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Quiz case: a clinical reasoning challenge in the emergency stroke setting
AbstractA right-handed woman in her 80s was admitted to the emergency department 1 h after sudden-onset global aphasia and right-sided hemiparesis. Medical history included arterial hypertension, dyslipidemia, hyperuricemia, aortic stenosis, osteoporosis, and recent pulmonary embolism. Medication consisted of apixaban, bisoprolol, hydrochlorothiazide, allopurinol, fenofibrate, and vitamin D. Vital parameters (blood pressure, heart rate, body temperature, oxygen saturation) and glycemia were all within normal range. Electrocardiogram showed a first-degree atrioventricular block. The patient was promptly transported to the e...
Source: Neurological Sciences - August 5, 2023 Category: Neurology Source Type: research

Microglia/macrophages require vitamin D signaling to restrain neuroinflammation and brain injury in a murine ischemic stroke model
In this study, we characterized the molecular m...
Source: Journal of Neuroinflammation - March 8, 2023 Category: Neurology Authors: Pan Cui, Wanting Lu, Junjie Wang, Fei Wang, Xiyue Zhang, Xiaodan Hou, Fang Xu, Yan Liang, Guoliang Chai and Junwei Hao Tags: Research Source Type: research

Serum 25-hydroxyvitamin D is associated with stroke history in a reverse J-shape
ConclusionUsing data from a large, cross-sectional cohort program, we found that circulating 25(OH)D was related to stroke history in a reverse J-shaped manner. Given how the causal relationship between circulating 25(OH)D and history of stroke has not been established, more high-quality evidence based on the reverse J-shaped feature is needed to elucidate the link between vitamin D and stroke risk, and the effect of vitamin D supplements on stroke prevention.
Source: Frontiers in Neurology - January 5, 2023 Category: Neurology Source Type: research

Association between white matter hyperintensity volume and social functioning limitations among stroke survivors
Existing literature on white matter hyperintensity volume (WMHV) in stroke patients has rarely focused on post-stroke outcomes related to social functioning limitations, such as transportation, social interaction, food preparation, grocery shopping, and housekeeping. Using prospective data from the VITamin D and OmegA-3 TriaL (VITAL) study, we evaluated the association between WMHV and social functioning limitations among 151 ischemic stroke patients.
Source: Journal of Stroke and Cerebrovascular Diseases - September 1, 2022 Category: Neurology Authors: Flora G. Chang, Natalia S. Rost, JoAnn E. Manson, Julie E. Buring, Pamela M. Rist Source Type: research

Vitamin D supplementation and risk of stroke: A meta-analysis of randomized controlled trials
ConclusionOur study revealed that additional vitamin D supplementation did not reduce the risk of stroke. Therefore, additional RCTs of similar design should not be encouraged to assess any association between vitamin D supplementation and reduced stroke risk.
Source: Frontiers in Neurology - August 18, 2022 Category: Neurology Source Type: research

Vitamin D level is associated with rupture of intracranial aneurysm in patients with subarachnoid hemorrhage
ConclusionVitamin D level is associated with rupture of intracranial aneurysm in patients with SAH. Patients with aneurysmal SAH have lower vitamin D levels than those with non-aneurysmal SAH.
Source: Frontiers in Neurology - August 11, 2022 Category: Neurology Source Type: research

Joint Association of Low Vitamin K1 and D Status With First Stroke in General Hypertensive Adults: Results From the China Stroke Primary Prevention Trial (CSPPT)
ConclusionLow concentrations of both vitamin K1 and 25(OH)D were associated with increased risk of stroke.
Source: Frontiers in Neurology - May 12, 2022 Category: Neurology Source Type: research

Effect of Vitamin D Supplementation on the Prognosis of Post-stroke Fatigue: A Retrospective Cohort Study
Conclusions: Our results indicated that vitamin D supplementation could improve fatigue symptoms and neurological outcomes in PSF patients with vitamin D deficiency. Subject to replication in other settings, a randomized controlled trial (RCT) might be undertaken to validate the potential beneficial impact of vitamin D supplementation in post-stroke patients found to be vitamin D deficient.
Source: Frontiers in Neurology - November 5, 2021 Category: Neurology Source Type: research

Low vitamin D levels and the long ‐term functional outcome of stroke up to 5 years
ConclusionVitamin D level less than 38.4  nmol/L at admission is a potential risk biomarker for poor functional outcome at 5-year prognosis in AIS patients, which might provide new ideas for the prognostic assessment of stroke.
Source: Brain and Behavior - September 2, 2021 Category: Neurology Authors: Ya ‐Ying Zeng, Cheng‐Xiang Yuan, Meng‐Xuan Wu, Lin Cheng, Sheng‐Nan Zhou, Ping‐lang Hu, Kai‐Li Fan, Wen‐Jie Tang, Jin‐Cai He Tags: ORIGINAL RESEARCH Source Type: research

Nutritional Supplementation of Naturally Occurring Vitamin D to Improve Hemorrhagic Stroke Outcomes
Vitamin D deficiency, if left untreated, is associated with bone disorders, cardiovascular damage, and an increased risk of ischemic stroke. While there are various nutritional options for the natural intake of vitamin D, we hope to elucidate the potential mechanisms dietary vitamin D may play in hemorrhagic stroke pathology. This scoping review outlines findings from studies relevant to the biochemical activity of vitamin D, the impact of vitamin D deficiency on hemorrhagic stroke outcomes, and the potential benefit of nutritional vitamin D on hemorrhagic stroke outcomes. Here, we analyze the relevant factors that can lea...
Source: Frontiers in Neurology - July 30, 2021 Category: Neurology Source Type: research

Association between Vitamin D and Risk of Stroke: A PRISMA-Compliant Systematic Review and Meta-Analysis
Conclusions: Our analysis indicated that lower circulating level of vitamin D was associated with an elevated risk of stroke, but extra supplement of vitamin D failed to show benefit in decreasing the risk of stroke. Further research and study are also needed to show the role of vitamin D in relation to stroke.Eur Neurol
Source: European Neurology - July 29, 2021 Category: Neurology Source Type: research

Role of vitamin D in cerebrovascular disease
Conclusions: After reviewing current literature on the subject, we conclude that there are some data to suggest the role of vitamin D in patients with stroke but it cannot be concluded as a risk factor for stroke. Larger population-based studies are needed to confirm the causative role of vitamin D in stroke.
Source: Annals of Indian Academy of Neurology - April 28, 2021 Category: Neurology Authors: Subhash Kaul Jayasree Manikinda Source Type: research

Telling friend from foe in emergency vertigo and dizziness: does season and daytime of presentation help in the differential diagnosis?
The objective of the present study was to analyze frequency and distribution patterns of specific vestibular and non-vestibular diagnoses in an interdisciplinary university emergency room (ER), including data on daytime and season of presentation. A retrospective chart analysis of all patients seen in a one-year period was performed. In the ER 4.23% of all patients presented with VD (818 out of 19,345). The most frequent-specific diagnoses were BPPV (19.9%), stroke/transient ischemic attack (12.5%), acute unilateral vestibulopathy/vestibular neuritis (UVH; 8.3%), and functional VD (8.3%). Irrespective of the diagnosis, the...
Source: Journal of Neurology - July 10, 2020 Category: Neurology Source Type: research

Risk Factors for the Occurrence of Benign Paroxysmal Positional Vertigo: A Systematic Review and Meta-Analysis
Conclusion: Female gender, vitamin D deficiency, osteoporosis, migraine, head trauma, and high TC level were risk factors for the occurrence of BPPV. However, the effects of other risk factors on BPPV occurrence need further investigations.
Source: Frontiers in Neurology - June 22, 2020 Category: Neurology Source Type: research

Vitamin D and Stroke: Effects on Incidence, Severity, and Outcome and the Potential Benefits of Supplementation
Vitamin D serum level has been positively associated with improved cardiovascular health, especially with reduction of stroke risk. This systemic review summarizes and synthesizes findings from studies relevant to the relationship between vitamin D and stroke risk, severity, and outcome; potential mechanisms explaining such a relationship; and outcomes from vitamin D supplementation. The literature shows that vitamin D deficiency is a significant risk factor for ischemic stroke, with sun exposure, sex, age, race, diabetes, and genetics playing a role as well. Stroke severity and short- and long-term outcomes also worsen wi...
Source: Frontiers in Neurology - June 9, 2020 Category: Neurology Source Type: research

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