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Specialty: Cardiology
Drug: Insulin

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Total 191 results found since Jan 2013.

Diabetes severity and the role of leisure time physical exercise on cardiovascular mortality: the Nord-Trlatin small letter o with strokendelag Health study (HUNT), Norway
Conclusions: The data suggest a more favourable effect of exercise in people with diabetes who used medication than in those who did not, suggesting that physical exercise should be encouraged as a therapeutic measure additional to medical treatment.
Source: Cardiovascular Diabetology - June 6, 2013 Category: Cardiology Authors: Børge MoeLiv Berit AugestadTom Nilsen Source Type: research

Good Fat, Bad Fat The Increasingly Complex Interplay of Adipose Tissue and the Cardiovascular System ∗
Obesity is present in more than 30% of adults in the United States and is a known risk factor for a variety of cardiovascular problems, including coronary artery disease, atrial fibrillation, congestive heart failure, and stroke (1). Obesity is considered to be present when there is an excess mass of adipose tissue in the body. There is now widespread acceptance of the notion that regional fat stores might have specific local or systemic effects. The best-known example of a local fat depot with a specific effect is the case of excess fat within the abdominal cavity, which seems to contribute to insulin resistance, raised b...
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - July 1, 2013 Category: Cardiology Source Type: research

Good Fat, Bad Fat: The Increasingly Complex Interplay of Adipose Tissue and the Cardiovascular System∗
Obesity is present in more than 30% of adults in the United States and is a known risk factor for a variety of cardiovascular problems, including coronary artery disease, atrial fibrillation, congestive heart failure, and stroke . Obesity is considered to be present when there is an excess mass of adipose tissue in the body. There is now widespread acceptance of the notion that regional fat stores might have specific local or systemic effects. The best-known example of a local fat depot with a specific effect is the case of excess fat within the abdominal cavity, which seems to contribute to insulin resistance, raised bloo...
Source: Journal of the American College of Cardiology - May 13, 2013 Category: Cardiology Authors: Sheldon E. Litwin Tags: Cardiometabolic Risk: Editorial Comment Source Type: research

Insulin resistance negatively affects long-term outcome in non-diabetic patients with coronary artery disease after therapies to reduce atherosclerotic risk factors.
CONCLUSIONS: The presence of IR despite optimized therapies to reduce atherosclerotic risk factors represents an adverse outcome predictor in non-diabetic patients with CAD. PMID: 23810069 [PubMed - as supplied by publisher]
Source: Journal of Cardiology - June 25, 2013 Category: Cardiology Authors: Kitta Y, Nakamura T, Uematsu M, Sugamata W, Deyama J, Fujioka D, Saito Y, Kawabata K, Obata JE, Kugiyama K Tags: J Cardiol Source Type: research

Obesity paradox in peripheral vascular disease
To prevent cardiovascular diseases, it is essential to control risk factors, among which obesity is a world-wide issue that we are currently facing . Obesity was found to be an independent cardiovascular risk factor by the Framingham Heart study, in which the participants were followed up over 26 years; a higher risk was observed in both men and women whose body weights increased after the young adult years . It has been shown that obesity, particularly visceral obesity, is closely related not only to classical cardiovascular risk factors such as dyslipidemia, diabetes, and hypertension, but also to insulin resistance, abn...
Source: Atherosclerosis - June 3, 2013 Category: Cardiology Authors: Johji Kato Tags: Invited Commentaries Source Type: research

Evaluation of the dual peroxisome proliferator–activated receptor α/γ agonist aleglitazar to reduce cardiovascular events in patients with acute coronary syndrome and type 2 diabetes mellitus: Rationale and design of the AleCardio trial
Conclusions: AleCardio will establish whether the PPAR-α/γ agonist aleglitazar improves cardiovascular outcomes in patients with diabetes and high-risk coronary disease.
Source: American Heart Journal - July 29, 2013 Category: Cardiology Authors: A. Michael Lincoff, Jean-Claude Tardif, Bruce Neal, Stephen J. Nicholls, Lars Rydén, Gregory G. Schwartz, Klas Malmberg, John B. Buse, Robert R. Henry, Hans Wedel, Arlette Weichert, Ruth Cannata, Diederick E. Grobbee Tags: Trial Design Source Type: research

Does hypoglycaemia increase the risk of cardiovascular events? A report from the ORIGIN trial
Conclusion Severe hypoglycaemia is associated with an increased risk for CV outcomes in people at high CV risk and dysglycaemia. Although allocation to insulin glargine vs. standard care was associated with an increased risk of severe and non-severe hypoglycaemia, the relative risk of CV outcomes with hypoglycaemia was lower with insulin glargine-based glucose-lowering therapy than with the standard glycaemic control. Trial Registration (ORIGIN ClinicalTrials.gov number NCT00069784).
Source: European Heart Journal - October 21, 2013 Category: Cardiology Authors: The ORIGIN Trial Investigators, Mellbin, Ryden, Riddle, Probstfield, Rosenstock, Diaz, Yusuf, Gerstein Tags: Disease management Source Type: research

Association of Sympathovagal Imbalance With Cardiovascular Risks in Young Prehypertensives
In conclusion, SVI in young prehypertensives is due to both increased sympathetic and decreased vagal tone. CV risks are linked to SVI and SVI predicts cardiac risk in prehypertensives.
Source: The American Journal of Cardiology - September 16, 2013 Category: Cardiology Authors: Gopal K. Pal, Chandrasekaran Adithan, Palghat H. Ananthanarayanan, Pravati Pal, Nivedita Nanda, Durgadevi Thiyagarajan, Avupati N. Syamsunderkiran, Venugopal Lalitha, Tarun K. Dutta Tags: Systemic Hypertension Source Type: research

Rationale, design, and organization of a randomized, controlled Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS) in patients with type 2 diabetes and established cardiovascular disease
Sitagliptin, an oral dipeptidyl peptidase-4 inhibitor, lowers blood glucose when administered as monotherapy or in combination with other antihyperglycemic agents. TECOS will evaluate the effects of adding sitagliptin to usual diabetes care on cardiovascular outcomes and clinical safety. TECOS is a pragmatic, academically run, multinational, randomized, double-blind, placebo-controlled, event-driven trial recruiting approximately 14,000 patients in 38 countries who have type 2 diabetes (T2DM), are at least 50 years old, have cardiovascular disease, and have an hemoglobin A1c value between 6.5% and 8.0%. Eligible participan...
Source: American Heart Journal - October 25, 2013 Category: Cardiology Authors: Jennifer B. Green, M. Angelyn Bethel, Sanjoy K. Paul, Arne Ring, Keith D. Kaufman, Deborah R. Shapiro, Robert M. Califf, Rury R. Holman Tags: Trial Design Source Type: research

Relationship of obesity and insulin resistance with the cerebrovascular reactivity: a case control study
Conclusions: We found a diminished vasomotor reactivity in individuals with obesity which was not explained by the presence of insulin resistance.
Source: Cardiovascular Diabetology - January 3, 2014 Category: Cardiology Authors: Marcela Rodríguez-FloresCarlos Cantú-BritoEduardo García-GarcíaClaudia Cano-Nigenda Source Type: research

Impact of Diabetes Mellitus on Early and Midterm Outcomes After Transcatheter Aortic Valve Implantation (from a Multicenter Registry)
In conclusion, DM does not significantly affect rates of complications in patients who underwent TAVI. Insulin-treated DM, but not orally treated DM, is independently associated with death and myocardial infarction at midterm follow-up and should be included into future TAVI-dedicated scores.
Source: The American Journal of Cardiology - November 13, 2013 Category: Cardiology Authors: Federico Conrotto, Fabrizio D'Ascenzo, Francesca Giordana, Stefano Salizzoni, Corrado Tamburino, Giuseppe Tarantini, Patrizia Presbitero, Marco Barbanti, Valeria Gasparetto, Marco Mennuni, Massimo Napodano, Marco L. Rossi, Michele La Torre, Gaetana Ferrar Tags: Valvular Heart Disease Source Type: research

The relationship between insulin-sensitive obesity and cardiovascular diseases in a Chinese population: Results of the REACTION study
Conclusion: Both general and abdominal obesity were associated with elevated prevalent cardiovascular diseases and 10-year CHD risk, regardless of the presence or absence of insulin resistance.
Source: International Journal of Cardiology - February 6, 2014 Category: Cardiology Authors: Jieli Lu, Yufang Bi, Tiange Wang, Weiqing Wang, Yiming Mu, Jiajun Zhao, Chao Liu, Lulu Chen, Lixin Shi, Qiang Li, Qin Wan, Shengli Wu, Guijun Qin, Tao Yang, Li Yan, Yan Liu, Guixia Wang, Zuojie Luo, Xulei Tang, Gang Chen, Yanan Huo, Zhengnan Gao, Qing Su, Tags: Original Articles Source Type: research

Determinants of exercise peak arterial blood pressure, circulatory power, and exercise cardiac power in a population based sample of Finnish male and female aged 30 to 47 years: the Cardiovascular Risk in Young Finns Study
Conclusions: Subject demographics and lifestyle-related factors should be taken into account when exercise blood pressure response, CP and ECP are used to evaluate patients' cardiac function in CPET.
Source: BMC Cardiovascular Disorders - March 13, 2014 Category: Cardiology Authors: Janne HulkkonenHeikki AatolaKristiina PälveTerho LehtimäkiNina Hutri-KähönenJorma ViikariOlli RaitakariMika Kähönen Source Type: research

Treatment patterns, risk factor control and functional capacity in patients with cardiovascular and chronic kidney disease in the cardiac rehabilitation setting
Conclusion Within a short period of 3–4 weeks, CR led to substantial improvements in key risk factors such as lipid profile, blood pressure, and physical fitness for all patients, even if CKD was present.
Source: European Journal of Preventive Cardiology - August 18, 2014 Category: Cardiology Authors: Voller, H., Gitt, A., Jannowitz, C., Karoff, M., Karmann, B., Pittrow, D., Reibis, R., Hildemann, S. Tags: Original scientific papers Source Type: research