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Drug: Morphine

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Total 5155 results found since Jan 2013.

In five wastewater treatment plants in Xinjiang, China: Removal processes for illicit drugs, their occurrence in receiving river waters, and ecological risk assessment
In conclusion, to enhance the understanding of the effects of illicit drugs on the environment, future research should expand the list of target analytes.PMID:37517667 | DOI:10.1016/j.chemosphere.2023.139668
Source: Chemosphere - July 30, 2023 Category: Chemistry Authors: Jie Zhao Jianjiang Lu Haijun Zhao Yujun Yan Hongyu Dong Source Type: research

Molecules, Vol. 28, Pages 5766: Targeting Members of the Chemokine Family as a Novel Approach to Treating Neuropathic Pain
ika Neuropathic pain is a debilitating condition that affects millions of people worldwide. Numerous studies indicate that this type of pain is a chronic condition with a complex mechanism that tends to worsen over time, leading to a significant deterioration in patients’ quality of life and issues like depression, disability, and disturbed sleep. Presently used analgesics are not effective enough in neuropathy treatment and may cause many side effects due to the high doses needed. In recent years, many researchers have pointed to the important role of chemokines not only in the development and maintenanc...
Source: Molecules - July 30, 2023 Category: Chemistry Authors: Katarzyna Pawlik Joanna Mika Tags: Review Source Type: research

Multimodal Pain Control Utilizing Buprenorphine for Robotic Assisted Laparoscopic Prostatectomy: A Quality Improvement Comparison to Conventional Opioid Management
CONCLUSIONS: Our study demonstrates buprenorphine's analgesic capabilities to maintain adequate pain control and patient satisfaction compared to conventional opioids during robotic assisted laparoscopic prostatectomy, while decreasing perioperative opioid use.PMID:37498667 | DOI:10.1097/UPJ.0000000000000436
Source: Cancer Control - July 27, 2023 Category: Cancer & Oncology Authors: Mohammad Hajiha Donna Lien Jo Ann Johnson Ivan Muchiutti Jasmine Sran Alexandra Vacaru Akin S Amasyali Leonard Soloniuk Kanha Shete Sonia Wraich Brian Hu Duane D Baldwin Ruth Belay Jonathan Malonado Mohamed Keheila Ashley Li Gary Stier Justin Calvert Melo Source Type: research

Cost-effectiveness analysis of epidural morphine/ropivacaine treatment in patients with cancer pain
CONCLUSION: To present a better cost-effectiveness ratio, a reduction in the cost of the new epidural technology or an increase in the value of the existing oral intervention would be required. However, the latter is not feasible and unlikely to occur. A value judgement to decide whether the incremental benefit associated with the use of the new intervention is worth the extra cost will have to be made by the healthcare provider. Interventions that can relieve cancer pain symptoms should be investigated continuously, in search of evidence to support clinical practice and promote better quality of life for patients.PMID:374...
Source: Cancer Control - July 27, 2023 Category: Cancer & Oncology Authors: Liliana Batista Vieira Carlos Marcelo de Barros Price Udo Price M árcia Helena Miranda Cardoso Podestá Samea Ara újo Pereira Alexander Itria Larissa Helena Torres Leonardo R égis Leira Pereira Source Type: research

Efficacy of opioids for traumatic pain in the emergency department: a systematic review and Bayesian network meta-analysis
Conclusion: Sufentanil, buprenorphine and fentanyl may be superior to other opioid medications in terms of pain relief and the incidence of dizziness, hypotension and pruritus, which might be selected as opioid analgesics for traumatic pain in the emergency setting.
Source: Frontiers in Pharmacology - July 27, 2023 Category: Drugs & Pharmacology Source Type: research

Preparation and Evaluation of the In situ Gel-forming Chitosan Hydrogels for Nasal Delivery of Morphine in a Single Unit dose in Rats to Enhance the Analgesic Responses
CONCLUSION: These data reveal that the IN-chitosan hydrogel could induce fast and prolonged analgesic effects of morphine compare to the IN/IP-Free Mor, which could be considered as an in situ gel-forming thermosensitive chitosan hydrogel for nasal delivery of wide ranges of therapeutic agents.PMID:37491854 | DOI:10.2174/1567201820666230724161205
Source: Current Drug Delivery - July 26, 2023 Category: Drugs & Pharmacology Authors: Hossein Kamali Mohsen Tafaghodi Farhad Eisvand S Mohammad Ahmadi-Soleimani Mina Khajouee Hosnieh Ghazizadeh Jafar Mosafer Source Type: research

Erector spinae plane blocks for analgesia after percutaneous nephrolithotomy: A pathway to reduce opioids
CONCLUSIONS: ESP regional blocks appear to offer an effective adjunct method for pain control after PCNL and may reduce post-PCNL opioid use while maintaining adequate patient analgesia.PMID:37494322 | DOI:10.5489/cuaj.8323
Source: Canadian Urological Association Journal - July 26, 2023 Category: Urology & Nephrology Authors: Jonathan H Berger Waseem Abdou Jacob L Roberts Michelle Leach John F Ryan Saisantosh V Attaluri John J Finneran Roger L Sur Manoj Monga Seth K Bechis Source Type: research

A synergistic analgesic effect of morphine in combination with the CB1 receptor agonist, ACPA, in normal, hypothyroid, and hyperthyroid male rats
Acta Neurobiol Exp (Wars). 2023;83(2):154-170. doi: 10.55782/ane-2023-014.ABSTRACTBoth cannabinoid and opioid receptors are involved in pain behavior. The administration of morphine and cannabis in rats has been shown to decrease thyroid weight and thyroid‑stimulating hormone (TSH) levels. We hypothesized that the third ventricle, due to its adjacency to the hypothalamus, is involved in the modulation of hypothalamic‑pituitary‑thyroid axis activity and descending pain pathways. The present study examined the effect of intra‑third ventricle administration of morphine and cannabis agents on the modulation of pain beh...
Source: Acta Neurobiologiae Experimentalis - July 26, 2023 Category: Neurology Authors: Mohammad-Reza Zarrindast Fatemeh Khakpai Source Type: research

Differential local field potential oscillations in the dorsal striatum and locomotor activity induced by morphine and haloperidol in mice
This study investigated striatal local field potential (LFP) oscillation and locomotor activity following treatments with morphine, a DA release enhancer, and haloperidol (HAL), a DA D2 receptor (D2R) antagonist in mice. After intracranial electrodes were placed into the dorsal striatum of male Swiss albino ICR mice, intraperitoneal injections of morphine or HAL were administered. LFP signals and spontaneous motor activity were recorded simultaneously. The results showed that morphine significantly increased locomotor speed, both low (30.3-44.9 Hz) and high (60.5-95.7 Hz) LFP gamma powers and delta (1-4 Hz)‑gamma (30.3-9...
Source: Acta Neurobiologiae Experimentalis - July 26, 2023 Category: Neurology Authors: Chayaporn Reakkamnuan Dania Cheaha Nifareeda Samerphop Jakkrit Nukitram Ekkasit Kumarnsit Source Type: research

A synergistic analgesic effect of morphine in combination with the CB1 receptor agonist, ACPA, in normal, hypothyroid, and hyperthyroid male rats
Acta Neurobiol Exp (Wars). 2023;83(2):154-170. doi: 10.55782/ane-2023-014.ABSTRACTBoth cannabinoid and opioid receptors are involved in pain behavior. The administration of morphine and cannabis in rats has been shown to decrease thyroid weight and thyroid‑stimulating hormone (TSH) levels. We hypothesized that the third ventricle, due to its adjacency to the hypothalamus, is involved in the modulation of hypothalamic‑pituitary‑thyroid axis activity and descending pain pathways. The present study examined the effect of intra‑third ventricle administration of morphine and cannabis agents on the modulation of pain beh...
Source: Acta Neurobiologiae Experimentalis - July 26, 2023 Category: Neurology Authors: Mohammad-Reza Zarrindast Fatemeh Khakpai Source Type: research

Differential local field potential oscillations in the dorsal striatum and locomotor activity induced by morphine and haloperidol in mice
This study investigated striatal local field potential (LFP) oscillation and locomotor activity following treatments with morphine, a DA release enhancer, and haloperidol (HAL), a DA D2 receptor (D2R) antagonist in mice. After intracranial electrodes were placed into the dorsal striatum of male Swiss albino ICR mice, intraperitoneal injections of morphine or HAL were administered. LFP signals and spontaneous motor activity were recorded simultaneously. The results showed that morphine significantly increased locomotor speed, both low (30.3-44.9 Hz) and high (60.5-95.7 Hz) LFP gamma powers and delta (1-4 Hz)‑gamma (30.3-9...
Source: Acta Neurobiologiae Experimentalis - July 26, 2023 Category: Neurology Authors: Chayaporn Reakkamnuan Dania Cheaha Nifareeda Samerphop Jakkrit Nukitram Ekkasit Kumarnsit Source Type: research

Geriatric Pain Protocol: Impact of Multimodal Pain Care for Elderly Orthopaedic Trauma Patients
Orthop Nurs. 2023 Jul-Aug 01;42(4):202-210. doi: 10.1097/NOR.0000000000000954.ABSTRACTHip fractures are costly, and associated complications are the leading cause of injury-related deaths in persons 65 years or older. Pain medications in this population can be more potent, have a longer duration of action, and have serious side effects (Chau et al., 2008). Hip fractures are projected to reach 6.26 million worldwide by 2050 (Gullberg et al., 1997; Kannus et al., 1996). Morrison et al. (2003) report that uncontrolled pain leads to increased hospital length of stay (LOS), delayed physical therapy, and long-term functional imp...
Source: Pain Physician - July 26, 2023 Category: Anesthesiology Authors: Paulina Andujo Kelsey Yue Karma McKelvey Grant J Dornan Kathleen Breda Source Type: research

Preparation and Evaluation of the In situ Gel-forming Chitosan Hydrogels for Nasal Delivery of Morphine in a Single Unit dose in Rats to Enhance the Analgesic Responses
CONCLUSION: These data reveal that the IN-chitosan hydrogel could induce fast and prolonged analgesic effects of morphine compare to the IN/IP-Free Mor, which could be considered as an in situ gel-forming thermosensitive chitosan hydrogel for nasal delivery of wide ranges of therapeutic agents.PMID:37491854 | DOI:10.2174/1567201820666230724161205
Source: Current Drug Delivery - July 26, 2023 Category: Drugs & Pharmacology Authors: Hossein Kamali Mohsen Tafaghodi Farhad Eisvand S Mohammad Ahmadi-Soleimani Mina Khajouee Hosnieh Ghazizadeh Jafar Mosafer Source Type: research

Erector spinae plane blocks for analgesia after percutaneous nephrolithotomy: A pathway to reduce opioids
CONCLUSIONS: ESP regional blocks appear to offer an effective adjunct method for pain control after PCNL and may reduce post-PCNL opioid use while maintaining adequate patient analgesia.PMID:37494322 | DOI:10.5489/cuaj.8323
Source: Canadian Urological Association Journal - July 26, 2023 Category: Urology & Nephrology Authors: Jonathan H Berger Waseem Abdou Jacob L Roberts Michelle Leach John F Ryan Saisantosh V Attaluri John J Finneran Roger L Sur Manoj Monga Seth K Bechis Source Type: research

A synergistic analgesic effect of morphine in combination with the CB1 receptor agonist, ACPA, in normal, hypothyroid, and hyperthyroid male rats
Acta Neurobiol Exp (Wars). 2023;83(2):154-170. doi: 10.55782/ane-2023-014.ABSTRACTBoth cannabinoid and opioid receptors are involved in pain behavior. The administration of morphine and cannabis in rats has been shown to decrease thyroid weight and thyroid‑stimulating hormone (TSH) levels. We hypothesized that the third ventricle, due to its adjacency to the hypothalamus, is involved in the modulation of hypothalamic‑pituitary‑thyroid axis activity and descending pain pathways. The present study examined the effect of intra‑third ventricle administration of morphine and cannabis agents on the modulation of pain beh...
Source: Acta Neurobiologiae Experimentalis - July 26, 2023 Category: Neurology Authors: Mohammad-Reza Zarrindast Fatemeh Khakpai Source Type: research