Age-Related Decline in Oligodendrogenesis Retards White Matter Repair in Mice [Basic Sciences]

Conclusions—
An age-related decline in cyclic AMP response element-binding protein–mediated oligodendrogenesis may compromise endogenous white matter repair mechanisms, and therefore, drugs that activate cyclic AMP response element-binding protein signaling provide a potential therapeutic approach for treating white matter injury in aging brains.

Source: Stroke - August 26, 2013 Category: Neurology Authors: Miyamoto, N., Pham, L.-D. D., Hayakawa, K., Matsuzaki, T., Seo, J. H., Magnain, C., Ayata, C., Kim, K.-W., Boas, D., Lo, E. H., Arai, K. Tags: Animal models of human disease, Other Stroke Treatment - Medical, Other Vascular biology Basic Sciences Source Type: research