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Pharmacological interventions for people with borderline personality disorder
CONCLUSIONS: This review included 18 more trials than the 2010 version, so larger meta-analyses with more statistical power were feasible. We found mostly very low-certainty evidence that medication may result in no difference in any primary outcome. The rest of the secondary outcomes were inconclusive. Very limited data were available for serious adverse events. The review supports the continued understanding that no pharmacological therapy seems effective in specifically treating BPD pathology. More research is needed to understand the underlying pathophysiologic mechanisms of BPD better. Also, more trials including como...
Source: Cochrane Database of Systematic Reviews - November 14, 2022 Category: General Medicine Authors: Jutta M Stoffers-Winterling Ole Jakob Storeb ø Johanne Pereira Ribeiro Mickey T Kongerslev Birgit A V öllm Jessica T Mattivi Erlend Faltinsen Adnan Todorovac Mie S J ørgensen Henriette E Callesen Christian P Sales Julie Perrine Schaug Erik Simonsen Kla Source Type: research

Fight Aging! Newsletter, August 8th 2016
In conclusion, spermidine inhibits lipid accumulation and necrotic core formation through stimulation of cholesterol efflux, albeit without changing plaque size or cellular composition. These effects, which are driven by autophagy in VSMCs, support the general idea that autophagy induction is potentially useful to prevent vascular disease. Intestinal Autophagy Important in Calorie Restriction and Longevity in Nematodes https://www.fightaging.org/archives/2016/08/intestinal-autophagy-important-in-calorie-restriction-and-longevity-in-nematodes/ Based on the evidence accumulated from many years of studies of ...
Source: Fight Aging! - August 7, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Inventory and analysis of literature on the organisation of eight European academic medical centres —A scoping review
by Ester M. M. Cardinaal, Heleen N. W. Duighuisen, Patrick P. T. Jeurissen, Hubert Berden Academic Medical Centres (AMCs) are important organisations for shaping healthcare. The purpose of this scoping review is to understand the scope and type of evidence related to the organisation of European AMCs. We selected the study population intending to obtain a demographic cross-section of E uropean countries: Czech Republic, Germany, Latvia, the Netherlands, Poland, Spain, Sweden and the UK. We focused our search strategy on the relationship between medical schools and AMCs, the organisation of governing bodies, and legal owne...
Source: PLoS One - March 10, 2023 Category: Biomedical Science Authors: Ester M. M. Cardinaal Source Type: research

The world needs One Repo
Suppose you’re a dinosaur lover, and you want to find information about sauropods. You go to Google, type ‘sauropod’ and hit the Search button, and you get a pretty good list of the best Web-pages about sauropods. Easy. Now suppose you’re a dinosaur researcher, and you want to find open-access scholarly papers about sauropods. More than that: suppose you want to text-mine them? Or analyze the papers’ metadata to see how open-access publication rates have changed through time, or what proportion of the authors are female? What if you need to verify that the papers conform to an institutional open-acces...
Source: BioMed Central Blog - January 22, 2016 Category: Journals (General) Authors: Mike Taylor Tags: Medical Evidence Open Access Publishing data repository Source Type: blogs

Risk Criteria in Hospital Site Selection: A Systematic Review
Conclusions Despite the critical role of hospitals in health service delivery in disasters and emergencies and the effect of hospital location on the quality of these services, few articles have considered hazards as the criteria for hospital site selection (HSS). Cost and demand are two groups of criteria that have been addressed more frequently in HSS studies. The decision makers should prospectively match the main objectives of hospital building with the HSS criteria according to the strategy of site selection and the availability of data and resources. Undoubtedly, being safe and remaining functional in emergencies and...
Source: PLOS Currents Disasters - May 1, 2017 Category: Global & Universal Authors: Moradian MJ Source Type: research

Earthquakes to Floods: A Scoping Review of Health-related Disaster Research in Low- and Middle-income Countries
Conclusion Our scoping review assessed the characteristics of peer-reviewed publications of empirical health-related disaster research conducted in LMICs and published in 2003-2012. To our knowledge, this is the first synthesis to focus exclusively on health-related empirical research conducted during disasters. We found that many health-related research publications focus on the most devastating events, namely those that affect the largest number of people and those with the highest mortality rates. The most common research topics were those requiring the most immediate attention, such as traumatology, wounds, and the res...
Source: PLOS Currents Disasters - August 30, 2018 Category: International Medicine & Public Health Authors: Catherine M. Tansey Source Type: research

Expanding Research Capacity in Sub-Saharan Africa Through Informatics, Bioinformatics, and Data Science Training Programs in Mali
Conclusion Bioinformatics and data science training programs in developing countries necessitate incremental and collaborative strategies for their feasible and sustainable development. The progress described here covered decades of collaborative efforts centered on training and research on computationally intensive topics. These efforts laid the groundwork and platforms conducive for hosting a bioinformatics and data science training program in Mali. Training programs are perhaps best facilitated through Africa’s university systems as they are perhaps best positioned to maintain core resources during lapses in sho...
Source: Frontiers in Genetics - April 11, 2019 Category: Genetics & Stem Cells Source Type: research

Blue Title Medicine Clearing for 2020 entry
Thread Starter Medicine Clearing for 2020 entry Follow 3 weeks ago 3w ago This is the thread for Medicine Clearing 2020 Entry.This thread will be locked until Summer 2020. The Medicine Clearing 2019 entry thread is here. This thread will be updated throughout mid to late August 2020 with the latest inf...
Source: The Student Room - December 1, 2019 Category: Universities & Medical Training Authors: ecolier Tags: Medicine Source Type: forums

Fight Aging! Newsletter, August 3rd 2020
In this study, we examined the effects of oxytocin on the Aβ-induced impairment of synaptic plasticity in mice. To investigate the effect of oxytocin on synaptic plasticity, we prepared acute hippocampal slices for extracellular recording and assessed long-term potentiation (LTP) with perfusion of the Aβ active fragment (Aβ25-35) in the absence and presence of oxytocin. We found that oxytocin reversed the impairment of LTP induced by Aβ25-35 perfusion in the mouse hippocampus. These effects were blocked by pretreatment with the selective oxytocin receptor antagonist L-368,899. Furthermore, the treatment with the...
Source: Fight Aging! - August 2, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Is student loan debt good or bad for full-time employment upon graduation from college?
Student loan debt represents an important phenomenon in the United States, as around 61% of bachelor’s degree recipients graduate with a debt of over $28,100. Although studies emphasize that holding student loan debt delays the transition to adulthood in terms of marriage and home ownership, little is known about its impact on employment and this limited research offers, at best, equivocal evidence. The current study draws from Conservation of Resources theory to argue that student loan debt acts as a major financial stressor for new labor market entrants during job search. Using archival data from 1,248 graduating senio...
Source: Journal of Applied Psychology - February 27, 2020 Category: Psychiatry & Psychology Source Type: research

The Readability of Online Educational Materials for Femoroacetabular Impingement Syndrome.
In this study of 59 unique websites on FAI, using five different validated readability formulas, we demonstrated that none of the top 30 webpages were written at the recommended reading level. They were found through three different search queries on the three most used search engines. Current FAI online education materials accessible to patients are written above the recommended levels, and it seems that to improve equity and accessibility in healthcare, universities, hospitals, and healthcare professional societies have a responsibility to ensure that the online materials are provided at more appropriate levels. Early de...
Source: The Journal of the American Academy of Orthopaedic Surgeons - November 18, 2020 Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research

To what extent do preclinical veterinary students in the UK utilize online resources to study physiology
Adv Physiol Educ. 2021 Mar 1;45(1):160-171. doi: 10.1152/advan.00215.2020.ABSTRACTOnline resources are becoming increasingly important in undergraduate education and have been associated with a number of advantages and positive outcomes on students' learning experience. However, online resource use by veterinary students for physiology learning remains poorly understood. Thus the present questionnaire-based study aims to investigate the extent to which first- and second-year veterinary students use online resources, including online video clips and social media, in their physiology learning and if this is influenced by fac...
Source: Advances in Physiology Education - March 4, 2021 Category: Physiology Authors: Khalil Saadeh Victoria Henderson Sharmini Julita Paramasivam Kamalan Jeevaratnam Source Type: research