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Drug: Cilostazol

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Total 208 results found since Jan 2013.

Two young stroke patients associated with regular intravenous immunoglobulin (IVIg) therapy
We recently experienced 2 young adult patients who developed ischemic stroke after regular intravenous immunoglobulin (IVIg) therapy for agammaglobulinemia with diagnosis of common variable immunodeficiency (CVID) in their childhood. Patient 1 was 26-year-old woman, who developed Wallenberg's syndrome 6days after the last IVIg therapy, but had no further stroke recurrence with cilostazol later. Patient 2 was 37-year-old man, who developed recurrent cerebral infarction in the territory of bilateral lenticulostriate branches like branch atheromatous disease (BAD) several days after the IVIg therapy.
Source: Journal of the Neurological Sciences - December 2, 2015 Category: Neurology Authors: Yumiko Nakano, Takeshi Hayashi, Kentaro Deguchi, Kota Sato, Nozomi Hishikawa, Toru Yamashita, Yasuyuki Ohta, Yoshiki Takao, Tomohiro Morio, Koji Abe Source Type: research

Blood Thinning Drug May Be Safer Option Against Recurrent Stroke
THURSDAY, Feb. 7, 2019 -- Taking the blood thinner Pletal (cilostazol) with either aspirin or clopidogrel (best known as Plavix) lowers stroke patients ' risk of a subsequent stroke better than taking aspirin or clopidogrel alone, a new study...
Source: Drugs.com - Daily MedNews - February 7, 2019 Category: General Medicine Source Type: news

Drugs to prevent stroke and dementia show promise in early trial
Treatments that prevent recurrence of types of stroke and dementia caused by damage to small blood vessels in the brain have moved a step closer, following a small study. The drugs - called cilostazol and isosorbide mononitrate - are already used to treat other conditions, such as heart disease and angina. This is the first time they have been tested in the UK for the treatment of stroke or vascular dementia.
Source: World Pharma News - April 29, 2019 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

Heart Meds May Prevent Vascular Dementia After Stroke Heart Meds May Prevent Vascular Dementia After Stroke
Cilostazol and isosorbide mononitrate have neuroprotective potential after lacunar stroke, which carries a high risk for vascular dementia and cognitive decline.Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - May 6, 2019 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Does Cilostazol Prevent Recurrent Stroke in Women? Does Cilostazol Prevent Recurrent Stroke in Women?
Although dual antiplatelet therapy using cilostazol is associated with a lower risk of recurrent stroke in men, it has no significant benefit for women, a sub-analysis of CSPS.com results suggests.Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - March 22, 2022 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Age-Related Decline in Oligodendrogenesis Retards White Matter Repair in Mice Basic Sciences
Conclusions— An age-related decline in cyclic AMP response element-binding protein–mediated oligodendrogenesis may compromise endogenous white matter repair mechanisms, and therefore, drugs that activate cyclic AMP response element-binding protein signaling provide a potential therapeutic approach for treating white matter injury in aging brains.
Source: Stroke - August 26, 2013 Category: Neurology Authors: Miyamoto, N., Pham, L.-D. D., Hayakawa, K., Matsuzaki, T., Seo, J. H., Magnain, C., Ayata, C., Kim, K.-W., Boas, D., Lo, E. H., Arai, K. Tags: Animal models of human disease, Other Stroke Treatment - Medical, Other Vascular biology Basic Sciences Source Type: research

Characterization of White Matter Injury in a Rat Model of Chronic Cerebral Hypoperfusion Brief Reports
Conclusions— White matter injury induced by chronic cerebral hypoperfusion can be characterized by disintegration of diverse white matter components. Cilostazol might be a therapeutic strategy against white matter disintegration in patients with vascular dementia.
Source: Stroke - January 25, 2016 Category: Neurology Authors: Choi, B.-R., Kim, D.-H., Back, D. B., Kang, C. H., Moon, W.-J., Han, J.-S., Choi, D.-H., Kwon, K. J., Shin, C. Y., Kim, B.-R., Lee, J., Han, S.-H., Kim, H. Y. Tags: Animal Models of Human Disease, Basic Science Research, Ischemia, Cerebrovascular Disease/Stroke Brief Reports Source Type: research

Importance of perioperative management for emergency carotid artery stenting within 24hours after intravenous thrombolysis for acute ischemic stroke: Case report
Conclusion Emergency carotid artery stenting for the acute internal carotid artery occlusion may be considered a safe procedure in preventing early stroke recurrence in selected patients.
Source: International Journal of Surgery Case Reports - July 26, 2016 Category: Surgery Source Type: research

Preventive Effect of Cilostazol on Pneumonia in Patients with Acute Cerebral Infarction
The antiplatelet drug cilostazol decreases the risk of ischemic stroke recurrence in patients with chronic cerebral infarction. Additionally, cilostazol reduces the occurrence of pneumonia in these patients. The purpose of this study was to investigate whether cilostazol is effective for preventing pneumonia in patients with acute cerebral infarction.
Source: Journal of Stroke and Cerebrovascular Diseases - May 11, 2018 Category: Neurology Authors: Yoshitsugu Nakamura, Hideto Nakajima, Fumiharu Kimura, Kiichi Unoda, Shigeki Arawaka Source Type: research

The use of cilostazol for secondary stroke prevention: isn't time to be evaluated in Western countries?
Authors: Di Napoli M, Singh P, Lattanzi S, Divani AD PMID: 31935129 [PubMed - as supplied by publisher]
Source: Expert Opinion on Pharmacotherapy - January 16, 2020 Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research

Cilostazol uncovers covert atrial fibrillation in non-cardioembolic stroke
We hypothesized that administration of cilostazol may clarify the occult atrial fibrillation (AF) during hospitalization in mild stroke patients, who has no history of AF.
Source: Journal of the Neurological Sciences - March 20, 2020 Category: Neurology Authors: Junya Aoki, Yasuyuki Iguchi, Takao Urabe, Hiroshi Yamagami, Kenichi Todo, Shigeru Fujimoto, Koji Idomari, Nobuyuki Kaneko, Takeshi Iwanaga, Tadashi Terasaki, Ryota Tanaka, Nobuaki Yamamoto, Akira Tsujino, Koichi Nomura, Koji Abe, Masaaki Uno, Yasushi Okad Source Type: research

Cilostazol improves endothelial function in patients with ischemic stroke: A randomized controlled single-center study with flow-mediated dilation technique
Recent CSPS.com study has shown the benefit of adding cilostazol on aspirin or clopidogrel for secondary stroke prevention [1]. Because a pleiotropic effect other than its anti-platelet effect such as vasodilatation and anti-atherosclerosis effect may underlie the effect [1], we examined the effects of adding cilostazol on clopidogrel on endothelial function in flow-mediated vasodilation (FMD) technique.
Source: Journal of the Neurological Sciences - June 8, 2022 Category: Neurology Authors: Yuka Shirai, Sono Toi, Utako Adachi, Yukiko Tsutsumi, Kazuo Kitagawa Source Type: research

Antiplatelet therapy for secondary prevention of lacunar stroke: a systematic review and network meta-analysis
ConclusionsThis meta-analysis suggests that cilostazol may be a priority option for secondary prevention of patients with LS. These findings still need further study in the future.
Source: European Journal of Clinical Pharmacology - November 7, 2022 Category: Drugs & Pharmacology Source Type: research

Cilostazol for treatment of cerebral infarction.
Authors: Noma K, Higashi Y Abstract INTRODUCTION: Stroke not only causes critical disability and death but is also a cause of anxiety with the possibility of secondary cardiovascular events including secondary ischemic stroke. Indeed, patients with a history of previous stroke have a high rate of stroke recurrence, indicating the clinical importance of secondary stroke prevention. Area of covered: This review provides an overview of the pooled evidence for cilostazol's use in the management of secondary stroke prevention. Among the various antiplatelet agents that are available, aspirin is the most frequently used ...
Source: Expert Opinion on Pharmacotherapy - September 14, 2018 Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research