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Drug: Melatonin
Nutrition: Antidoxidants
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Total 695 results found since Jan 2013.
Melatonin targets ferroptosis through bimodal alteration of redox environment and cellular pathways in NAFLD model
Biosci Rep. 2023 Sep 20:BSR20230128. doi: 10.1042/BSR20230128. Online ahead of print.ABSTRACTFerroptosis is a non-conventional cellular death caused by lipid peroxide induced iron deposition. Intracellular lipid accumulation followed by generation of lipid peroxides is an Hallmark of Non Alcoholic Fatty Liver Disease (NAFLD). Melatonin (MLT) is an important pineal hormone with tremendous antioxidant and anti-inflammatory properties. Various studies targeted ferroptosis in different diseases using melatonin. However, none of them focused the intrinsic mechanism of MLT's action to counteract ferroptosis in NAFLD. Hence, the ...
Source: Bioscience Reports - September 20, 2023 Category: Biomedical Science Authors: Moumita Saha Sanjib Das Krishnendu Manna Krishna Das Saha Source Type: research
Melatonin as a therapeutic agent for alleviating endothelial dysfunction in cardiovascular diseases: Emphasis on oxidative stress
Biomed Pharmacother. 2023 Sep 16;167:115475. doi: 10.1016/j.biopha.2023.115475. Online ahead of print.ABSTRACTThe vascular endothelium is vital in maintaining cardiovascular health by regulating vascular permeability and tone, preventing thrombosis, and controlling vascular inflammation. However, when oxidative stress triggers endothelial dysfunction, it can lead to chronic cardiovascular diseases (CVDs). This happens due to oxidative stress-induced mitochondrial dysfunction, inflammatory responses, and reduced levels of nitric oxide. These factors cause damage to endothelial cells, leading to the acceleration of CVD progr...
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Xiaolu Zhang Yujia Zheng Ziyu Wang Jiali Gan Bin Yu Bin Lu Xijuan Jiang Source Type: research
Melatonin alleviates early brain injury by inhibiting the NRF2-mediated ferroptosis pathway after subarachnoid hemorrhage
Free Radic Biol Med. 2023 Sep 15:S0891-5849(23)00636-6. doi: 10.1016/j.freeradbiomed.2023.09.012. Online ahead of print.ABSTRACTFerroptosis is a novel form of cell death that plays a critical role in the pathological and physiological processes of early brain injury following subarachnoid hemorrhage. Melatonin, as the most potent endogenous antioxidant, has shown strong protective effects against pathological changes following subarachnoid hemorrhage, but its impact on ferroptosis induced by subarachnoid hemorrhage remains unexplored. In our study, we established a subarachnoid hemorrhage model in male SD rats. We found th...
Source: Free Radical Biology and Medicine - September 17, 2023 Category: Biology Authors: Sheng-Ji Ma Chen Li Cong Yan Nan Liu Guang-You Jiang Hong-Rui Yang Hao-Chen Yan Ji-Yi Li Huai-Lei Liu Cheng Gao Source Type: research
Txnrd3 knockout enhancement of lung injury induced by Ni exposure via the VEGF-VEGFR-2 axis and alleviation of this effect by melatonin
In conclusion, Ni causes lung injury by activating the VEGF-VEGFR-2 pathway and Txnrd3 knockout aggravates injury after Ni exposure.PMID:37716496 | DOI:10.1016/j.fct.2023.114032
Source: Food and Chemical Toxicology - September 16, 2023 Category: Food Science Authors: Pinnan Liu Yue Sun Senqiu Qiao Wenxue Ma Lihua Xu Yue Liu Xiaoxue Gai Qiaohan Liu Jingzeng Cai Ziwei Zhang Source Type: research
Melatonin or vitamin C attenuates lead acetate-induced testicular oxidative and inflammatory damage in mice by inhibiting oxidative stress mediated NF- κB signaling
In this study, we aimed to determine the effects of lead acetate on reproductive function in male mice, identify the underlying mechanisms, and test counter measures to alleviate the toxic effects. Male mice were dosed with lead acetate (500 mg/L) in free drinking water for 12 weeks, and administered melatonin (5 mg/kg) or vitamin C (500 mg/kg) by intraperitoneal injection. Blood from the eyeball, testicles, and sperm from the caudal epididymis were collected after 12 weeks and analyzed. Pb exposure reduced sperm count and motility, increased sperm malformation (P < 0.01), disrupted testicular morphology and structure, ...
Source: Ecotoxicology and Environmental Safety - September 16, 2023 Category: Environmental Health Authors: Ze-Min Zhao Su Mei Qi-Yue Zheng Jiao Wang Yi-Ru Yin Jiao-Jiao Zhang Xian-Zhong Wang Source Type: research
Effects of cyclic adenosine monophosphate modulating agents during oocyte pre-maturation and the role of melatonin on in vitro maturation of bovine cumulus-oocyte complexes
In conclusion, bovine COC pre-maturation with C-type natriuretic peptide and forskolin, followed by IVM with 10-8 M melatonin improves meiotic resumption rates, TZPs, mitochondrial distribution and mRNA expression for SOD and CAT.PMID:37696223 | DOI:10.1016/j.anireprosci.2023.107327
Source: Animal Reproduction Science - September 11, 2023 Category: Zoology Authors: Bianca R Silva Laryssa G Barrozo Danisv ânia R Nascimento Francisco C Costa Ven ância A N Azevedo La ís R F M Paulino Everton P F Lopes Ana L P S Batista Francisco L N Aguiar Christina A Peixoto Mariana A M Donato Ana P R Rodrigues Jos é R V Silva Source Type: research
Active coatings based on oxidized chitin nanocrystals and silk fibroins for the control of anthracnose in 'Hass' avocados
Int J Biol Macromol. 2023 Sep 1:126673. doi: 10.1016/j.ijbiomac.2023.126673. Online ahead of print.ABSTRACTPostharvest avocado losses are mainly due to anthracnose disease caused by Colletotrichum gloeosporioides. Chemical fungicides are effective, but their negative effects on health and the environment have led to the search for sustainable alternatives such as biopolymer-based coatings and natural compounds. Therefore, chitin nanocrystals (NCChit) were extracted using a sustainable deep eutectic solvent (DES) and chemically modified into oxidized chitin nanocrystals (O-NCChit) or deacetylated chitin nanocrystals (D-NCCh...
Source: International Journal of Biological Macromolecules - September 3, 2023 Category: Biochemistry Authors: Catalina Ferreira Funes Alejandra Larach Ximena Besoain Daniela Duarte Serrano Caroline Hadad Romina Pedreschi Albert Nguyen Van Nhien Claudia Fuentealba Source Type: research
Melatonin suppresses Akt/mTOR/S6K activity, induces cell apoptosis, and synergistically inhibits cell growth with sunitinib in renal carcinoma cells via reversing Warburg effect
CONCLUSIONS: In conclusion, our results indicate that MLT treatment reverses the Warburg effect and promotes intracellular ROS production, which leads to the suppression of Akt/mTOR/S6K signaling pathway, induction of cell apoptosis, and synergistically inhibition of cell growth with sunitinib in RCC cells. Overall, this study provides new insights into the mechanisms underlying anti-tumor effect of MLT in RCC cells, and suggests that MLT might be a promising therapeutic for RCC.PMID:37642220 | DOI:10.1080/13510002.2023.2251234
Source: Redox Report : communications in free radical research - August 29, 2023 Category: Biochemistry Authors: Kai-Hua Xue Yi-Fan Jiang Ji-Yu Bai Di-Ze Zhang Yu-Hang Chen Jian-Bin Ma Zhi-Jing Zhu Xinyang Wang Peng Guo Source Type: research
