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Nutrition: Iron
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Total 290 results found since Jan 2013.
Iron-Induced Hydrocephalus: the Role of Choroid Plexus Stromal Macrophages
In conclusion, stromal macrophages account for ~10% of all choroid plexus cells, with more in aged rats. Treatments targeting macrophages (minocycline and clodronate liposomes) are associated with reduced iron-induced hydrocephalus.
Source: Translational Stroke Research - May 11, 2022 Category: Neurology Source Type: research
cPKC γ ameliorates ischemic injury in cultured neurons exposed to oxygen glucose deprivation/reoxygenation by inhibiting ferroptosis
In this study, primary cultured cortical neurons were used to establish 1h oxygen-glucose deprivation (OGD) and reoxygenation (R) 0-12h (i.e., 1h OGD/R 0-12h) as in vitro models of cell ischemia. After 1h OGD/R 0-12h, cyclooxygenase 2 (COX2) and acyl-CoA synthetase long-chain family member 4 (ACSL4) levels increased, and glutathione peroxidase 4 (GPx4) levels decreased significantly. Concurrently, GPx4 activity decreases, and iron levels increased. The inhibition of ferroptosis by Liproxstatin-1 ameliorated OGD-induced neuronal injury. Liproxstatin-1 administration prominently induced GPx4 expression and suppressed COX2 ex...
Source: Cell Research - April 14, 2022 Category: Cytology Authors: Haiping Wei Zhifeng Peng Yahong Chen Jia Guo Lixia Chen Kangmei Shao Source Type: research
Ferroptosis —A Novel Mechanism With Multifaceted Actions on Stroke
As a neurological disease with high morbidity, disability, and mortality, the pathological mechanism underlying stroke involves complex processes such as neuroinflammation, oxidative stress, apoptosis, autophagy, and excitotoxicity; but the related research on these molecular mechanisms has not been effectively applied in clinical practice. As a form of iron-dependent regulated cell death, ferroptosis was first discovered in the pathological process of cancer, but recent studies have shown that ferroptosis is closely related to the onset and development of stroke. Therefore, a deeper understanding of the relationship betwe...
Source: Frontiers in Neurology - April 11, 2022 Category: Neurology Source Type: research
Plaque Evaluation by Ultrasound and Transcriptomics Reveals BCLAF1 as a Regulator of Smooth Muscle Cell Lipid Transdifferentiation in Atherosclerosis
CONCLUSIONS: Plaque echogenicity correlated with enrichment of distinct molecular pathways and identified BCLAF1, previously not described in atherosclerosis, as the most significant gene. Functionally, BCLAF1 seems necessary for survival and transdifferentiation of SMCs into a macrophage-like phenotype. The role of BCLAF1 in plaque vulnerability should be further evaluated.PMID:35321563 | DOI:10.1161/ATVBAHA.121.317018
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 24, 2022 Category: Cardiology Authors: Urszula Rykaczewska Quanyi Zhao Peter Saliba-Gustafsson Mariette Lengquist Malin Kronqvist Otto Bergman Zhiqiang Huang Kent Lund Katarina Waden Vila Z Pons Kenneth Caidahl Josefin Skogsberg Vladana Vukojevic Jan H N Lindeman Joy Roy G öran K Hansson Ecka Source Type: research
Iron promotes neurological function recovery in mice with ischemic stroke through endogenous repair mechanisms
In this study, we first observed that changes in iron metabolism occured during neurological function recovery in the mice with distal middle cerebral artery occlusion (dMCAO). Our data showed that plasticity changes due to endogenous repair mechanisms resulted in improvements in cerebral cortex function. These changes involved gliosis, synaptic function reconstruction, remyelination, and activation of neural stem cells. In order to examine the potential role of iron, we synthesized liposomal-encapsulated deferoxamine (DFO) nanoparticles to further explore the effect and the mechanism of iron on the recovery of neurologica...
Source: Free Radical Biology and Medicine - February 24, 2022 Category: Biology Authors: Xin Guo Xiaofang Jin Kang Han Shaomeng Kang Siyu Tian Xin Lv Mudi Feng Huiwen Zheng Yong Zuo Guodong Xu Ming Hu Jing Xu Peiyuan Lv Yan-Zhong Chang Source Type: research
Dynamic Changes in Brain Iron Metabolism in Neonatal Rats after Hypoxia-Ischemia
The pathogenesis of hypoxic-ischemic white matter injury (WMI) in premature infants is still unclear, and the imbalance of cerebral iron metabolism may play an important role. Our study set out to investigate the changes in iron distribution, iron content and malondialdehyde (MDA) in disparate brain regions (parietal cortex, corpus callosum, hippocampus) within 84 days after hypoxia-ischemia (HI) in neonatal rats and to clarify the role of iron metabolism in WMI.
Source: Journal of Stroke and Cerebrovascular Diseases - February 10, 2022 Category: Neurology Authors: Ding-Wang Hu, Geng Zhang, Ling Lin, Xuan-Jing Yu, Feng Wang, Qing Lin Source Type: research
Discovery of novel diphenylbutene derivative ferroptosis inhibitors as neuroprotective agents
Eur J Med Chem. 2022 Jan 28;231:114151. doi: 10.1016/j.ejmech.2022.114151. Online ahead of print.ABSTRACTFerroptosis is a regulated and iron-dependent cell death. Ferroptosis inhibitors are promising for treating many neurological diseases. Herein, with phenotypic assays, we discovered a new diphenylbutene derivative ferroptosis inhibitor, DPT. Based on this hit, we synthesized fourteen new diphenylbutene derivatives, evaluated their ferroptosis inhibitory activities in HT22 mouse hippocampal neuronal cells, and found that three compounds exhibited improved inhibitory activities compared with DPT. Among these active compou...
Source: European Journal of Medicinal Chemistry - February 5, 2022 Category: Chemistry Authors: Yuying Fang Qingyun Tan Huihao Zhou Qiong Gu Jun Xu Source Type: research
Identification of a ferroptosis-related gene pair biomarker with immune infiltration landscapes in ischemic stroke: a bioinformatics-based comprehensive study
Ischemic stroke (IS) is a principal contributor to long-term disability in adults. A new cell death mediated by iron is ferroptosis, characterized by lethal aggregation of lipid peroxidation. However, a paucit...
Source: BMC Genomics - January 16, 2022 Category: Genetics & Stem Cells Authors: Jiaxin Fan, Mengying Chen, Shuai Cao, Qingling Yao, Xiaodong Zhang, Shuang Du, Huiyang Qu, Yuxuan Cheng, Shuyin Ma, Meijuan Zhang, Yizhou Huang, Nan Zhang, Kaili Shi and Shuqin Zhan Tags: Research Source Type: research
Repurposing Vorinostat for the Treatment of Disorders Affecting Brain
AbstractBased on the findings in recent years, we summarize the therapeutic potential of vorinostat (VOR), the first approved histone deacetylase (HDAC) inhibitor, in disorders of brain, and strategies to improve drug efficacy and reduce side effects. Scientific evidences provide a strong case for the therapeutic utility of VOR in various disorders affecting brain, including stroke, Alzheimer ’s disease, frontotemporal dementia, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, spinal muscular atrophy, X‐linked adrenoleukodystrophy, epilepsy, Niemann-Pick type C disease, and neuropsychiatric dis...
Source: NeuroMolecular Medicine - December 1, 2021 Category: Neurology Source Type: research
Credible Mendelian Randomization Studies in the Presence of Selection Bias Using Control Exposures
Selection bias is increasingly acknowledged as a limitation of Mendelian randomization (MR). However, few methods exist to assess this issue. We focus on two plausible causal structures relevant to MR studies and illustrate the data-generating process underlying selection bias via simulation studies. We conceptualize the use of control exposures to validate MR estimates derived from selected samples by detecting potential selection bias and reproducing the exposure–outcome association of primary interest based on subject matter knowledge. We discuss the criteria for choosing the control exposures. We apply the proposal i...
Source: Frontiers in Genetics - November 24, 2021 Category: Genetics & Stem Cells Source Type: research
