Does hypoglycaemia increase the risk of cardiovascular events? A report from the ORIGIN trial

Conclusion Severe hypoglycaemia is associated with an increased risk for CV outcomes in people at high CV risk and dysglycaemia. Although allocation to insulin glargine vs. standard care was associated with an increased risk of severe and non-severe hypoglycaemia, the relative risk of CV outcomes with hypoglycaemia was lower with insulin glargine-based glucose-lowering therapy than with the standard glycaemic control. Trial Registration (ORIGIN ClinicalTrials.gov number NCT00069784).

http://eurheartj.oxfordjournals.org/cgi/content/short/34/40/3137?rss=1

Source: European Heart Journal - October 21, 2013 Category: Cardiology Authors: The ORIGIN Trial Investigators, Mellbin, Ryden, Riddle, Probstfield, Rosenstock, Diaz, Yusuf, Gerstein Tags: Disease management Source Type: research