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Drug: Nicotine
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Acute effects of e-cigarette inhalation with or without nicotine on levels of microvesicles in the blood of human volunteers
Discussion: As little as 30 puffs of nicotine containing e-cigarette vapor cause increased levels of circulating MVs of endothelial and platelet origin, indicating possible vascular injury. This may lead to increased progression of atherosclerosis, the underlying cause of myocardial infarction and stroke.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Lundbäck, M., Mobarrez, F., Antoniewicz, L., Bosson Damewood, J. Tags: Tobacco, smoking control and health education Source Type: research
Too Much Sleep Linked To Greater Risk Of Disease & Death, Study Finds
(CNN) — The recommended amount of sleep for adults is six to eight hours a night. Sleeping more than those hours is associated with an increased risk of death and cardiovascular diseases, says a global study published Wednesday in the European Heart Journal.
Looking at data from 21 countries, across seven regions, the research team found that people sleeping more than the recommended upper limit of eight hours increased their risk of major cardiovascular events, like stroke or heart failure, as well as death by up to 41%.
But a possible reason for this could be that people have underlying conditions causing them to s...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - December 5, 2018 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Local TV Sleep Source Type: news
Mental Health, Sleep Deprivation and Career Stress in EMS and Fire
The human brain is a marvelous, yet complicated system. Researchers spend entire careers studying what makes the brain act or react to certain experiences. A mental health issue stemming from life’s experiences has culturally been seen as a sign of weakness, but actually is part of a very complex architecture that’s unique from person to person.
In order to gain an understanding of how stress plays a role in the lives of first responders, we need to start answering some hard questions: What leads to burn-out? What’s associated with PTSD? How is lack of sleep affecting the mental health states of first responders? The...
Source: JEMS Special Topics - December 13, 2018 Category: Emergency Medicine Authors: Morgan K. Anderson, MPH Tags: Exclusive Articles Resiliency Operations Source Type: news
Clinical, radiological, and histological characteristics of Chinese type 2 diabetic patients with diabetic scleredema: an observational study
ConclusionOur reports suggest that DS is relatively rare in Chinese patients with diabetes. DS occurs both in middle-aged and elderly patients (male predominantly), overweight or obese, having long-term poorly controlled type 2 diabetes, and presenting a high incidence of microvascular complications, hypertension, neuropathy, and ischemic cerebral stroke. High LDL-C level, nicotine abuse, and alcohol abuse may be risk factors. MRI could be preferable to assess the severity of DS non-invasively.
Source: International Journal of Diabetes in Developing Countries - December 18, 2018 Category: Endocrinology Source Type: research
Energy Drinks Have Become Wildly Popular With Teens. Here ’s Why it’s a Public Health Concern
This article was originally published on Undark. Read the original article.
Source: TIME: Health - June 28, 2019 Category: Consumer Health News Authors: Sara Talpos / Undark Tags: Uncategorized Food & Drink onetime syndication Source Type: news
PERSPECTIVES Small Heat Shock Proteins, Amyloid Fibrils, and Nicotine Stimulate a Common Immune Suppressive Pathway with Implications for Future Therapies
The α7 nicotinic acetylcholine receptor (α7nAChR) is central to the anti-inflammatory function of the vagus nerve in a physiological mechanism termed the inflammatory reflex. Studies on the inflammatory reflex have been instrumental for the current development of the field of bioelectronic medicine. An independent investigation of the biological role of αB-crystallin (HspB5), the most abundant gene transcript present in active multiple sclerosis lesions in human brains, also led to α7nAChR. Induction of experimental autoimmune encephalomyelitis (EAE) in HspB5–/– mice results in greater p...
Source: Cold Spring Harbor perspectives in medicine - June 30, 2019 Category: Research Authors: Rothbard, J. B., Kurnellas, M. P., Ousman, S. S., Brownell, S., Rothbard, J. J., Steinman, L. Tags: Bioelectronic Medicine PERSPECTIVES Source Type: research
Effect of Cigarette Smoking on Functional Outcomes in Patients with Spontaneous Intracerebral Hemorrhage
This study aimed to evaluate the relationship between cigarette smoking and outcomes in patients with spontaneous intracerebral hemorrhage (ICH). Methods: This was a retrospective review of consecutive ICH patients enrolled in the ICH Outcomes Project from 2009 to 2017. Patients with age ≥18 years and baseline modified Rankin Scale (mRS) score 0-2 were included.
Source: Journal of Stroke and Cerebrovascular Diseases - July 2, 2019 Category: Neurology Authors: Natasha Ironside, Ching-Jen Chen, Josephine Pucci, Edward Sander Connolly Source Type: research
12 Innovations That Will Change Health Care and Medicine in the 2020s
Pocket-size ultrasound devices that cost 50 times less than the machines in hospitals (and connect to your phone). Virtual reality that speeds healing in rehab. Artificial intelligence that’s better than medical experts at spotting lung tumors. These are just some of the innovations now transforming medicine at a remarkable pace.
No one can predict the future, but it can at least be glimpsed in the dozen inventions and concepts below. Like the people behind them, they stand at the vanguard of health care. Neither exhaustive nor exclusive, the list is, rather, representative of the recasting of public health and medic...
Source: TIME: Health - October 25, 2019 Category: Consumer Health News Authors: TIME Staff Tags: Uncategorized HealthSummit19 technology Source Type: news
Full-Thickness Skin Grafts and Quilting Sutures for the Reconstruction of Internal Nasal Lining
Facial Plast Surg 2020; 36: 297-304 DOI: 10.1055/s-0040-1713116Restoration of the inner nasal lining is an essential factor in successful nasal reconstruction. Among various methods, free full-thickness skin grafting represents a readily available and feasible technique. A prerequisite for success is a secure and immobile fixation to the undersurface of the nourishing forehead flap. This retrospective study aims to evaluate the results of multiple quilting sutures to secure free full-thickness skin grafts for the reconstruction of the inner nasal lining in partial and extended nasal reconstruction. Between February 1, 2015...
Source: Facial Plastic Surgery - June 16, 2020 Category: Cosmetic Surgery Authors: Gostian, PD Dr. med. Antoniu-Oreste Balk, Dr. med. Matthias Stegmann, Dr. med. Achim Iro, Prof. Dr. med. Dr. h.c. Heinrich Wurm, Prof. Dr. med. Jochen Tags: Original Research Source Type: research
Temporal proteomic changes induced by nicotine in human cells: A quantitative proteomics approach
J Proteomics. 2021 Apr 22:104244. doi: 10.1016/j.jprot.2021.104244. Online ahead of print.ABSTRACTNicotine is a prominent active compound in tobacco and many smoking cessation products. Some of the biological effects of nicotine are well documented in in vitro and in vivo systems; however, nominal data are available concerning the time-dependent changes on protein and phosphorylation events in response to nicotine. Here, we profiled the proteomes of SH-SY5Y and A549 cell lines subjected to acute (15 min, 1 h and 4 h) or chronic (24 h, 48 h) nicotine exposures. We used sample multiplexing (TMTpro16) and quantified more than...
Source: Journal of Proteomics - April 25, 2021 Category: Biochemistry Authors: Jos é Navarrete-Perea Steven P Gygi Joao A Paulo Source Type: research
Nicotine Exposure Along with Oral Contraceptive Treatment in Female Rats Exacerbates Post-cerebral Ischemic Hypoperfusion Potentially via Altered Histamine Metabolism
AbstractSmoking-derived nicotine (N) and oral contraceptives (OCs) synergistically exacerbate ischemic brain damage in the female, and the underlying mechanisms remain elusive. Our published study showed that N toxicity is exacerbated by OC via altered mitochondrial electron transport chain function. Because mitochondria play an important role in cellular metabolism, we investigated the global metabolomic profile of brains of adolescent and adult female Sprague-Dawley rats exposed to N with or without OC (N+/ −OC). Rats were randomly exposed to saline or N+/−OC for 16–21 days followed by random allocation into two c...
Source: Translational Stroke Research - September 6, 2021 Category: Neurology Source Type: research
Smoking cessation adherence:recurrent cardiovascular events after five years of first manifestation
ConclusionsSmoking cessation after a first cardiovascular event should be a key objective for both patients and physicians to reduce the risk for recurrent vascular events. More efforts are needed to maintain smoking cessation in patients at very high cardiovascular risk.Key messagesSmoking cessation consultation can increase adherence to smoking cessation and helps in reducing the excess risk of recurrent cardiovascular events.Smoking is highly addictive and cessation can be extremely difficult, even after a life-threatening vascular event.
Source: The European Journal of Public Health - October 20, 2021 Category: General Medicine Source Type: research
Erectile Dysfunction Associated With Use of E-Cigarettes, Report Finds
This study highlights a novel finding that ENDS use could have serious implications on men’s se xual health.”El-Shahawy and colleagues analyzed data collected from December 2016 to January 2018 as part of thePopulation Assessment of Tobacco or Health (PATH) study —a national longitudinal study of tobacco use and how it affects the health of people in the United States. The researchers specifically focused on male participants 20 years and older who responded to questions about erectile dysfunction; their use of ENDS; current or past history of smoking; and previous diagnoses of diabetes, hypertension, high cholestero...
Source: Psychiatr News - December 7, 2021 Category: Psychiatry Tags: American Journal of Preventive Medicine E-cigarettes erectile dysfunction PATH Study Source Type: research
