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Challenge to the Intestinal Mucosa During Sepsis
Conclusion The impact of sepsis on the gut is manifold, e.g., sepsis mediated alteration of the gut-blood barrier and increase in the intestinal permeability, which may correlate with the phenomena of bacterial translocation and lymphatic activation (“toxic-lymph”). Systemic consequences of sepsis are widespread and concern to the coagulative system, the microbiome as well as enzymes, such as pancreatic proteases, MMPs and IAPs. Nevertheless, the therapeutic approaches for modulating the mucosal immune system are still rarely effective in daily routine. Recent published studies showing that treatment with ...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research

Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate
We present cryo-EM studies of theE. coli enzyme that show how asymmetric hexameric rings of ClpX bind symmetric heptameric rings of ClpP and interact with protein substrates. Subunits in the ClpX hexamer assume a spiral conformation and interact with two-residue segments of substrate in the axial channel, as observed for other AAA+ proteases and protein-remodeling machines. Strictly sequential models of ATP hydrolysis and a power stroke that moves two residues of the substrate per translocation step have been inferred from these structural features for other AAA+ unfoldases, but biochemical and single-molecule biophysical ...
Source: eLife - February 28, 2020 Category: Biomedical Science Tags: Structural Biology and Molecular Biophysics Source Type: research

Dynamic Arterial Elastance During Experimental Endotoxic Septic Shock: A Potential Marker of Cardiovascular Efficiency
Dynamic arterial elastance (Eadyn), the ratio between pulse pressure variation (PPV) and stroke volume variation (SVV), has been suggested as a dynamic parameter relating pressure and flow. We aimed to determine the effects of endotoxic septic shock and hemodynamic resuscitation on Eadyn in an experimental study in 18 New Zealand rabbits. Animals received placebo (SHAM, n = 6) or intravenous lipopolysaccharide (E. Coli 055:B5, 1 mg⋅kg–1) with or without (EDX-R, n = 6; EDX, n = 6) hemodynamic resuscitation (fluid bolus of 20 ml⋅kg–1 and norepinephrine for restoring mean arterial pressure). Continuous arterial pressu...
Source: Frontiers in Physiology - October 1, 2020 Category: Physiology Source Type: research

Bacteriological and therapeutic features of lung abscess
Conclusion: The identification of the responsible bacteria in lung abcess remains difficult. Management is based mainly on antibiotics wich is often probabilistic, in some cases associated with physiotherapy, percutaneous scan-guided drainage or rarely surgery.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Kallel, N., khemakhem, R., Abdelmouleh, K., Moussa, N., Yangui, I., Kammoun, S. Tags: Respiratory infections Source Type: research

A Multicentric, Randomized, Controlled Phase III Study of Centhaquine (Lyfaquin ®) as a Resuscitative Agent in Hypovolemic Shock Patients
ConclusionCenthaquine is an efficacious resuscitative agent for treating hypovolemic shock. The efficacy of centhaquine in distributive shock is being explored.Trial RegistrationClinical Trials Registry, India; ctri.icmr.org.in, CTRI/2019/01/017196; clinicaltrials.gov, NCT04045327.
Source: Drugs - June 1, 2021 Category: Drugs & Pharmacology Source Type: research

Prevalence of COVID-19 Mimics in the Emergency Department
Conclusion Several potentially fatal diseases remain masked among the wave of COVID-19 mimics. It is imperative that a thorough differential diagnostic panel be considered prior to the rendering of a COVID-19 diagnosis.PMID:34334560 | DOI:10.2169/internalmedicine.6434-20
Source: Internal Medicine - August 2, 2021 Category: Internal Medicine Authors: Satoshi Kurihara Mikio Nakajima Richard H Kaszynski Yasuhiro Yamamoto Koichiro Santo Ryo Takane Hayato Tokuno Ayaka Ishihata Hitoshi Ando Maki Miwa Shoichiro Hamada Tomotsugu Nakano Masamitsu Shirokawa Hideaki Goto Yoshihiro Yamaguchi Source Type: research

Bihemispheric Cortical Infarcts in an Adult Secondary to < b > < i > Escherichia coli < /i > < /b > K1 Meningitis
This study demonstrates the necessity of early diagnosis and treatment ofE. coli meningitis to prevent neurological complications, including stroke.Case Rep Neurol 2021;13:572 –577
Source: Case Reports in Neurology - August 24, 2021 Category: Neurology Source Type: research

Neuroinductive properties of mGDNF depend on the producer, < i > E < /i > . < i > Coli < /i > or human cells
by Dzhirgala V. Shamadykova, Dmitry Y. Panteleev, Nadezhda N. Kust, Ekaterina A. Savchenko, Ekaterina Y. Rybalkina, Alexander V. Revishchin, Galina V. Pavlova The glial cell line‐derived neurotrophic factor (GDNF) is involved in the survival of dopaminergic neurons. Besides, GDNF can also induce axonal growth and creation of new functional synapses. GDNF potential is promising for translation to treat diseases associated with neuronal death: neurodege nerative disorders, ischemic stroke, and cerebral or spinal cord damages. Unproductive clinical trials of GDNF for Parkinson’s disease treatment have induced to study th...
Source: PLoS One - October 11, 2021 Category: Biomedical Science Authors: Dzhirgala V. Shamadykova Source Type: research

UCHL1 protects against ischemic heart injury via activating HIF-1 α signal pathway
Redox Biol. 2022 Mar 18;52:102295. doi: 10.1016/j.redox.2022.102295. Online ahead of print.ABSTRACTUbiquitin carboxyl-terminal esterase L1 (UCHL1) has been thought to be a neuron specific protein and shown to play critical roles in Parkinson's Disease and stroke via de-ubiquiting and stabilizing key pathological proteins, such as α-synuclein. In the present study, we found that UCHL1 was significantly increased in both mouse and human cardiomyocytes following myocardial infarction (MI). When LDN-57444, a pharmacological inhibitor of UCHL1, was used to treat mice subjected to MI surgery, we found that administration of LDN...
Source: Cancer Control - March 27, 2022 Category: Cancer & Oncology Authors: Bingchuan Geng Xiaoliang Wang Ki Ho Park Kyung Eun Lee Jongsoo Kim Peng Chen Xinyu Zhou Tao Tan Chunlin Yang Xunchang Zou Paul M Janssen Lei Cao Lei Ye Xuejun Wang Chuanxi Cai Hua Zhu Source Type: research

Therapeutic Use and Chronic Abuse of CNS Stimulants and Anabolic Drugs
Curr Issues Mol Biol. 2022 Oct 15;44(10):4902-4920. doi: 10.3390/cimb44100333.ABSTRACTThe available evidence suggests that affective disorders, such as depression and anxiety, increase risk for accelerated cognitive decline and late-life dementia in aging individuals. Behavioral neuropsychology studies also showed that cognitive decline is a central feature of aging impacting the quality of life. Motor deficits are common after traumatic brain injuries and stroke, affect subjective well-being, and are linked with reduced quality of life. Currently, restorative therapies that target the brain directly to restore cognitive a...
Source: Current Issues in Molecular Biology - October 26, 2022 Category: Molecular Biology Authors: Daniela Coli ță Cezar-Ivan Coli ță Dirk M Hermann Eugen Coli ță Thorsten R Doeppner Ion Udristoiu Aurel Popa-Wagner Source Type: research

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