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Total 496 results found since Jan 2013.

Rationale and design to assess the efficacy and safety of HT047 in patients with acute ischemic stroke: A multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase II trial
This study is a 1st-in-human trial of HT047 to explore the efficacy and safety in acute ischemic stroke patients. The results will provide the appropriate dosage and evidence of therapeutic benefit of HT047 for stroke recovery. Trial registration: ClinicalTrials.gov (NCT02828540) Registered July 11, 2016.
Source: Medicine - October 1, 2019 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research

The add-on effect of dengzhan shengmai capsules on secondary prevention of ischemic stroke: A multicentre, randomised, placebo-controlled clinical trial.
CONCLUSIONS: The addition of DZSM capsules to standard secondary preventive agents provides additional benefits after the initial onset of ischemic stroke, reducing recurrent stroke without increasing severe adverse events. However, further study is needed to elucidate the role of DZSM on the updated practice of conventional secondary prevention for ischemic stroke. PMID: 31519277 [PubMed - in process]
Source: Complementary Therapies in Medicine - September 16, 2019 Category: Complementary Medicine Authors: Cai Y, Zhang X, Huang Y, Wang L, Sun J, Liang W, Ou A, Yu B, Guo J, Zhao M, Ni X, Chen S Tags: Complement Ther Med Source Type: research

Want To Live Longer? Study Suggests You Should Ditch Soda
This study, as well as other research on the connection between diet and sugary beverages and health risks, is observational and cannot show cause and effect. That’s a major limitation, researchers say, as it’s impossible to determine whether the association is due to a specific artificial sweetener, a type of beverage, obesity or another hidden health issue. “The cause behind these associations isn’t clear,” said Bergquist. “Other potential biological causes could be attributed to experimental evidence linking consumption of artificial sweeteners to sugar cravings, appetite stimulation ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - September 3, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News CNN Soda Source Type: news

Buyang Huanwu Tang (Boyang Hwano Tang) for the treatment of post-stroke fatigue: Protocol for a systematic review of randomized controlled trials
Conclusion: The conclusion of our systematic review will provide evidence to judge whether BHT is an effective intervention for patients with PSF. Ethics and dissemination: Ethical approval is not required, as this study is based on the review of published research. This review will be published in a peer-reviewed journal and disseminated both electronically and in print. Trial registration number: PROSPERO CRD42019130178.
Source: Medicine - September 1, 2019 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Botany, traditional uses, phytochemistry, pharmacology and toxicology of Ilex pubescens Hook et Arn
ConclusionsThis review summarizes the results from current studies of I. pubescens, which is one of the valuable medicinal sources from traditional herbs. Some conventional uses have been evaluated by pharmacological investigation. In addition, unresolved issues include molecular mechanisms underlying bioactivities, pharmacokinetics, toxicology and efficacy, which are still being studied and explored before achieving integration into clinical medicines.
Source: Journal of Ethnopharmacology - August 9, 2019 Category: Drugs & Pharmacology Source Type: research

Safety and Efficacy of the C-117 Formula for Vulnerable Carotid Artery Plaques (Spchim): A Randomized Double-Blind Controlled Pilot Study.
Conclusion: The C-117 formula may be antiatherosclerotic by strengthening statins to reduce the low-density lipoprotein levels and reducing the carotid plaque Crouse scores. Clinical trials with large sample sizes, long-term interventions, and follow-up are needed to investigate the efficacy of the C-117 formula. Clinical Trials Registration: This trial is registered with clinicaltrials.gov identifier: NCT03072225 (registered retrospectively on 1st March 2017). PMID: 31391862 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - August 9, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Use of Chinese herbal medicines by rheumatoid arthritis patients was associated with lower risk of stroke: A retrospective cohort study.
CONCLUSION: The CHMs use was associated with lower risk of stroke for RA patients, suggesting that it could be integrated into conventional therapy to prevent subsequent stroke incident. PMID: 31331548 [PubMed - in process]
Source: Complementary Therapies in Medicine - July 25, 2019 Category: Complementary Medicine Authors: Lai NS, Livneh H, Fan YH, Lu MC, Liao HH, Tsai TY Tags: Complement Ther Med Source Type: research

Computational systems pharmacology reveals an antiplatelet and neuroprotective mechanism of Deng-Zhan-Xi-Xin injection in the treatment of ischemic stroke
Publication date: Available online 23 July 2019Source: Pharmacological ResearchAuthor(s): Jing Zhao, Chao Lv, Qiuling Wu, Huawu Zeng, Xin Guo, Jian Yang, Saisai Tian, Weidong ZhangAbstractHerbs are typically prescribed in traditional Chinese medicine (TCM) to treat complex diseases. The multicomponent nature of herbal drug ingredients makes it difficult to readily understand their mode of action. To decipher their molecular mechanisms, here we proposed a novel computational systems pharmacology based approach, which consisted of transcriptome profiling, data collection, statistical analysis, network algorithm, bioinformati...
Source: Pharmacological Research - July 24, 2019 Category: Drugs & Pharmacology Source Type: research

Herbal Formula Fo Shou San Attenuates Alzheimer's Disease-Related Pathologies via the Gut-Liver-Brain Axis in APP/PS1 Mouse Model of Alzheimer's Disease.
In this study, to identify the differentially gut-liver-brain axis among APP/PS1 mice, FSS-treated APP/PS1 mice, and control mice, behavioral tests were performed to assess the cognitive ability and hematoxylin-eosin staining was used to assess neuronal damage in the hippocampus; immunohistochemistry, western blotting, a quantitative chromogenic end-point Tachypleus amebocyte lysate (TAL) assay kit, Malondialdehyde (MDA) assay kit, AP Assay Kit, and real-time quantitative PCR (qPCR) were used to assess the level of LPS, MDA, AP, and gut bacteria. We found that FSS regulates gut-liver-brain axis to regulate AP and gut bacte...
Source: Evidence-based Complementary and Alternative Medicine - July 20, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Chinese Herbal Medicine and Acupuncture Reduced the Risk of Stroke After Bell's Palsy: A Population-Based Retrospective Cohort Study
The Journal of Alternative and Complementary Medicine, Ahead of Print.
Source: The Journal of Alternative and Complementary Medicine - July 18, 2019 Category: Complementary Medicine Authors: Gil Ton Hsien-Yin Liao Jen-Huai Chiang Yi-Hung Chen Yu-Chen Lee Source Type: research

Network pharmacology study of traditional Chinese medicines for stroke treatment and effective constituents screening
ConclusionsThis paper details a novel strategy for exploring the characteristics and mechanisms of herbal medicines from a systematic standpoint in an attempt to identify those affecting specific target pathways related to stroke. Using this methodology on our natural products library, we found a number of lead candidates with multi-target activity.Graphical abstract
Source: Journal of Ethnopharmacology - June 28, 2019 Category: Drugs & Pharmacology Source Type: research

Natural Products from Mediterranean Diet: From anti-hyperlipidemic Agents to Dietary Epigenetic Modulators.
CONCLUSION: Many of the natural products found in Mediterranean diet contribute in the treatment of hyperlipidemia, however the effects seem to be dose and/or consumption frequency related, which highlights the fact that a healthy diet can only be effective in reversing disease markers if it is consistent and within the frame of a healthy life style. PMID: 31264546 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Biotechnology - June 27, 2019 Category: Biotechnology Authors: Georgia-Eirini D, Athina S, Wim VB, Christos K, Theodoros C Tags: Curr Pharm Biotechnol Source Type: research

Add-On Effects of Chinese Herbal Medicine for Post-Stroke Spasticity: A Systematic Review and Meta-Analysis
Conclusions: Noting the quality concerns of the included trials, this review suggested that CHM appeared to be a promising, well-tolerated add-on therapy to RC for reducing spasticity and improving PSS patients’ daily activities.
Source: Frontiers in Pharmacology - June 26, 2019 Category: Drugs & Pharmacology Source Type: research

Realgar and cinnabar are essential components contributing to neuroprotection of Angong Niuhuang Wan with no hepatorenal toxicity in transient ischemic brain injury.
In this study, we compared the neuropharmacological effects of AGNHW and modified AGNHW in an experimental ischemic stroke rat model. Male SD rats were subjected to 2 h of middle cerebral artery occlusion (MCAO) plus 22 h of reperfusion. Although oral administration of AGNHW for 7 days in the rats increased arsenic level in the blood and liver tissue, there were no significant changes in the arsenic level in kidney, mercury level in the blood, liver and kidney as well as hepatic and renal functions in MCAO rats. AGNHW revealed neuroprotective properties by reducing infarction volume, preserving blood-brain barrier in...
Source: Toxicology and Applied Pharmacology - June 13, 2019 Category: Toxicology Authors: Tsoi B, Wang S, Gao C, Luo Y, Li W, Yang D, Yang D, Shen J Tags: Toxicol Appl Pharmacol Source Type: research

Flavonoids in hypertension: a brief review of the underlying mechanisms.
Abstract Flavonoids are a diverse group of bioactive polyphenolic compounds abundant in dietary plants and herbs. Regular consumption of flavonoids exerts cardio-vasculoprotective effects and may reduce the onset or progression of many cardiovascular diseases, particularly hypertension. Observational studies suggest inverse associations among either of these three combinations: a) anthocyanin intake and risk of myocardial infarction (MI), b) flavanone intake and risk of ischemic stroke and c) flavonol intake and risk of type 2 diabetes mellitus. Human randomized controlled trials (RCTs) show that catechins and que...
Source: Current Opinion in Pharmacology - May 14, 2019 Category: Drugs & Pharmacology Authors: Maaliki D, Shaito AA, Pintus G, El-Yazbi A, Eid AH Tags: Curr Opin Pharmacol Source Type: research