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Focal Anticoagulation by Somatic Gene Transfer: Towards Preventing Cardioembolic Stroke
Cardioembolic stroke (CS) has emerged as a leading cause of ischaemic stroke (IS); distinguished by thrombi embolising to the brain from cardiac origins; most often from the left atrial appendage (LAA). Contemporary therapeutic options are largely dependent on systemic anticoagulation as a blanket preventative strategy, yet this does not represent a nuanced or personalised solution. Contraindications to systemic anticoagulation create significant unmedicated and high-risk cohorts, leaving these patients at risk of significant morbidity and mortality.
Source: Heart, Lung and Circulation - June 12, 2023 Category: Cardiology Authors: Megha Kadian, Cindy Y. Kok, Dhanya Ravindran, Freda Passam, Leonardo Pasalic, Eddy Kizana Tags: Original Article Source Type: research

Transcatheter aortic valve replacement with or without anesthesiologist: results from a high-volume single center
Conclusion In patients at low or intermediate risk undergoing transfemoral TAVR, a safe procedure can be performed under local anesthesia without the presence of an anesthesiologist in the catheterization laboratory.
Source: Journal of Cardiovascular Medicine - November 12, 2022 Category: Cardiology Tags: Research articles: Valvular heart disease Source Type: research

FMD and SCAD: Sex-Biased Arterial Diseases With Clinical and Genetic Pleiotropy
Circ Res. 2021 Jun 11;128(12):1958-1972. doi: 10.1161/CIRCRESAHA.121.318300. Epub 2021 Jun 10.ABSTRACTMultifocal fibromuscular dysplasia (FMD) and spontaneous coronary artery dissection are both sex-biased diseases disproportionately affecting women over men in a 9:1 ratio. Traditionally known in the context of renovascular hypertension, recent advances in knowledge about FMD have demonstrated that FMD is a systemic arteriopathy presenting as arterial stenosis, aneurysm, and dissection in virtually any arterial bed. FMD is also characterized by major cardiovascular presentations including hypertension, stroke, and myocardi...
Source: Circulation Research - June 10, 2021 Category: Cardiology Authors: Esther S H Kim Jacqueline Saw Daniella Kadian-Dodov Malissa Wood Santhi K Ganesh Source Type: research

Effect of morphine use on oral P2Y12 platelet inhibitors in acute myocardial infarction: Meta-analysis
ConclusionCo-administration of morphine with P2Y12 inhibitors possibly decreases their efficacy in platelet inhibition. However, this did not translate into higher adverse outcomes due to low event rates, inadequate for analysis. A large randomized study is needed to evaluate the narcotic-P2Y12 interaction.
Source: Indian Heart Journal - March 20, 2019 Category: Cardiology Source Type: research

The safety of morphine use in acute coronary syndrome: a meta-analysis
Conclusion The use of morphine for pain control in ACS was associated with an increased risk of in-hospital recurrent MI. Randomised clinical trials are needed to further investigate the safety of morphine in ACS.
Source: Heart Asia - March 19, 2019 Category: Cardiology Authors: Ghadban, R., Enezate, T., Payne, J., Allaham, H., Halawa, A., Fong, H. K., Abdullah, O., Aggarwal, K. Tags: Open access Original research Source Type: research

Effect of morphine use on oral P2Y12 platelet inhibitors in acute myocardial infarction: Meta-analysis.
CONCLUSION: Co-administration of morphine with P2Y12 inhibitors possibly decreases their efficacy in platelet inhibition. However, this did not translate into higher adverse outcomes because of low event rates, inadequate for analysis. A large randomized study is needed to evaluate the narcotic-P2Y12 interaction. PMID: 31280824 [PubMed - in process]
Source: Indian Heart J - February 28, 2019 Category: Cardiology Authors: Vaidya GN, Khan A, Ghafghazi S Tags: Indian Heart J Source Type: research

Morphine and Ticagrelor Interaction in Primary Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction: ATLANTIC-Morphine
ConclusionsMorphine-treatment was associated with increased GP IIb/IIIa inhibitor use, less pre-PCI TIMI 3 flow, and more bleeding. Judicious morphine use is advised with non-opioid analgesics preferred for non-severe acute pain.Trial Registrationclinicaltrials.gov identifier: NCT01347580.
Source: American Journal of Cardiovascular Drugs - October 23, 2018 Category: Cardiology Source Type: research

Correlates of pre-hospital morphine use in ST-elevation myocardial infarction patients and its association with in-hospital outcomes and long-term mortality: the FAST-MI (French Registry of Acute ST-elevation and non-ST-elevation Myocardial Infarction) programme
Conclusion In two independent everyday-life cohorts, pre-hospital morphine use in STEMI patients was not associated with worse in-hospital complications and 1-year mortality. Clinical trial registration Clinicaltrials.gov identifier: NCT00673036 (FAST-MI 2005); NCT01237418 (FAST-MI 2010).
Source: European Heart Journal - March 31, 2016 Category: Cardiology Authors: Puymirat, E., Lamhaut, L., Bonnet, N., Aissaoui, N., Henry, P., Cayla, G., Cattan, S., Steg, G., Mock, L., Ducrocq, G., Goldstein, P., Schiele, F., Bonnefoy-Cudraz, E., Simon, T., Danchin, N. Tags: Acute coronary syndromes Source Type: research

0209: Long-term clinical impact of pre-hospital morphine use in ST-elevation myocardial infarction patients. FAST-MI 2010 registry
Conclusion Pre-hospital morphine use was not associated with an increase of in-hospital complication and one-year mortality; and, could be more used as recommended in the current guidelines.
Source: Archives of Cardiovascular Diseases Supplements - February 12, 2015 Category: Cardiology Source Type: research