Filtered By:
Drug: Polyethylene Glycol

This page shows you your search results in order of relevance. This is page number 9.

Order by Relevance | Date

Total 2716 results found since Jan 2013.

Bowel preparation in patients with Diabetes mellitus: Development of a procedure model
CONCLUSION: Split dosing of PEG preparations are recommended in diabetes patients with expected motility disorders. Extensive counseling about preparation intake and dietary recommendations should be offered.PMID:35545113 | DOI:10.1055/a-1791-1627
Source: Zeitschrift fur Gastroenterologie - May 11, 2022 Category: Gastroenterology Authors: Henning Ernst Adamek Laura Bergmann Karsten M üssig Source Type: research

Evaluation of the effect of guanabenz-loaded nanoparticles on chronic toxoplasmosis in mice
Exp Parasitol. 2023 Jan 12:108460. doi: 10.1016/j.exppara.2023.108460. Online ahead of print.ABSTRACTChronic toxoplasmosis which is positively correlated with many neuropsychiatric problems has no curative treatment till now; due to the resistant tissue cysts especially in the brain. In search of an effective treatment guanabenz-loaded polyethylene glycol poly lactic-co-glycolic acid (PEG-PLGA) nanoparticles was evaluated against chronic experimental toxoplasmosis. For this purpose, each mouse was infected with 10 cysts of Toxoplasma gondii (ME 49 strain). Treated mice received either guanabenz alone (5 mg/kg/day) in subgr...
Source: Experimental Parasitology - January 15, 2023 Category: Parasitology Authors: Wesam Moustafa Abdelhamid Elgendy Yusuf Ahmed Yusuf Haggag Kholoud Abd Allah El-Nouby Samy Ibrahim El-Kowrany Sirria Mostafa El Marhoumy Source Type: research

Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo. « Back to Top Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/ It seems...
Source: Fight Aging! - August 6, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Report on four cases with decreased recovery due to neutralizing antibodies specific for PEGylated recombinant factor VIII
CONCLUSION: The number of patients with inhibitory anti-PEG antibodies was significant, and the presence of inhibitors against PEGylated rFVIII emphasizes the importance of individual monitoring when switching FVIII concentrates to ensure safety and efficacy of the treatment.PMID:37543216 | DOI:10.1016/j.jtha.2023.07.019
Source: Thrombosis and Haemostasis - August 5, 2023 Category: Hematology Authors: Andreas Hillarp P ål A Holme Erik P W åland Marie S Le Carola E Henriksson Geir E Tj ønnfjord Ragnhild J M åseide Source Type: research

Poly-l-glutamic acid modification modulates the bio-nano interface of a therapeutic anti-IGF-1R antibody in prostate cancer
Biomaterials. 2023 Aug 14;301:122280. doi: 10.1016/j.biomaterials.2023.122280. Online ahead of print.ABSTRACTModifying biological agents with polymers such as polyethylene glycol (PEG) has demonstrated clinical benefits; however, post-market surveillance of PEGylated derivatives has revealed PEG-associated toxicity issues, prompting the search for alternatives. We explore how conjugating a poly-l-glutamic acid (PGA) to an anti-insulin growth factor 1 receptor antibody (AVE1642) modulates the bio-nano interface and anti-tumor activity in preclinical prostate cancer models. Native and PGA-modified AVE1642 display similar ant...
Source: Biomaterials - August 20, 2023 Category: Materials Science Authors: Sonia Vicente-Ruiz Ana Armi ñán Katia Maso Elena Gallon Oleksandr Zagorodko Julie Movellan Fernanda Rodr íguez-Otormín Maike Baues Jan-Niklas May Federica De Lorenzi Twan Lammers Mar ía J Vicent Source Type: research

Sample preparation, crystallization and structure solution of HisC from Mycobacterium tuberculosis
Histidinolphosphate aminotransferase (HisC; Rv1600) from Mycobacterium tuberculosis was overexpressed in M. smegmatis and purified to homogeneity using nickel–nitrilotriacetic acid metal-affinity and gel-filtration chromatography. Diffraction-quality crystals suitable for X-ray analysis were grown by the hanging-drop vapour-diffusion technique using 30% polyethylene glycol monomethyl ether 2000 as the precipitant. The crystals belonged to the hexagonal space group P3221, with an unusual high solvent content of 74.5%. X-ray diffraction data were recorded to 3.08 Å resolution from a single crystal using in-house Cu KÎ...
Source: Acta Crystallographica Section F - March 28, 2013 Category: Biochemistry Authors: Nasir, N.Vyas, R.Biswal, B.K. Tags: histidinolphosphate aminotransferase HisC Mycobacterium tuberculosis Rv1600 crystallization communications Source Type: research

Crystallization and structural analysis of 2-hydroxyacid dehydrogenase from Ketogulonicigenium vulgare.
Abstract L-2-Hydroxyacid dehydrogenase (HDH) from Ketogulonicigenium vulgare Y25 was cloned and overexpressed in Escherichia coli. The protein was purified and crystallized by the sitting-drop vapour-diffusion method with polyethylene glycol 3350 as precipitant. The crystal structure of HDH was determined at 1.64 Å resolution using the molecular replacement method with the crystal structure of hydroxyl (phenyl) pyruvate reductase from Coleus blumei Benth as the search model. The overall structure of HDH was similar to that of hydroxyl(phenyl)pyruvate reductase, consisting of two compact domains separated by a de...
Source: Biotechnology Letters - September 26, 2013 Category: Biotechnology Authors: Han X, Xiong X, Hu X, Li M, Zhang W, Liu X Tags: Biotechnol Lett Source Type: research

Management of faecal incontinence and constipation in adults with central neurological diseases.
CONCLUSIONS: There is still remarkably little research on this common and, to patients, very significant issue of bowel management. The available evidence is almost uniformly of low methodological quality. The clinical significance of some of the research findings presented here is difficult to interpret, not least because each intervention has only been addressed in individual trials, against control rather than compared against each other, and the interventions are very different from each other.There was very limited evidence from individual trials in favour of a bulk-forming laxative (psyllium), an isosmotic macrogol l...
Source: Cochrane Database of Systematic Reviews - December 18, 2013 Category: Journals (General) Authors: Coggrave M, Norton C Tags: Cochrane Database Syst Rev Source Type: research