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Drug: Dexamethasone
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Total 160 results found since Jan 2013.
1,25(OH) < sub > 2 < /sub > D < sub > 3 < /sub > and Its Analogue Calcipotriol Inhibit the Migration of Human Synovial and Mesenchymal Stromal Cells in a Wound Healing Model - a Comparison with Glucocorticoids
In this study, calcipotriol was studied in different in vitro methods to find out its effect on synovial and mesenchymal stromal cells. Primary human cell lines of osteoarthritis or rheumatoid arthritis patients (five mesenchymal stromal cells, MSC, and four synovial stromal cells, SSC) were cultured to study migration and proliferation of the cells in a wound healing model. The media was supplemented with calcipotriol, 1,25(OH)2D3, dexamethasone, betamethasone, methylprednisolone or control solution in 1 nM-100 nM concentrations. To see possible toxic effects of calcipotriol, concentrations up to 10µM in SSCs and MSCs we...
Source: Mol Biol Cell - August 9, 2023 Category: Molecular Biology Authors: Huovinen Jere Palosaari Sanna Pesonen Paula A Huhtakangas Johanna Lehenkari Petri Source Type: research
Vitamin D attenuates DNCB-induced atopic dermatitis-like skin lesions by inhibiting immune response and restoring skin barrier function
In conclusion, our study demonstrated that calcifediol significantly protected mice against DNCB-induced AD. In a mouse model of AD, calcifediol may reduce inflammatory cell infiltration and chemokines by inhibiting the phosphorylation of STAT3 and may restore skin barrier function through the downregulation of AQP3 protein expression and inhibition of cell proliferation.PMID:37393836 | DOI:10.1016/j.intimp.2023.110558
Source: International Immunopharmacology - July 2, 2023 Category: Allergy & Immunology Authors: Renwei Lu Ziqi Peng Panpan Lian Junaid Wazir Chaode Gu Chujun Ma Lulu Wei Li Li Wenyuan Pu Jun Liu Hongwei Wang Zhonglan Su Source Type: research
Randomized Phase III Trial of Pemetrexed Versus Docetaxel in Patients With Non-Small-Cell Lung Cancer Previously Treated With Chemotherapy
CONCLUSION: Treatment with pemetrexed resulted in clinically equivalent efficacy outcomes, but with significantly fewer side effects compared with docetaxel in the second-line treatment of patients with advanced NSCLC and should be considered a standard treatment option for second-line NSCLC when available.PMID:37196429 | DOI:10.1200/JCO.22.02546
Source: Clinical Lung Cancer - May 17, 2023 Category: Cancer & Oncology Authors: Nasser Hanna Frances A Shepherd Frank V Fossella Jose R Pereira Filippo De Marinis Joachim von Pawel Ulrich Gatzemeier Thomas Chang Yao Tsao Miklos Pless Thomas Muller Hong-Liang Lim Christopher Desch Klara Szondy Radj Gervais None Shaharyar Christian Man Source Type: research
Pharmacovigilance follow-up of patients in the context of the COVID-19 pandemic
DISCUSSION: This survey, based on real-time pharmacological and medical assessment of ADRs and weekly meetings in a specific national committee, made it possible to identify relevant safety signals which contribute to patient care with no delay. The main safety signal highlighted was serious cardiac damage under hydroxychloroquine, alone or combined with azithromycin and also with lopinavir/ritonavir. This signal has contributed to the evolution of the recommendations for these 2 drugs. The methodology of this survey has been taken over and is still going on for the pharmacovigilance monitoring of vaccines against COVID-19...
Source: Therapie - February 8, 2023 Category: Psychiatry & Psychology Authors: Aur élie Grandvuillemin Fanny Rocher Marie Blanche Valnet-Rabier Milou-Daniel Drici Anne Dautriche French Pharmacovigilance Network Source Type: research
Chronic psychological stress exacerbates aortic medial calcification via glucocorticoids
This study aims to explore the effects and mechanism of chronic psychological stress on aortic medial calcification (AMC). Rat arterial calcification model was established by nicotine gavage in combination with vitamin D3 (VitD3) intramuscular injection, and rat model of chronic psychological stress was induced by humid environment. Aortic calcification in rats was evaluated by using Alizarin red staining, aortic calcium content detection, and alkaline phosphatase (ALP) activity assay. The expression levels of the related proteins, including vascular smooth muscle cells (VSMCs) contractile phenotype marker SM22α, osteobla...
Source: Atherosclerosis - January 3, 2023 Category: Cardiology Authors: Yan-Qing Li Pan-Na Huang Hao-Zhe Zhang Lu-Yu Han Ruo-Xiang Miao Wan-Yun Feng Hua Pan Lin Feng Xin-Hua Wu Juan He Xu Teng Xiao-Ning Wang Source Type: research
Myoclonus status revealing COVID 19 infection
DISCUSSION: Our patient presented with acute isolated multifocal myoclonus status without cognitive impairment. These movements were prominent, spontaneous, worsened by action, and sensitive to touch and sound. The anatomical source of this myoclonus could be cortical or subcortical despite the absence of evident EEG discharges. Several diseases can cause acute myoclonus such as severe hypoxia, metabolic disturbances, and paraneoplastic syndromes. these diagnoses were ruled out in our patient. Post-vaccinal origin was also suggested, but its accountability was not proven. Thus, the two hypothetic etiologies raised were eit...
Source: Herpes - November 29, 2022 Category: Infectious Diseases Authors: Dina Ben Mohamed Rania Zouari Jihen Ketata Fatma Nabli Samir Blel Samia Ben Sassi Source Type: research
No Adverse Effects on Periarticular Tissue by Intra-articular Vitamin D analogue Calcipotriol in a Reduced-Dose Zymosan-Induced Arthritis Model in Rats
Basic Clin Pharmacol Toxicol. 2022 Nov 18. doi: 10.1111/bcpt.13815. Online ahead of print.ABSTRACTCalcipotriol, a vitamin D analogue, is an antiproliferative and anti-inflammatory drug currently used in psoriasis. Here, our aim was to analyse the safety of calcipotriol for cartilage and bone in alleviated-dose (0.1mg instead of usual ≥1mg dose) zymosan-induced arthritis in rats. Theoretically, high doses of vitamin D or analogues could have detrimental effects on bone or cartilage. The rats were divided into four groups: vehicle (n=9), dexamethasone 0.1 mg/kg (n=9), calcipotriol 0.1 mg/kg (n=8) and negative control (n=10...
Source: Cancer Control - November 18, 2022 Category: Cancer & Oncology Authors: Jere Huovinen Jesse Lohela Sami Kauppinen Mikko Finnil ä Sakari Laaksonen Hanna-Marja Voipio Johanna A Huhtakangas Petri Lehenkari Source Type: research
Weight loss and vitamin D improve hyporesponsiveness to corticosteroids in obese asthma
CONCLUSION: We found a reduced response to dexamethasone in PBMCs of O and OA patients with respect to NOA and HC subjects, that inversely correlated with the adiponectin/leptin ratio and vitamin D levels. Bariatric surgery improved corticosteroid responses in O and OA patients and normalized adiponectin/leptin ratio and vitamin D levels. Exposure of PBMCs to vitamin D potentiated the antiproliferative effects of corticosteroids. Dexamethasone and vitamin D induced similar MKP-1 expression in O and OA patients.PMID:36098275 | DOI:10.18176/jiaci.0861
Source: Journal of Investigational Allergology and Clinical Immunology - September 13, 2022 Category: Allergy & Immunology Authors: M Bantul à V Tubita J Roca-Ferrer J Mullol A Valero I Bobolea M Pascal A de Hollanda J Vidal C Picado E Arismendi Source Type: research
