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Drug: Zovirax

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Total 57 results found since Jan 2013.

Outcome of Age-Adapted Approach to HLA-Identical Related Hematopoietic Stem Cell Transplantation in Severe Sickle Cell Disease: Saudi Experience
In this study, we reviewed the outcome of SCD patients who underwent transplant at our institution using standard protocols (NMA regimen in patients ≥14 years and myeloablative regimen in < 14 years) to address whether age remains a risk factor that influences HSCT outcome in SCD.Children (<14 years) with severe SCD received myeloablative conditioning using one of two regimens: first regimen was cyclophosphamide (Cy) 200mg/kg, busulfan (Bu) 16mg/kg, and thymoglobulin (ATG) 10mg/kg and recently we use thiotepa 8mg/kg, Bu 16mg/kg, and fludarabine (Flu) 160mg/m2. Bu pharmacokinetics was performed to target AUC of 900...
Source: Blood - November 21, 2018 Category: Hematology Authors: Alzahrani, M., Damlaj, M., Essa, M., Alahmari, B., Alaskar, A., Hejazi, A., Basher, E., Abujoub, R., Ghazi, S., Abuelgasim, K., Salama, H., Gmati, G., Alsultan, A. Tags: 732. Clinical Allogeneic Transplantation: Results: Poster II Source Type: research

Central nervous system varicella zoster vasculopathy in an immunocompromised patient
ConclusionThis clinical case and review of the literature highlights the challenges in the diagnosis and management of VZV CNS vasculopathy in immunocompromised patients.
Source: IDCases - December 29, 2018 Category: Infectious Diseases Source Type: research

Mitochondrial A3243G mutation causes mitochondrial encephalomyopathy in a Chinese patient: Case report
Rationale: Mitochondrial mutations are associated with a wide spectrum of clinical abnormalities. More than half of these mutations are distributed in the 22 mitochondrial tRNA genes, including tRNALeu(UUR). In particular, the A3243G mutation in the tRNALeu(UUR) gene causes mitochondrial encephalomyopathy. Patient concerns: A 12-year-old boy was admitted to Shaoxing People's Hospital because there is a reduction in the volume of speech, dysphonia, unable to write, recognize words, and unable to wear clothes, accompanied by unstable walking after treatment of unexplained fever and somnolence. Diagnoses: The proband ...
Source: Medicine - May 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Infectious Diseases: Images in Clinical Medicine
Editor: V. Dimov, M.D., Cleveland ClinicHypoglossal Nerve Palsy during Meningococcal Meningitis. NEJM, 10/2014.Herpes Zoster Involving the S1 Dermatome. NEJM, 05/2014.Tinea Faciei. NEJM, 05/2014.Disseminated Cryptococcosis in a CLL patient. 05/2014.Scrofuloderma due to Mycobacterium tuberculosis. NEJM, 06/2012.Leonine Facies in Lepromatous Leprosy. NEJM, 04/2012.Intestinal Infestation with Ancylostoma ceylanicum. NEJM, 03/2012.Kerion celsi form of tinea capitis caused by a T-cell hypersensitivity reaction. NEJM, 03/2012.Eye can see a nest of worms! Thelazia callipaeda. Lancet, 03/2012.Madura Foot. NEJM, 01/2012.Paragonimia...
Source: Clinical Cases and Images - August 22, 2009 Category: General Medicine Tags: Images Infectious Diseases Source Type: news

An unusual neurological syndrome in a haemodialysis patient
Nisha Jose, V Jayaprakash, A Deiva, M JayakumarIndian Journal of Nephrology 2021 31(3):293-295 Advanced age and immunosuppressed states allow for complications of herpes zoster such as encephalitis. In this case report, we describe a patient with encephalopathy two days after initiation of antiviral therapy. After the necessary imaging and cerebrospinal fluid (CSF) analysis, it became evident that the neurological syndrome was due to acyclovir. Despite currently practised renal dose modification, the patient developed acyclovir-induced neurotoxicity and required intensification of his dialysis schedule to eliminate the dr...
Source: Indian Journal of Nephrology - June 19, 2021 Category: Urology & Nephrology Authors: Nisha Jose V Jayaprakash A Deiva M Jayakumar Source Type: research

Zoster-associated limb paralysis mimicking acute stroke: a case report
ConclusionBrachial plexus neuritis due to varicella zoster infection should be considered in an acute monoparesis of a limb as it is a treatable and reversible condition
Source: Journal of Medical Case Reports - July 30, 2021 Category: General Medicine Source Type: research

Case Report: Late-Onset Mitochondrial Disease Uncovered by Metformin Use in a Patient With Acute Verbal Auditory Agnosia
ConclusionsTo our knowledge, this is the first report of a patient having late-onset MELAS syndrome that manifested as acute verbal auditory agnosia, which was identified after the patient began using metformin. Metformin is known to inhibit mitochondrial function and could trigger clinical features of MELAS syndrome. We encourage clinicians to maintain a high level of awareness that diabetes mellitus can be caused by mitochondrial disease and to exercise caution in the prescription of metformin.
Source: Frontiers in Neurology - March 25, 2022 Category: Neurology Source Type: research

Herpes simplex encephalitis presenting as a stroke-like episode following a migraine attack: a case report
Rinsho Shinkeigaku. 2022 Jun 24. doi: 10.5692/clinicalneurol.cn-001745. Online ahead of print.ABSTRACTA 23-year-old woman, who had been suffering from migraine since primary school age, presented with left arm paralysis three days after one such migraine attack. On admission, brain MRI diffusion-weighted imaging (DWI) demonstrated high-signal-intensity lesions in the white matter of the right fronto-parietal lobe, and no abnormal lesions were evident in the limbic system. Although the patient had a fever of 38.7°C, the CSF cell count was not elevated. On the 4‍th day, the left arm paralysis worsened, with an increase in...
Source: Herpes - June 26, 2022 Category: Infectious Diseases Authors: Moeno Yamamoto Masaki Namekawa Masanori Ishikawa Hiroyuki Watanabe Mutshuo Oyake Nobuya Fujita Source Type: research

Valacyclovir-associated acute kidney injury and encephalopathy in an elderly woman with normal kidney function: a case report
AbstractA 72-year-old Japanese woman was treated by 3000  mg/day of valacyclovir for the herpes zoster in her left back. She had been treated as hypertension with no renal insufficiency. In two days, she visited an emergency room of a regional stroke care center with dysarthria, dexterity disorder and gait disturbance. Neither head CT nor MRI found intra cranial lesions, then, laboratory tests revealed that her serum creatinine level was 4.63 mg/dL. She was transferred and admitted to our hospital on the following day and received hemodialysis under the diagnosis of AKI due to acyclovir accompanied with encephalopathy. A...
Source: CEN Case Reports - November 18, 2022 Category: Urology & Nephrology Source Type: research