelot, N Bihry, O Brault‐Melin, P Assayag, A Cohen‐Solal, D Chemla, D Logeart Tags: Original Paper Source Type: research
Characteristics of dysphagia in older patients evaluated at a tertiary center
ConclusionsSwallowing problems in older patients are not uncommon. The clinician needs to be diligent to inquire about dysphagia because a large number of these patients will require treatment.
Level of Evidence4. Laryngoscope, 2014
Source: The Laryngoscope - September 5, 2014 Category: ENT & OMF Authors: Pelin Kocdor, Eric R. Siegel, Rachel Giese, Ozlem E. Tulunay‐Ugur Tags: Laryngology Source Type: research
